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Case Comprehensive Cancer Center Newsletter

November 4, 2013

gersonMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

Remind our Senators of the Necessity of Government Investment in Scientific Research

Below is a remarkable and high impact message delivered by Massachusetts Sen. Elizabeth Warren. We all agree with what she says, but to be effective we need to respond both individually and collectively. Please review and consider a response to Senator Warren and our senators:

Sen. Elizabeth Warren
Sen. Robert Portman
Sen. Sherrod Brown

Senator Warren Calls on Congress to Double NIH Funding, Promotes Critical Government Investments in Scientific Research
In remarks to the Boston Chamber of Commerce on Monday, U.S. Senator Elizabeth Warren (D-MA) called on Congress to double funding for the National Institutes of Health (NIH) and stressed the importance of supporting innovation and basic scientific research. "What drives the Massachusetts economy – and the American economy – is innovation," said Senator Warren. "Innovation makes us soar. And government-supported research is a critical first step in generating that innovation." Senator Warren also said, "I know some will say that we cannot afford to double our investments in medical research. They are wrong. Research creates economic growth. It reduces health care costs. It creates a better life for our people. And yet, the success rate for NIH grants has dropped by nearly 50% over the last 10 years. That makes no sense. There is good work to be done-work to save lives and work to boost our economy. We cannot afford NOT to increase our investments in medical research."


CASE CCC IN THE NEWS

Pediatric and AYA Cancers to be the Focus of Conferences this Week in San Diego, Cleveland
The Plain Dealer - Nov 3, 2013
The needs of childhood, adolescent and young adult cancer patients are taking center stage at two conferences this week. The gatherings, in San Diego and Cleveland, are meant to spur collaboration to come up with more effective treatments for a patient population whose needs are vastly different from those of their adult counterparts...On Wednesday, University Hospitals Rainbow Babies & Children's Hospital will serve as the host center of the annual three-day conference of Critical Mass. Started in 2006 by the Lance Armstrong Foundation as the Livestrong Young Adult Alliance, the group – now an entity separate from the foundation – serves as a coalition of dozens of organizations around the country that focuses on the needs of adolescent and young adult cancer patients...

"We've had huge success and great stride in pediatrics, but the survival rate [for adolescents and young adults] has been flat," said Dr. John Letterio, division chief of pediatric hematology and oncology at UH Rainbow and UH Case Medical Center.

Cleveland Clinic to Buy Ohio Cancer Specialists
Crain's Business Cleveland - Nov 1, 2013
The Cleveland Clinic said it will acquire Ohio Cancer Specialists, a Mansfield-based cancer treatment center with 43 employees. The agreement will make Ohio Cancer Specialists, or OCS, part of the Clinic's Taussig Cancer Institute..."The OCS team provides wonderful, state-of-the-art treatment to its patients, and we look forward to enhancing the excellent clinical care that Ohio Cancer Specialists provide," said Dr. Brian J. Bolwell, chairman of the Clinic's Taussig Cancer Institute.

FDA OK's Gazyva for CLL; 1st Drug with Breakthrough Therapy Designation to Get FDA Approval
The Plain Dealer - Nov 1, 2013
The U.S. Food and Drug Administration today approved Gazyva (generic name: obinutuzumab) for use in combination with chlorambucil to treat patients with previously untreated chronic lymphocytic leukemia, or CLL...Dr. Mikkael Sekeres, a hematologist/oncologist at the Cleveland Clinic Taussig Cancer Institute, said the new drug is a "fairly big deal," but cautioned that it might not be the right choice for every patient with CLL. "I think the challenge with how to use this drug is, what patient population would you choose?" Sekeres said. "On study, the average age was 73 years."

Leukemia Drug Pulled From Sale by FDA
Wall Street Journal - Oct 31, 2013
The Food and Drug Administration told the manufacturer of a new leukemia drug called Iclusig to stop marketing and selling the medicine because of an increasing number of strokes, heart attacks and other serious side effects...Mikkael Sekeres, director of the Cleveland Clinic's leukemia program, said the events surrounding Iclusig are "a clear demonstration that the accelerated approval process works."

Second Thoughts from Sekeres: Show Me The Money: What Price Clinical Cancer Research?
Oncology Times - Oct 29, 2013
Dr. Mikkael Sekeres discusses the costs associated with conducting clinical trials of new cancer drugs.

New Clinical Trial Tests Drug to Control Mesothelioma Cancer Stem Cells
Asbestos.com - Oct 23, 2013
A recently launched, international clinical trial that involves the targeted killing of mesothelioma cancer stem cells soon could provide a much-needed breakthrough for patients around the world..."The potential is there. If this (trial) turns out positive, it would be a big step forward for mesothelioma patients. It could become the next drug to be used," oncologist James Stevenson, M.D., principal investigator at the Cleveland Clinic, told Asbestos.com...

