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Case Comprehensive Cancer Center Newsletter

July 28, 2014

MESSAGE FROM THE DIRECTOR

gerson

Stan Gerson, MD
Director, Case CCC

House/Senate FY 2015 Defense Appropriations Bills

Summary provided by the Coalition for Clinical and Translational Science

On Thursday, July 17th, the Senate Appropriations Committee unanimously approved a Fiscal Year (FY) 2015 Department of Defense (DoD) Appropriations Bill by voice vote.

After being approved and reported out of Committee, the Senate's FY 2015 Defense Appropriations Bill now awaits consideration by the full Senate. The full House previously approved the House's FY 2015 Defense Appropriations Bill in June. The House and Senate will need to negotiate the differences between the two FY 2015 defense appropriations measures and create a compromise bill before sending the legislation to the president for enactment.

While considering the legislation, Senators from both sides of the aisle spoke highly of the bill's meaningful investment in medical research activities. The Senate's FY 2015 DoD Appropriations bill increases funding for medical research by 5% ($789.2 million) over the funding level recommend by the Committee in FY 2014. Both the Peer-Reviewed Medical Research Program and the Peer-Reviewed Cancer Research Program would benefit from this additional research funding.

Of interest to Case CCC, the Senate FY 2015 Defense Appropriations bill includes:

  • $120 million for the DoD Peer-Reviewed Breast Cancer Research Program
  • $50 million for the DOD Peer-Reviewed Cancer Research Program
  • $247.5 million for the DoD Peer-Reviewed Medical Research Program
  • $10 million for the DoD Peer-Reviewed Ovarian Cancer Research Program
  • $64 million for the DoD Peer-Reviewed Prostate Cancer Research Program

Of interest to Case CCC, the House FY 2015 Defense Appropriations bill includes:

  • $3.2 million for the DoD Peer-Reviewed Bone Marrow Failure Disease Research Program
  • $120 million for the DoD Peer-Reviewed Breast Cancer Research Program
  • $15 million for the DoD Peer-Reviewed Cancer Research Program
  • $10.5 million for the DoD Peer-Reviewed Lung Cancer Research Program
  • $20 million for the DoD Peer-Reviewed Ovarian Cancer Research Program
  • $80 million for the DoD Peer-Reviewed Prostate Cancer Research Program
  • $8 million for the DoD Peer-Reviewed Global HIV/AIDS Prevention Program
  • $12.9 million for the DoD Peer-Reviewed HIV/AIDS Program

CASE CCC IN THE NEWS

Brain Tumor Causes and Risk Factors Elude Scientists
Digital Journal - July 25, 2015
Today, nearly 700,000 people in the U.S. are living with a brain tumor, and yet, when it comes to pinpointing causes or risk factors, scientists are still searching for answers...At the American Brain Tumor Association (ABTA) annual Patient and Family Conference in Chicago, July 25-26, Jill Barnholtz-Sloan, PhD, associate professor, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, will be the keynote speaker and provide an update on possible causes and risk factors for brain tumors. As Dr. Barnholtz-Sloan explains, many environmental and genetic risk factors have been studied, but researchers have not uncovered a risk factor that accounts for a large number of brain tumors.

Cigars, Hookah More Popular Than Cigarettes Among Local High School Students, Survey Shows
The Plain Dealer - July 24, 2014
One in five high-school students in Cuyahoga County uses tobacco, with flavored cigars and hookah the most popular ways to smoke it, according to new data released Thursday by the Prevention Research Center for Healthy Neighborhoods at Case Western Reserve University..."We've kind of known that the little cigars were sneaking up on cigarettes, but we were surprised by hookah," PRCHN Associate Director Erika Trapl, the lead research investigator, told The Plain Dealer. "Ever since our Clean Indoor Act was approved, we've seen an increase in the number of hookah bars in the county," said Trapl, assistant professor of epidemiology and biostatistics at CWRU and member of the Case Comprehensive Cancer Center.

Lab Chat: Discussing Personalized Treatments for Cancer with the Clinic's Dr. Mohamed Abazeed
Freshwater Cleveland - July 24, 2014
Welcome to the latest round of Lab Chat, in which our resident Post-Doctoral Research Associate, Amar Desai, attempts to demystify the often complex and mysterious field of biomedical research. Today, our intrepid writer takes on the roadblocks to diagnosing and treating cancer – and how improvements in medical technology are offering avenues to better results...Here to further explain this concept and offer real-life examples is Case Comprehensive Cancer Center member Mohamed Abazeed, MD, PhD, one of Cleveland's brightest new scientific minds...


RESEARCH HIGHLIGHTS/MEMBER NEWS

Khorana and Ahluwalia Elected to ASCO Committees

Dr. Alok KhoranaCase Comprehensive Cancer Center member Alok Khorana, MD, Director of the Gastrointestinal Malignancies Program at Cleveland Clinic, is the new ASCO Chair-Elect of the Clinical Practice Guidelines Committee for the 2014-2015 term. Dr. Khorana will serve a one-year term, followed by one year as Chair and one year as Immediate Past Chair.

