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Case Comprehensive Cancer Center Newsletter

March 10, 2014

CASE CCC IN THE NEWS

University Hospitals Unveils New Website, App to Help Patients Find Cancer Clinical Trials
The Plain Dealer - Mar 4, 2014
A website and mobile-device app designed by University Hospitals Seidman Cancer Center is providing cancer patients with information on clinical trials that they might be able to access as part of their treatment. The website and app have information on more than 150 available cancer clinical trials offered in collaboration with the Case Comprehensive Cancer Center...About 75 percent of cancer patients who go online for information about their disease are looking for information about clinical trials, said Dr. Neal Meropol, chief of the division of hematology/oncology at UH and Case Western Reserve University School of Medicine...In spring 2013, the Clinic launched its Cancer Clinical Trials App with information on trials, patient resources, financial services, support groups and treatment guides.


ANNOUNCEMENTS

Dr. Nima Sharifi Recognized with 2014 AACR Outstanding Achievement in Cancer Research Award

Nima SharifiNima Sharifi, MD, Kendrick family endowed chair for prostate cancer research, Department of Cancer Biology, Cleveland Clinic Lerner Research Institute and member of the Case Comprehensive Cancer Center, will be recognized with the 34th Annual American Association for Cancer Research (AACR) Outstanding Achievement in Cancer Research Award at the AACR Annual Meeting 2014, April 5-9 in San Diego, California.

Since 1979, the AACR Award for Outstanding Achievement in Cancer Research has honored an investigator younger than 40 years of age to recognize his or her meritorious achievements within the field of cancer research.

Dr. Sharifi is being recognized for his seminal contributions as a young investigator to the field of prostate cancer biology. He will present his lecture, Androgen Metabolism Drivers in Prostate Cancer: From Mechanism to Therapy, Monday, April 7, 4:30 pm PT, in room 20D in the San Diego Convention Center.

Dr. Charis Eng Honored with 17th Annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship

Charis EngThe American Association for Cancer Research (AACR) will award the 17th annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship to Charis Eng, MD, PhD, at the AACR Annual Meeting 2014, April 5-9 in San Diego, California.

Dr. Eng is the Sondra J. and Stephen R. Hardis endowed chair in cancer genomic medicine, founding director of the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute, and long-time member of the Case Comprehensive Cancer Center. She is being recognized for her unstinting support and active promotion of women working in cancer research, medicine, and genetics. She will present her lecture, PTEN Hamartoma Tumor Syndrome Previvorship: What now?, Saturday, April 5, 5:15 pm PT, in Ballroom 20D in the San Diego Convention Center.


RESEARCH HIGHLIGHTS

Researchers Find Byproducts from Gum Disease Incite Deadly Oral Cancer Growth

Fengchun YeResearchers from Case Western Reserve University have discovered how byproducts in the form of small fatty acids from two bacteria prevalent in gum disease incite the growth of deadly Kaposi's sarcoma-related (KS) lesions and tumors in the mouth.

The discovery could lead to early saliva testing for the bacteria, which, if found, could be treated and monitored for signs of cancer before it develops into a malignancy, researchers say.

"These new findings provide one of the first looks at how the periodontal bacteria create a unique microenvironment in the oral cavity that contributes to the replication the Kaposi's sarcoma Herpesvirus (KSHV) and development of KS," said Fengchun Ye, the study's lead investigator from Case Western Reserve School of Dental Medicine's Department of Biological Sciences.

Contributing to the study were Case Western Reserve University researchers Abdel-Malek Shahir and Nabil Bissada, from the Department of Periodontics; Xiaolan Yu, Jingfeng Sha, Zhimin Feng, Betty Eapen, Stanley Nithianantham, and Aaron Weinberg, from the dental school's Department of Biological Sciences; and Biswajit Das and Jonathan Karn, from the Department of Molecular Biology & Microbiology at the School of Medicine. [more]

CWRU Wins $1.9 Million Grant to Lead Artificial Platelet Study

Anirban Sen GuptaA research team led by biomedical engineers at Case Western Reserve University and collaborating with the Cleveland Clinic Foundation has received a $1.9 million National Institutes of Health grant to develop injectable artificial platelets that halt bleeding by sticking to bleeding sites and signaling natural platelets to home in on them.

The technology has broad applications to staunch bleeding in patients suffering from traumatic injury or surgery, as well as those with clotting disorders from deficiencies in platelet number or defects in platelet functions.

Lead researcher Anirban Sen Gupta, an assistant professor of biomedical engineering at Case Western Reserve, plans to use this five-year grant to further refine the design of artificial platelets’ shape, size and molecular surface-modifications, to mimic key morphological and functional aspects of natural platelets, and to test the design in several biologic models.

Sen Gupta will lead the effort to optimize the artificial platelet design, while Keith McCrae, MD, in the department of Hematologic Oncology and Blood Disorders at Cleveland Clinic, will guide the biologic model testing. Marvin Nieman, an assistant professor of pharmacology at Case Western Reserve School of Medicine and an expert in platelet biology, will provide necessary consultation.

