MOLECULAR BASIS OF CANCER
PROGRAM LEADERS
|
George R. Stark, PhD Professor, Molecular Genetics starkg@ccf.org |
|
Susann M. Brady-Kalnay, PhD Associate Professor, Molecular Biology & Microbiology smb4@case.edu |
Program Themes | Program Information | Program Members | Focus Groups
PROGRAM THEMES
- To determine how specific stimuli alter gene expression to generate inflammatory responses that predispose to malignancy
- To investigate the roles in carcinogenesis and the mechanisms of aberrant cell migration, inappropriate activation of growth factor receptors and misregulation of the core transcriptional machinery
- To bring sophisticated up-to-date high resolution analysis of protein structure increasingly to bear on proteins that play important roles in cancer
PROGRAM INFORMATION
The major scientific focus of this program is to provide improved understanding of some of the major signaling pathways that contribute to cancer, especially the important connection between inflammation and cancer and the roles of EGFR, nuclear receptors, transcription factors and chromatin remodeling proteins in specific malignancies (breast, colorectal and lung cancer, glioma). Structural biology and functional screening are being utilized to determine structures of molecules of interest in cancer and to identify novel molecular targets.
The Molecular Basis of Cancer Program is organized around 3 focus areas:
- Inflammation and Cancer - includes studies of pathogen associated molecular patterns (PAMPS) and cytokines, which induce inflammation, and inducible transcription factors, especially STAT3 and NFkB, which mediate the cellular responses.
- Aberrant Signaling - includes contributions to cancer of cell migration, aberrant activation of growth factor receptors, aberrant gene expression through misregulation of core transcriptional machinery and chromatin remodeling.
- Structural Biology - includes determination of high resolution structures of proteins important in cancer.
PROGRAM MEMBERS
Eben Alsberg, PhD
Assistant Professor, Biomedical Engineering
eben.alsberg@case.edu
Bela Anand-Apte, MD, PhD
Associate Professor, Ophthalmology/Cell Biology
anandab@ccf.org
Erik D. Andrulis, PhD
Assistant Professor, Molecular Biology & Microbiology
erik.andrulis@case.edu
Suneel S. Apte, MBBS, DPhil
Associate Professor, Biomedical Engineering
aptes@bme.ri.ccf.org
Harihara Baskaran, PhD
Associate Professor, Chemical Engineering
hxb35@case.edu
W. Henry Boom, MD
Professor, Medicine-Infectious Diseases
whb@case.edu
Susann M. Brady-Kalnay, PhD
Associate Professor, Molecular Biology & Microbiology
smb4@case.edu
Matthias Buck, PhD
Associate Professor, Physiology & Biophysics
mxb150@case.edu
Paul R. Carey, PhD
Professor, Biochemistry
prc5@case.edu
Cathleen R. Carlin, PhD
Professor, Physiology & Biophysics
cxc39@case.edu
Pamela B. Davis, MD, PhD
Professor, Pediatrics-Pulmonology
pbd@case.edu
Paul E. DiCorleto, PhD
Professor, Cell Biology, Physiology & Biophysics
dicorlp@ccf.org
Thomas T. Egelhoff, PhD
Professor, Cell Biology
tte@case.edu
Maria Febbraio, PhD
Associate Professor, Cell Biology
febbram@ccf.org
Paul L. Fox, PhD
Professor, Cell Biology
foxp@ccf.org
Candece L. Gladson, MD
Staff, Cancer Biology
gladsoc@ccf.org
Anton V. Gorbachev, PhD
Instructor, Immunology
gorbaca@ccf.org
Edward M. Greenfield, PhD
Professor, Orthopaedics
emg3@case.edu
Thomas A. Hamilton, PhD
Professor, Immunology
hamiltt@ccf.org
Saikh Jaharul Haque, PhD
Assistant Professor, Cancer Biology
haquej@ccf.org
Arie Horowitz, DSc
Assistant Staff, Molecular Cardiology
horowia@ccf.org
Mukesh K. Jain, MD
Professor, Medicine-Cardiology
mukesh.jain2@case.edu
Eckhard Jankowsky, PhD
Associate Professor, Biochemistry
exj13@case.edu
Hung-Ying Kao, PhD
Associate Professor, Biochemistry
hxk43@case.edu
Ruth A. Keri, PhD
Associate Professor, Pharmacology
rak5@case.edu
Jeffrey A. Kern, MD
Professor, Medicine-Pulmonary & Critical Care
jeffrey.kern@UHhospitals.org
Alan D. Levine, PhD
Professor, Medicine-Gastroenterology
adl4@case.edu
Xiaoxia Li, PhD
Professor, Immunology
lix@ccf.org
Paul N. MacDonald, PhD
Associate Professor, Pharmacology
pnm2@case.edu
Danny Manor, PhD
Associate Professor, Nutrition
danny.manor@case.edu
Keith R. McCrae, MD
Professor, Medicine-Hematology/Oncology
keith.mccrae@case.edu
Saurav Misra, PhD
Assistant Professor, Molecular Cardiology
misras@ccf.org
Monica M. Montano, PhD
Associate Professor, Pharmacology
mxm126@case.edu
Timothy W. Nilsen, PhD
Professor, RNA Molecular Biology
twn@case.edu
Noa Noy, PhD
Professor, Pharmacology
noa.noy@case.edu
Patricia Parsons-Wingerter, PhD
Adjunct Staff, Cell Biology, John Glenn Research Center, NASA
patricia.parsons@grc.nasa.gov
John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu
Edward F. Plow, PhD
Professor, Molecular Cardiology
plowe@ccf.org
Aaron Proweller, MD, PhD
Assistant Professor, Medicine- Cardiovascular Medicine
aaron.proweller@case.edu
Jun Qin, PhD
Professor, Molecular Cardiology
qinj@ccf.org
Diana L. Ramirez-Bergeron, PhD
Assistant Professor, Medicine-Cardiology
diana.ramirez@case.edu
Takao Sakai, MD, PhD
Assistant Professor, Biomedical Engineering
sakait@ccf.org
Alvin H. Schmaier, MD
Professor, Medicine-Hematology/Oncology
alvin.schmaier@case.edu
Ganes C. Sen, PhD
Professor, Molecular Genetics
seng@ccf.org
Menachem Shoham, PhD
Associate Professor, Biochemistry
mxs10@case.edu
Roy L. Silverstein, MD
Professor, Cell Biology
silverr2@ccf.org
Daniel I. Simon, MD
Professor, Medicine-Cardiology
daniel.simon@UHhospitals.org
Khalid Sossey-Alaoui, PhD
Project Staff, Molecular Cardiology
sosseyk@ccf.org
George R. Stark, PhD
Professor, Molecular Genetics
starkg@ccf.org
Derek J. Taylor, PhD
Assistant Professor, Pharmacology
derek.taylor@case.edu
Qing K. Wang, PhD, MBA
Professor, Molecular Cardiology
wangq2@ccf.org
Robert J. Weil, MD
Staff, Neurological Surgery
weilr@ccf.org
Michael A. Weiss, MD, PhD
Professor, Biochemistry
michael.weiss@case.edu
Wei Xin, MD, PhD
Assistant Professor, Pathology
wei.xin@case.edu
Vivien C. Yee, PhD
Associate Professor, Biochemistry
vcy2@case.edu
Qing Yin Zheng, MD
Assistant Professor, Otolaryngology
qyz@case.edu
Alan J. Zhu, PhD
Assistant Professor, Cell Biology, Genetics
zhua@ccf.org