Case Comprehensive Cancer Center: Weekly Newsletter

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October 8, 2012
MESSAGE FROM THE DIRECTOR Stan Gerson, MD Director, Case CCC We are two weeks away from the site visit and it is a buckle-down time for program leaders and core directors. More than 70 members and staff are directly involved in slides, updated databases and documents, logistics, and rehearsals. Our preparation will yield a very solid presentation of our center, programs and shared resources. Our review team is informed, and balanced. I expect a careful assessment and a fair review. If you have been asked to participate, you will receive instructions on agenda, decorum, and choreography next week. Before I get back to work on the details and planning for the site visit, I would like to share two forward-looking thoughts. First, please consider applying to the Provocative Questions RFA that was recently reissued. Many of us are ideal respondents. Harold Varmus places a good deal of emphasis on this process, and as a center we will do well with a number of applications and perhaps a few awards. These topics represent a consensus of important areas of research. The links are below. Second, I was recently asked about potential topics for the NCI to consider. These often lead to NCI workshops and even RFAs. I have four (derived from recent insights from program leaders) and would like your suggestions. My suggestions are: Clinical trial design in the genomic era with particular attention to clinical decision making Validated mouse lines and human primary tumor xenografts in drug development New imaging modalities as clinical trial endpoints – imaging drug delivery, PET-MR, PET endpoints Genomic targeted drug development – identifying novel mutations * * * * * * * Provocative Questions links: Group A: Cancer Prevention and Risk (R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-015.html (R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-016.html Group B: Mechanisms of Tumor Development or Recurrence (R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-017.html (R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-018.html Group C: Tumor Detection, Diagnosis, and Prognosis (R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-019.html (R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-020.html Group D: Cancer Therapy and Outcomes (R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-021.html (R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-022.html Provocative Questions homepage: http://provocativequestions.nci.nih.gov/

CASE CCC IN THE NEWS Minority Women with Breast Cancer Cleveland Fox 8-Sep 27, 2012 Dr. Sonja Harris-Haywood, a physician with University Hospitals, shared some important statistics with Fox 8 News viewers Thursday morning. