Case Comprehensive Cancer Center: Weekly Newsletter

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November 19, 2012
CASE CCC IN THE NEWS Stem Cells' Promise Hits Funding Wall in Michigan Detroit Free Press - Nov 17, 2012 But even with those exceptions, Dr. Stanton Gerson, director of the NCRM, sees bioscience as a way to re-ignite business -- even outside the ... Stem Cell Therapy: What Physicians Should Know MD News - Nov 16, 2012 And there's more, much more, according to Stanton Gerson, MD, director of UH Seidman Cancer Center and the Case Comprehensive Cancer Center, and Marcos JG de Lima, MD, director of UH Seidman's Hematologic Malignancies and Stem Cell Transplant Program which focuses on non-embryonic stem cells. Breast Cancer Vaccine Researcher Vincent Tuohy Gets $1 Million Gift Plain Dealer - Nov 15, 2012 Vincent Tuohy, an immunologist at the Clinic's Lerner Research Institute, is the beneficiary of the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research, created through a $1 million endowment given by the couple Options Shifting for First-line Treatment of Renal Cell Carcinoma ASCO Post - Nov 15, 2012 "Kidney cancer is fundamentally a VEGF-driven disease," noted Brian R. Rini, MD, of the Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, and Glickman Urologic and Kidney Institute. FUNDING OPPORTUNITIES Friends For An Earlier Breast Cancer Test Friends For An Earlier Breast Cancer Test, a non-profit organization dedicated to promoting awareness and education and to raising funds for research into earlier detection of breast cancer, is requesting applications for pilot projects that focus on new methods to improve detection of early breast cancer. This organization is especially interested in the development of new techniques in the areas of biological or immunologic methods of early detection, with the hope that pilot projects will provide preliminary data that leads to applications for more substantial peer-reviewed funding. Deadline: December 1 MARK YOUR CALENDARS Miltenyi Biotec Seminar and Machine Demonstration A representative from Miltenyi Biotec will be on campus Thursday, November 29 to give a seminar discussion and live demonstration of a new machine they have developed for aiding in the digestion and dissociation of tumor tissue for growing cells ex vivo, called the gentleMACS. Learn how MACS® Technology provides unique, reliable, and convenient solutions for your research. The combined product portfolio offers an unrivalled resource for researchers: from tissue dissociation through cell isolation, cell culture and analysis, to small animal preclinical imaging. Discover solutions optimized to deliver outstanding results while saving you time. Brian Kierce, Miltenyi Biotec District Sales Manager, will present, Tissue dissociation and downstream magnetic cell isolation technologies, at 11 am in Wolstein Research Building 2-136. He will also be available to give live demonstrations of the machine later in the day. If anyone would like to try out the machine using their favorite tumor/tissue, or see the machine in action please contact Kristy Miskimen (216.368.5363, klm64@case.edu). So You Want To Do Comparative Effectiveness Research? The Nuts and Bolts of CER Registration is open for So You Want To Do Comparative Effectiveness Research? The Nuts and Bolts of CER, to be held Friday, December 14 in the WRB Auditorium. This half-day symposium will help heighten the understanding of comparative effectiveness research (CER), identify strategies to evaluate competing treatments and highlight the various research design methods available to perform CER. The course will be taught at an introductory level and is designed to provide resources for investigators to pursue future research projects. There is $25 registration fee, though this fee is waived for trainees, scholars, and K awardees. CER is defined as the direct comparison of existing health care interventions to determine which work best for which patients and which pose the greatest benefits and harms. CER is receiving increasing importance nationally and internationally as a priority area of investigation and has led to the establishment of the Patient-Centered Outcomes Research Institute (PCORI). ANNOUNCEMENTS Case CCC Clinical Trials Admin Staff Hold Office Hours at the Cleveland Clinic Case CCC clinical trials