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Case Comprehensive Cancer Center Newsletter

December 2, 2013

gersonMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

IOM Report on Genomics

Dear Cancer Center Members:
Please take the time to review an important new analysis from the Institute of Medicine, Genome-based Diagnostics: Demonstrating Clinical Utility in Oncology. The document provides expert opinions on development and use of biomarkers for detection, diagnosis, prognosis, and drug response in oncology; this includes genomic biomarkers. Although it does not specifically address genomic mutations as predictors of treatment and response, that is the direction it is headed. Given the importance of IOM reports in setting national standards, please consider and reference this document in your research and grant submissions. Also, a good bit of the orientation is towards validation through clinical trials and the development of approved companion diagnostics.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center


CASE CCC IN THE NEWS

University Hospitals Performs Rare Procedure During Brain Bypass; Patient Goes Home for Holidays
The Plain Dealer - Nov 28, 2013
On Monday, Eric Wagner finally got surgical staples, lining a 6.25 inch curved scar, removed from the left side of his skull. He had gotten them 10 days earlier, during a 12-hour operation at University Hospitals Case Medical Center...Brain scans showed that Wagner had a ruptured aneurysm, a leaking blister on a blood vessel that was letting blood flow into his brain. Neuroradiologist Dr. Jeffrey Sunshine, UH's vice chairman of radiology, closed off the blister with a series of small titanium coils that stemmed the blood flow to that weakened area.

Debating the FDA Decision to Suspend Marketing and Sales of the Leukemia Drug Ponatinib (Iclusig)
Oncology Times - Nov 26, 2013
Early data reported late last year from the Phase II trials for the BCR-ABL tyrosine kinase inhibitor ponatinib (Iclusig) fielded much attention –so much, that the drug was approved for the treatment of chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) under the FDA's priority review program, which expedites the review process of promising new drugs. The latest findings give sufficient reason to pause and review the drug's safety, said OTs Clinical Advisory Editor for Hematology/Oncology, Mikkael Sekeres, MD, MS, Director of the Cleveland Clinic Taussig Cancer Institute's Leukemia Program and Chair of the Hematology/Oncology Pharmacy and Therapeutics Committee, and member of the Case Comprehensive Cancer Center.

Cleveland-based Akrotome Imaging's Technology Designed to Help Surgeons Find, Remove Cancer
The Plain Dealer - Nov 25, 2013
Women who have undergone a lumpectomy to remove a cancerous tumor from their breast – and the surgeons who treat them – don't know for several days if the tumor has been completely removed. Jim Basilion, a professor in the departments of radiology, biomedical engineering and pathology at CWRU and co-director of the Cancer Imaging Program for the Case Comprehensive Cancer Center, and his two partners at Akrotome Imaging Inc. hope that their patented guided imaging technology will one day eliminate the need for repeat lumpectomies (something that between 20 and 60 percent of women must endure) and also will save money in the process.

Borderline and Atypical ALK-Negative NSCLC May Benefit From Crizotinib; Researchers Say the Criteria Used Should Be Expanded, but Other Experts Say the Clinical Implications Remain Unproven
Oncology Times - Nov 25, 2013
The criteria used to identify patients with non-small-cell lung cancers (NSCLCs) who can benefit from treatment with crizotinib may omit an estimated 8.5 percent of patients who could benefit from the drug, according to research published in the November 15 issue of Cancer...Still, Nathan Pennell, MD, PhD, of the Department of Solid Tumor Oncology at Cleveland Clinic and the Case Comprehensive Cancer Center, said, it remains to be seen how relevant the findings are in actual clinical practice.

Genomic Test Helps Men with Prostate Cancer Choose Proper Treatment Path
Freshwater - Nov 21, 2013
Eric Klein, chair of the Glickman Urology and Kidney Institute at the Cleveland Clinic, along with a team of researchers at the Clinic and Genomic Health, have developed a genomic test that determines the aggressiveness of prostate cancer and therefore helps doctors and patients decide the proper course of treatment.


