The Athymic Animal & Xenograft Core consists of two physical sites, one at Case Western Reserve University and one at Cleveland Clinic at the Taussig Cancer Institute. The purpose of the core is to help principal investigators of CWRU and Cleveland Clinic perform tumor experiments, angiogenesis studies, and pharmacokinetic studies in mice. The Core routinely conducts animal experiments involving several syngeneic murine tumor models, and several human xenograft (athymic nude mouse, and NSG – NOD scid IL2Rg mouse) tumor models. In addition, the Core has developed several orthotopic tumor models: brain, lung, breast, renal, spleen, skin, ovarian, prostate, bladder, and pancreas. The Core is always willing to develop additional new models.
Core services utilize murine models to facilitate in vivo cancer drug screening, drug evaluation and drug development. Core services include drug administration (sub-cutaneous, intravenous, intraperitoneal, prolonged slow-release silastic capsule), blood drawing (repetitive - saphenous vein, or terminal – cardiac puncture) for pharmacokinetic pharmacodynamic (PK/PD) studies, absorption distribution metabolism excretion (ADME) studies, syngeneic and xenograft tumor models, orthotopic tumor models. The goal is to help in evaluation of new pharmacologic agents by providing data on tumor growth, metastasis, angiogenesis, and gene expression. The facility also provides consultation services to assist the investigator in all aspects of animal tumor model development.
NSG mouse (NOD/SCID/IL2Rgamma) breeding:
Athymic mouse (NCR nu/nu) breeding:
Athymic mouse (NOD/SCID) breeding:
Animal housing, mice:
Animal housing, rats:
Experimental techniques training:
Services Provided at CWRU
Services Provided at the Taussig Cancer Institute, Cleveland Clinic
Remember to acknowledge the valuable services provided by Cancer Center Core Facilities in your research papers and publications:
"This research was supported by the Athymic Animal and Xenograft Core Facility of the Case Comprehensive Cancer Center (P30CA043703)."
|CWRU FACILITY||TAUSSIG FACILITY|
|Location: School of Medicine, East B21, 22, 23
Wolstein Research Bldg, SB162
|Location: Lerner Research Institute, NC4-12B|
|Manager: Kristen Lozada
|Director: Daniel J. Lindner, MD, PhD
|Experimental Design Consultant: Ruth Keri, PhD
|Research Technologist: Yvonne Parker
|Veterinary Services: W. John Durfee, DVM
|Core Technician: Pamela Steele