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Case Comprehensive Cancer Center

Developmental Therapeutics

Developmental Therapeutics

Program Information

The overarching goal of the Developmental Therapeutics Program (DTP) is to identify and evaluate innovative and novel drugs that will overcome intrinsic cancer cell proliferation and survival mechanisms and to translate these findings into the clinic. The program seeks an enhanced understanding of factors influencing cell replication and signaling that can to be influenced by novel anti-cancer agents. The program leaders foster an environment for facilitated interaction of bench scientists and clinicians involved in anticancer drug development and thus provide a platform for improved patient outcomes. The DTP encourages both bench to bedside as well as bedside to bench research.

Bench to Bedside

Program Themes

  • To facilitate discovery and clinical development of novel anti-cancer agents targeting DNA including the following:
    • DNA polymerase, ribonucleotide reductase and nucleoside analogues
    • DNA repair
    • Epigenetics and differentiation
  • To augment research and discovery of novel strategies for therapeutic targeting of tumor signal transduction and the microenvironment including the following:
    • Signal transduction
    • Phosphatase inhibition
    • Microenvironment including endothelial and immune factors

Program Activities

Developmental Therapeutics Journal Club
Thursdays at 9am in the 4th floor conference room of the ORIGINAL Taussig Cancer Institute, the ‘R’ building (room R4-013). Breakfast and free parking is provided by a DT Co-Leader.

Program Announcements

NCI CTEP Agents
The NCI has relationships with a variety of biotech and pharmaceutical companies to provide access to new agents for either preclinical or clinical studies. To view the current NCI portfolio, visit the CTEP website and view "CTEP Agents and Active Agreements" located in the "Agents/Drugs" page under the Protocol Development tab.

If you are interested in working with any of the agents on the list, please contact Dr. Afshin Dowlati at afshin.dowlati@case.edu.

Pilot Funds
There are limited funds available for pilot projects for members of the Case Comprehensive Cancer Center for:

  • Performing correlative and biomarker studies on physician investigator initiated studies
  • Performing pharmacokinetics on early phase trials

If you are interested in applying‌ for pilot funds from DTP:

Program Members

Mohamed Abazeed, MD, PhD
Assistant Professor, Translational Hematology and Oncology Research
abazeem@ccf.org

Jame Abraham, MD
Professor, Hematology and Medical Oncology
abrahaj5@ccf.org

Drew Adams, PhD
Assistant Professor, Genetics & Genome Sciences
dja59@case.edu

David J. Adelstein, MD
Professor, Hematology and Medical Oncology
adelstd@ccf.org

Manmeet S. Ahluwalia, MD
Visiting Assistant Professor, Brain Tumor and Neuro-Oncology Center
ahluwam@ccf.org

Gene H. Barnett, MD
Professor, Brain Tumor and Neuro-Oncology Center
barnetg@ccf.org

Tithi Biswas, MBBS, MD
Clinical Associate Professor, Radiation Oncology
tithi.biswas@UHhospitals.org

G. Thomas Budd, MD
Professor, Hematology and Medical Oncology
buddg@ccf.org

Chris G. Dealwis, PhD
Associate Professor, Pharmacology
cxd114@case.edu

Analisa DiFeo, PhD
Assistant Professor, General Medical Sciences (Oncology)
analisa.difeo@case.edu

Afshin Dowlati, MD
Professor, Hematology and Oncology
axd44@case.edu

Jennifer R. Eads, MD
Assistant Professor, Hematology and Oncology
jennifer.eads@UHhospitals.org

Rachel A. Egler, MD, MS
Assistant Professor, Hematology and Oncology
rachel.egler@UHhospitals.org

Stanton L. Gerson, MD
Director, Case Comprehensive Cancer Center
Professor, Medicine-Hematology/Oncology
slg5@case.edu

Michael K. Gibson, MD, PhD
Associate Professor, Hematology and Oncology
michael.gibson@UHhospitals.org

Stephen R. Grobmyer, MD
Professor, Breast Center
grobmys@ccf.org

Alok Khorana, MD
Professor, Hematology and Medical Oncology
khorana@ccf.org

Smitha S. Krishnamurthi, MD
Associate Professor, Hematology and Oncology
ssk7@case.edu

