STEM CELLS AND HEMATOLOGIC MALIGNANCIES
PROGRAM LEADERS
|
Kevin D. Bunting, PhD Associate Professor, Medicine-Hematology/Oncology kdb10@case.edu |
|
Hillard M. Lazarus, MD Professor, Medicine-Hematology/Oncology hml@case.edu |
Program Themes | Focus Areas | Program Members
PROGRAM THEMES
The overall goals of the Stem Cell and Hematologic Malignancies Program are to link the basic biology of hematopoietic stem cells and immune cells with therapeutic stem cell transplant and hematologic malignancy clinical trials. Coordinated research efforts within each of the scientific focus areas of this Program address the following specific aims:
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Stem Cells and Transplantation
- To determine the critical signaling pathways in hematopoietic stem cells (HSCs) and in immune effector cells
- To develop mesenchymal stem cell (MSC) transplantation strategies as new therapy for malignant diseases
- To develop umbilical cord blood (UCB) transplantation as an alternate HSC source for treating hematological malignancies
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Hematologic Malignancies
- To define stem cell failure processes leading to myelodysplastic syndrome and leukemias in terms of defects in DNA repair mechanisms and clonal evolution
- To develop novel therapeutics for hematologic malignancies
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Developing Initiative: Immune Cell Biology and Therapeutics
- To develop a basic and translational approach to immune-mediated anti-cancer therapies
FOCUS AREAS
The Program is organized into two scientific focus areas, with a third initiative in development. The basic biology efforts focus on stem cell proliferation, transplantation and differentiation modulation by signal transduction, intercellular interactions and alterations in gene expression, and use animal models and analysis of human samples of normal and malignant hematopoietic cells. The Hematologic malignancies focus area is focused on the clinical treatment of leukemias, lymphomas, myelomas, and myelodysplastic syndromes. The immune cell biology initiative is developing a cancer immunology focus from an existing strong base of immunobiology. This area links basic immunology with research into cell based immunobiology, adoptive cell therapy, cell based cancer vaccines, and innate immunity. It is aimed toward development of cellular anti-tumor immunotherapy and exploration of novel methods for treating GVHD in the course of allogeneic stem cell transplantation.
PROGRAM MEMBERS
Anjali S. Advani, MD
Assistant Professor, Hematology & Medical Oncology
advania@ccf.org
Donald D. Anthony, Jr., MD, PhD
Assistant Professor, Medicine-Rheumatology
dda3@case.edu
Jeffery J. Auletta, MD
Assistant Professor, Pediatric Hematology/Oncology, Infectious Diseases
jeffery.auletta@case.edu
David S. Bardenstein, MD
Associate Professor, Ophthalmology
david.bardenstein@UHhospitals.org
Rose Chu Beck, MD, PhD
Assistant Professor, Pathology
rose.beck@case.edu
Brian J. Bolwell, MD
Professor, Hematology & Medical Oncology
bolwelb@ccf.org
Kevin D. Bunting, PhD
Associate Professor, Medicine-Hematology/Oncology
kdb10@case.edu
Arnold I. Caplan, PhD
Professor, Biology
aic@case.edu
Venugopalan Cheriyath, PhD
Staff, Taussig Cancer Center
cheriyv@ccf.org
Peter A. Cohen, MD
Associate Professor, Center for Surgery Research
cohenp@ccf.org
Kenneth R. Cooke, MD
