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MOLECULAR BASIS OF CANCER

PROGRAM LEADERS

Dr. Stark George R. Stark, PhD
Professor, Molecular Genetics
starkg@ccf.org
Dr. Brady-Kalnay Susann M. Brady-Kalnay, PhD
Associate Professor, Molecular Biology & Microbiology
smb4@case.edu

Program Themes | Program Information | Program Members | Focus Groups


PROGRAM THEMES

  • To determine how specific stimuli alter gene expression to generate inflammatory responses that predispose to malignancy
  • To investigate the roles in carcinogenesis and the mechanisms of aberrant cell migration, inappropriate activation of growth factor receptors and misregulation of the core transcriptional machinery
  • To bring sophisticated up-to-date high resolution analysis of protein structure increasingly to bear on proteins that play important roles in cancer

PROGRAM INFORMATION

The major scientific focus of this program is to provide improved understanding of some of the major signaling pathways that contribute to cancer, especially the important connection between inflammation and cancer and the roles of EGFR, nuclear receptors, transcription factors and chromatin remodeling proteins in specific malignancies (breast, colorectal and lung cancer, glioma). Structural biology and functional screening are being utilized to determine structures of molecules of interest in cancer and to identify novel molecular targets.

The Molecular Basis of Cancer Program is organized around 3 focus areas:

  1. Inflammation and Cancer - includes studies of pathogen associated molecular patterns (PAMPS) and cytokines, which induce inflammation, and inducible transcription factors, especially STAT3 and NFkB, which mediate the cellular responses.
  2. Aberrant Signaling - includes contributions to cancer of cell migration, aberrant activation of growth factor receptors, aberrant gene expression through misregulation of core transcriptional machinery and chromatin remodeling.
  3. Structural Biology - includes determination of high resolution structures of proteins important in cancer.

PROGRAM MEMBERS

Eben Alsberg, PhD
Assistant Professor, Biomedical Engineering
eben.alsberg@case.edu

Bela Anand-Apte, MD, PhD
Associate Professor, Ophthalmology/Cell Biology
anandab@ccf.org

Erik D. Andrulis, PhD
Assistant Professor, Molecular Biology & Microbiology
erik.andrulis@case.edu

Suneel S. Apte, MBBS, DPhil
Associate Professor, Biomedical Engineering
aptes@bme.ri.ccf.org

Harihara Baskaran, PhD
Associate Professor, Chemical Engineering
hxb35@case.edu

W. Henry Boom, MD
Professor, Medicine-Infectious Diseases
whb@case.edu

Susann M. Brady-Kalnay, PhD
Associate Professor, Molecular Biology & Microbiology
smb4@case.edu

Matthias Buck, PhD
Associate Professor, Physiology & Biophysics
mxb150@case.edu

Paul R. Carey, PhD
Professor, Biochemistry
prc5@case.edu

Cathleen R. Carlin, PhD
Professor, Physiology & Biophysics
cxc39@case.edu

Pamela B. Davis, MD, PhD
Professor, Pediatrics-Pulmonology
pbd@case.edu

Paul E. DiCorleto, PhD
Professor, Cell Biology, Physiology & Biophysics
dicorlp@ccf.org

Thomas T. Egelhoff, PhD
Professor, Cell Biology
tte@case.edu

Maria Febbraio, PhD
Associate Professor, Cell Biology
febbram@ccf.org

Paul L. Fox, PhD
Professor, Cell Biology
foxp@ccf.org

Candece L. Gladson, MD
Staff, Cancer Biology
gladsoc@ccf.org

Anton V. Gorbachev, PhD
Instructor, Immunology
gorbaca@ccf.org

Edward M. Greenfield, PhD
Professor, Orthopaedics
emg3@case.edu

Thomas A. Hamilton, PhD
Professor, Immunology
hamiltt@ccf.org

Saikh Jaharul Haque, PhD
Assistant Professor, Cancer Biology
haquej@ccf.org

Arie Horowitz, DSc
Assistant Staff, Molecular Cardiology
horowia@ccf.org

Mukesh K. Jain, MD
Professor, Medicine-Cardiology
mukesh.jain2@case.edu

Eckhard Jankowsky, PhD
Associate Professor, Biochemistry
exj13@case.edu

Hung-Ying Kao, PhD
Associate Professor, Biochemistry
hxk43@case.edu

Ruth A. Keri, PhD
Associate Professor, Pharmacology
rak5@case.edu

Jeffrey A. Kern, MD
Professor, Medicine-Pulmonary & Critical Care
jeffrey.kern@UHhospitals.org

Alan D. Levine, PhD
Professor, Medicine-Gastroenterology
adl4@case.edu

Xiaoxia Li, PhD
Professor, Immunology
lix@ccf.org

Paul N. MacDonald, PhD
Associate Professor, Pharmacology
pnm2@case.edu

Danny Manor, PhD
Associate Professor, Nutrition
danny.manor@case.edu

Keith R. McCrae, MD
Professor, Medicine-Hematology/Oncology
keith.mccrae@case.edu

Saurav Misra, PhD
Assistant Professor, Molecular Cardiology
misras@ccf.org

Monica M. Montano, PhD
Associate Professor, Pharmacology
mxm126@case.edu

Timothy W. Nilsen, PhD
Professor, RNA Molecular Biology
twn@case.edu

Noa Noy, PhD
Professor, Pharmacology
noa.noy@case.edu

Patricia Parsons-Wingerter, PhD
Adjunct Staff, Cell Biology, John Glenn Research Center, NASA
patricia.parsons@grc.nasa.gov

John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu

Edward F. Plow, PhD
Professor, Molecular Cardiology
plowe@ccf.org

Aaron Proweller, MD, PhD
Assistant Professor, Medicine- Cardiovascular Medicine
aaron.proweller@case.edu

Jun Qin, PhD
Professor, Molecular Cardiology
qinj@ccf.org

Diana L. Ramirez-Bergeron, PhD
Assistant Professor, Medicine-Cardiology
diana.ramirez@case.edu

Takao Sakai, MD, PhD
Assistant Professor, Biomedical Engineering
sakait@ccf.org

Alvin H. Schmaier, MD
Professor, Medicine-Hematology/Oncology
alvin.schmaier@case.edu

Ganes C. Sen, PhD
Professor, Molecular Genetics
seng@ccf.org

Menachem Shoham, PhD
Associate Professor, Biochemistry
mxs10@case.edu

Roy L. Silverstein, MD
Professor, Cell Biology
silverr2@ccf.org

Daniel I. Simon, MD
Professor, Medicine-Cardiology
daniel.simon@UHhospitals.org

Khalid Sossey-Alaoui, PhD
Project Staff, Molecular Cardiology
sosseyk@ccf.org

George R. Stark, PhD
Professor, Molecular Genetics
starkg@ccf.org

Derek J. Taylor, PhD
Assistant Professor, Pharmacology
derek.taylor@case.edu

Qing K. Wang, PhD, MBA
Professor, Molecular Cardiology
wangq2@ccf.org

Robert J. Weil, MD
Staff, Neurological Surgery
weilr@ccf.org

Michael A. Weiss, MD, PhD
Professor, Biochemistry
michael.weiss@case.edu

Wei Xin, MD, PhD
Assistant Professor, Pathology
wei.xin@case.edu

Vivien C. Yee, PhD
Associate Professor, Biochemistry
vcy2@case.edu

Qing Yin Zheng, MD
Assistant Professor, Otolaryngology
qyz@case.edu

Alan J. Zhu, PhD
Assistant Professor, Cell Biology, Genetics
zhua@ccf.org

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