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FUNDING AGENCIES:

BASIC SCIENCE OF CANCER FOCUS GROUPS

NUCLEAR RECEPTORS

Leaders: David Danielpour, PhD
Associate Professor, General Medical Sciences (Oncology)
dxd49@case.edu
 
Noa Noy, PhD
Professor, Pharmacology
noa.noy@case.edu

SUMMARY

The Nuclear Receptors focus group includes investigators with interest in nuclear hormone receptors, ligand-activated transcription factors that regulate gene expression in response to small hydrophobic hormones, such as steroid hormones, vitamin D, thyroid hormone, and metabolites of vitamin A, long chain fatty acids, and cholesterol. Nuclear receptors and their ligands control key aspects of cellular metabolism, differentiation, proliferation, and apoptosis, and they play key roles in multiple biological functions during embryonic development and in the adult. The group aims to obtain new insights into molecular mechanisms that underlie the transcriptional activities of nuclear receptors, that govern their cross-talk with other signaling pathways, that integrate into biological functions at the cellular and organismal levels, and that are ultimately involved in human health and disease. Of special interest is the utilization of information derived from these investigations for developing strategies that will target receptors and their associated coregulators for prevention of and therapeutic interventions in cancer.

MEMBERS

David Danielpour, PhD
Associate Professor, General Medical Sciences (Oncology)
dxd49@case.edu

Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu

Hung-Ying Kao, PhD
Associate Professor, Biochemistry
hxk43@case.edu

Ruth A. Keri, PhD
Associate Professor, Pharmacology
rak5@case.edu

Paul N. MacDonald, PhD
Associate Professor, Pharmacology
pnm2@case.edu

Monica M. Montano, PhD
Associate Professor, Pharmacology
mxm126@case.edu

Noa Noy, PhD
Professor, Pharmacology
noa.noy@case.edu

John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu

Girish C. Shukla, PhD
Assistant Professor, Biology
g.shukla@csuohio.edu


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