TRANSLATIONAL RESEARCH CORE FACILITY
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Director:
John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu
Operations Director: Paul Hartman, MS
Manager of Dahms Clinical Research Unit Core Lab
phh@case.edu
CCF Site Director:
Ram N. Ganapathi, PhD
Professor, Hematology & Medical Oncology
ganapar@ccf.org
The mission of the Translational Research Core (TRC) Facility is to enable and assist research studies using clinical samples from patients enrolled in clinical trials. The scientific director fosters interactions between basic scientists and clinicians to ensure the inclusion of scientifically sound correlative studies in Phase I and Phase II clinical trials. TRC personnel, in cooperation with Cancer Center nurses and the Dahms Clinical Research Unit, procure, log, process, store and ship research samples as per instructions specific to each clinical trial protocol. The core also does sample processing for multi-parametric flow cytometry and protein isolation, Western blotting, telomerase assays and ELISA assays. TRC personnel also assist in preparing methods sections and budgets for LOIs and protocols, as well as submitting data and reimbursement forms, as per CTEP-sponsored Translational Research Initiative (TRI) stipulations. The TRC provides clinicians with a well-trained laboratory team to ensure proper handling, tracking, data management, delivery and analyses of the research samples critical to the correlative studies component of Case CCC clinical trials.
List of Services:
- Consultation and Data Management
a. Protocol startup
b. Identification of relevant laboratory correlates
c. Generation of correlate sections for LOIs and protocols
d. Development of instructions and SOPs
e. Budget development
f. Assistance with CTEP reimbursement
g. Data entry and tracking of samples using the Oncore database
h. Data analysis - Sample Processing
a. Aliquot whole blood
b. Routine Blood Processing
c. Lymphocyte separation
d. RNA Isolation
e. DNA Isolation
f. Protein Isolation - Sample Receiving, Storage, and Distribution
a. Sample retrieval & logging
b. Pathology
c. Shipping (off campus)
d. Delivery (on campus) - Lab Analysis
a. Western Blot
b. Western Blot Reprobing
c. Flow cytometry processing
d. Laser Scanning Cytometry
e. Histology
f. Path Analysis
g. Telomerase Assay
Fees
Please click here to see fees. (PDF)
Contact for Information
| Location: | Dahms Clinical Research Unit 7th Floor, Horvitz Tower |
| Director: | John J. Pink, PhD |
| Phone: | 216/368-5420 |
| E-mail: | john.pink@case.edu |
| Operations Director: | Paul Hartman, MS |
| Phone: | 216/844-1369 |
| E-mail: | phh@case.edu |
| CCF Site Director: | Ram N. Ganapathi, PhD |
| Phone: | 216/444-2085 |
| E-mail: | ganapar@ccf.org |
| Manager: | Erin Hohler |
| Phone: | 216/844-5562 |
| Fax: | 216/983-0815 |
| E-mail: | emh14@case.edu |