The Sen Gupta laboratory, with collaborators here and at other institutions, plans to use the insight gained from the NIH-funded research, to further develop artificial platelet technologies for treating multiple diseases. To this end, the lab is already researching the role of platelets in the immune response rejecting organ transplants, with William Baldwin, MD, at Cleveland Clinic, and the platelet role in breast cancer metastasis, with assistant professor William Schiemann, co-leader of the Breast Cancer Program at Case Comprehensive Cancer Center. [more]


FUNDING OPPORTUNITIES

American Nuclear Society

The American Nuclear Society is accepting nominations for the Radiation Science and Technology Award. This award recognizes outstanding creative applications of radiation sciences and engineering principles. Qualification is based on meritorious scientific and engineering achievement that has important implications for radiation science and technology. The work may have been performed at any time in the past, but the findings must have been reported in peer reviewed scientific journals. In addition, the feasibility of industrial application(s) must have been established although the work need not be in widespread use at the time of the award. The nominee need not be an ANS member. Any ANS member can nominate a worthy candidate.
Deadline: April 15

Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials

The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, kxk384@case.edu, 216.844.4176.
LOI deadline: April 15

Brian Werbel Memorial Fund

Applications are currently being accepted for summer cancer research fellowship funding, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July.

Deadline: April 25


SAVE THE DATE

Screening for Cancer in Women: 2014

Registration is now open for Screening for Cancer in Women: 2014, Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.

Optimal strategies in cancer screening and detection are constantly evolving, and best practices are changing. This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.

This comprehensive symposium is aimed at primary care providers and cancer specialists with updates that can be incorporated into their practices:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Impact of the Affordable Care Act
  • Racial and economic disparities within cancer screening and detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Visit the conference website for more details and registration information.

EVENTS

calendar

Mon, March 10

Pathology Research Seminar Series
Saptarsi Haldar, MD
Assistant Professor, Medicine, Case Cardiovascular Research Institute
CWRU/UH
Topic: Targeting Chromatin Dependent Signal Transduction in Heart Failure
12 pm WRB 1-413

Genomic Medicine Institute of CCF Integrative and Translational Seminar Series
Paul Wade, PhD
PI, Eukaryotic Transcriptional Regulation Group
National Institute of Environmental Health Sciences
National Institutes of Health
Topic: DNA Methylation and Chromatin Architecture: The Nuts and Bolts of Gene Regulation
12:30 pm NE1-205 Cleveland Clinic

Physiology & Biophysics Seminar
Jason Mears, PhD
Assistant Professor, Pharmacology
CWRU
Topic: Structural Studies of Drp1 Self-assembly Provide Insights into the Mechanism of Mitochondrial Fission
4 pm Robbins E-501

Div. of Hem/Onc Fellows Case Conference
Terri Goebel, DO
Div. of Hem/Onc
CWRU/UH
Topic: An Incidental Finding
AND
Peter Oppelt, MD
Div. of Hem/Onc
CWRU/UH
Topic: Melanoma
5 pm Wearn 137


Tues, March 11

Molecular Genetics Seminar
Elizabeth Hulme Berezovsky, PhD
Postdoctoral Fellow, Runge lab, Molecular Genetics
Cleveland Clinic
Topic: Plumbagin-Induced Stress Resistance and Lifespan Extension
9:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
Minoru Fukuda, PhD
Professor, Pathology
Sanford Burnham Medical Research Institute
Topic: Role of Heparan Sulfate in Colon Stem Cells of Intestine
12 pm WRB 1-413

Cancer Biology Seminar
Matthew Summers, PhD
Assistant Staff, Cancer Biology
CWRU/Cleveland Clinic
Topic: New Insights into Cell Cycle Checkpoint Deregulation in Cancer
2 pm NC1-202 Cleveland Clinic


Wed, March 12

Hematology and Oncology Division Research Conference
Topic: TBD
8 am Lerner B-151

Pathology Grand Rounds
Richard M. DeMay, MD
Professor and Director, Pathology-Cytopathology
University of Chicago
Topic: Cytopathology of the Pancreas
8 am Pathology Amphitheatre

Immunology Seminar
Stefania Gallucci, MD
Associate Professor, Microbiology and Immunology
Associate Professor, Autoimmunity Center
Temple University
Topic: Dendritic Cells, Type I Interferons and Autoimmunity
12 pm NC1-202 Cleveland Clinic

PRCHN Seminar Series
Johnie Rose, MD, PhD
Assistant Professor, Family Medicine and Community Health
CWRU/UH
Topic: The Affordable Care Act: Implications for Public Health and Prevention
12 pm BioEnterprise Ground Fl.

