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Case Comprehensive Cancer Center Newsletter

March 18, 2013

CASE CCC IN THE NEWS

New MRI Method Fingerprints Tissues and Diseases: Aims for Fast and Affordable Scans, Early and Quick Diagnoses
Science Daily - Mar 13, 2013
"The overall goal is to specifically identify individual tissues and diseases, to hopefully see things and quantify things before they become a problem," said Mark Griswold...Griswold has been working on this goal with Case Western Reserve's Vikas Gulani, MD...Jeffrey L. Sunshine, MD, professor of radiology and a radiologist at UH Case Medical Center; and Jeffrey L. Duerk, dean of Case School of Engineering and professor of biomedical engineering.

Would-be Dads Should Think Twice Before Trying Low-testosterone, Experts Say
Plain Dealer - Mar 12, 2013
When patients are referred to Dr. Edward Cherullo, a urologist at UH Case Medical Center, it's often because the man has suggested to his ...

Anesthesia During Colonoscopy May Cause Aspiration
Medscape - Mar 11, 2013
Gregory S. Cooper, MD, from the Division of Gastroenterology, University Hospitals Case Medical Center, and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, and colleagues published the results of their ...

Role Identified for Early Palliative Care Among Patients with NSCLC
Healio - Mar 7, 2013
Perspective by Nathan Pennell, MD, PhD. In 2010, a landmark study was published (Temel JS. N Engl J Med. 2010;363:733-742) showing that early integrated palliative care improves the quality of life of patients...

Novel 24-gene Signature May Predict Outcomes in AML
Healio - Mar 1, 2013
Perspective by Yogen Saunthararajah, MD. The disease label 'acute myeloid leukemia' (AML) – though based on clear morphologic criteria – captures a diverse group of biological entities, driven by a variety of genetic and epigenetic abnormalities


ANNOUNCEMENTS

Member Funding Updates

Several Cancer Center Members received R01s from the NCI recently:

gersonDr. Jean-Eudes Dazard received a multi-PI grant, Survival Bump Hunting for Funding Informative Subgroups in High Dimensional Data. One of the questions of interest is to uncover hidden subgroups of individuals with differential survival (say in response to treatment), and characterize the genomic determinants that define these groups. The researchers will develop a new methodology that is designed to find extreme subgroups of patients within a population, specifically methods on how to focus the search on genes who relate most strongly to extreme survival and how to integrate various kinds of genomic profiles using three different strategies that are meant to improve subgroup finding and also glean more biological insights.

gersonDr. Candece Gladson received a grant for her study, Mechanisms Promoting Angiogenesis in Glioblastoma, which has the potential to provide a paradigm shift in the understanding of tumor-associated angiogenesis in general and will suggest novel regimens for improved anti-angiogenesis therapy in glioblastoma.

gersonDr. John Letterio received funding for his project, Small Molecule Induction of 15-PGDH: A Target in Colon Cancer Chemoprevention. This study aims to define the capacity and efficacy of a novel class of small molecules (the triterpenoids) to induce 15-PGDH, the mechanisms involved in this induction, and the capacity of selected triterpenoids administered as a dietary supplement to either enhance the activity of or to overcome the resistance to celecoxib.

Disease Team sign-off and PRMC Review and Approval

Message from: Neal Meropol, MD, Associate Director for Clinical Research, and Robert Dreicer, MD, Deputy Associate Director for Clinical Research

Effective immediately, Protocol Review and Monitoring Committee (PRMC) approval will not be granted if Disease Team sign offs are not on file in the PRMC study file.

One of the functions of the Case CCC Clinical Trials Disease Teams is to "recommend action to PRMC for trial advocacy, priority" by providing "pre-review by experts in their field for scientific merit, prioritization, and intent to accrue patients" (Case CCC Clinical Trials Operations Manual). Disease Team sign off from both hospitals is a longstanding requirement, but the PRMC has sometimes reviewed protocols without this sign off.

Please note that the overall responsibility of following-up and obtaining sign-offs rests with the PI and the study team. The PRMC will continue to send PRMC sign off forms to both hospital Disease Team leaders; however, PRMC staff are not responsible for obtaining the signatures – this falls with the PI.

Questions should be directed to Katarzyna Karelus, Clinical Research Office Administrative Director, kxk384@case.edu, 216.844.4176.


FUNDING OPPORTUNITIES/AWARDS

Computational Genomic Epidemiology of Cancer Postdoctoral Training Program

The Case CCC invites applications to its 2-3 year NCI-funded Computational Genomic Epidemiology of Cancer Postdoctoral Training Program. The program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare trainees for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways comprising genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer.

Candidates with an MD, PhD, or MD/PhD degree, strong quantitative skills, and an interest in a career in genetics research are encouraged to apply.

Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE)

All Faculty members are invited to submit outlines for pilot projects to be funded by the NIH P50 GI SPORE. Proposals must be submitted through CTSC Webgrants. Please note that a SPORE project must be directed toward translational research of a GI malignancy. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples.

More information on grant application is available at webgrants.case.edu or through John Pounardjian, hxp125@case.edu, 216.368.1976. Information is also posted on the CWRU GI SPORE website.

Deadline: April 1

Barrett's Esophagus Translational Research Network (BETRNet)

All Faculty members at participating institutions are invited to submit applications for Individual and/or Cross BETRNet pilot projects of up to $50,000 to be funded by the U54 BETRNet. Note that a BETRNet project must be directed toward translational research related to Barret's Esophagus. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples.

