GI SPORE

The Case GI SPORE proposal provides for a cutting edge Specialized Program of Research Excellence in gastrointestinal malignancies with emphasis on colorectal cancers and with additional attention to adenocarcinoma of the esophagus. This comprehensive program builds on the resources of the Case Comprehensive Cancer Center to propose four translational research projects to bring new molecular advances to patients with GI Cancers. The four SPORE translational research projects constitute novel and cutting edge approaches to GI cancers.


SPORE Projects

Project 1: Targeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and Prevention
Co-Leaders: Sanford D. Markowitz, MD, PhD and James K.V. Willson, MD

Project 2: Detection of Advanced Colon Adenoma via Stool DNA (sDNA) Methylation Testing
Co-Leaders: Gregory S. Cooper, MD and Li Li, MD, PhD

Project 3: Identifying Mutational Drivers of Late Stage Colon Cancer
Co-Leaders: Joseph E. Willis, MD and Zhenghe John Wang, PhD

Project 4: Identification of Esophageal Adenocarcinoma Susceptibility Genes
Co-Leaders: Amitabh Chak, MD, MS and Robert C. Elston, PhD