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Case Comprehensive Cancer Center Newsletter

February 10, 2014

CASE CCC IN THE NEWS

UH Rainbow Launches NE Ohio's Only Phase 1 Clinical Trials Program for Young Cancer Patients
The Plain Dealer - Feb 6, 2014
Earlier this year UH Rainbow – the pediatric affiliate of the Case Comprehensive Cancer Center at Case Western Reserve University – became the first hospital in Northeast Ohio to make Phase 1 trials available for pediatric cancer patients. The first study to open is testing a new combination of drugs in up to 30 patients with relapsed leukemia or lymphoma...By the end of February, two other Phase 1 trials will be ready to enroll patients. Dr. Robin Norris, a pediatric oncologist at UH, is the national primary investigator for one of the trials, testing the safety of a new drug for patients whose cancer (solid tumor) has returned...Another UH Rainbow oncologist, Dr. Alex Huang, had received funding from the foundation and had also organized a team to raise money for the foundation's Million Mile Run in 2013.

Cleveland Doctors Studying Stem Cells with Success (video)
Fox 8 - Feb 5, 2014
Case Comprehensive Cancer Center members Drs. Jeremy Rich and David Wald discuss cell-based therapies conducted through the National Center for Regenerative Medicine.

Early Promise for a Blood Thinner Without the Bleeding Risk
US News & World Report - Feb 5, 2014
An experimental drug appears to prevent dangerous blood clots, without raising the risk of excessive bleeding – at least in animals..."The holy grail in this field is to be able to give something that prevents clots, without causing bleeding," said Dr. Alvin Schmaier, a professor at Case Western Reserve University in Cleveland, who wrote an editorial published with the study.

VeloSano Cycling Event Registration Now Open
Westlake Bay Village Observer - Feb 4, 2014
Registration for VeloSano, the annual cycling event to raise money for cancer research at Cleveland Clinic, is now open to the public. Cyclists can choose either a one- or two-day cycling experience...and 100 percent of funds raised by participants will directly benefits cancer research at Cleveland Clinic..."Funds raised by VeloSano and its riders will help our physicians and researchers generate discoveries and explore novel therapies for treating cancer," said Brian J. Bolwell, M.D., FACP, chairman of Cleveland Clinic's Taussig Cancer Institute. "We encourage all Northeast Ohioans to join the movement and consider participating in the event as a cyclist or a volunteer."

New Agent Misses the Mark in Advanced Prostate Cancer
Medscape - Feb 4, 2014
A promising investigational agent for metastatic castration-resistant prostate cancer has failed to meet its primary end point in a phase 3 trial. There was no significant improvement in overall survival when orteronel (Takeda) was added to prednisone. Median overall survival with orteronel plus prednisone was similar to that with placebo plus prednisone. The study was terminated for failing to meet its primary end point. However, orteronel –did lead to a notable improvement in radiographic progression-free survival,– reported lead author Robert Dreicer, MD, MS, professor of medicine at the Cleveland Clinic Lerner College of Medicine, and chair of the Department of Solid Tumor Oncology at the Cleveland Clinic Foundation.

Transforming Oncology Care With PET/MR
Imaging Technology News - Feb 3, 2014
By Pablo Ros, MD, PhD, MPH. Following commercial availability of the Philips Ingenuity TF PET/MR in late 2011, University Hospitals Seidman Cancer Center continues to see the benefits of this hybrid modality.

Maintenance Chemo Delays Progression in Metastatic CRC
Medscape - Jan 27, 2014
Maintenance treatment with capecitabine ( Xeloda) and bevacizumab ( Avastin) significantly delayed disease progression, compared with observation, in patients with metastatic colorectal cancer. There was also a trend toward improved overall survival, although this did not reach statistical significance, according to final results from the CAIRO3 trial, which were presented here at the 2014 Gastrointestinal Cancers Symposium...Study discussant Neal J. Meropol, MD, from the University Hospitals Seidman Cancer Center and Case Western Reserve University in Cleveland, noted that the CAIRO3 findings show that it is "feasible yet challenging to conduct a window-of-opportunity study after induction therapy."