Cancer Society: Racial Disparities in Breast Cancer Survival Persist
Helio/HemOnc Today - Oct 23, 2013
Survival differences based on race and ethnicity still persist among patients with breast cancer, with black women continuing to demonstrate the poorest survival, according to statistics released by the American Cancer Society...Dr. Jame Abraham, Director of the Breast Oncology Program at the Cleveland Clinic Taussig Cancer Institute offers a perspective on this story.

Meet ASCO Board of Directors Member Neal J. Meropol, MD
ASCO Connection- Oct 22, 2013
A Nine-Question and Answer Introduction to ASCO Board of Directors Member Dr. Neal J. Meropol, Professor of Medicine and Chief of Hematology and Oncology, University Hospitals (UH) Case Medical Center and Case Western Reserve University; Associate Director, Clinical Research, Case Comprehensive Cancer Center; Associate Director, Clinical Programs, Seidman Cancer Center, UH Medical Center.


ANNOUNCEMENTS

Biomedical Engineering Researchers Aim Nanotechnology at Micrometastases

Efstathios KarathanasisA group of researchers led by Dr. Efstathios Karathanasis, Assistant Professor of Biomedical Engineering and Radiology at CWRU, received two grants totaling nearly $1.7 million to build nanoparticles that seek and destroy metastases too small to be detected with current technologies. The group will spend the next five years perfecting molecular coatings, called ligands, that enable nanochains injected into a patient's blood to home in on micrometastases. The National Cancer Institute awarded the group $1.6 million to pursue the work. They also received $60,000 from the Ohio Cancer Research Associates to increase the efficiency and rapid dispersal of chemotherapy drugs the nanochains tote inside the metastases.

The grants will build on earlier work within the CWRU School of Medicine by Drs. Karathanasis, Mark Griswold, Professor of Radiology and Director of MRI Research, and Ruth Keri, Professor of Pharmacology and Associate Director of Basic Research at the Case Comprehensive Cancer Center. They and colleagues invented a nanochain that explodes a barrage of chemotherapy drugs inside a tumor.

Other members of the research group include Vikas Gulani, Assistant Professor of Radiology and Director of MRI at UH Case Medical Center, Chris Flask, Director of the Imaging Research Core Facility in the Case Comprehensive Cancer Center and Assistant Professor of Radiology, and William Schiemann, Associate Professor in the Case Comprehensive Cancer Center.


FUNDING OPPORTUNITIES

Case Comprehensive Cancer Center Call for Applications

The Case Comprehensive Cancer Center has released the following pilot grant funding opportunities:

  • Pilot Grants: Opportunities for Developing Patient-Derived Xenografts will support the development of patient-derived tumor xenografts (PDX) that will benefit collaborative, multi-investigator projects within the Cancer Center. This RFA is open to all Cancer Center members, regardless of institution.
    Deadline: November 15
  • Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making will provide seed money to foster collaborations and promote and increase institution-wide capacity and competitiveness in the use of tumor genomic evaluation for clinical decision-making. Case CCC members with faculty appointment at all levels (eligible to apply for independent nationally competitive research grants) are encouraged to apply. Proposals from both junior and senior investigators are encouraged. Research proposals must involve patients and/or their tissues.
    Deadline: December 2
  • Pilot Grants: Planning for Multi-Investigator Proposals will provide funding to further the important goal of facilitating successful applications for large multi-investigator grants (e.g., P01, P50, U54) in the current funding cycle. Applicants must demonstrate they are in communication with appropriate NIH administration, other structures within NIH, or other funding agencies (e.g., formal invitation, preparatory meeting, LOI and/or positive response to RFA or PA). Applicants must be Cancer Center members with faculty appointments, demonstrate intent to apply for national funding within a defined timeline, and describe new research that could not be achieved without the collaboration.
    Deadline: Open
Dan David Prize Scholarships

The Dan David Prize laureates annually donate twenty scholarships of $15,000 each to outstanding doctoral and postdoctoral students of exceptional promise in the chosen fields for the current year: History and Memory, Combatting Memory Loss, and Artificial Intelligence. Ten scholarships are awarded to doctoral and post-doctoral students at universities throughout the world and ten scholarships at Tel Aviv University. Advanced doctoral postdoctoral students of excellent achievement and promise studying topics related to the fields chosen for this year are invited to apply.
Deadline: February 28, 2014

EVENTS

calendar

November 4

Pathology Research Seminar Series
Xiongwei Zhu, PhD
Associate Professor, Pathology
CWRU/UH
Topic: Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease
12 pm WRB 1-413

