Case Comprehensive Cancer Center: Weekly Newsletter

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February 11, 2013
CASE CCC IN THE NEWS Exercise May Cut Prostate Cancer in Whites, But Not Blacks Everyday Health - Feb 8, 2013 But Timothy Gilligan M.D., a medical oncologist with the Cleveland Clinic in Ohio, says he is skeptical of the findings. Tamoxifen May Have Long-term Benefits in Fighting Breast Cancer Plain Dealer - Feb 4, 2013 "While you do get more side effects long term, the benefits significantly outweighed the side effects," said Dr. Rosemary Leeming, a surgical oncologist at University Hospitals... Because the ATLAS trial focused on a large patient population that was followed for a long period of time, oncologists probably will be very receptive to the findings, said Dr. G. Thomas Budd, a medical oncologist at the Cleveland Clinic Taussig Cancer Institute Cancer Research by the Numbers The Cancer Genome Atlas - Feb 6, 2013 Biostatistician Dr. Jill Barnholtz-Sloan strives to make a difference in the field of cancer research while inspiring her students at the same time. Learn more about how she uses TCGA data in her career in this TCGA in Action Researcher Profile. ANNOUNCEMENTS Finke Receives NCI R01 Dr. Jim Finke was awarded an R01 from the National Cancer Institute to study the individual contributions of inflammatory proteins and their impact in promoting the activation and migration of highly active MDSC subsets, particularly those expressing the chemokine receptor CXCR2, with the hope that research findings may lead to new targets for therapeutic intervention. Pizarro Receives Grant to Study Gastric Cancers Dr. Theresa Pizarro, Associate Professor of Pathology and Medicine at CWRU, recently received a grant from the DeGregorio Family Foundation for her proposal, Role of the novel IL-1 family member, IL-33, in the gastritis-metaplasiacarcinoma sequence. Dr. Pizarro will work with Dr. Li Li, co-investigator, and Dr. Wei Xin, collaborator, on this project. Tissue Microarray Survey The Cancer Center is considering an initiative to build a series of Tissue Microarrays (TMAs) for member usage. We would like to assess the needs of our members so that we can start with the most feasible and useful TMAs. Please take this short survey regarding your research goals and needs. December CTSC Core Utilization Pilot Awards Congratulations to the recipients of the December CTSC Core Utilization Pilot Awards: Shu Chen, PhD: Identification of novel substrates of LRRK2, a Parkinson disease associated kinase Evren Gurkan-Cavusoglu, PhD: Analysis of the cell cycle dynamics for fludarabine or ABT-737 resistant Nalm-6 cells Youwei Zhang, PhD: Roles of long non-coding RNAs (lncRNAs) in DNA damage response Edward Medof, MD, PhD: Evidence for a plasma membrane complex containing C5a receptor (C5aR), IL-6-receptor (IL-6R), and vascular endothelial cell growth factor receptor-2 (VEGFR-2) that governs vascular endothelial cell (EC) viability and growth signaling Catherine Stein, PhD: Exploration of pathways underlying resistance to M. tuberculosis infection Reminder: Registration of Studies in Clinicaltrials.gov and Reporting of Clinical Trial Results Section 801 of the Food and Drug Administration Amendments Act (FDAAA 801) requires Responsible Parties to register and submit summary results of clinical trials with Clinicaltrials.gov. Clinical trial results registration became effective as of September 2008. The FDA is currently empowered to enforce the reporting requirements, as well as financial penalties on non-compliant investigators and institutions. Clinical trial and result registration is centralized within the Case CCC, and April Firstencel, Case CCC Registration Coordinator, has been working with investigators, study staff and statisticians to ensure the Case CCC complies with federal requirements. This announcement serves as a reminder about our on-going efforts and the need for everybody's assistance and collaboration to meet these obligations. Please direct questions to April Firstencel, Case CCC Registration Coordinator for Clinicaltrials.gov, 216.286.2294, april.firstencel@case.edu. FUNDING OPPORTUNITIES/AWARDS American Association for Cancer Research The AACR is accepting applications for the following funding opportunities: The Fight Colorectal Cancer-AACR Fellowship, in memory of Lisa Dubow represents a joint effort to encourage and support a postdoctoral or clinical research fellow to conduct translational or clinical research that focuses on novel therapeutic approaches for late-stage metastatic colorectal cancer. This grant will support a project designed to lead to individualized therapeutic options for treatment or the development of promising new cancer