BETRNet

The BETRNet projects include discovery of genes that cause Barrett's esophagus to run in certain families, genes that become targets of DNA methylation in Barrett's and in esophageal cancers, and genes that are either turned on or turned off in Barrett's esophagus and in esophageal cancers. The overall aims of the Network are to develop new methods of identifying individuals at risk for Barrett's esophagus, early detection of Barrett's and esophageal cancers, and monitoring Barrett's esophagus to recognize when it is likely to progress to cancer.


BETRNet Projects

Project 1: Whole Exome Approaches For Esophageal Adenocarcinoma Susceptibility Genes
Principal Investigator: Amitabh Chak, MD, MS
Co-Investigators: Sanford D. Markowitz, MD, PhD, Kishore Guda, DVM, PhD, Robert C. Elston, PhD, and Jill S. Barnholtz-Sloan, PhD

Project 2: The Biology and Translation of Epigenetic Alterations in Barrett’s Esophagus
Principal Investigator: William M. Grady, MD
Co-Investigator: Andrew M. Kaz, MD
Biostatisticians: Jill S. Barnholtz-Sloan, PhD and Chao-Jen Wong, PhD

Project 3: Non-Coding and Coding RNAs as Biomarkers of Cancer Risk in Barrett’s Esophagus
Principal Investigator: Sanford D. Markowitz, MD, PhD
Co-Investigators: Kishore Guda, DVM, PhD, [an error occurred while processing this directive], and Patrick Leahy, PhD