ANNOUNCEMENTS

Drs. Richard Padgett and Edward Plow Honored by AAAS

Richard A. Padgett, PhD and Edward F. Plow, PhD were recently named as Fellows of the American Association for the Advancement of Science (AAAS) for their contributions to science. Dr. Padgett was recognized for his work with RNA processing, particularly in the areas of RNA splicing, the diversity of splicing mechanisms, and connections with disease. Dr. Plow was honored for his work with vascular biology, particularly for elucidating mechanisms of platelets, integrins, and plasminogen, and outstanding services to the cardiovascular community.

Ohio Cancer Research Associates Honors Dr. Stan Gerson for Contributions to Cancer Research

Ohio Cancer Research Associates, OCRA, an organization dedicated to the cure and prevention of the many forms of cancer, honored Case Comprehensive Cancer Center Director Dr. Stanton L. Gerson for his contributions to cancer research at the OCRA's Singular Sensation ceremony and banquet on November 22. Dr. Gerson was recognized for his substantial impact on patients and their families, his strong community advocacy, and for his work in cancer research.

Case CCC ACS IRG Pilot Award Recipients

Congratulations to the recent recipients of the Case CCC ACS IRG pilot awards:

  • HyeonJoo Cheon, PhD: P53-dependent Regulation of STAT 1 Expression and Consequences for Cancer Therapy
  • Frederic Reu, MD: Preclinical Studies on a New Anti-Myeloma Drug Candidate
  • Basem M. William, MD: Modulation of graft versus leukemia (GVL) and graft versus host (GVH) responses by oral azacytidine hypomethylating therapy after allogeneic stem cell transplantation (SCT); An ancillary correlative science study
  • Rong Xu, PhD: Network-based approaches in discovering novel off-targets underlying cardiotoxic effects caused by targeted cancer drugs

These funds are designed to provide seed money to support junior faculty members with an interest in cancer research who do not have national grant support of their own.

ASH Annual Meeting - Case CCC Participants

The American Society of Hematology Annual Meeting will be held December 7-10 in New Orleans. The Case CCC is pleased to have many members participating, presenting, and leading sessions. Please support your colleagues if you are attending the meeting. Congratulations to everyone!


FUNDING OPPORTUNITIES

AACI Translational Cancer Research Fellowship

The Case Comprehensive Cancer Center may nominate ONE candidate for the AACI Translational Cancer Research Fellowship. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline. The AACI fellowship will provide a one-year non-renewable grant to support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution. Interested candidates should forward a letter of support from their mentor and their 4-page NIH biosketch to Terri Daso at tld6@case.edu by Friday, December 13.
Internal Deadline: December 13
External Deadline: February 3, 2014

Reissue of Genomics RFA

After internal discussion and a number of questions raised about the RFA: Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making, the Cancer Center reissued a revised RFA. We apologize to those investigators who worked feverishly to apply for the original deadline of December 2. However, we may not have been clear in our description of the overall intention and orientation of the work we would like to promote. The revised proposal makes clear that we would like to encourage human tumor high-throughput sequencing, including RNAseq, that is designed to inform future clinical studies in prognosis, treatment or treatment futility.
Revised Deadline: January 7, 2014

Society of Surgical Oncology

The Society of Surgical Oncology is accepting applications for the Clinical Investigator Award. The purpose of the award is to promote patient-oriented research conducted by surgical oncologists in clinical and translational science. Applicants must be surgical oncologists within 10 years of completion of training, and full SSO members for at least 6 months prior to application submission to be eligible for the award.
Deadline: January 13, 2014


MARK YOUR CALENDARS

Free Health and Wellness Webinar

On Wednesday, December 4 at 12 pm Dr. Smitha Krishnamurthi will present an online webinar discussing results of research on cancers of the pancreas, colon and rectum. She will review how the results of research have affected how medical professionals choose treatments; the way health decisions are made; and the health of the community. This educational event will end with opportunities for the attendees and community to ask questions and give suggestions for research ideas that are important to their community. The presentation will last 20 minutes followed by a brief Q&A session. Register by calling 216.285.4069.

Ohio Practice-Based Research Festival 2.0: The growing intersection of primary care and public health

Practice-based research networks are organizations of community practices that collaborate with academic and community partners to facilitate scientific discovery. For nearly two decades, hundreds of Northeast Ohio healthcare providers have conducted ground-breaking research through participation in practice-based research networks.

