The Case CCC is comprised of over 370 members, who span 32 departments of the Schools of Medicine, Nursing, Dentistry, Engineering, Applied Social Sciences, and the College of Arts and Sciences at Case Western Reserve University, located at CWRU, UHCMC, Cleveland Clinic, and MetroHealth Medical Center (MHMC).

The research efforts of the Case CCC members are organized into eight interdisciplinary scientific programs. The clinical research effort is supported by 11 Clinical Trials Disease Teams that develop and prioritize clinical trials, and a single Protocol Review and Monitoring System, Data Safety and Monitoring Plan integrate cancer research, cancer therapeutics, and prevention services at the partner institutions and throughout the region.

Our Center's large scale multi-investigator efforts include the GI Specialized Program of Research Excellence (SPORE), Barrett's Esophagus Translational Research Network (BETRNet), and Ohio Brain Tumor Working Group.