therapeutics for patients with metastatic colorectal cancer. Emphasis will be placed on proposed projects which will translate into clinical applications within a few year period, including those with predictive biomarker studies. Deadline Extended: February 13 The QuadW Foundation-AACR Fellowship for Clinical/Translational Sarcoma Research represents a joint effort to encourage and support a postdoctoral or clinical research fellow to conduct translational or clinical sarcoma research and to establish a successful career path in this field. Deadline: February 19 The AACR Clinical and Translational Cancer Research Fellowships are open to postdoctoral and clinical research fellows working at an academic, medical or research institution who will be in the first five years of their postdoctoral training at the start of the grant term. Proposed research projects may be in any area of clinical and/or translational cancer research. Deadline: February 27 American Cancer Society IRG Awards The Case CCC, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges in the University are eligible. Grants, not to exceed $30,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs. LOI Deadline: February 18 Application Deadline: April 5 Lymphoma Research Foundation The Lymphoma Research Foundation (LRF) Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL), Follicular Lymphoma (FL) and Mantle Cell Lymphoma (MCL) Consortiums are seeking proposals for high quality research studies in the following three disease areas: CLL and SLL Collaborative Grant FL Pathways Grant MCL Exploratory/ Development Gran Applications to this initiative must include the study of primary CLL/SLL, FL or MCL patient samples to assure relevance to the human disease. In addition, applicants are required to explicitly delineate how the proposed research will incorporate collaborative interactions between/among investigators in different disciplines (e.g. pathology & medical oncology, basic science research & clinical investigators) and/or different institutions. Deadline: February 19 MARK YOUR CALENDARS Breast Cancer Program in Development Annual Retreat Drs. William Schiemann and Lyndsay Harris, Co-Leaders of the Breast Cancer Program in Development, invite you to attend the program Annual Retreat on Monday, March 11 from 9 am-3 pm in the Dively Building on CWRU campus. The agenda and program information will be available soon. Melanoma Mini-Symposium A melanoma mini-symposium is scheduled from 3-7 pm on Monday, March 11 in the Wolstein Research Building Auditorium. The purpose of this symposium is to provide a forum for physician scientists and biomedical researchers to foster communication and develop new collaborations on melanoma research. Please watch the newsletter for updates. Annual Cancer Center Retreat The Annual Cancer Center Scientific Retreat will commence the evening of Thursday, July 11 and continue through Friday, July 12. Location and agenda are still be finalized. Details will be posted in the newsletter in the coming months.	EVENTS February 11 Pathology Research Seminar Series Charles Glabe, PhD Professor, Molecular Biology & Biochemistry University of California, Irvine Topic: Conformational Polymorphisms of Amyloid in Alzheimer' Disease 12 pm WRB 1-413 Cancer Biology Midterm Review Seminar Matthew Summers, PhD Assistant Staff, Cancer Biology Cleveland Clinic Topic: Dynamics of Ubiquitin-mediated Cell Cycle Control 2 pm NC1-202 Cleveland Clinic Sequencing Data Interest Group (SDIG) Daniel Sprockett Research Assistant, Dermatology CWRU/UH AND Marie Tuttle, MD Assistant Professor, Dermatology CWRU/UH Topic: NGS Tools for Investigating the Human Microbiome 2:30 pm WRB 1-403 February 12 Molecular Genetics Departmental Seminar Maupali Dasgupta, PhD Postdoctoral Research Fellow, Stark Lab, Molecular Genetics Cleveland Clinic Topic: Post-translational Modifications of Stat3 and Their Roles in Directing Gene Activation 9:30 am NE1-205 Cleveland Clinic Cancer Biology Invited Speaker Seminar Aaron Severson, PhD Assistant Professor, Biology, Geology, Environmental Science Cleveland State University Topic: Establishing and Removing Sister Chromatid Cohesion to Promote Normal Gamete Formation in C. elegans 11 am NC1-202 Cleveland Clinic Immunology Seminar Series Richard Zigmond, PhD Professor, Neurosciences CWRU Topic: A New Phenotype for an Old Mouse: A Critical Role in the Conditional Lesion Response of Inflammation Near Axotomized Cell Bodies 12 pm WRB 1-413 Medicine Grand Rounds Vikram Kashyap, MD, FACS Chief, Div. of Vascular Surgery and Endovascular Therapy Co-Director, UH Harrington Heart & Vascular Institute CWRu/UH Topic: AAA and EVAR as well as TVAR 12 pm Kulas Auditorium, Lakeside 5th Fl. Research & Technology Management Seminar Charles Wessner, PhD Director Technology, Innovation, and Entrepreneurship The National Academies Topic: The Global Innovation Imperative: The Challenge of Sustaining US Leadership 4 pm WRB 1-413 February 13 Hematology and Oncology Division Research Conference Hyunseok Kang, MD Fellow, Hematology and Medical Oncology Emory University/Winship Cancer Institute Topic: Exploring Novel Therapeutic and Preventive Strategies in Head and Neck Cancer 8 am Lerner B-151 Genetics and Genome Sciences Seminar Christopher Cullis, PhD Professor and Chair, Biology CWRU Topic Transgenerational Inheritance in Flax – Epigenetics or Programmed Genome Rearrangements? 