Breast Cancer Seminar
Ofer Reizes, PhD
Assistant Professor, Cell Biology
Cleveland Clinic
Topic: The Role of Cancer Stem Cell Gap Junctions in Triple Negative Breast Cancer
AND
G. Thomas Budd, MD
Professor, Solid Tumor Oncology
Cleveland Clinic
Topic: Opportunities for Translational Studies in a Completed Phase III Clinical Trial
5:30 pm WRB 1-413


Thurs, March 13

Molecular Genetics Guest Speaker
Ludmila Prokunina-Olsson, PhD
Div. of Cancer Epidemiology and Genetics
National Cancer Institute, NIH
Topic: The Paradoxical Role of the Novel Human Interferon, Interferon Lambda 4 (IFNL4), in Infections and Cancer
9:30 am NE1-205 Cleveland Clinic

Molecular Biology and Microbiology Seminar
Ryan Stultz
Student, McDonald lab, Molecular Biology and Microbiology
CWRU
Topic: Tracking the Post-fusion Events of HIV in Primary Human Macrophages
AND
David McDonald, PhD
Assistant Professor, Molecular Biology and Microbiology
CWRU
Topic: Pity the Pore Immigrant
1 pm Rottman Seminar Room, Wood W203

Prostate Cancer Working Group Seminar Series and Journal Club
Owen N. Witte, MD
Director, Broad Stem Cell Research Center
Distinguished Professor, Microbiology, Immunology and Molecular Genetics
Investigator, Howard Hughes Medical Institute
University of California, Los Angeles
Topic: Prostate Stem Cells and Cancer Progression
4 pm NA1-138 Cleveland Clinic


Fri, March 14

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Mitchell Smith, MD, PhD
Professor, Solid Tumor Oncology
Cleveland Clinic
Topic: ABC's of B-cells Behaving Badly: Apoptosis, B cell Receptors, CyclinD1
AND
Jennifer Yu, MD, PhD
Cleveland Clinic
Topic: Flagging Down Glioma Initiating Cells With Sema3C
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Owen N. Witte, MD
Director, Broad Stem Cell Research Center
Distinguished Professor of Microbiology, Immunology and Molecular Genetics
Investigator, Howard Hughes Medical Institute
University of California, Los Angeles
Topic: Defining Kinase Targets in Advanced Prostate Cancer
12 pm BRB 105

Cancer Center Research in Progress
David Danielpour, PhD
Professor, Div. of General Medical Sciences-Oncology
CWRU/UH
Topic: Androgenic Control of Growth Factor Receptor Signaling in Prostate Cancer
4 pm WRB 3-136


Mon, March 17

Genomic Medicine Institute Integrative and Translational Seminar Series
Matt Cannon, PhD
Fellow, Serre lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Post-natal Epigenetic Reprogramming of the Liver in Mice
12:30pm NE1-205 Cleveland Clinic

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence
Details

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

ADDITIONAL UPCOMING SEMINARS & EVENTS

1st Annual Multidisciplinary Colorectal Oncology Course
April 23
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH


PREVIOUSLY ANNOUNCED OPPORTUNITIES

James S. McDonnell Foundation (JSMF) Scholar Awards program
Deadline: March 12

Childhood Brain Tumor Foundation Pediatric Brain Tumor Grant Awards
Deadline: March 14

Childhood Brain Tumor Foundation Astrocytoma Research Award
Deadline: March 14

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 17

Damon Runyon Fellowship Award
Deadline: March 17

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE)
Deadline: March 28

Case-Coulter Translational Research Partnership
LOI Deadline: March 28

Skin Disease Research Center Pilot and Feasibility (P&F) Program
Deadline: March 31

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Sta Op Tegen Kanker Dream Team Translational Cancer Research Grant
Deadline: April 1

Alex's Lemonade Stand Foundation Bridge Grant
Deadline: April 10

Alex's Lemonade Stand Foundation Springboard Grant
Deadline: April 10

Brian Werbel Memorial Fund Summer Cancer Research Fellowships
Deadline: April 25

GlaxoSmithKline Discovery Fast Track Challenge
Deadline: May 16

HHMI Investigator Program National Competition
Deadline: June 3

Lung Cancer Research Foundation
Deadline: June 16, 2014

Damon Runyon Fellowship Award
Deadline: August 15

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

NIH Will Open the Research Performance Progress Report (RPPR) for All Type 5 Non-SNAP Progress Reports on April 25, 2014 (NOT-OD-14-064)

Notice of Online Data Submission and Access to the National Institutes of Health (NIH) database of Genotypes and Phenotypes (dbGaP)(NOT-OD-14-065)

Notice of Reissuance of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship Funding Opportunity Announcements (NOT-OD-14-066)

Notice of NIBIB's Participation in RFA-HG-14-020 "Development of Software and Analysis Methods for Biomedical Big Data in Targeted Areas of High Need (U01)" (NOT-EB-14-004)

Translational Research at the Aging/Cancer Interface (TRACI) (R01)(PA-12-136)

Additional Research Training Positions for NIAAA-, NIDA-, or NCI-Supported NRSA Institutional Training (T32) Grants (Admin Supp)(PA-14-146)

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)(PA-14-147)

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity)(PA-14-148)

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)(PA-14-149)

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30)(PA-14-150)

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33)(PA-14-151)

The NCI Transition Career Development Award (K22)(PAR-12-121)


HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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