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Case Comprehensive Cancer Center Newsletter

May 20, 2013

CASE CCC IN THE NEWS

Studies Work to Reinvigorate Clinical Trial Participation from Inside Out
PhysBiz Tech - May 17, 2013
"Although clinical trials are the key to developing new, better cancer treatments, less than 10 percent of cancer patients participate in them," said Neal J. Meropol, MD, study author and Chief of the Division of Hematology and Oncology at UHCMC and Case Western Reserve University School of Medicine, in a news release.

Seeking Calm on the Cancer Ward
New York Times - May 16, 2013
By Mikkael Sekeres, MD. When people choose to have their leukemia treated aggressively, it's a big commitment, more so than for almost any other cancer...

Will We See an Angelina Jolie-Effect Due to Her Double Mastectomy Decision?
Fox Business - May 15, 2013
"I congratulate her for doing this," says Dr. Lyndsay Harris, director of the Breast Cancer Program at University Hospitals Case Medical Center. "It raises awareness of the fact that there are certain genetic abnormalities which have a very high risk of developing breast cancer."...While Jolie's decision was bold and her choice to speak out noble, Dr. Julian Kim, division chief of Surgical Oncology at University Hospitals Case Medical Center, says her high likelihood of developing cancer is not common.

Repurposed Cancer Drug to Enter Phase I Trials for Alzheimer's Disease This Year
Med City News - May 14, 2013
ReXceptor thinks it can do that by using a drug that's already been approved by the U.S. Food and Drug Administration. Bexarotene, marketed by Medicis as Targretin, is approved for treatment of cutaneous T-cell lymphoma. But last year, CWRU neuroscience professor Gary Landreth and then-graduate student Paige Cramer published a paper in Science detailing how the drug, when administered to mice, cleared 25 percent of amyloid beta build up in the brain and reversed some of the cognitive impairment of Alzheimer's disease within 72 hours of a single dose.

Cleveland Clinic Receives $1 Million Gift to Stage Cycling Event Benefiting Cancer Research
Crain's Cleveland Business - May 14, 2013
"We are incredibly grateful to Stewart and Donna Kohl for this generous gift," said Dr. Brian J. Bolwell, chairman of Cleveland Clinic's Taussig Cancer Institute, in the release. "Funds raised by VeloSano and its riders will help our physicians and researchers generate discoveries and explore novel therapies for treating cancer."

Study: Simple Exercise Could Reduce Cancer Risk
KSTP.com - May 13, 2013
"Merely sitting the entire day can put you at risk for some cancers, according to some research, and so just getting up through the course of the day every hour and walking around, something that simple can minimize the risk for cancer perhaps," Dr. Dale Shepard of Cleveland Clinic said.

Nanoparticles Offer 'Infinite' Possibilities for Cancer Treatment
Helio/HemOnc Today - May 13, 2013
"Anticancer drugs do not discriminate normal cells from cancer cells," Vinod Labhasetwar, PhD, staff researcher in the department of biomedical engineering at Cleveland Clinic's Lerner Research Institute, told HemOnc Today.


ANNOUNCEMENTS

Madabhushi and Team Awarded NIH R21 Clinical Trial Grant for CAD Directed MRI Guided Laser Ablation for Prostate Cancers

MadabhushiDr. Anant Madabhushi has been awarded a NIH R21 Quick Clinical Trials grant for his project, Decision Support for MRI Guidance and Evaluation of Laser Ablation of Prostate Cancer. In collaboration with interventional radiologist Dr. Dan Sperling at the New Jersey Institute of Radiology, Dr. Madabhushi and his team will be developing and applying advanced computerized image analysis and pattern recognition methods for targeting the focal lesion via laser interstitial thermal therapy (LITT), a novel focal ablative therapy for treating low to intermediate risk of prostate cancers. During the course of this two-year, $540,000 project, Dr. Madabhushi and his team which includes Co-I Dr. Satish Viswanath will also be developing computerized image analysis methods for quantitatively evaluating imaging marker changes to assess treatment response after LITT. Dr. Madabhushi and Dr. Sperling expect to be able to enroll 30 patients during the course of this clinical trial which is being sponsored by the National Cancer Institute.


MARK YOUR CALENDARS

Race for the Place- Join Our Team!

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 2 at Beachwood Place Mall. The Case CCC has created a team. Click here to join the team or to show your support by making a donation. Contact Gillian Todd for more information.

