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Focus Groups
Regulation of Cell Death – Apoptosis and Autophagy
Leaders
 |
Alexandru Almasan, PhD |
 |
Clark W. Distelhorst, MD |
Summary
This Focus Group is composed of Cancer Center members who share a common interest in regulation of cell death in cancer cells. The overall goal is to foster collaborative research that capitalizes on the expertise of individual laboratories to collectively gain improved insight into mechanisms of cell death. The overall long range goal is to develop basic understanding that will identify novel biological targets for cancer treatment.
Two central themes that are emerging are: Mechanism of Bim regulation in response to a wide range of apoptosis inducers; and, novel approaches to regulating Bcl-2 protein family members as therapeutic targets.
Members
Alexandru Almasan, PhD
Professor, Cancer Biology, Radiation Oncology
almasaa@ccf.org
L.R. Devireddy, PhD
Assistant Professor, Pathology
laxminarayana.devireddy@case.edu
Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu
Subrata Haldar, PhD
Associate Professor, Pharmacology
shaldar@metrohealth.org
Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology
lindned@ccf.org
Shigemi Matsuyama, PhD
Associate Professor, Medicine-Hematology/Oncology
sxm193@case.edu
John J. Mieyal, PhD
Professor, Pharmacology
jjm5@case.edu
Edward Stavnezer, PhD
Professor, Biochemistry
exs44@case.edu
Saba Valadkhan, MD, PhD
Assistant Professor, RNA Molecular Biology
saba.valadkhan@case.edu
Xiongwei Zhu, PhD
Associate Professor, Pathology
xiongwei.zhu@case.edu