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BETRNet

Barrett's Esophagus Translational Research Network (BETRNet)


In October 2011, the Case Comprehensive Cancer Center and Case Western Reserve University (CWRU) School of Medicine received a highly competitive $5.4 million grant to study genetic determinants of Barrett's esophagus and esophageal adenocarcinoma. This five-year award from the National Cancer Institute will support the Barrett's Esophagus Translational Research Network (BETRNet), which consists of multiple centers collaborating to develop an understanding of the basis of Barrett's esophagus and its conversion to esophageal carcinoma. Researchers will also work to determine the role genetics and environmental factors play in the development and progression of these diseases, with the ultimate goal of reducing the mortality associated with this deadly cancer.

Faculty

Principal Investigators

Amitabh Chak, MD, MS, BETRNet Principal Investigator
Project Leader, Project 1
Co-Project Leader, Project 2
Gastroenterologist
CWRU/UHCMC

Sanford Markowitz, MD, PhD
Project Leader, Project 2
Co-Project Leader, Project 3

Co-Investigator, Project 1
Molecular Geneticist
CWRU/UHCMC

Kishore Guda, DVM, PhD
Project Leader, Project 3
Co-Project Leader, Project 1
Molecular Geneticist
CWRU/UHCMC

Case Western Reserve University Faculty

Nathan A. Berger, MD
Director, Development Program
Co-Investigator, Project 1
Oncologist
CWRU/UHCMC

Jill Barnholtz-Sloan, PhD
Co-Director, Patient-Virtual Biorepository Core
Co-Investigator, Project 2

Biostatistician/Genetic Epidemiologist
CWRU/UHCMC

Joseph E. Willis, MD
Co-Director, Patient-Virtual Biorepository Core
Co-Investigator, Project 1
Co-Investigator, Project 2
Co-Investigator, Project 3
Pathologist
CWRU/UHCMC

Outside Faculty

William M. Grady, MD
Gastroenterologist
University of Washington/Fred Hutchinson Cancer Research Center

Nicholas Shaheen, MD, MPH
Gastroenterologist
University of North Carolina at Chapel Hill

Marcia Canto, MD, MHS
Gastroenterologist
Johns Hopkins University

Ganapathy A. Prasad, MD
Gastroenterologist
Mayo Clinic

Jean S. Wang, MD, PhD
Gastroenterologist
Washington University in Saint Louis

Prashanthi Nagavenkata Thota, MD
Gastroenterologist
Cleveland Clinic

Deepa Patil, MD
Pathologist
Cleveland Clinic