Genomics Seminar
Pauline Funchain, MD
Clinical Cancer Genomics Fellow, Eng Lab, Genomics Medicine Institute
Cleveland Clinic
Topic: In Sickness and In Health: Portraits of the Relationship between Humans and Bacteria
12:30 pm NE1-205 Cleveland Clinic

Physiology and Biophysics Seminar
William Skach, MD
Professor, Biochemistry & Molecular Biology
Oregon Health & Science University
Topic: From GFP to CFTR: Cotranslational Protein Folding in Cystic Fibrosis
4 pm SOM E-501


November 5

Radiation Oncology Grand Rounds
Tithi Biswas, MD
Associate Professor, Radiation Oncology
CWRU/UH
Topic: Small Cell Lung Cancer: The Controversy
8:10 am Lerner Tower B-181

Molecular Genetics Departmental Seminar
Jarnail Singh, PhD
Project Staff, Padgett lab, Molecular Genetics
Cleveland Clinic
Topic: Somatic Spliceosomal Factor Mutations Lead to Alternative Splicing Patterns in Myeloid Neoplasms
9:30 am NE1-205 Cleveland Clinic

Medicine Grand Rounds
Thomas Daniel, MD
Professor Emeritus, Medicine and International Health
CWRU/UH
Topic: Latent Tuberculous Infection
12 pm Kulas Auditorium

Immunology Seminar Series
James Ignatz-Hoover
PhD Candidate, Wald lab, Pathology
CWRU
Topic: Probing the Role of GSK3 Beta in AML
AND
Janice Jun
PhD Candidate, Abbott lab, Pathology
Topic: NF-κB, Interrupted: Role of a Novel Ubiquitination Site on IKKγ/NEMO
12 pm WRB 1-413

Cancer Biology Invited Speaker
Bing-Cheng Wang, PhD
John and Josephine Wootton Professor
Professor, Pharmacy, Oncology, Physiology & Biophysics
Rammelkamp Center for Research
CWRU/MetroHealth Medical Center
Topic: It Takes Two to Tango: EphA2 Receptor and Ephrin-A Ligand Bidirectional Signaling in Tumorigenesis
2 pm NC1-202 Cleveland Clinic

Lerner Research Institute Seminar
Cheng-Kui Qu, MD, PhD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: Metabolic Regulation of Stem Cells
4 pm NA5-03 Cleveland Clinic

DNA Damage/Repair Focus Group Meeting
Stan Gerson, MD
Director, Case Comprehensive Cancer Center
CWRU/UH
4 pm WRB 3-136


November 6

Hematology and Oncology Research Conference
Jonathan Wynbrandt, MD
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: Quality Improvement and Patient Safety in Seidman Cancer Center
8 am Lerner B-151

Pathology Faculty Candidate
Mary Markiewicz, PhD
Research Assistant Professor, Pathology and Immunology
Washington University in St. Louis
Topic: Understanding the Roles of NKG2D and NKG2D Ligands in Autoimmune Diabetes and Tumor Immunity
12 pm WRB 5-136

Lerner Research Institute Seminar
David Serre, PhD
Assistant Professor, Genomic Medicine Institute
CWRU/Cleveland Clinic
Topic: Genomic Perspectives on Malaria Parasite Biology
2 pm NE1-205 Cleveland Clinic

Developmental Therapeutics Program Roundtable Seminar
5 pm WRB 2-136


November 7

Molecular Genetics Guest Speaker
Anne Bresnick, PhD
Professor, Biochemistry
Albert Einstein College of Medicine of Yeshiva University
Topic: Myosin, Motility and Metastasis
9:30 am NE1-205 Cleveland Clinic

Immunology Journal Club
Elane Reyes
Graduate Student, Anthony lab, Immunology/Pathology
CWRU
Topic: Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection
12 pm WRB 5-136

21st Annual Robert R. Kohn Lecture
Martin W. Hetzer, PhD
Professor, Molecular and Cell Biology Laboratory
Jesse and Caryl Philips Foundation Chair
Salk Institute
Topic: Identification of Long-lived Proteins and Their Role in Aging
4 pm WRB 1-413

Frontiers in Digestive Health Lecture Series
William Grady, MD
Rodger C. Haggitt Endowed Chair in Gastroenterology
Professor and Chief, Gastroenterology
University of Washington/Fred Hutchinson Cancer Research Center
Topic: The Colorectal Cancer Epigenome
5 pm BRB 105