ANNOUNCEMENTS

CTSC Core Utilization Pilot Award Recipients

Congratulations to the recipients of the November 2013 Clinical and Translational Science Collaborative (CTSC) Core Utilization Pilot Awards:

  • Marvin Nieman, PhD: Analysis of the Phosphoproteome in Thrombin Stimulated Platelets
  • Zhenghe John Wang, PhD: Targeting Glutamine Metabolism for Cancer Therapy
Disease Team sign-off and PRMC protocol submission

Effective immediately, the Protocol Review and Monitoring Committee (PRMC) will not be accepting protocol submissions without Disease Team sign-offs from both institutions. One of the functions of the Case CCC Clinical Trials Disease Teams is to "recommend action to PRMC for trial advocacy and priority" by providing "pre-review by experts in their field for scientific merit, prioritization, and intent to accrue patients" (Case CCC Clinical Trials Operations Manual). Disease Team sign-off from both hospitals has been a longstanding requirement and protocol submissions will no longer be accepted by PRMC without it. Please note that the overall responsibility of following-up and obtaining sign-offs rests with the PI and the study team. Contact April Firstencel, PRMC Manager, at 216.286.2294 or april.firstencel@case.edu with any questions.

Vote for Dr. Stan Gerson for the AACR Nominating Committee

Last chance to vote for Dr. Stan Gerson, who is on the ballot for the American Association for Cancer Research (AACR) Nominating Committee. The election will close this Friday, February 14. Voting instructions will be distributed to all voting members of AACR. Election results will be announced in March 2014 and elected candidates will assume office at the AACR Annual Meeting 2014 in April.

Please show your support for Dr. Gerson and vote for him! It would be great to have local votes that place our director on the Nominating Committee, which selects candidates for major awards, the annual meeting program committee, and the slate of candidates for national positions.


CORE FACILITY SPOTLIGHT

Imaging Research Core Facilitates Research Using Bioluminescent Imaging Technology

When Dr. Bill Schiemann and his lab needed to conduct research using Bioluminescent Imaging technology to investigate breast cancer metastasis in a single animal, they tapped into the resources available through the Imaging Research Core, led by Dr. Chris Flask. Together, the investigators produced a video publication, In vivo Dual Substrate Bioluminescent Imaging, in the "Journal of Visualized Experiments (JoVE)", a PubMed-indexed video journal. The publication demonstrated how to construct, visualize, and quantify the bioluminescent reactions of both firefly and renilla luciferase enzymes expressed in metastatic breast cancer cells during their growth and metastasis in vivo.

The Imaging Research Core provides access to in vivo preclinical imaging techniques including Magnetic Resonance Imaging, XRay, CT, and PET. More advanced, specialized imaging techniques can also be obtained through collaboration with one of 25 imaging research faculty in the Core and the Case Center for Imaging Research (CCIR).

"The expertise of the Case Comprehensive Cancer Center Imaging Core provided us with a unique and powerful opportunity to not only image breast tumor development and metastasis in real-time in mice, but also to simultaneously visualize the flux through oncogenic signaling systems that mediate these deadly events," said Dr. Schiemann. "More importantly, these innovative imaging systems also provided us with novel insights into how alterations with the tumor microenvironment or the administration of breast cancer chemotherapies impact oncogenic signaling systems during breast cancer metastasis and disease recurrence."


SAVE THE DATE

Team Science Workshop

On Monday, February 17 the Clinical and Translational Science Collaborative (CTSC) will host a Team Science Workshop from 1-4 pm in the Wolstein Research Building Auditorium. This workshop is a forum to enhance our understanding of Team Science and how it can advance research efforts through collaboration. Team Science is a collaborative and multidisciplinary research effort that joins together researchers to explore a specific research problem with specific targeted goals. Team Science collaborations can join together individuals from the same department, other institutions, community organizations, and/or other organizations that typically do not interact with one another. Teams can vary in focus from training, clinical translation, public health issues, and scientific discovery.

