CWRU Links
Translational Research & Pharmacology

Services and Technologies

List of Services

  • Consultation on design and implementation of Correlative Studies for Clinical Trials
  • Sample Handling (receiving, tracking, storage, distribution)
  • Sample Processing (blood, tissue and paraffin block processing)
    • Routine Blood Processing (PBMC, serum, or plasma isolation)
    • DNA, RNA, protein extraction
    • Flow or laser scanning cytometry staining
  • Lab Analysis
    • Standard ELISAs (Fluorescent or Luminescent platforms)
    • MSD Multiplex Analysis (Mesoscale Electrochemiluminescence platform)
    • Comet assays
  • Preclinical Drug Testing
    • Single or multiple agent cytotoxicity (MTT or DNA content assays)
    • Multiple agent analysis (Synergy analysis)
    • Other single or multiple agent assays (e.g., flow cytometry)
    • Cell Line verification (STR analysis)
    • Mycoplasma testing
  • Pharmacokinetic assay development
    • Pharmacokinetic expertise for investigator-initiated early phase studies with planned PK analyses
    • Sample procurement schedules for pharmacokinetic assays given anticipated or known PK profiles of investigational agents
    • Design and development of analytical methods
    • Adoption and validation of established analytical procedures
  • Pharmacokinetic assay performance
    • Quantitative measurement of drugs, metabolites, and other small molecules
    • Pharmacokinetic data analysis

Translational Research Laboratory Resources

  • Mesoscale (MSD) SECTOR® Imager 2400 multiplex analyzer
  • Maxwell 16 research system (automated DNA/RNA isolation)
  • Nanodrop 2.0 spectrophotometer
  • Leica phase contrast inverted microscope
  • Comet analysis electrophoresis system & Komet version 5.5 analysis Software
  • Refrigerated centrifuges & microcentrifuges
  • -70 C Freezers with integrated alarm systems
  • Laminar flow hoods and CO2 Tissue Culture Incubators

Pharmacology Laboratory Resources

  • Applied Biosystems API 3200 triple quadrupole tandem mass spectrometer
  • Shimadzu LC-20 series HPLC system
  • SPD-M20A photodiode array/RF-10AxL fluorescence detectors
  • SIL-20AC refrigerated autosampler
  • Agilent 6540 accurate-mass quadrupole time-of-flight (Q-TOF) mass spectrometer
  • Agilent 1290 ultra-high performance liquid chromatography (UPLC) system
  • Photodiode array (PDA) detector
  • Equipment for biological sample preparation and storage
  • Computers and data storage devices
  • Software for pharmacokinetic and pharmacodynamic analyses

Acknowledgement

Remember to acknowledge the valuable services provided by Cancer Center Core Facilities in your research papers and publications: 
"This research was supported by the Translational Research Core Facility of the Case Comprehensive Cancer Center (P30 CA43703)."

Contact for Information

Seidman Cancer CenterDirector: John J. Pink, PhD
216.368.5420
jrp16@case.edu

Operations Director: Paul Hartman, MS
216.844.1369
phh@case.edu

Manager: Erin Hohler
Seidman Cancer Center, Rm. 3608
216.286.3889/216.368.3890
fax 216.983.0815
emh14@case.edu

Cancer Pharmacology LabCo-Director (Pharmacology): Yan Xu, PhD
216.368.0315
Wolstein Research Building
yan.xu@case.edu

Taussig Cancer InstituteDirector: Daniel J. Lindner, MD, PhD
216.445.0548
lindned@ccf.org

Manager: Marcella Mance
Taussig Cancer Institute R4-054
216.444.5393
mancem@ccf.org

Director

John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu

Co-Director (Pharmacology)

Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu

Cleveland Clinic Site Director

Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology
lindned@ccf.org

Operations Director

Paul Hartman, MS
Manager of Dahms Clinical Research Unit Core Lab
phh@case.edu

Preclinical Drug Development & Testing Laboratory

Additional services are offered through the Preclinical Drug Development & Testing Laboratory.