Impact of Genomics on Cancer Diagnosis and Treatment: Open Drug Policy Forum

The Case CCC, in partnership with five other Midwest comprehensive cancer centers, will convene a public forum on the emerging revolution in genetic testing known as precision or personalized medicine on Monday, June 10. Experts from the FDA, NCI, CMS, pharmaceutical industry, public health sector, and the cancer research community will participate in dynamic lectures and discussions to consider the complexities of integrating genetic testing into cancer care.

This forum is free and open to the public. We are nearly at capacity, so please register today if you are planning to attend: http://goo.gl/xEuwA.

More information is on the Cancer Center site.

Annual Scientific Retreat

The Annual Cancer Center Scientific Retreat will commence the evening of Thursday, July 11 with a speaker and reception in the Wolstein Research Building Auditorium. The Retreat will continue the next day, Friday, July 12, at Corporate College East. The agenda is still be finalized. Details will be circulated soon!


FUNDING OPPORTUNITIES/AWARDS

Department of Defense Breast Cancer Research Program

Applications to the Fiscal Year 2013 Breast Cancer Research Program (BCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity. The BCRP challenges the scientific community to design research that will address the urgency of ending breast cancer. Specifically, the BCRP seeks to accelerate high–impact research with clinical relevance, encourage innovation and stimulate creativity, facilitate multidisciplinary collaborations, and support future breast cancer leaders.

  • The BCRP Postdoctoral Fellowship Award supports exceptionally talented recent doctoral or medical graduates in pursuit of innovative, high–impact breast cancer research during their postdoctoral training and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research.
    Pre-Application Deadline: June 18
    Application Deadline: July 2
  • The BCRP Era of Hope Scholar Award supports individuals who are early in their careers and have demonstrated significant potential for innovation in breast cancer research.
    Pre-Application Deadline: June 18
    Application Deadline: July 2
  • The BCRP Innovator Award supports visionary individuals who have demonstrated creativity, innovative work, and leadership in any field including, but not limited to, breast cancer. The Innovator Award will provide these individuals with the funding and freedom to pursue their most novel, visionary, high–risk ideas that could ultimately lead to ending breast cancer.
    Pre-Application Deadline: June 25
    Application Deadline: September 25
  • The BCRP Breakthrough Award mechanism is being offered for the first time in FY13. The intent of the Breakthrough Award is to support promising research that has the potential to lead to or make breakthroughs in breast cancer. Each individual may submit only two pre–applications as a PI or Initiating PI.
    Pre-Application Deadline: June 25
    Application Deadline: September 25
Department of Defense Prostate Cancer Research Program

Applications to the Fiscal Year 2013 Prostate Cancer Research Program (PCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity. The mission of the FY13 PCRP is to find and fund research that will lead to the elimination of death from prostate cancer and enhance the well–being of men experiencing the impact of the disease.

  • The PCRP Biomarker Development Award was introduced in FY12 to fund near–term validation or qualification studies that will advance known prostate cancer biomarkers into the clinical setting. Specifically, this award will support high–impact research aimed at multi–institutional validation and/or qualification of prostate cancer biomarkers for crucial decision– making in prostate cancer management, including detection of aggressive disease, prognosis and progression, and prediction and assessment of response to therapy.
    Pre-Application Deadline: June 19
    Application Deadline: October 9
  • The PCRP Idea Development Award supports new ideas that represent innovative approaches to prostate cancer research and have the potential to make an important contribution to the PCRP mission. Although groundbreaking research often involves a degree of risk, applications should be based on a sound scientific rationale that is established through logical reasoning and/or critical review and analysis of the literature.
    Pre-Application Deadline: June 19
    Application Deadline: October 9
  • The PCRP Laboratory–Clinical Transition Award supports product–driven preclinical studies of promising lead agents or medical devices that have the potential to revolutionize prostate cancer clinical care. This award is intended to fund Principal Investigators (PIs) who lack support to conduct the preclinical studies needed to advance lead agents or medical devices to human testing.
    Pre-Application Deadline: June 19
    Application Deadline: October 9
  • The PCRP Synergistic Idea Development Award supports new ideas that represent innovative approaches to prostate cancer research involving two or three independent, faculty–level (or equivalent) Principal Investigators. These investigators should use complementary and synergistic perspectives to address a central problem or question in prostate cancer research. This award is designed to support both new and pre–existing partnerships.
    Pre-Application Deadline: June 19
    Application Deadline: October 9
  • The PCRP Transformative Impact Award supports prostate cancer research with near–term clinical relevance that will transform and revolutionize the clinical management of prostate cancer and make a major contribution to the elimination of death from prostate cancer and enhancing the well–being of men experiencing the impact of the disease.
    Pre-Application Deadline: June 19
    Application Deadline: October 9
Department of Defense Ovarian Cancer Research Program

Applications to the Fiscal Year 2013 Ovarian Cancer Research Program (OCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity. The overall goal of the FY13 OCRP is to eliminate ovarian cancer by supporting innovative, high–impact research.