The National Institutes of Health has been explicit in its support of Scientists working in teams to solve complex problems. The National Center for the Advancement of Translational Sciences promotes this model. The partner institutions will demonstrate their support of a team science environment by enhancing the infrastructure through pilot funding, technology transfer resources and support, and other shared resources.

Inaugural Case Comprehensive Cancer Center Academic Drug Development Seminar

The Inaugural Case Comprehensive Cancer Center Academic Drug Development Seminar, will be held on February 26 at 4pm in the Global Cardiovascular Innovation Center, 10000 Cedar Avenue. This first seminar will feature a presentation by Dr. Goutham Narla, Assistant Professor, Medicine and Transformative Molecular Medicine at CWRU/UH, on Drugging the Undruggable: Small Molecule Activators of Tumor Suppressor Genes.

As part of the Case CCC Developmental Therapeutics Program, this series will gather clinicians, scientists, medical chemists, computer-aided drug designers, screeners, and commercialization personnel in the same room as a stimulating presentation so that all attendees can learn and benefit from the sparked interaction. More details will be circulated in the near future, but please save the date and plan to attend this event. Free parking is available.

Retreat: Engaging in Cultural Competence through Awareness, Knowledge and Action

Please mark your calendars for Thursday, March 13 from 2-5 pm to join the Case Comprehensive Cancer Center and the Case Center for Reducing Health Disparities as they explore issues related to cultural competence. Extend your knowledge and raise your awareness about the dynamic variety of people and communities the Case CCC serves. This retreat will feature a keynote address by Dr. Sonja Harris-Haywood, and will provide perspective on the growing need to be culturally competent and facilitate the impact of cultural beliefs within the health care setting, specifically in research.

The retreat is intended for investigators, research nurses, regulatory coordinators, outreach and training and education personnel. Pre-registration is required. Please direct any questions to Katarzyna Karelus at 216.844.4176 or katarzyna.karelus@case.edu.

Screening for Cancer in Women: 2014

Please mark your calendars and plan to attend Screening for Cancer in Women: 2014, on Wednesday, May 21 from 8 am - 3 pm at the Embassy Suites Hotel in Independence.

Optimal strategies in cancer screening and detection are constantly evolving and best practices are changing.

 

This update is aimed at primary care providers and cancer specialists with guides that can be incorporated into their practices:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Impact of the Affordable Care Act and racial and economic disparities on cancer detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Pre-registration is required. Check the Cancer Center website for more information.


FUNDING OPPORTUNITIES

Case GI SPORE Request for Project Proposals

All Faculty members are invited to submit Concept Proposals for consideration to be incorporated as full projects in the Case GI SPORE P50 award. All proposals must be directed towards translational research of a GI malignancy, with at least one specific aim that involves direct study of patients or of human tissues. Opportunities will include:

  • the possibility of current inclusion and funding as a full Project in the currently funded GI SPORE;
  • opportunities for start-up support from the GI SPORE pilot project program commencing Sept. 2014;
  • opportunities for inclusion as a full project proposed in the SPORE competing renewal proposal that will be prepared starting in January 2015 for submission in September 2015.

Deadline: February 15

Brian Werbel Memorial Fund

Applications are currently being accepted for summer cancer research fellowship funding, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July.

Deadline: April 25

EVENTS

calendar

February 10

Genetics Student Seminar
Angela Lager
Student, Genetics and Genome Sciences
CWRU
Topic: Cell Reprogramming Technologies for the Treatment of Genetic Disorders of Myelin
11 am BRB 105

Pathology Research Seminar Series
Vincent Monnier, MD
Professor, Pathology
CWRU
Topic: Oxidative and Carbonyl Stress in the Complications of Diabetes and Age-Related Diseases
12 pm WRB 1-413

Genomic Medicine Institute Seminar Series
Jonathan Haines, PhD
Chair, Epidemiology and Biostatistics
Mary W. Sheldon, MD Professor of Genomic Sciences
CWRU
Topic: How Electronic Health Records Can Help Us Understand the Genetics of Multiple Sclerosis
12:30 pm NE1-205 Cleveland Clinic

