Leader

Danny Manor, PhD Associate Professor, Nutrition danny.manor@case.edu

Summary

Members of this focus group investigate the role of cell surface and extracellular cues as well as their signaling pathways in tumorigenesis. This focus group will facilitate interactions among the Cancer Center Members that research similar biological processes in different types of cancer.

Tumor cells are influenced by their extracellular environment which can facilitate uncontrolled growth, invasion and metastasis. The cues that regulate tumor cells include growth factors, cell adhesion molecules and extracellular matrix proteins. In most tumor cells, growth factor signaling is constitutively active indicating its importance to tumorigenesis. These types of molecules may be produced by the tumor cells themselves or synthesized by the surrounding stromal cells in their local environment.

These extracellular or cell surface cues converge on various signaling pathways to regulate cell adhesion, growth and migration. The ability of tumor cells not only to recognize these cues but to alter their surrounding environment is key to both migration and invasion which are prerequisites for metastasis. Improved clinical treatment and the creation of novel therapeutics require that we understand the basic signaling pathways that regulate metastatic progression.

Members

Eben Alsberg, PhD
Associate Professor, Biomedical Engineering
eben.alsberg@case.edu

Suneel S. Apte, MBBS, DPhil
Associate Professor, Biomedical Engineering
aptes@ccf.org

Joseph Baar, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
joseph.baar@UHhospitals.org

Harihara Baskaran, PhD
Associate Professor, Chemical Engineering
hxb35@case.edu

Barbara Bedogni, PhD
Assistant Professor, Biochemistry
bxb278@case.edu

Susann M. Brady-Kalnay, PhD
Professor, Molecular Biology & Microbiology
smb4@case.edu

Matthias Buck, PhD
Associate Professor, Physiology & Biophysics
mxb150@case.edu

Tatiana V. Byzova, PhD
Assistant Professor, Molecular Cardiology
byzovat@ccf.org

Cathleen R. Carlin, PhD
Professor, Molecular Biology and Microbiology
cxc39@case.edu

Afshin Dowlati, MD
Associate Professor, Medicine-Hematology/Oncology
axd44@case.edu

Thomas T. Egelhoff, PhD
Professor, Cell Biology
tte@case.edu

Paul L. Fox, PhD
Professor, Cell Biology
foxp@ccf.org

Candece L. Gladson, MD
Professor, Cancer Biology
gladsoc@ccf.org

Edward M. Greenfield, PhD
Professor, Orthopaedics
emg3@case.edu

Alex Y.C. Huang, MD, PhD
Associate Professor, Pediatric Hematology/Oncology
alex.y.huang@case.edu

Mark W. Jackson, PhD
Assistant Professor, Pathology
mark.w.jackson@case.edu

Mukesh K. Jain, MD
Professor, Medicine-Cardiology
mukesh.jain2@case.edu

Hung-Ying Kao, PhD
Professor, Biochemistry
hxk43@case.edu

Ruth A. Keri, PhD
Associate Professor, Pharmacology
rak5@case.edu

Zhenghong Lee, PhD
Associate Professor, Radiology, Biomedical Engineering
zxl11@case.edu

Alan D. Levine, PhD
Professor, Medicine-Gastroenterology
adl4@case.edu

Patrick C. Ma, MD, MSc
Assistant Professor, Translational Hematology and Oncology Research
map@ccf.org

Danny Manor, PhD
Associate Professor, Nutrition
danny.manor@case.edu

Keith R. McCrae, MD
Professor, Hematologic Oncology and Blood Disorders
mccraek@ccf.org

Patricia Parsons-Wingerter, PhD
Adjunct Staff, Cell Biology, John Glenn Research Center, NASA
patricia.parsons@grc.nasa.gov

Edward F. Plow, PhD
Professor, Molecular Cardiology
plowe@ccf.org

Jun Qin, PhD
Professor, Molecular Cardiology
qinj@ccf.org

Cheng-Kui Qu, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
cxq6@case.edu

Diana L. Ramirez-Bergeron, PhD
Assistant Professor, Medicine-Cardiology
diana.ramirez@case.edu

Brian I. Rini, MD
Professor, Solid Tumor Oncology
rinib2@ccf.org

Takao Sakai, MD, PhD
Assistant Professor, Biomedical Engineering
sakait@ccf.org

William P. Schiemann, PhD
Associate Professor, General Medical Sciences-Oncology
william.schiemann@case.edu

Alvin H. Schmaier, MD
Professor, Medicine-Hematology/Oncology
alvin.schmaier@case.edu

Andrew E. Sloan, MD
Associate Professor, Neurological Surgery
andrew.sloan@UHhospitals.org

Horst A. von Recum, PhD
Associate Professor, Biomedical Engineering
horst.vonrecum@case.edu

Bing-Cheng Wang, PhD
Professor, Medicine-Nephrology
bxw14@case.edu

Qing K. Wang, PhD, MBA
Professor, Molecular Cardiology
wangq2@ccf.org

Zhenghe John Wang, PhD
Associate Professor, Genetics
zxw22@case.edu

David L. Wilson, PhD
Professor, Biomedical Engineering
dlw@case.edu

Yu-Chung Yang, PhD
Professor, Biochemistry
yxy36@case.edu

Lan Zhou, MD, PhD
Assistant Professor, Pathology
lan.zhou@case.edu