administrative staff is now holding office hours at the Cleveland Clinic in JJN2-326: April Firstencel, Registration Coordinator for ClinicalTrials.gov and NCI/CTRP Cleveland Clinic office hours: Thursdays 8:30 am-5 pm april.firstencel@case.edu David Goldblatt, Protocol Review & Monitoring Committee Manager Cleveland Clinic office hours: Fridays 9 am-3 pm david.goldblatt@case.edu Please feel free to stop by their office in the JJ building with any questions regarding PRMC, Clinicaltrials.gov, NCI/CTRP and OnCore issues. Cancer Care Video Challenge The Office of the National Coordinator for Health Information Technology (ONC) in conjunction with the National Cancer Institute (NCI), invites cancer patients, survivors, and their families and friends to create short, compelling videos sharing a personal story that describes a goal of a cancer patient or survivor, and how technology (such as health IT or consumer eHealth tools) is used to support meeting that goal. There are a variety of tools and applications that can be used to help patients and their families navigate the various aspects of living with or transitioning from cancer treatment to survivorship. The purpose of the challenge is to generate videos that will inspire and motivate others to become more engaged in their care, through the use of consumer e-health tools and other health IT to improve communication and collaboration with their health care team (doctors, nurses, and other allied health care professionals), and better manage their cancer-related care. The deadline to submit a video is December 21. Cash prizes are available to the winners.	EVENTS November 19 Cancer Center Chalk Talk Lyndsay Harris, MD Professor, Medicine-Hematology/Oncology CWRU/UH Topic: TBD 12 pm WRB 3-136 Immunology Invited Speaker Seminar Series Xiaoyu Hu, MD, PhD Assistant Professor, Immunology Cornell University Topic: Regulation of Inflammation by Notch Signaling 1:30 pm NC1-202 Cleveland Clinic Sequencing Data Interest Group Yaomin Xu, PhD Assistant Professor, Statistical Genetics and Bioinformatics CWRU/Cleveland Clinic Topic: Reproducible Analysis on NGS Epigenomic Data 2:30 pm WRB 1-402 Physiology and Biophysics Seminar William Evans, PhD Vice President and Head, Muscle Metabolism Discovery Performance Unit GlaxoSmithKline Topic: Skeletal Muscle as a Target for Drug Discovery: New Indications for Aging and Cachexia 4 pm SOM E501 Skeletal Research Center Justin Lathia, PhD Assistant Professor, Cell Biology CWRU/Cleveland Clinic Topic: Holding on to Stemness: Interrogating Adhesion Mechanisms in the Perivascular Niche that Instruct Brain Tumor Stem Cells 4 pm Millis 123 November 20 Radiation Oncology Physics Seminar Peter Park PhD Candidate, Medical Physics University of Texas MD Anderson Cancer Center Topic: How to Cope With Uncertainties in Proton Therapy: Current and Future Prospect 8 am Lerner B-151 Medicine Grand Rounds Wendy Levinson, MD Professor and Chair, Medicine University of Toronto Topic: Professionalism in Health Care: A Novel and Practical Approach for Physicians and Teams 12 pm Kulas Auditorium, Lakeside 5th Fl. November 21 Hematology and Oncology Research Conference canceled November 22 Happy Thanksgiving! November 23 Cancer Center Research in Progress canceled Cancer Center Seminar Series canceled Hematology/Oncology Fellows Conference/Curriculum Series Taussig Cancer Institute Grand Rounds canceled Case CCC Calendar LRI Calendar UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS ADDITIONAL UPCOMING SEMINARS & EVENTS The Cancer Genome Atlas 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA November 27-28 Crystal City, Virginia Details American Society of Hematology (ASH) Annual Meeting December 8-11 Atlanta, Georgia Details So You Want To Do Comparative Effectiveness Research? The Nuts and Bolts of CER December 14 7:30 am - 12 pm WRB 1-413 Details Pacific Symposium on Biocomputing 2013 January 3-7, 2013 Fairmont Orchid, Hawaii Details

