CELL DEATH REGULATION
PROGRAM LEADERS
|
Clark W. Distelhorst, MD Professor, Medicine-Hematology/Oncology, Pharmacology cwd@case.edu |
|
Nancy L. Oleinick, PhD Professor, Radiation Oncology nlo@case.edu |
|
Alexandru Almasan, PhD Associate Professor, Cancer Biology, Radiation Oncology almasaa@ccf.org |
Program Themes | Program Information | Program Members | Focus Groups
PROGRAM THEMES
- Identification of gene expression changes that mediate hormonal effects on cancer cells
- Investigation of signaling pathways that regulate cell proliferation and cell death
PROGRAM INFORMATION
The central theme of this Program is to understand the signaling pathways that regulate cell proliferation and cell death, and the hormonal regulation of these processes. Aberrancies of cell growth and cell death are fundamental problems that contribute to the pathogenesis of virtually all forms of cancer. Also, many forms of cancer therapy have the intent of inhibiting cell proliferation or inducing cell death. Hormonal regulation of both cell proliferation and cell death are of direct relevance to the pathogenesis of cancer, the prevention of cancer and the treatment of cancer. Also, glucocorticosteroid hormones are among the most effective agents employed in the treatment of a wide variety of lymphoid malignancies and epidemiological studies have provided strong evidence that estrogens provide a protective role against colon cancer. The efficacy of glucocorticoids in treating lymphoid malignancies stems from their ability to induce apoptosis in immature lymphocytes. Two specific hormone-responsive malignancies are topics of basic investigation with translational potential in this program: breast cancer and lymphoid malignancies. Research in this program is particularly relevant to cancers in which cell proliferation and cell death decisions are regulated by members of the nuclear receptor family. Although hormone-responsive malignancies are the central cancer-related feature of this program, our work is also contributing to an understanding of the regulation of cell proliferation and cell death relevant to other types of cancer.
PROGRAM MEMBERS
Munna L. Agarwal, PhD
Assistant Professor, Genetics
mla16@case.edu
Alexandru Almasan, PhD
Associate Professor, Cancer Biology, Radiation Oncology
almasaa@ccf.org
Mark R. Chance, PhD
Professor, Physiology & Biophysics
mark.chance@case.edu
Peter M. Chumakov, MD, PhD
Professor, Molecular Genetics
chumakp@ccf.org
Jay P. Ciezki, MD
Staff, Radiation Oncology
ciezkij@ccf.org
Clemencia Colmenares, PhD
Professor, Cancer Biology
colmenc@ccf.org
L.R. Devireddy, PhD
Assistant Professor, Pathology
laxminarayana.devireddy@case.edu
Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu
George I. Gorodeski, MD, PhD
Professor, Reproductive Biology
gig@case.edu
Subrata Haldar, PhD
Associate Professor, Pharmacology
shaldar@metrohealth.org
Janet A. Houghton, PhD
Professor and Chair, Cancer Biology
houghtj@ccf.org
Philip H. Howe, PhD
Professor, Cancer Biology, Physiology & Biophysics
howep@ccf.org
Ge Jin, PhD
Assistant Professor, Biological Sciences
ge.jin@case.edu
David R. Kaplan, MD, PhD
Professor, Pathology
drk5@case.edu
Malcolm E. Kenney, PhD
Professor, Chemistry
mek9@case.edu
Minh Lam, PhD
Instructor, Dermatology
minh.lam@case.edu
John J. Letterio, MD
Professor, Pediatric Hematology/Oncology
john.letterio@UHhospitals.org
Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology
lindned@ccf.org
Guangbin Luo, PhD
Assistant Professor, Genetics
gxl35@case.edu
Roger M. Macklis, MD
Professor, Radiation Oncology
macklir@ccf.org
Shigemi Matsuyama, PhD
Assistant Professor, Medicine-Hematology/Oncology
sxm193@case.edu
Edward V. Maytin, MD, PhD
Assistant Professor, Dermatology, Biomedical Engineering
maytine@ccf.org
John J. Mieyal, PhD
Professor, Pharmacology
jjm5@case.edu
Nancy L. Oleinick, PhD
Professor, Radiation Oncology
nlo@case.edu
Neena Singh, MD, PhD
Associate Professor, Pathology
neena.singh@case.edu
Jason W. Sohn, PhD
Associate Professor, Radiation Oncology
jason.sohn@case.edu
Dennis W. Stacey, PhD
Professor, Molecular Genetics
staceyd@ccf.org
Edward Stavnezer, PhD
Professor, Biochemistry
exs44@case.edu
John H. Suh, MD
Professor, Radiation Oncology
suhj@ccf.org
Saba Valadkhan, MD, PhD
Assistant Professor, RNA Molecular Biology
saba.valadkhan@case.edu
Tao Yan, PhD
Assistant Professor, Radiation Oncology
txy13@case.edu
Youwei Zhang, PhD
Assistant Professor, Pharmacology
yxz169@case.edu