Dr. Manmeet AhluwaliaIn addition, Dr. Manmeet Ahluwalia, Associate Director of Clinical Trials, Operations and Section Head of NeuroOncology Outcomes in the Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center of the Cleveland Clinic Neurological Institute, and member of the Case Comprehensive Cancer Center, has been elected to serve as a member of the ASCO Cancer Education Committee on the Central Nervous System Tumors Track.

Madabhushi Team Awarded Patent

Dr. Anant MadabhushiAnant Madabhushi, PhD, Professor of Biomedical Engineering and member of the Case Comprehensive Cancer Center, has been awarded U.S. patent 8,774,479, System and method for automated segmentation, characterization and classification of possibly malignant lesions and stratification of malignant tumors.

The invention relates to a method and software for segmentation and classification of tumors automatically identified on radiologic imaging. The methodology involves computerized extraction of features on imaging that can characterize the risk and malignancy of the lesion. Co-inventors include Shannon Agner (Washington University, St Louis) and Mark Rosen (University of Pennsylvania).


FUNDING OPPORTUNITIES

2014 Audrey Meyer Mars International Fellowship

The American Cancer Society annually awards to qualified physicians and dentists from other countries the Audrey Meyer Mars International Fellowship in Clinical Oncology. The purpose of the Fellowship is to provide one year of advanced training in clinical oncology at one of the National Cancer Institute designated cancer centers participating in the program.
Deadline: December 1

Support of Multi-investigator Initiatives in the Case CCC

The Case CCC will provide two modes of support to new research teams that plan to submit large multi-investigator grant applications (usually non-R support mechanisms):

  • Administrative support and funding for travel are available to encourage team member meetings and meetings with external advisors.
  • Pilot project funding for research teams with an established track record of collaborative research is available to support key research initiatives that are necessary to generate competitive multi-investigator proposals.

Requests are competitive. The research team must demonstrate the active engagement of members, clearly articulate the significance and innovation of the project, and provide a roadmap for acquisition of external funding. Advocacy and support of the specific program leaders interacting with the team is required.

Discussion with Dr. Ruth Keri, Associate Director for Basic Research (ruth.keri@case.edu), is strongly encouraged before developing an application. Complete description and instructions are available on the Cancer Center website.
Deadline: Open


MARK YOUR CALENDARS

SOM Institutional Scientific Core Facility Retreat

The Second Annual SOM Institutional Scientific Core Facility Retreat is scheduled for August 25. Retreat participation is by invitation only and is primarily for Core Facility Directors and Managers, as well as Administrative/Clerical Staff. However, there will be limited additional seating available. If you would like to attend, please follow this link to request an invitation.

NCRM Cancer Stem Cell Conference

The Case Comprehensive Cancer Center and National Center for Regenerative Medicine (NCRM) invite you to attend the Cancer Stem Cell Conference (CSC 2014), August 17-20, 2014 at the Cleveland Convention Center.

This four-day conference will feature 53 internationally recognized speakers from 25 institutions around the world, including Michael Clarke, John Condeelis, Antonio Iavarone, Robert Kerbel, Jan Lotvall, Luis Parada, Tannishtha Reya, Jeff Rosen, M. Celeste Simon, and Irving Weissman.

if you plan on staying overnight, we encourage you to book rooms at the Hyatt Regency Cleveland at the Arcade, the official hotel for the NCRM Cancer Stem Cell Conference. The discounted rate of $129/night is only available until August 1.

Please direct any questions to Michael Gilkey: michael.gilkey@case.edu.

EVENTS

calendar

Tues, July 29

Cancer Biology Faculty Candidate
Yusuke Shiozawa, MD, PhD
Research Investigator, Periodontics and Oral Medicine
University of Michigan
Topic: Bone as a Target: Solving the Mystery of Prostate Cancer Metastasis
11 am NC1-202 Cleveland Clinic


Wed, July 30

Hematology and Oncology Division Research Conference Curriculum Series
Cheng Chee, MD
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: Fellowship Curriculum Series: Intro to Early Stage Colorectal Cancer
8 am Lerner Tower B-151

Cancer Center Faculty Candidate Seminar
Wenge Zhu, PhD
Assistant Professor, Biochemistry and Molecular Biology
George Washington University Medical Center
Topic: Maintenance Of Genomic Stability In Human Cell
9 am WRB 3-136


Thurs, July 31

Leaders in AIDS Research
Andrew Rice, PhD
Professor, Molecular Virology & Microbiology
Baylor College of Medicine
Topic: HIV Gene Regulation and Latency
1 pm SOM W203


Mon, August 4

Genomic Medicine Institute
Zhigang Liu, PhD
Zhang lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Nuclear Beta-catenin is Associated with Higher Expression of AMACR in Colon Cancer
12:30 pm NC1-202 Cleveland Clinic

Cancer Biology Staff Candidate
James Jackson, PhD
Instructor, Genetics
University of Texas M.D. Anderson Cancer Center
Topic: Mutant p53: Breast Cancer's Vulnerability?
1:30 pm NC1-202 Cleveland Clinic


Tues, August 5

THOR Seminar
Clemens Burda, PhD
Professor, Chemistry, Materials Science & Engineering
CWRU
Topic: Design and Control of Gold Nanoparticles for Drug Delivery Applications
1 pm R3-027 Cleveland Clinic


Thurs, August 7

Prostate Cancer Working Group Seminar Series and Journal Club
Joshua Lang, MD, MS
Assistant Professor, Medicine
University of Wisconsin Carbone Cancer Center
Topic: Circulating Biomarkers: Technology, Translation and Clinical Integration
3 pm NE1-205 Cleveland Clinic


Fri, August 8

Hem/Onc Fellows
Jennifer Eads, MD and Evi Stavrou, MD
Fellows, Div. of Hem/Onc
CWRU/UH
Topic: Developing a Research Plan during Fellowship
8 am Wearn 137/Breen Conf Rm.


Thurs, August 14

Special Seminar
Dr. Irit Sagi
Department of Biological Regulation
Weizmann Institute of Science
Topic: Controlling Extracellular Remodeling as a Strategy to Fight Inflammatory Diseases and Cancer
12 pm BRB 105

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Cancer Stem Cell Conference
August 17-20, 2014
Cleveland Convention Center
Details

ASTRO Review
November 15, 2014
Crowne Plaza, Independence, OH
Registration

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Registration

ADDITIONAL UPCOMING SEMINARS & EVENTS

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details


PREVIOUSLY ANNOUNCED OPPORTUNITIES

DoD Lung Cancer Research Program Concept Award
LOI Deadline: July 29
Application Deadline: August 12

Linda K. Arena Endowed Scholarship Award For Lung Cancer Education
Deadline: July 28

Greenwall Foundation: Making a Difference in Real-World Bioethics Dilemmas
LOI Deadline: August 1

ACSR Young Investigator Pilot Award
Deadline: August 1

American Cancer Society Clinical Research Professor
LOI Deadline: August 1
Application Deadline: October 15

Mesothelioma Applied Research Foundation Research Grant Program
Deadline: August 8

Uniting Against Lung Cancer
Deadline: August 13

Damon Runyon Cancer Research Foundation Fellowship Awards
Deadline: August 15

DoD Breast Cancer Research Program Breast Cancer Innovator Award
Deadline: August 15

DoD Breast Cancer Research Program Era of Hope Scholar Award
Deadline: August 15

Harrington Prize for Innovation in Medicine
Deadline: August 15

American Society of Cytopathology Foundation Patient Advocacy Grant
Deadline: August 15

DoD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: August 27
Confidential Letters of Recommendation: September 10
Application Deadline: September 10

DoD Prostate Cancer Research Program Collaborative Undergraduate Historically Black Colleges and Universities (HBCU) Student Summer Training Program Award
Pre-Application Deadline: August 27
Application Deadline: September 10

DoD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: August 27
Confidential Letters of Recommendation: September 10
Application Deadline: September 10

DoD Bone Marrow Failure Idea Development Award
Deadline: August 28

R. Robert & Sally Funderburg Research Award in Gastric Cancer
Deadline: August 29

Center for Global Health Short-Term Scientist Exchange Program
Deadline: September 1; December 1; March 1; June 1

Lymphoma Research Foundation Adolescent/Young Adult Cooperative Group Correlative Studies Grant
Deadline: September 3

Lymphoma Research Foundation Clinical Investigator Career Development Grant Program
Deadline: September 3

Lymphoma Research Foundation Lymphoma Clinical Research Mentoring Program (LCRMP)
Deadline: September 3

Lymphoma Research Foundation Postdoctoral Fellowship Grant
Deadline: September 3

2014 AICR Conference Scholarship
Deadline: September 5

AAAS Marion Milligan Mason Award for Women in the Chemical Sciences
Deadline: September 15

Prostate Cancer Foundation Global Treatment Sciences Challenge Award for Lethal Prostate Cancer
Deadline: September 22

Elsa U. Pardee Foundation
Deadline: October 1; February 1; June 1

CTSC KL2 Training Program
Deadline: October 27

Center for Cancer Research Clinical Investigator Development Program
Deadline: October 31

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Centers of Cancer Nanotechnology Excellence (CCNE)(U54)

NIH Transformative Research Awards (R01)(RFA-RM-14-003)

Comparative Health System Performance in Accelerating PCOR Dissemination (U19)(RFA-HS-14-011)

AHRQ Health Services Research Projects (R01)(PA-14-291)

AHRQ Health Services Research Demonstration and Dissemination Grants (R18)(PA-14-290)


HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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