NCI CANCER BULLETIN November 13, 2012 News Featured Article: Study Shows Importance of Early End-of-Life Care Discussions Drug May Reduce Cognitive Decline Following Radiation for Brain Metastases Brazil's Strong Antismoking Policies Credited with Saving Lives Possible Cause of Doxorubicin-Induced Heart Damage Identified Study Reveals New Mechanism of Action for Class of Targeted Therapy Also in the News: Radium-223 Improves Survival in Men with Metastatic Prostate Cancer Also in the Journals: Genetic Factors Linked to Lung Cancer in Asian Women Who Have Never Smoked Multimedia NIH Research Radio: A Clinical Trial for HIV-Positive Cancer Patients In Depth Decades Later, Chernobyl Accident Yields Clues to Leukemia Risk Featured Clinical Trial: Dietary Intervention for Patients Receiving Chemoradiotherapy for Lung Cancer DREAMing Big to Solve Cancer Research Challenges Updates FDA Update: New Treatment Approved for Chronic Myelogenous Leukemia CDC Update: Global Study Documents Tobacco Use, Secondhand Smoke Exposure among Women of Childbearing Age Cancer.gov Update: Newly Launched NCI Map Stories Show Geographic Patterns of Cancer Notes

PREVIOUSLY ANNOUNCED OPPORTUNITIES
AACR Dharma Master Jiantai Innovative Grant for Lung Cancer Research Deadline: November 20 Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research Deadline: November 20 Limited Submission: NIH Director's Early Independence Award Internal Deadline: November 26 LOI Deadline: December 30 Full Application: January 30, 2013 Limited Submission: Rita Allen Foundation Scholars Program Internal Deadline: November 26 External Deadline: January 25, 2013 AACR Minority Scholar in Cancer Research Award Deadline: November 30 AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students Deadline: November 30 AACR-Women in Cancer Research (WICR) Scholar Awards Deadline: November 30 AACR-National Brain Tumor Society Career Development Award for Translational Brain Tumor Research Deadline: November 30 Alex's Lemonade Stand Foundation Innovation Grants Deadline: December 3 Conquer Cancer Foundation of ASCO Medical Student Rotation for Underrepresented Populations Deadline: December 3 Weatherhead Institute for Family Medicine and Community Health Pilot Deadline: December 3 DOD Breast Cancer Research Program Postdoctoral Fellowship Award Pre-Application Deadline: December 4 Application Deadline: December 18 CTSC Explorys Collaborative Pilots Deadline: December 14 Alex's Lemonade Stand Foundation Epidemiology Awards Deadline: December 17	Alex's Lemonade Stand Foundation Young Investigator Awards Deadline: December 17 Association for Research of Childhood Cancer Deadline: January 1, 2013 2013 CTSC Annual Pilot Grant Funding LOI Deadline: January 15, 2013 Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC) Deadline: Open AACR Scholar-in-Training Awards - Other Conferences and Meetings Deadline: Open Case CCC Protocol Specific Research Support (PSRS) Deadline: Open International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships Application Deadline: Open International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program Application Deadline: Open James S. McDonnell Foundation Collaborative Activity Awards Deadline: Open NCI Short-Term Scientist Exchange Program Application Deadline: Open SAIC-Frederick Support of the Cancer Genome Atlas Program Application Deadline: Open Solving Kids' Cancer Therapeutic Development Initiative Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)(PA-13-018) NCI Mentored Patient-Oriented Research Career Development Award to Promote Diversity (K23)(PAR-12-052) NCI Mentored Research Scientist Development Award to Promote Diversity (K01)(PAR-12-050) Validation of Molecular Diagnostics to Predict Patient Outcomes Using Specimens from Multi-Site Cancer Trials (R21)(PA-12-014) NCI Established Investigator Award in Cancer Prevention and Control (K05)(PAR-12-065) Validation and Advanced Development of Emerging Molecular Analysis Technologies for Cancer Research (R33)(RFA-CA-13-002) Validation and Advanced Development of Emerging Technologies for Biospecimen Science (R33)(RFA-CA-13-004) Early-Stage Innovative Molecular Analysis Technology Development for Cancer Research (R21)(RFA-CA-13-001) Early-Stage Development of Innovative Technologies for Biospecimen Science (R21)(RFA-CA-13-003) Biomechanisms of Peripheral Nerve Damage by Anti-Cancer Therapy (R01)(PA-12-082) Biomechanisms of Peripheral Nerve Damage by Anti-Cancer Therapy (R21 (PA-12-083) The NCI Transition Career Development Award to Promote Diversity (K22)(PAR-12-06)
Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216.844.8317 phone 216.844.7832 fax gillian.irwin@case.edu	HELP US HELP YOU! If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu.