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Developmental Therapeutics
Program Leaders
 |
Afshin Dowlati, MD |
 |
Ernest C. Borden, MD |
Program Information
The overarching goal of the Developmental Therapeutics Program (DTP) is to identify and evaluate innovative and novel drugs that will overcome intrinsic cancer cell proliferation and survival mechanisms and to translate these findings into the clinic. The program seeks an enhanced understanding of factors influencing cell replication and signaling that can to be influenced by novel anti-cancer agents. The program leaders foster an environment for facilitated interaction of bench scientists and clinicians involved in anticancer drug development and thus provide a platform for improved patient outcomes. The DTP encourages both bench to bedside as well as bedside to bench research.
Program Themes
- To facilitate discovery and clinical development of novel anti-cancer agents targeting DNA including the following:
- DNA polymerase, ribonucleotide reductase and nucleoside analogues
- DNA repair
- Epigenetics and differentiation
- To augment research and discovery of novel strategies for therapeutic targeting of tumor signal transduction and the microenvironment including the following:
- Signal transduction
- Phosphatase inhibition
- Microenvironment including endothelial and immune factors
Program Activities
Early Phase Clinical Trials Meetings
Third Wednesday of the month at 5 pm in Wolstein Research Building 2-136
In Development
Center for Cancer Drug Development
Program Announcements
NCI CTEP Agents
The NCI has relationships with a variety of biotech and pharmaceutical companies to provide access to new agents for either preclinical or clinical studies. To view the current NCI portfolio, visit the CTEP website and view "CTEP Agents and Active Agreements" located under the Protocol Development tab.
If you are interested in working with any of the agents on the list, please contact Dr. Afshin Dowlati at afshin.dowlati@case.edu.
Pilot Funds
There are limited funds available for pilot projects for members of the Case Comprehensive Cancer Center for:
- Performing correlative and biomarker studies on physician investigator initiated studies
- Performing pharmacokinetics on early phase trials
If you are interested in applying for pilot funds from DTP:
- Print the application.
- Submit the application(s) to Marybeth.lipka@uhhospitals.org.
- Applications will be reviewed by the Developmental Therapeutic Program Core Committee and you will be notified of the status of your application within 4-8 weeks.
Upcoming
Fall 2012: CTEP Early Drug Development Meeting: October 15 and 16, NIH Campus, Bethesda, MD
Program Members
David J. Adelstein, MD
Professor, Solid Tumor Oncology
adelstd@ccf.org
Manmeet S. Ahluwalia, MD
Assistant Professor, Brain Tumor and Neuro-Oncology Center
ahluwam@ccf.org
James M. Anderson, MD, PhD
Professor, Pathology
james.anderson@case.edu
Bruce J. Averbook, MD
Associate Professor, Surgery
baverbook@metrohealth.org
Joseph Baar, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
joseph.baar@UHhospitals.org
Gene H. Barnett, MD
Professor, Brain Tumor and Neuro-Oncology Center
barnetg@ccf.org
Elma D. Baron, MD
Associate Professor, Dermatology
edb4@case.edu
Jerome L. Belinson, MD
Professor, Obstetrics & Gynecology
belinsj@ccf.org
Anthony J. Berdis, PhD
Assistant Professor, Pharmacology
ajb15@case.edu
Joseph A. Bokar, MD, PhD
Assistant Professor, Medicine/Hematology-Oncology
jab5@case.edu
Ernest C. Borden, MD
Professor, Translational Hematology and Oncology Research
bordene@ccf.org
G. Thomas Budd, MD
Professor, Solid Tumor Oncology
buddg@ccf.org
Clemens Burda, PhD
Professor, Chemistry
cxb77@case.edu
Mellar P. Davis, MD, FCCP
Professor, Solid Tumor Oncology
davism6@ccf.org
Chris G. Dealwis, PhD
Associate Professor, Pharmacology, Proteomics
cxd114@case.edu
Peter de Blank, MD
Assistant Professor, Pediatric Hematology/Oncology
peter.deBlank@UHhospitals.org
Afshin Dowlati, MD
Associate Professor, Medicine-Hematology/Oncology
axd44@case.edu
Rachel A. Egler, MD, MS