Richard T. Lee, MD
Associate Professor, Hematology and Oncology
richard.t.lee@case.edu

John J. Letterio, MD
Professor, Hematology and Oncology
john.letterio@UHhospitals.org

Liraz Levi, PhD, MSc
Instructor, General Medical Sciences (Oncology)
lxl301@case.edu

Nathan A. Levitan, MD
Professor, Hematology and Oncology
nathan.levitan@UHhospitals.org

Benjamin D. Li, MD
Director, Cancer Center, MetroHealth Medical Center 
Professor, Oncology
bli@metrohealth.org

Philip A. Linden, MD
Associate Professor, Surgery
philip.linden@UHhospitals.org

Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology
lindned@ccf.org

Edward V. Maytin, MD, MPH
Assistant Professor, Biomedical Engineering
janice.lyons@UHhospitals.org

Neal Meropol, MD
Professor, Hematology and Oncology
neal.meropol@case.edu

John J. Mieyal, PhD
Professor, Pharmacology
jjm5@case.edu

Monica M. Montano, PhD
Associate Professor, Pharmacology 
mxm126@case.edu

Alberto J. Montero, MBA, MD
Associate Professor, Hematology and Medical Oncology
montero2@ccf.org

Goutham Narla, MD, PhD
Associate Professor, General Medicine
gxn71@case.edu

David M. Peereboom, MD
Professor, Brain Tumor and Neuro-Oncology Center
peerebd@ccf.org

Nathan A. Pennell, MD, PhD
Associate Professor, Hematology and Medical Oncology
penneln@ccf.org

James G. Phillips, PhD
Assistant Professor, Translational Hematology and Oncology Research
phillij5@ccf.org

Irina Pikuleva, PhD
Professor, Pharmacology
irina.pikuleva@case.edu

John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu

Jon Pokorski, PhD
Assistant Professor, Macromolecular Science and Engineering 
jon.pokorski@case.edu

Frederic J. Reu, MD
Assistant Professor, Hematologic Oncology and Blood Disorders
reuf@ccf.org

Lisa R. Rogers, DO
Professor, Neurology
lisa.rogers1@UHhospitals.org

Peter G. Rose, MD
Professor, Obstetrics & Gynecology
rosep@ccf.org

Yogen Saunthararajah, MD
Professor, Hematologic Oncology and Blood Disorders
saunthy@ccf.org

Dale R. Shepard, MD, PhD
Assistant Professor, Hematology and Medical Oncology
shepard@ccf.org

Girish C. Shukla, PhD
Associate Professor, Biological, Geological, and Environmental Sciences
g.shukla@csuohio.edu

Paula Silverman, MD
Associate Professor, Hematology and Oncology
paula.silverman@uhhospitals.org

Andrew E. Sloan, MD
Professor, Neurological Surgery
andrew.sloan@UHhospitals.org

Davendra P.S. Sohal, MD, MPH
Assistant Professor, Hematology and Medical Oncology
sohald@ccf.org

James P. Stevenson, MD
Associate Staff, Hematology and Medical Oncology
stevenj5@ccf.org

John H. Suh, MD
Professor, Radiation Oncology
suhj@ccf.org

Ahmad Tarhini, MD, PhD
Associate Professor, Medicine
tarhina1@ccf.org

Theodoros N. Teknos, MD
Professor, Otolaryngology
theodoros.teknos@UHhospitals.org

Gregory P. Tochtrop, PhD
Associate Professor, Chemistry
gpt6@case.edu

Vamsidhar Velcheti, MD
Assistant Professor, Hematology and Medical Oncology
velchev@ccf.org

Michael A. Vogelbaum, MD, PhD
Professor, Neurosurgery
vogelbm@ccf.org

Steven E. Waggoner, MD
Associate Professor, Reproductive Biology
steven.waggoner@UHhospitals.org

David N. Wald, MD, PhD
Assistant Professor, Pathology
dnw@case.edu

Program Leaders

John J. Letterio, MD
Professor, Pediatric Hematology/Oncology
john.letterio@UHhospitals.org

Yogen Saunthararajah, MD
Professor, Hematologic Oncology and Blood Disorders
saunthy@ccf.org