Div. of Hem/Onc Fellows Case Conference
Mital Patel, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Chronic Leukemias – The Road Less Travelled
AND
Andy Parchman, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Medullary Thyroid Cancer: Advances in Diagnosis and Treatment
5 pm SCC Learning Lab


February 11

Radiation Oncology Grand Rounds
Min Yao, MD, PhD
Associate Professor, Radiation Oncology
CWRU/UH
Topic: Management of Laryngeal Squamous Cell Carcinoma
8:10 am Lerner Tower B-151

Cellular and Molecular Medicine Seminar Series
Sung-Ho Huh, PhD
Research Instructor, Developmental Biology
Washington University
Topic: Signaling Requirement for Cochlear Development: An essential and cooperative role for the FGF family
10 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Tom Richardson
PhD Candidate, Harding lab, Pathology
CWRU
Topic: TLR2 and ERK Signaling Control Macrophage Responses to Mycobacterium Tuberculosis and the Balance of Inflammatory Mechanisms and Th1 Activation
12 pm WRB 1-413

Neurosciences Guest Speaker
Katrina Podsypanina, MD, PhD
Assistant Professor and Director, Breast Cancer Research Unit, Div. of Experimental Medicine
University of Montreal
Topic: Right Cell, Wrong Place
1 pm NE1-205 Cleveland Clinic

Cancer Biology Seminar Series
Arishya Sharma
Graduate Student, Almasan lab, Cancer Biology
Cleveland Clinic
Topic: mTORC1 and Autophagy Determine Fludarabine Resistance in Leukemic Cells
2 pm NC1-202 Cleveland Clinic


February 12

Hematology and Oncology Division Research Conference
Alvin Schmaier, MD
Professor, Div. of Hem/Onc
CWRU/UH
Topic: Novel Targets for Anticoagulation from the Plasma Contact and Kallirkein/Kinins Systems - Anticoagulation without Alteration in Hemostasis
8 am Lerner B-151

Pathology Grand Rounds
Yan Zheng, MD, PhD
PGY2, Pathology
CWRU/UH
Topic: Is RBC Fragmentation Equal to Thombotic Thrombocytopenic Purpura (TTP)?
AND
Zhenjian Cai, MD, PhD
PGY2, Pathology
CWRU/UH
Topic: Loss of Coup-TFII is Associated with Pancreatic Carcinogenesis
8 am Pathology Amphitheatre

Neurosciences Guest Speaker
Eric Lagasse, PharmD, PhD
Associate Professor Pathology
Director, Cancer Stem Cell Center
McGowan Institute for Regenerative Medicine
University of Pittsburgh
Topic: From Stem Cells to Cancer Stem Cells in the Intestinal Epithelium: Progress and Problems
10 am NE1-205 Cleveland Clinic

Pathology Faculty Candidate
Nita Salzman, MD, PhD
Associate Professor, Pediatrics
Medical College of Wisconsin
Topic: Paneth Cells, Antimicrobial Peptides, and Intestinal Homeostasis
10 am WRB 5-136

Development and Differentiation: from Structure to Function Symposium Series
Alexander Meissner, PhD
Associate Professor, Stem Cell and Regenerative Biology
Principal Faculty, Harvard Stem Cell Institute
Harvard University
Topic: Mechanisms of Epigenetic Regulation
11 am WRB 1-413

Immunology Students/Fellows Research in Progress Seminar Series
Justin Johnson
Graduate Student, Tuohy lab, Immunology
Cleveland Clinic
Topic: Autoimmunity to Anti-Mullerian Hormone (AMH) extends fertility in C57BL/6 Mice
AND
Kathy Ayasoufi
Graduate Student, Valujskikh lab, Immunology
Topic: B Cells and CD40/CD 154 interactions are required for CD8 T Cell recovery following Antibody-Mediated Lymphoablation
12 pm NC1-202 Cleveland Clinic

Development and Differentiation: from Structure to Function Symposium Series
Alexander Meissner, PhD
Associate Professor, Stem Cell and Regenerative Biology
Principal Faculty, Harvard Stem Cell Institute
Harvard University
Topic: DNA Methylation Dynamics in Stem Cells and Development
3:30 pm WRB 1-413