Clinicians, investigators, practice staff, and volunteers from primary care, public health and community settings are invited to attend a one-day festival, Ohio Practice-Based Research Festival 2.0: The growing intersection of primary care and public health, this Saturday, December 7 from 8 am - 3 pm at the Embassy Suites, Cleveland - Rockside. This festival will focus on the growing intersection of primary care and public health. This is an opportunity to share your ideas, disseminate your research findings, get input from others, learn about funding opportunities, develop your ideas, and build collaborations for future research endeavors. There is no cost to attend the festival, but registration is required.

Retreat: Engaging in Cultural Competence through Awareness, Knowledge and Action

Please mark your calendars for Thursday, March 13, 2014 from 2-5 pm to join the Case Comprehensive Cancer Center and the Case Center for Reducing Health Disparities as they explore issues related to cultural competence. Extend your knowledge and raise your awareness about the dynamic variety of people and communities the Case CCC serves. This retreat will feature a keynote address by Dr. Sonja Harris-Haywood, and will provide perspective on the growing need to be culturally competent and facilitate the impact of cultural beliefs within the health care setting, specifically in research.

Pre-registration will be required due to limited space in the Wolstein Research Building Auditorium. Additional information will be posted soon. Please direct any questions to Katarzyna Karelus at 216.844.4176 or katarzyna.karelus@case.edu.

EVENTS

calendar

December 2

Genetics Student Seminar
Yanhui Li
Student, Genetics
CWRU
Topic: A Schizosaccharomyces Pombe Transposon Insertion Library for High-Throughput Genome-wide Studies
11 am BRB 105

Pathology Research Seminar Series
Lamis Yehia
PhD Candidate, Eng lab, Pathology
CWRU/Cleveland Clinic
Topic: Identification and Characterization of Novel Predisposition Genes in PTEN Mutation Negative Cowden Syndrome Using Next Generation Approaches
12 pm WRB 1-413

Genomic Medicine Institute
Chiara Federici, PhD
Postdoctoral Research Fellow, Aldred lab, Genomic Medicine Institute
Cleveland Clinic
Topic: DNA Damage in Patients with Pulmonary Arterial Hypertension
12:30 pm NE1-205 Cleveland Clinic

Pharmacology Dissertation Defense
Meghana Gupta
PhD Candidate, Manor lab, Pharmacology
CWRU
Topic: Regulation of Dbl Family Guanine Nucleotide Exchange Factors
1 pm Webster Conference Room, W331


December 3

Radiation Oncology Grand Rounds
Valdir C. Colussi, PhD, DABR
Assistant Professor and Clinical Director, Medical Physics
CWRU/UH
Topic: Brachytherapy: Back to the Future?
8:10 am Lerner B-181

Molecular Genetics Departmental Seminar
Yanhui Li
Graduate Student, Runge lab, Molecular Genetics
Cleveland Clinic
Topic: A Schizosaccharomyces pombe Transposon Insertion Library for High-Throughput Genome-wide Studies
9:30 am NE1-205 Cleveland Clinic

Cancer Biology Staff Candidate
Ram Mani, PhD
Research Investigator, Michigan Center for Translational Pathology
University of Michigan
Topic: The Origins and Functional Consequences of ETS Gene Fusions in Prostate Cancer
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Elane Reyes
PhD Candidate, Anthony lab, Pathology
CWRU/UH
Topic: Characterization of B Cell Subsets in Chronic HCV
12 pm WRB 1-413

Medicine Grand Rounds
Smitha Krishnamurthi, MD
Associate Professor, Div. of Hem/Onc
Medical Director, Clinical Trials Unit, Seidman Cancer Center
CWRU/UH
Topic: Advances in Treatment of Pancreatic Cancer
12 pm Kulas Auditorium, Lakeside 5th Floor

DNA Damage and Response Meeting
Hisashi Tananka, MD, PhD
Assistant Professor, Molecular Genetics
CWRU/Cleveland Clinic
Title: Replication Fork Salling and Template Switching: A Mechanism of Genome Instability
4 pm WRB 3-136


December 4

Hematology and Oncology Research Conference
Joseph Baar, MD, PhD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: Targeting the Tumor Microenvironment for Breast Cancer Immunotherapy
8 am Lerner B-151

Pathology Faculty Candidate
Kai McKinstry, PhD
Instructor, Pathology
University of Massachusetts
Topic: Maximizing Memory CD4 T Cell-mediated Protection Against Influenza
12 pm WRB 1-413