11 am BRB 105 Immunology Faculty Research in Progress Trine Jorgensen, PhD Assistant Staff, Immunology Cleveland Clinic Topic: Faculty Update 12 pm NC1-202 Cleveland Clinic Case GI SPORE Seminar Series: Moved to March 6 Sanford Markowitz, MD, PhD Professor, Div. of Hem/Onc Principal Investigator, Case GI SPORE CWRU/UH Topic: Case GI SPORE: Genetic Studies of Colon Cancer 5:30 pm Lerner B-151 February 14 Pathology Special Seminar Parameswaran Ramakrishnan, PhD Postdoctoral Fellow, Div. of Biology California Institute of Technology Topic: Regulation of the Regulator, NF-κB, in the Immune System 12 pm WRB 5-136 February 15 Cancer Center Research in Progress canceled Hematology/Oncology Fellows Conference/Curriculum Series Topic: TBD 8 am Wearn 137/Breen Conference Rm. Taussig Cancer Institute Grand Rounds David Gaffney, MD, PhD Professor and Medical Director University of Utah/Huntsman Cancer Hospital Topic: The Role of Radiation in Cervical and Endometrial Cancer 8 am R3/002-003 Cleveland Clinic Cancer Center Seminar Series Philip S. Low, PhD Ralph C. Corley Distinguished Professor of Chemistry Director of the Purdue Center for Drug Discovery Purdue University Topic: Ligand-Targeted Imaging and Therapeutic Agents for Cancer and Inflammatory Diseases 12 pm BRB 105 Case CCC Calendar LRI Calendar UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS IMPACT: Improving Sickle Cell Patient Adherence Through Collaborative Teaching March 23 Wolstein Research Building Brochure and Registration Breast Cancer Conference May 17 Hilton Cleveland East ADDITIONAL UPCOMING SEMINARS & EVENTS 16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRC3): The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity February 20-22 Seven Springs Mountain Resort, Seven Springs, PA Details National GvHD Health Symposium November 1

PREVIOUSLY ANNOUNCED OPPORTUNITIES
Fight Colorectal Cancer-AACR Fellowship, in memory of Lisa Dubow Deadline Extended: February 13 Case CCC ACS IRG LOI Deadline: February 18 Application Deadline: April 5 Leukemia and Lymphoma Society Translational Research Program LOI Deadline: March 1 Full Application Deadline: March 15 Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program Deadline: March 4 Childhood Brain Tumor Foundation Deadline: March 12 Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC) Deadline: Open AACR Scholar-in-Training Awards - Other Conferences and Meetings Deadline: Open Case CCC Protocol Specific Research Support (PSRS) Deadline: Open	International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships Application Deadline: Open International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program Application Deadline: Open James S. McDonnell Foundation Collaborative Activity Awards Deadline: Open NCI Short-Term Scientist Exchange Program Application Deadline: Open SAIC-Frederick Support of the Cancer Genome Atlas Program Application Deadline: Open Solving Kids' Cancer Therapeutic Development Initiative Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities Notice of Participation of Additional NIH Institutes and Centers in PA-11-110 "Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30)" (NOT-OD-13-032) Notice of Participation of Additional NIH Institutes and Centers in PA-11-111 "Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31)" (NOT-OD-13-033) Notice of Intent to Publish the Reissuance of Funding Opportunity Announcement "NIH Pathway to Independence Award (Parent K99/R00)" (NOT-OD-13-034) NIH Requires Use of RPPR for All SNAP and Fellowship Progress Reports, and Expands RPPR Functionality (NOT-OD-13-035) New Review Criteria for NIH Construction (C06 and UC6) and Modernization (G20) Grant Applications (NOT-OD-13-038) NCI Experimental Therapeutics-Clinical Trials Network with Phase 1 Emphasis (ET-CTN) (UM1)(RFA-CA-13-006) Obesity Policy Evaluation Research (R01)(PA-13-110)
Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216.844.8317 phone 216.844.7832 fax gillian.irwin@case.edu	HELP US HELP YOU! If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu.