March 10, 2014
CASE CCC IN THE NEWS
University Hospitals Unveils New Website, App to Help Patients Find Cancer Clinical Trials
Dr. Nima Sharifi Recognized with 2014 AACR Outstanding Achievement in Cancer Research Award
Nima Sharifi, MD, Kendrick family endowed chair for prostate cancer research, Department of Cancer Biology, Cleveland Clinic Lerner Research Institute and member of the Case Comprehensive Cancer Center, will be recognized with the 34th Annual American Association for Cancer Research (AACR) Outstanding Achievement in Cancer Research Award at the AACR Annual Meeting 2014, April 5-9 in San Diego, California.
Since 1979, the AACR Award for Outstanding Achievement in Cancer Research has honored an investigator younger than 40 years of age to recognize his or her meritorious achievements within the field of cancer research.
Dr. Sharifi is being recognized for his seminal contributions as a young investigator to the field of prostate cancer biology. He will present his lecture, Androgen Metabolism Drivers in Prostate Cancer: From Mechanism to Therapy, Monday, April 7, 4:30 pm PT, in room 20D in the San Diego Convention Center.
Dr. Charis Eng Honored with 17th Annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
The American Association for Cancer Research (AACR) will award the 17th annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship to Charis Eng, MD, PhD, at the AACR Annual Meeting 2014, April 5-9 in San Diego, California.
Dr. Eng is the Sondra J. and Stephen R. Hardis endowed chair in cancer genomic medicine, founding director of the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute, and long-time member of the Case Comprehensive Cancer Center. She is being recognized for her unstinting support and active promotion of women working in cancer research, medicine, and genetics. She will present her lecture, PTEN Hamartoma Tumor Syndrome Previvorship: What now?, Saturday, April 5, 5:15 pm PT, in Ballroom 20D in the San Diego Convention Center.
Researchers Find Byproducts from Gum Disease Incite Deadly Oral Cancer Growth
Researchers from Case Western Reserve University have discovered how byproducts in the form of small fatty acids from two bacteria prevalent in gum disease incite the growth of deadly Kaposi's sarcoma-related (KS) lesions and tumors in the mouth.
The discovery could lead to early saliva testing for the bacteria, which, if found, could be treated and monitored for signs of cancer before it develops into a malignancy, researchers say.
"These new findings provide one of the first looks at how the periodontal bacteria create a unique microenvironment in the oral cavity that contributes to the replication the Kaposi's sarcoma Herpesvirus (KSHV) and development of KS," said Fengchun Ye, the study's lead investigator from Case Western Reserve School of Dental Medicine's Department of Biological Sciences.
Contributing to the study were Case Western Reserve University researchers Abdel-Malek Shahir and Nabil Bissada, from the Department of Periodontics; Xiaolan Yu, Jingfeng Sha, Zhimin Feng, Betty Eapen, Stanley Nithianantham, and Aaron Weinberg, from the dental school's Department of Biological Sciences; and Biswajit Das and Jonathan Karn, from the Department of Molecular Biology & Microbiology at the School of Medicine. [more]
CWRU Wins $1.9 Million Grant to Lead Artificial Platelet Study
A research team led by biomedical engineers at Case Western Reserve University and collaborating with the Cleveland Clinic Foundation has received a $1.9 million National Institutes of Health grant to develop injectable artificial platelets that halt bleeding by sticking to bleeding sites and signaling natural platelets to home in on them.
The technology has broad applications to staunch bleeding in patients suffering from traumatic injury or surgery, as well as those with clotting disorders from deficiencies in platelet number or defects in platelet functions.
Lead researcher Anirban Sen Gupta, an assistant professor of biomedical engineering at Case Western Reserve, plans to use this five-year grant to further refine the design of artificial platelets’ shape, size and molecular surface-modifications, to mimic key morphological and functional aspects of natural platelets, and to test the design in several biologic models.
Sen Gupta will lead the effort to optimize the artificial platelet design, while Keith McCrae, MD, in the department of Hematologic Oncology and Blood Disorders at Cleveland Clinic, will guide the biologic model testing. Marvin Nieman, an assistant professor of pharmacology at Case Western Reserve School of Medicine and an expert in platelet biology, will provide necessary consultation.
The Sen Gupta laboratory, with collaborators here and at other institutions, plans to use the insight gained from the NIH-funded research, to further develop artificial platelet technologies for treating multiple diseases. To this end, the lab is already researching the role of platelets in the immune response rejecting organ transplants, with William Baldwin, MD, at Cleveland Clinic, and the platelet role in breast cancer metastasis, with assistant professor William Schiemann, co-leader of the Breast Cancer Program at Case Comprehensive Cancer Center. [more]
American Nuclear Society
The American Nuclear Society is accepting nominations for the Radiation Science and Technology Award. This award recognizes outstanding creative applications of radiation sciences and engineering principles. Qualification is based on meritorious scientific and engineering achievement that has important implications for radiation science and technology. The work may have been performed at any time in the past, but the findings must have been reported in peer reviewed scientific journals. In addition, the feasibility of industrial application(s) must have been established although the work need not be in widespread use at the time of the award. The nominee need not be an ANS member. Any ANS member can nominate a worthy candidate.
Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials
The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, firstname.lastname@example.org, 216.844.4176.
Brian Werbel Memorial Fund
Applications are currently being accepted for summer cancer research fellowship funding, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July.
Deadline: April 25
SAVE THE DATE
Screening for Cancer in Women: 2014
Registration is now open for Screening for Cancer in Women: 2014, Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.
Optimal strategies in cancer screening and detection are constantly evolving, and best practices are changing. This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.
This comprehensive symposium is aimed at primary care providers and cancer specialists with updates that can be incorporated into their practices:
CME credit will be offered. Visit the conference website for more details and registration information.
Mon, March 10
Pathology Research Seminar Series
Genomic Medicine Institute of CCF Integrative and Translational Seminar Series
Physiology & Biophysics Seminar
Div. of Hem/Onc Fellows Case Conference
Tues, March 11
Molecular Genetics Seminar
Immunology Seminar Series
Cancer Biology Seminar
Wed, March 12
Hematology and Oncology Division Research Conference
Pathology Grand Rounds
PRCHN Seminar Series
Breast Cancer Seminar
Thurs, March 13
Molecular Genetics Guest Speaker
Molecular Biology and Microbiology Seminar
Prostate Cancer Working Group Seminar Series and Journal Club
Fri, March 14
Hematology/Oncology Fellows Conference/Curriculum Series
Taussig Cancer Institute Grand Rounds
Cancer Center Seminar Series
Cancer Center Research in Progress
Mon, March 17
Genomic Medicine Institute Integrative and Translational Seminar Series
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS
Screening for Cancer in Women: 2014
Case CCC Annual Scientific Retreat
ADDITIONAL UPCOMING SEMINARS & EVENTS
1st Annual Multidisciplinary Colorectal Oncology Course
PREVIOUSLY ANNOUNCED OPPORTUNITIES
James S. McDonnell Foundation (JSMF) Scholar Awards program
Alex's Lemonade Stand Foundation Springboard Grant
NIH BULLETIN – Notices and Funding Opportunities
HELP US HELP YOU!
If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at email@example.com.
Connect with Us