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GI Cancer Genetics

Program Focus Areas

The Cancer Genetics Program is organized around three broad scientific Focus Areas:

  • To elucidate the role of tumor suppressor genes and oncogenes in the genesis of human cancers
  • To identify cancer susceptibility genes active in the human population and to develop new molecular assays for cancer risk assessment and for cancer early detection
  • To develop new methods and model systems for the discovery of cancer causing genes, and to advance application of cancer genetics to clinical cancer care

These Focus Areas intersect with a specific disease emphasis on gastrointestinal cancers, particularly colon cancers and adenocarcinomas of the esophagus, but have also led to significant advances in understanding other tumors including human sarcomas, brain and breast tumors.

Program Information

The leaders of the Cancer Genetics Program established an internationally recognized team science oriented program deciphering the genetic origins of cancers with a focus particularly in colon cancers and adenocarcinomas of the esophagus, but have also led to significant advances in understanding other tumors including human sarcomas.

The Program is supported by numerous multi-investigator grants, including a newly awarded GI SPORE, and program members have made multiple seminal observations and discoveries that include finding: causative genes for colon cancer, a molecular screening test for colon cancer, and alterations in histone methylation at target gene enhancers that acts as an epigenetic signature of colon cancer.

Program Members

Mohamed Abazeed, MD, PhD
Associate Staff, Translational Hematology and Oncology Research
abazeem@ccf.org

Jill S. Barnholtz-Sloan, PhD
Associate Director for Bioinformatics
Professor, General Medical Sciences (Oncology)
jsb42@case.edu

Nathan A. Berger, MD
Director, Center for Science, Health and Society
Professor, Medicine-Hematology and Oncology
nab@case.edu

Amitabh Chak, MD, MS
Professor, Medicine-Gastroenterology
axc22@case.edu

Mark R. Chance, PhD
Vice Dean for Research
Professor, General Medical Sciences
mark.chance@case.edu

Fabio Cominelli, MD, PhD
Professor and Chief, Medicine-Gastroenterology
fxc90@case.edu

Dawn M. Dawson, MD
Assistant Professor, Pathology
dmd2@case.edu

Stephen Fink, PhD
Assistant Professor, Medicine-Hematology and Oncology 
stephen.fink@case.edu

Claudio Fiocchi, MD
Professor, Pathobiology, Gastroenterology
fiocchc@ccf.org

Meg Gerstenblith, MD
Assistant Professor, Dermatology
meg.gerstenblith@UHhospitals.org

Kishore Guda, DVM, PhD
Assistant Professor, General Medical Sciences (Oncology)
gkishore@yahoo.com

Emina Huang, MD
Professor, Stem Cell Biology and Regenerative Medicine
huange2@ccf.org

Sudha K. Iyengar, PhD
Professor, Epidemiology & Biostatistics
ski@case.edu

Mehmet Koyutürk, PhD
Associate Professor, Electrical Engineering and Computer Science
mxk331@case.edu

Thomas LaFramboise, PhD
Associate Professor, Genetics
txl80@case.edu

Sanford D. Markowitz, MD, PhD
Co-Leader, GI Cancer Genetics Program
Professor, Medicine-Hematology and Oncology
sxm10@case.edu

Alexander Miron, PhD
Associate Professor, Genetics and Genome Sciences
alexander.miron@case.edu

Brian P. Rubin, MD, PhD
Professor, Anatomic Pathology, Molecular Genetics
rubinb2@ccf.org

Peter C. Scacheri, PhD
Associate Professor, Genetics and Genome Sciences
pxs183@case.edu

David Serre, PhD
Assistant Professor, Genetics
serred@ccf.org

Paul J. Tesar, PhD
Associate Professor, Genetics
paul.tesar@case.edu

Martina L. Veigl, PhD
Associate Professor, General Medical Sciences (Oncology)
mlv2@case.edu

Zhenghe John Wang, PhD
Co-Leader, GI Cancer Genetics Program
Professor, Genetics and Genome Sciences
zxw22@case.edu

Joseph E. Willis, MD
Professor, Pathology
joseph.willis@case.edu

Anthony Wynshaw-Boris, MD, PhD
Professor and Chair, Genetics and Genome Sciences
ajw168@case.edu

Program Leaders

Sanford D. Markowitz, MD, PhD
Professor, Medicine-Hematology and Oncology
sxm10@case.edu

Zhenghe John Wang, PhD
Professor, Genetics
zxw22@case.edu