Case CCC Breast Cancer Program Seminar
Cheryl Thompson, PhD
Assistant Professor, Family Medicine
CWRU/UH
Topic: Sleep and Cancer Phenotype
AND
Tithi Biswas, MD
Associate Professor, Radiation Oncology
CWRU/UH
Topic: Surgery for Stage IV Breast Cancer
5:30 pm Robbins E-501/Cleveland Clinic R3-002


February 13

Immunology Journal Club
Hana Russo
Student, Immunology
CWRU/UH
Topic: Th17 Cell Differentiation is Regulated by the Circadian Clock
12 pm WRB 5-136


February 14

Cancer Center Research in Progress cancelled

Hematology/Oncology Fellows Conference/Curriculum Series
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Alberto Montero, MD
Staff, Solid Tumor Oncology
Cleveland Clinic
Topic: Myeloid Derived Suppressor Cells in Solid Tumors: Challenges and Therapeutic Opportunities
AND
Gregory Videtic, MD
Staff, Radiation Oncology
Cleveland Clinic
Topic: Update in Lung Cancer Radiotherapy
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Amnon Schlegel, MD, PhD
University of Utah
Topic: Intestinal Lxr Induction of Acsl3 Delays Absorption of Ingested Lipids
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Theodore Brasky, PhD
Assistant Professor, Medicine
Ohio State University
Topic: Omega 3 Fatty Acids and Prostate Cancer Risk
12 pm BRB 105

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

ADDITIONAL UPCOMING SEMINARS & EVENTS

2014 Multidisciplinary Head and Neck Cancer Update
February 14-15
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL
Details

International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery
February 21-23
The Naples Beach Hotel & Golf Club
Naples, FL
Details

1st Annual Multidisciplinary Colorectal Oncology Course
April 23
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details


PREVIOUSLY ANNOUNCED OPPORTUNITIES

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training (POST) Program
Deadline: February 10

2014 Bladder Cancer Research Innovation Award
LOI Deadline: February 12
Application Deadline: April 23

Leukemia & Lymphoma Society Translational Research Program
LOI Deadline: February 15
Application Deadline: March 1

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21

Dan David Prize Scholarships
Deadline: February 28

CWRU Department of Medicine Team Science Challenge
Deadline: March 1

Bladder Cancer Advocacy Network 2014 Young Investigator Awards
Deadline: March 5

James S. McDonnell Foundation (JSMF) Scholar Awards program
Deadline: March 12

Childhood Brain Tumor Foundation Pediatric Brain Tumor Grant Awards
Deadline: March 14

Childhood Brain Tumor Foundation Astrocytoma Research Award
Deadline: March 14

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 17

Damon Runyon Fellowship Award
Deadline: March 17

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE)
Deadline: March 28

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Brian Werbel Memorial Fund Summer Cancer Research Fellowships
Deadline: April 25

HHMI Investigator Program National Competition
Deadline: June 3

Damon Runyon Fellowship Award
Deadline: August 15

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

NIH Implements Option for Applicants to Switch between the SBIR/STTR programs and the SBIR Direct to Phase II pilot of the SBIR/STTR Reauthorization Act of 2011 (NOT-OD-14-048)

New Requirements in the Funding Opportunity Announcement PAR-14-073 "Shared Instrumentation Grant Program (S10)" (NOT-OD-14-049)

Timetable for Next Round Resubmission of New Investigator R01 Applications Changed for October 2014 Council (NOT-OD-14-050)

Notice of Revised Term of Award for All Recovery Act Awards to Repeal Section 1512 Reporting Requirement Effective February 1, 2014 (NOT-OD-14-054)

PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])(PA-14-071)

PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])(PA-14-072)

Shared Instrumentation Grant Program (S10)(PAR-13-008)

Revision Applications for Research on Metabolic Reprogramming to Improve Immunotherapy (R01)(PAR-14-085)

Revision Applications for Research on Metabolic Reprogramming to Improve Immunotherapy (U01)(PAR-14-086)

Revision Applications for Research on Metabolic Reprogramming to Improve Immunotherapy (P01)(PAR-14-087)


HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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