More information on grant application is available at webgrants.case.edu or through Angele Latham, axl350@case.edu, 216.368.1674.

Deadline: May 10

Computational Genomic Epidemiology of Cancer Postdoctoral Training Program

The Case CCC invites applications to its 2-3 year NCI-funded Computational Genomic Epidemiology of Cancer Postdoctoral Training Program. The program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare trainees for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways comprising genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer.

Candidates with an MD, PhD, or MD/PhD degree, strong quantitative skills, and an interest in a career in genetics research are encouraged to apply.

EVENTS

calendar

March 18

Cancer Center Faculty Candidate
Jayakrishnan Nandakumar, PhD
NIH Postdoctoral Fellow
University of Colorado at Boulder
Topic: Roles of the Telomere Protein Complex POT1-TPP1 in Chromosome End Protection and End Replication
11 am Wood Bldg W331

Pathology Research Seminar Series
Rebecca Chan, MD, PhD
Associate Professor, Pediatrics
University of Indiana
Topic: Shp2 Phosphatase Function in FLT3-ITD-Induced Leukemia
12 pm WRB 1-413

Physiology and Biophysics Seminar
Gabriela Popescu, PhD
Associate Professor, Biochemistry
State University of New York - Buffalo
Topic: NMDA Receptors: Learning from Singles
4 pm SOM / Robbins Building, E-501


March 19

Radiation Oncology Grand Rounds
Tarun Podder, PhD
Associate Professor, Radiation Oncology
CWRU/UH
Topic: Motion Management in Radiation Therapy Part II
8:10 am Lerner Tower B-181

Molecular Genetics Departmental Seminar
Yusuke Matsumoto, PhD
Postdoctoral Research Fellow, Ogino Lab, Molecular Genetics
Cleveland Clinic
Topic: Intranuclear Persistent Infection of a Negative Strand RNA Virus, Borna Disease Virus
9:30 am NE1-205 Cleveland Clinic

Cancer Biology Seminar
Candece Gladson, MD
Professor, Cancer Biology
CWRU/Cleveland Clinic
Topic: Lyn Promotion of Glioblastoma Tumor Cell Survival
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Rafick-Pierre Sékaly, PhD
Chief Scientific Officer and Co-Director
The Vaccine and Gene Therapy Institute of Florida
Topic: Inflammation: Drivers and Consequences in Vaccines and HIV Infection
12 pm WRB 1-413

Medicine Grand Rounds
Sahil Parikh, MD
Director, Experimental Interventional Cardiology Laboratory, Div. of Cardiovascular Medicine
CWRU/UH
AND
Jackson Wright, MD, PhD
Program Director, William Dahms Clinical Research Unit
Director, Clinical Hypertension Program, Div. of Nephrology and Hypertension
CWRU/UH
Topic: Resistant Hypertension: Contemporary and Promising Management Strategies
12 pm Kulas Auditorium, Lakeside 5th Fl.


March 20

Hematology and Oncology Division Research Conference
Paolo Caimi, MD
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: Phase I Clinical Trial of Fludarabine and Methoxyamine
8 am Lerner B-151

Pathology Special Seminar
Yina Huang, PhD
Assistant Professor, Pathology and Immunology
Washington University
Topic: Activation of T Cell Migration
12 pm WRB 1-413


March 21

Cancer Trainee Seminar
Santosh Rao, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Prostate Cancer
AND
Anthony Scott
Wang Lab, Genetics
CWRU
Topic: Role of Paxillin Tyrosine-88 Phosphorylation in Colorectal Cancer Development
12 pm WRB 3-136


March 22

Hematology and Oncology Fellows Conference
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Stephen Hahn, MD
Chair, Radiation Oncology
Abramson Cancer Center
Topic: Proton Therapy and Assessing the Value of High Technology Therapies
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Efstathios Karathanasis, PhD
Assistant Professor, Biomedical Engineering and Radiology
CWRU
Topic: TBD
12 pm BRB 105

Cancer Center Research in Progress
Lachelle Weeks
Graduate Student, Gerson Lab, Div. of Hem/Onc
CWRU/UH
Topic: Uracil DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity To Pemetrexed
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

IMPACT: Improving Sickle Cell Patient Adherence Through Collaborative Teaching
March 23
Wolstein Research Building
Brochure
Registration

Breast Cancer Conference
May 17
Hilton Cleveland East
Brochure
Registration

Impact of Genomics on Cancer Diagnosis and Treatment: Open Drug Policy Forum
June 24
9 am - 3 pm Wolstein Research Building

Annual Cancer Center Scientific Retreat
July 11-12

 

ADDITIONAL UPCOMING SEMINARS & EVENTS

National GvHD Health Symposium
November 1


PREVIOUSLY ANNOUNCED OPPORTUNITIES

Case CCC ACS IRG
(LOI Deadline: February 18)
Application Deadline: April 5

Call for Pilot Projects: Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE)
Deadline: April 1

Barrett's Esophagus Translational Research Network (BETRNet)
Deadline: May 10

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Notice of Pre-Application Teleconference Meeting for RFA-CA-13-006 "NCI Experimental Therapeutics-Clinical Trials Network with Phase 1 Emphasis (ET-CTN)(UM1)"(NOT-CA-13-007)

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31)(PA-11-111)

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR)(R43/R44)(PA-13-140)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.