Assistant Professor, Pediatrics
rachel.egler@UHhospitals.org
Paul J. Elson, ScD
Associate Staff, Quantitative Health Sciences
elsonp@ccf.org
Lois C. Friedman, PhD
Professor, Psychiatry
lois.friedman@UHhospitals.org
Pingfu Fu, PhD
Associate Professor, Epidemiology & Biostatistics
pxf16@case.edu
Stanton L. Gerson, MD
Director, Case Comprehensive Cancer Center
Professor, Medicine-Hematology/Oncology
slg5@case.edu
Jeffrey M. Hardacre, MD
Associate Professor, Surgery
jeffrey.hardacre@UHhospitals.org
Lyndsay Harris, MD
Professor, Medicine-Hematology/Oncology
lyndsay.harris@UHhospitals.org
Kord Honda, MD
Assistant Professor, Dermatology
kord.honda@UHhospitals.org
Charles L. Hoppel, MD
Professor, Clinical Pharmacology
clh5@case.edu
Damir Janigro, PhD
Professor, Cell Biology
janigrd@ccf.org
Smitha S. Krishnamurthi, MD
Associate Professor, Medicine-Hematology/Oncology
ssk7@case.edu
Charles A. Kunos, MD, PhD
Assistant Professor, Radiation Oncology
kunosc@summahealth.org
Gary E. Landreth, PhD
Professor, Neurosciences
gel2@case.edu
Pierre Lavertu, MD
Professor, Otolaryngology
pierre.lavertu@UHhospitals.org
Rosemary A. Leeming, MD
Assistant Professor, Surgery
rosemary.leeming@UHhospitals.org
Nathan A. Levitan, MD
Professor, Medicine-Hematology/Oncology
nxl8@case.edu
Patrick C. Ma, MD, MSc
Assistant Professor, Translational Hematology and Oncology Research
map@ccf.org
Charles J. Nock, MD
Assistant Professor, Medicine-Hematology/Oncology
charles.nock@UHhospitals.org
Timothy E. O'Brien, MD
Associate Professor, Medicine-Hematology/Oncology
tobrien@metrohealth.org
Richard A. Padgett, PhD
Professor, Molecular Genetics
padgetr@ccf.org
David M. Peereboom, MD
Associate Professor, Brain Tumor and Neuro-Oncology Center
peerebd@ccf.org
Nathan A. Pennell, MD, PhD
Associate Staff, Solid Tumor Oncology
penneln@ccf.org
John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu
Kimberly E. Resnick, MD
Assistant Professor, Gynecologic Oncology
Kimberly.Resnick@UHhospitals.org
Frederic J. Reu, MD
Assistant Professor, Hematologic Oncology and Blood Disorders
reuf@ccf.org
Lisa R. Rogers, DO
Professor, Neurology
lisa.rogers@uhhospitals.org
Peter G. Rose, MD
Professor, Obstetrics & Gynecology
rosep@ccf.org
Yogen Saunthararajah, MD
Associate Professor, Hematologic Oncology and Blood Disorders
saunthy@ccf.org
Mark D. Schluchter, PhD
Professor, Epidemiology & Biostatistics
mds11@case.edu
Dale R. Shepard, MD, PhD
Assistant Professor, Solid Tumor Oncology
shepard@ccf.org
Girish C. Shukla, PhD
Assistant Professor, Biology
g.shukla@csuohio.edu
Paula Silverman, MD
Associate Professor, Medicine-Hematology/Oncology
pxs7@case.edu
Andrew E. Sloan, MD
Associate Professor, Neurological Surgery
andrew.sloan@UHhospitals.org
Davendra Sohal, MD, MPH
Assistant Staff, Solid Tumor Oncology
sohald@ccf.org
David W. Stepnick, MD, FACS
Associate Professor, Otolaryngology
david.stepnick@UHhospitals.org
James P. Stevenson, MD
Associate Staff, Solid Tumor Oncology
stevenj5@ccf.org
Jean T. Stevenson, MD
Associate Professor, Surgery
jstevenson@metrohealth.org
John H. Suh, MD
Professor, Radiation Oncology
suhj@ccf.org
Gregory P. Tochtrop, PhD
Associate Professor, Chemistry
gpt6@case.edu
Joan E. Trey, MD
Associate Professor, Medicine-Hematology/Oncology
jet2@case.edu
Pierre L. Triozzi, MD
Staff, Solid Tumor Oncology
triozzp@ccf.org
Vincent K. Tuohy, PhD
Professor, Immunology
tuohyv@ccf.org
Michael A. Vogelbaum, MD, PhD
Professor, Neurosurgery
vogelbm@ccf.org
Steven E. Waggoner, MD
Associate Professor, Reproductive Biology
steven.waggoner@UHhospitals.org
David N. Wald, MD, PhD
Assistant Professor, Pathology
dnw@case.edu
Robert J. Weil, MD
Staff, Neurological Surgery
weilr@ccf.org
Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu
Yu-Chung Yang, PhD
Professor, Biochemistry
yxy36@case.edu
Kristine M. Zanotti, MD
Assistant Professor, Reproductive Biology
kristine.zanotti@UHhospitals.org
Maciej Zborowski, PhD
Associate Professor, Biomedical Engineering
zborowm@ccf.org
Mei Zhang, PhD
Assistant Professor, Biomedical Engineering
mxz128@case.edu
Alan J. Zhu, PhD
Assistant Professor, Cell Biology, Genetics
zhua@ccf.org