BASIC SCIENCE OF CANCER FOCUS GROUPS

NUCLEAR RECEPTORS

SUMMARY

The Nuclear Receptors focus group includes investigators with interest in nuclear hormone receptors, ligand-activated transcription factors that regulate gene expression in response to small hydrophobic hormones, such as steroid hormones, vitamin D, thyroid hormone, and metabolites of vitamin A, long chain fatty acids, and cholesterol. Nuclear receptors and their ligands control key aspects of cellular metabolism, differentiation, proliferation, and apoptosis, and they play key roles in multiple biological functions during embryonic development and in the adult. The group aims to obtain new insights into molecular mechanisms that underlie the transcriptional activities of nuclear receptors, that govern their cross-talk with other signaling pathways, that integrate into biological functions at the cellular and organismal levels, and that are ultimately involved in human health and disease. Of special interest is the utilization of information derived from these investigations for developing strategies that will target receptors and their associated coregulators for prevention of and therapeutic interventions in cancer.

MEMBERS

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