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Case Comprehensive Cancer Center

Postdoctoral Openings

Postdoctoral Openings

Lab of:                                 Nima Sharifi, MD

Department:                      Cancer Biology

Postdocs Needed:           1

Position Description: A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology. 

Our laboratory is focused on molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

  1. Metabolic and genetic changes required for androgen synthesis
  2. Clinical validation in patients and clinical trials utilizing innovative approaches
  3. Animal models of advanced prostate cancer for translational and therapeutic studies
  4. Identifying targets for the development of new pharmacologic therapies

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44).  We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51) and that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51).   We are currently working toward defining the relationship between metabolite generation and treatment response in patients and identifying new chemical entities that are determinants of treatment response.

Previously, we discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite.  This metabolic pathway occurs in patient tumors (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33). 

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates should hold a doctoral degree with a background in molecular biology, metabolism or cancer biology.  Candidates must have proficiency in verbal and written English. 

Application Information: Candidates with an interest in the position should send their cv and contact information for 3 references to:
Nima Sharifi, MD
Kendrick Family Chair for Prostate Cancer Research
Department of Cancer Biology
Lerner Research Institute
Cleveland Clinic, 9500 Euclid Avenue
Cleveland, OH 44195
sharifn@ccf.org

Current as of:                    June 14, 2017


Lab of:                                 Susann M. Brady-Kalnay, PhD

Department:                      Molecular Biology and Microbiology

Postdocs Needed:           1

Position Description: A postdoctoral position is available to develop molecular imaging agents aimed at detecting tumor cells. We are recruiting a highly motivated and creative team player to help us develop innovative methods in molecular imaging of cancer. This NIH-funded work is being conducted at Case Western Reserve University in Cleveland, OH.

The project will involve members of the Case Center for Imaging Research. The scientific team includes postdocs, graduate students, and research associates with expertise in physics, chemistry, tumor biology and biomedical engineering. Minimum qualifications include a Ph.D. in chemistry, physics, biology, or biomedical engineering.

The position is open for a 2-3 year postdoctoral fellowship. U.S. citizens and permanent residents will be considered for a training grant position.

Application Information: Interested individuals should send their CV Susann Brady-Kalnay (susann.brady-kalnay@case.edu), who will provide further information on formal application procedures.

Susann M. Brady-Kalnay, PhD
Department of Molecular Biology and Microbiology
Case Western Reserve University
Cleveland, OH 44106
susann.bradykalnay@case.edu

Current as of:                    June 14, 2017