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Ohio Brain Tumor Working Group

The purpose of this group is to plan for the formation of the Ohio Brain Tumor Specialized Program of Research Excellence (SPORE) .


Steven Rosenfeld, MD, PhD
Peter Houghton, PhD
Jill Barnholtz-Sloan, PhD

Major Participating Institutions

Case Western Reserve University (CWRU)
University Hospitals Case Medical Center (UHCMC)
Cleveland Clinic
Nationwide Children's Hospital
Greehey Children's Cancer Research Institute
Cincinnati Children's Hospital

Planned Structure of Ohio Brain Tumor SPORE

Administrative Core: Steven Rosenfeld, MD, PhD; Peter Houghton, PhD; Jill Barnholtz-Sloan, PhD; Yingli Wolinsky, PhD, MBA

Biospecimen/Tissue Core: Nilsa Ramirez, MD

Biostatistics & Informatics Core: Jill Barnholtz-Sloan, PhD; Michael Kattan, PhD

Career Enhancement Program: Nathan Berger, MD

Developmental Research Program: Nathan Berger, MD

Scientific Projects

Project 1: Reducing Communication between Cancer Stem Cells as an Anti-Glioblastoma Therapy
Justin Lathia, PhD (CWRU/Cleveland Clinic)
Manmeet Ahluwalia, MD (CWRU/Cleveland Clinic)

Project 2: Targeting EphA2 Signaling to Treat Glioblastoma
Bingcheng Wang, PhD (CWRU/MetroHealth)
Dolores Hambardzumyan, PhD (CWRU/Cleveland Clinic)
David Peereboom, MD (CWRU/Cleveland Clinic)

Project 3: Blocking GBM Invasion and Proliferation by Targeting the Mitotic Kinesin Eg5
Steven Rosenfeld, MD, PhD (CWRU/Cleveland Clinic)
Monica Venere, PhD (CWRU/Cleveland Clinic)
Manmeet Ahluwalia, MD (CWRU/Cleveland Clinic)

Project 4: Developing BRAF-Specific Therapies for Astrocytoma
Peter Houghton, PhD (Greehey)
Maryam Fouladi, MD (Cincinnati)