  • The OCRP Clinical Translational Leverage Award mechanism supports the leveraging of existing human–based ovarian cancer resources in translational research to address high–impact research ideas or unmet needs in ovarian cancer, particularly correlative or adjunct analyses associated with clinical trials.
    Pre-Application Deadline: June 21
    Application Deadline: September 11
  • The OCRP Resource Development Award mechanism is being offered for the first time in FY13. The OCRP recognizes the critical need for improved human–based resources to advance the field of ovarian cancer research. Consequently, the Resource Development Award has been established to support product– driven research aimed at developing well–annotated tools for use by the ovarian cancer research community to facilitate research in this disease. Specifically, this includes either developing a human–based resource or increasing the utility of an existing human–based resource.
    Pre-Application Deadline: June 21
    Application Deadline: September 11
2013 Fall Clinical Investigator Award in Breast Cancer Research

The James Ewing Foundation of the Society of Surgical Oncology (SSO) and Susan G. Komen for the Cure® are accepting applications for the 2013 Fall Clinical Investigator Award in Breast Cancer Research. The purpose of this award is to promote patient-oriented research conducted by surgical oncologists in clinical and translational science, and is open to surgical oncologists within 10 years of completion of training. Applicants must be full SSO members for at least six months prior to application submission.

Deadline: July 8

American Cancer Society Clinical Research Professor

The American Cancer Society offers a limited number of grants to mid-career investigators who have made seminal contributions in the area of cancer control that have changed the direction of clinical, psychosocial, behavioral, health policy or epidemiologic cancer research. Furthermore, it is expected that these investigators will continue to provide leadership in their research area.
LOI Deadline: August 1
Application Deadline: October 15

EVENTS

calendar

May 20

Special Seminar
Mohammed Orloff, PhD
Project Scientist, Genomic Medicine Institute
Cleveland Clinic
Topic: Integrative 'Omics' Reveal Inflammatory Gene Network Associated with Barrett Esophagus/Esophageal Adenocarcinoma
12:30 pm NE1-205 Cleveland Clinic

CTTE-2013 Short Course: Cell-based Therapies and Tissue Engineering
Camillo Ricordi, MD
Professor, Surgery
University of Miami
Topic: Moving Cell-based Therapies from the Bench to the Bedside: Challenges and Opportunities
5 pm Clapp 108


May 21

Radiation Oncology Grand Rounds
Anant Madabhushi, PhD
Associate Professor, Biomedical Engineering
CWRU
Topic: Quantitative Data Convergence: Implications in Targeted Therapy and Predicting Disease Aggressiveness
8:10 am Lerner B-181

Molecular Genetics Departmental Seminar
Melissa Mullen Davis, PhD
Postdoctoral Research Fellow, Luse Lab, Molecular Genetics
Cleveland Clinic
Topic: The Pausing Factor Gdown1 Can Load into RNA Polymerase II Complexes Despite Competition From the Essential Initiation Factor TFIIF
9:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
Jackelyn Golden
Graduate Student, Cooper Lab, Dermatology
CWRU/UH
Topic: Identifying Monocyte Populations in Human Psoriasis and a Murine Psoriasis Model
AND
Jaffre Athman
Graduate Student, Harding Lab, Pathology
CWRU
Topic: Trafficking of Immune Stimuli During Mycobacterium Infection
12 pm WRB 1-413

Medicine Grand Rounds
Charles Carpenter, MD
Director, AIDS Center
Brown University
Physician in Chief
Miriam Hospital
Topic: A Unique Epidemic: The First Three Decades
12 pm Kulas Auditorium, Lakeside 5th Fl.

