CWRU Links
GU Malignancies

Program Themes

  • Molecular basis of prostate and renal cancer development and progression
  • Novel biomarkers and tumor-based targets for chemoprevention and treatment
  • Stromal and host factors in prostate and renal cancer including inflammation, immunomodulation and angiogenesis
  • Translational research and novel investigator-initiated clinical trials

Program Information

The overarching goal of the GU Malignancies Program is to explore fundamental biologic pathways of critical importance to the development and progression of prostate and renal cancer and to foster translational, investigator-initiated clinical trials to advance therapeutic options.

To provide additional structure and promote cohesion within the larger Program, investigators have been further organized around two scientific focus areas:

  • Prostate Cancer - includes genetic susceptibility and molecular basis, chemoprevention, molecular biomarkers of prognosis and therapeutic targeting of the IGF and PI3K/Akt/mTOR axis
  • Renal Cancer - includes molecular and clinical biomarkers of prognosis, response and resistance; immunomodulatory effects of treatment, and therapeutic targeting of angiogenesis and the PI3K/Akt/mTOR axis

Program Members

Tatiana V. Byzova, PhD
Assistant Professor, Molecular Cardiology

Steven C. Campbell, MD, PhD
Professor, Urology

Edward E. Cherullo, MD
Associate Professor, Urology

Jay P. Ciezki, MD
Associate Professor, Radiation Oncology

Matthew M. Cooney, MD
Associate Professor, Medicine-Hematology/Oncology

David Danielpour, PhD
Professor, General Medical Sciences (Oncology)

Joseph A. DiDonato, PhD
Assistant Professor, Cancer Biology

James H. Finke, PhD
Professor, Immunology

Jorge A. Garcia, MD
Assistant Professor, Solid Tumor Oncology

Brian R. Gastman, MD
Associate Professor, Plastic Surgery and Immunology

Timothy D. Gilligan, MD
Associate Professor, Solid Tumor Oncology

Sanjay Gupta, PhD
Professor, Urology

Hannelore Heemers, PhD
Associate Staff, Cancer Biology

Warren D.W. Heston, PhD
Professor, Cancer Biology, Urology

Christopher J. Hoimes, DO
Assistant Professor, Medicine-Hematology/Oncology

Hui (Grace) Jin, PhD
Instructor, Pharmacology

Bethany Kerr, PhD
Assistant Professor, Molecular Cardiology

Simon P. Kim, MD, MPH
Assistant Professor, Urology

Eric A. Klein, MD
Professor, Urology

Gregory T. MacLennan, MD
Professor, Pathology

Cristina Magi-Galluzzi, MD, PhD
Professor, Anatomic Pathology

Carvell Nguyen, MD, PhD
Assistant Professor, Surgery-Urology

Lee E. Ponsky, MD
Associate Professor, Urology

Brian I. Rini, MD
Professor, Solid Tumor Oncology

Nima Sharifi, MD
Associate Professor, Cancer Biology

Robert H. Silverman, PhD
Professor, Cancer Biology

Jonathan D. Smith, PhD
Professor, Cellular and Molecular Medicine

Andrew J. Stephenson, MD
Associate Professor, Urology

Giuseppe Strangi, PhD
Professor, Physics

Charles S. Tannenbaum, PhD
Assistant Professor, Immunology

Angela H. Ting, PhD
Assistant Professor, Molecular Medicine

Bing-Cheng Wang, PhD
Professor, Medicine-Nephrology

Ping Xia, PhD
Professor, Radiation Oncology

Hui Zhu, MD
Assistant Professor, Urology

Program Leaders


Brian I. Rini, MD
Professor, Solid Tumor Oncology


Nima Sharifi, MD
Associate Professor, Cancer Biology

Call for Proposals: Multi-investigator Grants Aligned with Themes of the GU Malignancies Program

Funds have been allocated for multi-investigator grants that are aligned with the themes of the GU Malignancies Program of the Case Comprehensive Cancer Center. We anticipate funding TWO one-year awards with $30,000 of support.
The GU program is in need of 1) projects that are aligned with programmatic strengths and interests (such as, but not limited, to androgen signaling in prostate cancer and immunotherapy across GU malignancies) with an eye toward the eventual development of program project grants, and 2) the genesis and development of new ideas from investigators not traditionally in the GU program, as well as new avenues for established GU investigators. Funding decisions will therefore be made with regard to 1) the potential of a project to contribute to a GU program project grant and 2) whether the proposal has fresh ideas with high impact potential.
Proposals should have:
  • Cover page that includes proposal title, investigator(s), affiliations and contact information
  • Brief budget
  • NIH biosketch of each investigator
  • Proposal that is no more than 2 pages in length (not including references). Each proposal should include an explicit statement about the potential fit into a program project or about the novelty of the proposal, as per the needs of the GU Malignancies Program.
Please send proposals to and by October 1, 2015.