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Focus Groups
Nuclear Receptor Signaling & Hormone Responsive Cancers
Leaders
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David Danielpour, PhD |
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Noa Noy, PhD |
Summary
The Nuclear Receptor Signaling and Hormone Responsive Cancers focus group includes investigators with interest in nuclear hormone receptors, ligand-activated transcription factors that regulate gene expression in response to small hydrophobic hormones, such as steroid hormones, vitamin D, thyroid hormone, and metabolites of vitamin A, long chain fatty acids, and cholesterol. Nuclear receptors and their ligands control key aspects of cellular metabolism, differentiation, proliferation, and apoptosis, and they play key roles in multiple biological functions during embryonic development and in the adult. The group aims to obtain new insights into molecular mechanisms that underlie the transcriptional activities of nuclear receptors, that govern their cross-talk with other signaling pathways, that integrate into biological functions at the cellular and organismal levels, and that are ultimately involved in human health and disease. Of special interest is the utilization of information derived from these investigations for developing strategies that will target receptors and their associated coregulators for prevention of and therapeutic interventions in cancer.
Activities
Members
David Danielpour, PhD
Professor, General Medical Sciences (Oncology)
dxd49@case.edu
Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu
Hung-Ying Kao, PhD
Professor, Biochemistry
hxk43@case.edu
Ruth A. Keri, PhD
Associate Professor, Pharmacology
rak5@case.edu
Paul N. MacDonald, PhD
Associate Professor, Pharmacology
pnm2@case.edu
Monica M. Montano, PhD
Associate Professor, Pharmacology
mxm126@case.edu
Noa Noy, PhD
Professor, Pharmacology
noa.noy@case.edu
John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu
Girish C. Shukla, PhD
Assistant Professor, Biology
g.shukla@csuohio.edu