Theodore J. Castele Lecture
Sanjiv Sam Gambhir, MD, PhD
Virginia and D.K. Ludwig Professor in Cancer Research
Chairman, Radiology
Stanford University
Topic: Novel Strategies for the Earlier Detection of Cancer
5 pm WRB 1-413


May 22

Hematology and Oncology Division Research Conference
Brad Clifford, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: EGFR Testing in African American Non-small Cell Lung Cancer Patients — A Review of Discrepant Data
8 am Lerner B-151

Pathology Grand Rounds
Anand Dighe, MD, PhD
Associate Professor, Pathology
Harvard University
Topic: Clinical Laboratory Informatics: Building an Infrastructure to Enhance Value
8 am Institute of Pathology B22

Cancer Center Faculty Candidate
Pier Paolo Scaglioni, MD
Assistant Professor, Hematology/Oncology
UT Southwestern/Simmons Comprehensive Cancer Center
Topic: Genotype-specific Cancer Vulnerabilities: The Case of PML-RARA and Mutant KRAS
11 am WRB 3-136

Affymetrix Seminar
Topic: DNA, RNA and Systems Biology for Yesterday, Today and the Future
11:30 am WRB 1-413
RSVP to susan_vigilante@affymetrix.com

Immunology Seminar
Riccardo Dalla-Favera, MD
Professor and Director, Institute for Cancer Genetics
Uris Professor of Pathology
Columbia University
Topic: Molecular Pathogenesis of B Cell Lymphoma
12 pm NC1-202 Cleveland Clinic


May 23

Immunology Journal Club
Fred Allen
Graduate Student, Huang Lab, Div. of Pediatric Hem/Onc
CWRU/UH
Topic: Trypanosoma Cruzi Trans-sialidase Initiates a Program Independent of the Transcription Factors RORɤt and Ahr That Leads to IL-17 Production by Activated B Cells
12 pm WRB 5-136


May 24

Breast Cancer 2013: Seeing the Future
8 am - 3 pm Doubletree by Hilton Cleveland East Beachwood
Pre-registration required

Hematology and Oncology Fellows Conference
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Shetal Shah, MD
Diagnostic Radiology
Cleveland Clinic
Topic: Imaging Therapy Response: Practical Tips
8 am R3/002-003 Cleveland Clinic

Cancer Center Research in Progress
Deborah Sim Barkauskas
Graduate Student, Huang Lab, Pathology
Topic: Watching Cells Crossing the Blood-Brain Barrier: Implication for Autoimmunity, Cell Therapy and Tumor Metastasis
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Impact of Genomics on Cancer Diagnosis and Treatment: Open Drug Policy Forum
June 10
9 am - 3 pm Wolstein Research Building Auditorium
Draft Agenda
Registration

Annual Cancer Center Scientific Retreat
July 11-12

 

ADDITIONAL UPCOMING SEMINARS & EVENTS

National GvHD Health Symposium
November 1


PREVIOUSLY ANNOUNCED OPPORTUNITIES

NCI Provocative Questions
LOI Deadline: May 20
Applications Deadline: June 20

Ovarian Cancer Research Fund Program Project Development Grants
LOI Deadline: May 23
Application Deadline: August 23

Ovarian Cancer Research Fund Liz Tilberis Scholars Early Career Awards
LOI Deadline: May 23
Application Deadline: August 23

Ovarian Cancer Research Fund Ann Schreiber Mentored Investigator Award
LOI Deadline: May 23
Application Deadline: August 23

Lasker Clinical Research Scholars Program
LOI Deadline: May 24
Application Deadline: June 24

Lustgarten Foundation
Concept Deadline: May 24
Full Application Deadline: August 9

Chris4Life Colon Cancer Pilot Study Grant Program
Deadline: June 1

Department of Defense Ovarian Cancer Academy Award - Early-Career Investigator
Pre-Application Deadline: June 12
Application Deadline: August 28

Department of Defense Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: June 12
Application Deadline: August 28

Department of Defense Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: June 12
Application Deadline: August 28

James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex Systems
Deadline: June 14

Request for Proposals for Pilot Collaborations with LMICs in Global Cancer Research or Global Health Research at NCI-Designated Cancer Centers
Deadline: June 14

Mesothelioma Applied Research Foundation Research Grant Funding
Deadline: August 2

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Notice of Change to Funds Available and Anticipated Number of Awards for RFA-FD-13-022 Postmarketing Surveillance of Generic Drug Usage and Substitution Patterns (U01)(NOT-FD-13-007)

Notice of Change to Funds Available and Anticipated Number of Awards for RFA-FD-13-020 Collection of Dose Adjustment and Therapeutic Monitoring Data to Aid Narrow Therapeutic Index Drug Classification (U01)(NOT-FD-13-009)

Notice of Change to Funds Available and Anticipated Number of Awards for RFA-FD-13-019 Evaluation of Dissolution Methods for Complex Parenteral Dosage Forms (U01)(NOT-FD-13-010)

Research on the Role of Epigenetics in Social, Behavioral, Environmental and Biological Relationships, throughout the Life-Span and across Generations (R21)(RFA-TW-13-002)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.