LRI Seminar
Angela Ting, PhD
Assistant Professor, Genomic Medicine Institute
CWRU/Cleveland Clinic
Topic: DNA Methylation in Cancer: Location, Function and Intervention
2 pm NE1-205 Cleveland Clinic

LRI Seminar
Susan F. Steinberg, MD
Professor, Pharmacology
Columbia University
Topic: The Structural Determinants of Protein Kinase C-delta Activity: The Rules of Phosphorylation..... or Phosphorylation Rules!
3 pm NC1-202 Cleveland Clinic

Developmental Therapeutics Round Table Discussion
Ernest Borden, MD
Professor, Translational Hematology and Oncology Research
CWRU/Cleveland Clinic
Topic: Circulating Tumor Cells: Case CCC Past and Future
AND
Joseph DiDonato, PhD
Assistant Professor, Cancer Biology CWRU/Cleveland Clinic
Topic: Apoliprotein A1: Antitumor Effects
5 pm WRB 2-136


December 5

Immunology Journal Club
Jaffre Athman
Student, Immunology
CWRU
Topic: Bacteria Activate Sensory Neurons that Modulate Pain and Inflammation
12 pm WRB 5-136

Special RT-PLMI Lecture
Xavier Leleu, MD, PhD
Associate Professor, Hematology
Hopital Claude Huriez, Part of the Academic Hospital of Lille (CHRU), France
Topic: Addressing the Challenges in Multiple Myeloma: Evidence for the Benefit of Heavy/Light Chain Pair Testing
12 pm Room NA1-138 Cleveland Clinic


December 6

Cancer Center Research in Progress canceled

Hematology/Oncology Fellows Conference/Curriculum Series canceled

Taussig Cancer Institute Grand Rounds canceled

Cancer Center Seminar Series
Erwin G. Van Meir, PhD
Professor, Neurosurgery and Hematology & Medical Oncology
Leader, Winship Cancer Institute Cancer Cell Biology Program
Director, Emory Graduate Program in Cancer Biology
Director, Laboratory for Molecular Neuro-Oncology
Emory University
Topic: P53 Bystander Tumor Suppression through Galectin-3 Secretion
12 pm BRB 105

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

ADDITIONAL UPCOMING SEMINARS & EVENTS

2014 Multidisciplinary Head and Neck Cancer Update
February 14-15, 2014
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL
Details


PREVIOUSLY ANNOUNCED OPPORTUNITIES

Sidney Kimmel Foundation Scholar Award
Deadline: December 4

Sidney Kimmel Foundation Translational Science Award
Deadline: December 4

AACR-Aflac Inc. Career Development Award for Pediatric Cancer Research
Deadline: December 11

AACI Translational Cancer Research Fellowship
Internal Deadline: December 13
External Deadline: February 3, 2014

AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students
Deadline: December 13

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Ohio Brain Tumor SPORE Working Group Pilot Grants
Deadline: December 16

Conquer Cancer Foundation of ASCO Medical Student Rotation for Underrepresented Populations
Deadline: December 17

Conquer Cancer Foundation of ASCO Resident Travel Award for Underrepresented Populations (RTA)
Deadline: December 17

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: December 19
Application Deadline: January 9, 2014

Ohio Brain Tumor SPORE Working Group Career Development Scholars Training Program
Deadline: December 23

Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making
Revised Deadline: December 2

2014 CTSC Annual Pilot Grant Funding
Deadline: January 15, 2014

Radiological Society of North America Research Seed Grants
Deadline: January 15, 2014

International Association for the Study of Lung Cancer Fellowship and Young Investigators Programs
Deadline: January 16, 2014

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: February 1, 2014

Radiological Society of North America Research Medical Student Grants
Deadline: February 1, 2014

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21, 2014

Dan David Prize Scholarships
Deadline: February 28, 2014

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

NCI Small Grants Program for Cancer Research (NCI Omnibus R03)(PAR-14-007)

Validation of Molecular Diagnostics to Predict Patient Outcomes Using Specimens from Multi-Site Cancer Trials (R21)(PA-12-014)

Biomechanisms of Peripheral Nerve Damage by Anti-Cancer Therapy (R21)(PA-12-083)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

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