November 8

Hematology/Oncology Fellows Conference/Curriculum Series
Cheng Chee, MD
Masumi Ueda, MD
Nathan Langer, MD
CWRU/UH
Topic: Cancer Biology Series: GI Cancers
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Julia White, MD
Professor, Radiation Oncology
Director, Breast Radiation Oncology
Vice Chair Clinical Research
Klotz Chair for Cancer Research
Ohio State University Comprehensive Cancer Center
Topic: Optimizing Breast Cancer Radiotherapy: RTOG Clinical Trials
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Dale W. Laird, PhD
Professor, Canada Research Chair in Gap Junctions and Disease
Department of Anatomy and Cell Biology
University of Western Ontario
Topic: The Role of Large Pore Connexin and Pannexin Channels in Cancer
10:00 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Peter C. Adamson, MD
Chair, Children's Oncology Group
Professor, Pediatrics and Pharmacology
University of Pennsylvania
Chief, Division of Clinical Pharmacology and Therapeutics
Children's Hospital of Philadelphia
Topic: Development of Targeted New Agents for Children with Cancer
12 pm BRB 105

Cancer Center Research in Progress
James W. Jacobberger, PhD
Professor, Div. of General Medical Sciences-Oncology
Associate Director for Shared Resources
Director, Cytometry & Imaging Microscopy Core Facility
Case Comprehensive Cancer Center
Topic: Cell Cycle Modeling
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

ADDITIONAL UPCOMING SEMINARS & EVENTS

13th Annual Multidisciplinary Genitourinary Oncology Course
November 19
InterContinental Hotel & Bank of America Conference Center
Details


PREVIOUSLY ANNOUNCED OPPORTUNITIES

2013 Movember-Prostate Cancer Foundation Challenge Award
Deadline: November 6

Stand Up To Cancer (SU2C)-Farrah Fawcett Foundation Human Papillomavirus (HPV) Translational Research Team Grant
Deadline: November 6

Stand Up To Cancer (SU2C)-Lustgarten Foundation Pancreatic Cancer Convergence Dream Team Translational Research Grant
Deadline: November 7

Pilot Grants: Opportunities for Developing Patient-Derived Xenografts
Deadline: November 15

Alex's Lemonade Stand Foundation Innovation Awards
LOI Deadline: November 11
Application Deadline: March 3, 2014

Prostate Cancer Foundation 2014 Young Investigator Award
Deadline: November 13

Robert Wood Johnson Foundation Health Policy Fellows
Deadline: November 13

A Survivorship Action Partnership – United States of America (ASAP USA)
Deadline: November 13

Melanoma Research Alliance Young Investigator Awards
Proposal Deadline: November 13

Melanoma Research Alliance Established Investigator Academic-Industry Partnership Awards
Proposal Deadline: November 13

Burroughs Wellcome Fund Innovation in Regulatory Science Award
Deadline: November 18

Caring for Carcinoid Foundation-AACR Grant for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research
Application Deadline: November 19

Kure It-AACR Grant for Kidney Cancer Research
Application Deadline: November 19

Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making
Deadline: December 2

Sidney Kimmel Foundation Scholar Award
Deadline: December 4

Sidney Kimmel Foundation Translational Science Award
Deadline: December 4

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Ohio Brain Tumor SPORE Working Group Pilot Grants
Deadline: December 16

Conquer Cancer Foundation of ASCO Medical Student Rotation for Underrepresented Populations
Deadline: December 17

Conquer Cancer Foundation of ASCO Resident Travel Award for Underrepresented Populations (RTA)
Deadline: December 17

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: December 19
Application Deadline: January 9, 2014

Ohio Brain Tumor SPORE Working Group Career Development Scholars Training Program
Deadline: December 23

2014 CTSC Annual Pilot Grant Funding
Deadline: January 15, 2014

Radiological Society of North America Research Seed Grants
Deadline: January 15, 2014

International Association for the Study of Lung Cancer Fellowship and Young Investigators Programs
Deadline: January 16, 2014

Radiological Society of North America Research Medical Student Grants
Deadline: February 1, 2014

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Notice of National Cancer Institute (NCI) Participation in PA-13-359 "Nutrition and Alcohol-Related Health Outcomes (R01)"(NOT-CA-14-002)

Notice of National Cancer Institute (NCI) Participation in PA-13-360 "Nutrition and Alcohol-Related Health Outcomes (R03)"(NOT-CA-14-003)

Notice of National Cancer Institute (NCI) Participation in PA-13-361 "Nutrition and Alcohol-Related Health Outcomes (R21)"(NOT-CA-14-004)

Translational Research at the Aging/Cancer Interface (TRACI)(R01)(PA-12-136)

Biomarkers of Infection-Associated Cancers (R01)(PA-11-158)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01)(PA-11-160)

Cancer Detection, Diagnosis, and Treatment Technologies for Global Health (UH2/UH3)(RFA-CA-13-015)

Identifying Non-coding RNA Targets for Early Detection of Cancer (R01)(PA-12-213)

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)(PAR-13-169)

Analysis of Genome-Wide Gene-Environment (G x E) Interactions (R21)(PAR-13-382)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax
gillian.irwin@case.edu

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