Associate Professor, Pediatric Hematology/Oncology
kenneth.cooke@UHhospitals.org
Brenda W. Cooper, MD
Associate Professor, Medicine-Hematology/Oncology
bxc12@case.edu
Kevin D. Cooper, MD
Professor, Dermatology
kevin.cooper@UHhospitals.org
Edward A. Copelan, MD
Staff, Hematologic Oncology & Blood Disorders
copelae@ccf.org
Robert M. Dean, MD
Associate Staff, Hematologic Oncology & Blood Disorders
deanr@ccf.org
George R. Dubyak, PhD
Professor, Physiology & Biophysics
gxd3@case.edu
Robert L. Fairchild, PhD
Professor, Immunology
fairchr@ccf.org
Claudio Fiocchi, MD
Professor, Pathobiology, Gastroenterology
fiocchc@ccf.org
Stanton L. Gerson, MD
Director, Case Comprehensive Cancer Center
Professor, Medicine-Hematology/Oncology
slg5@case.edu
Neil S. Greenspan, MD, PhD
Professor, Pathology
neil.greenspan@case.edu
Clifford V. Harding, MD, PhD
Professor, Pathology
cvh3@case.edu
Stephen E. Haynesworth, PhD
Associate Professor, Biology
seh5@case.edu
Eric D. Hsi, MD
Professor, Clinical Pathology
hsie@ccf.org
Alex Y.C. Huang, MD, PhD
Assistant Professor, Pediatric Hematology/Oncology
alex.y.huang@case.edu
Matt E. Kalaycio, MD
Professor, Hematology & Medical Oncology
kalaycm@ccf.org
Julian A. Kim, MD
Professor, Surgical Oncology
julian.kim@UHhospitals.org
Henry B. Koon, MD
Assistant Professor, Medicine-Hematology/Oncology
henry.koon@case.edu
Gary K. Koski, PhD
Assistant Professor, Surgery
koskig@ccf.org
Mary J. Laughlin, MD
Associate Professor, Medicine-Hematology/Oncology
mjl13@case.edu
Hillard M. Lazarus, MD
Professor, Medicine-Hematology/Oncology
hml@case.edu
Michael M. Lederman, MD
Professor, Medicine-Infectious Diseases
mxl6@case.edu
Jaroslaw P. Maciejewski, MD, PhD
Professor, Hematology & Medical Oncology
maciejj@ccf.org
M. Edward Medof, MD, PhD
Professor, Pathology
mxm16@case.edu
Howard J. Meyerson, MD
Associate Professor, Clinical Pathology
howard.meyerson@case.edu
Robert H. Miller, PhD
Professor, Neurosciences
rhm3@case.edu
Booki Min, PhD, DVM
Assistant Professor, Immunology
minb@ccf.org
George F. Muschler, MD
Professor, Biomedical Engineering, Orthopaedic Surgery
muschler@bme.ri.ccf.org
Gregory E. Plautz, MD
Associate Professor, Center for Surgery Research
plautzg@ccf.org
Brad L. Pohlman, MD
Staff, Hematologic Oncology & Blood Disorders
pohlmab@ccf.org
Cheng-Kui Qu, MD, PhD
Assistant Professor, Medicine-Hematology/Oncology
cxq6@case.edu
Richard M. Ransohoff, MD
Professor, Neurology
ransohr@ccf.org
Shenandoah Robinson, MD
Associate Professor, Pediatric Neurosurgery
shenandoah.robinson@UHhospitals.org
David R. Samols, PhD
Professor, Biochemistry
drs10@case.edu
Mikkael A. Sekeres, MD, MS
Assistant Professor, Hematology & Medical Oncology
sekerem@ccf.org
Suyu Shu, PhD
Professor, General Surgery
shus@ccf.org
Ronald M. Sobecks, MD
Assistant Professor, Hematologic Oncology & Blood Disorders
sobeckr@ccf.org
Kingman P. Strohl, MD
Professor, Medicine-Pulmonary & Critical Care
kps@case.edu
John W. Sweetenham, MD
Professor, Hematologic Oncology & Blood Disorders
sweetej@ccf.org
Man-Sun Sy, PhD
Professor, Pathology
mxs92@case.edu
Magdalena Tary-Lehmann, PhD
Associate Professor, Pathology
mxt27@case.edu
Pierre L. Triozzi, MD
Staff, Solid Tumor Oncology
triozzp@ccf.org
Aaron Weinberg, DMD, PhD
Professor, Dental Medicine-Biological Sciences
axw47@case.edu
Maciej Zborowski, PhD
Associate Professor, Biomedical Engineering
zborowm@ccf.org
Lan Zhou, MD, PhD
Assistant Professor, Pathology
lan.zhou@case.edu