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Imaging Research Core Facility
Director: Chris A. Flask, PhD
Assistant Professor, Radiology and Biomedical Engineering
flask@case.edu
Assistant Director: Lan Lu, PhD
Instructor, Radiology
Lulan07@gmail.com
Concorde R4 microPET Scanner
We have a microPET R4 scanner manufactured by Concorde MicroSystems, Knoxville, TN. The scanner uses LSO crystals to detect annihilation photons in temporal coincidence. The field of view is 8 cm long by 10 cm diameter and can accommodate a pair of mice or a rat. Spatial resolution in images is about 2 mm isotropic. Data are collected in "listmode" fashion allowing temporal binning to be specified retrospectively. Detailed performance characteristics of this scanner have been published [1].
PET imaging is done using radiolabeled pharmaceuticals. The most commonly used label is 18F but 11C, 13N, 15O and some others have been used. The most common radiopharmaceutical used is 2-fluoro-[18F]-2-deoxy-glucose (aka FDG) and this is routinely available. Please contact Raymond Muzic regarding availability of other radiopharmaceuticals.
To keep animals still for imaging, anesthesia is routinely used. Isoflurane is the preferred anesthetic and we have a special anesthesia machine designed for mice and rats.
Availability
This instrument is part of the imaging facility and as such is treated as a university resource. Researchers from all departments are welcome to develop projects and protocols that use it.
Fees
| $250/hour | Basic scan charges, standard image reconstruction |
| $25/animal | Insertion of catheter in tail vein |
| $40/dose | FDG |
| $20/hour | Isoflurane anesthesia |
Contact
The R4 microPET scanner was purchased on grant from The Ohio Board of Regents Hayes Investment Fund, PI: J. Duerk.
For More Information
Marketing for the scanner is being done via PETNET Pharmaceuticals.
View the Pubmed entry for the Knoess 2003 article.