CWRU Links
Translational Research & Pharmacology

Services and Technologies

List of Services

  • Consultation on design and implementation of Correlative Studies for Clinical Trials
  • Sample Handling (receiving, tracking, storage, distribution)
  • Sample Processing (blood, tissue and paraffin block processing)
    • Routine Blood Processing (PBMC, serum, or plasma isolation)
    • DNA, RNA, protein extraction
    • Flow or laser scanning cytometry staining
  • Lab Analysis
    • Standard ELISAs (Fluorescent or Luminescent platforms)
    • MSD Multiplex Analysis (Mesoscale Electrochemiluminescence platform)
    • Comet assays
  • Preclinical Drug Testing
    • Single or multiple agent cytotoxicity (MTT or DNA content assays)
    • Multiple agent analysis (Synergy analysis)
    • Other single or multiple agent assays (e.g., flow cytometry)
    • Cell Line verification (STR analysis)
    • Mycoplasma testing
  • Pharmacokinetic assay development
    • Pharmacokinetic expertise for investigator-initiated early phase studies with planned PK analyses
    • Sample procurement schedules for pharmacokinetic assays given anticipated or known PK profiles of investigational agents
    • Design and development of analytical methods
    • Adoption and validation of established analytical procedures
  • Pharmacokinetic assay performance
    • Quantitative measurement of drugs, metabolites, and other small molecules
    • Pharmacokinetic data analysis

Translational Research Laboratory Resources

  • Mesoscale (MSD) SECTOR® Imager 2400 multiplex analyzer
  • Maxwell 16 research system (automated DNA/RNA isolation)
  • Nanodrop 2.0 spectrophotometer
  • Leica phase contrast inverted microscope
  • Comet analysis electrophoresis system & Komet version 5.5 analysis Software
  • Refrigerated centrifuges & microcentrifuges
  • -70 C Freezers with integrated alarm systems
  • Laminar flow hoods and CO2 Tissue Culture Incubators

Pharmacology Laboratory Resources

  • Applied Biosystems API 3200 triple quadrupole tandem mass spectrometer
  • Shimadzu LC-20 series HPLC system
  • SPD-M20A photodiode array/RF-10AxL fluorescence detectors
  • SIL-20AC refrigerated autosampler
  • Agilent 6540 accurate-mass quadrupole time-of-flight (Q-TOF) mass spectrometer
  • Agilent 1290 ultra-high performance liquid chromatography (UPLC) system
  • Photodiode array (PDA) detector
  • Equipment for biological sample preparation and storage
  • Computers and data storage devices
  • Software for pharmacokinetic and pharmacodynamic analyses


Remember to acknowledge the valuable services provided by Cancer Center Core Facilities in your research papers and publications: 
"This research was supported by the Translational Research Core Facility of the Case Comprehensive Cancer Center (P30 CA43703)."

Contact for Information

Seidman Cancer CenterDirector: John J. Pink, PhD

Operations Director: Paul Hartman, MS

Manager: Erin Hohler
Seidman Cancer Center, Rm. 3608
fax 216.983.0815

Cancer Pharmacology LabCo-Director (Pharmacology): Yan Xu, PhD
Wolstein Research Building

Taussig Cancer InstituteDirector: Daniel J. Lindner, MD, PhD

Manager: Marcella Mance
Taussig Cancer Institute R4-054


John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)

Co-Director (Pharmacology)

Yan Xu, PhD
Professor, Chemistry

Cleveland Clinic Site Director

Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology

Operations Director

Paul Hartman, MS
Manager of Dahms Clinical Research Unit Core Lab

Preclinical Drug Development & Testing Laboratory

Additional services are offered through the Preclinical Drug Development & Testing Laboratory.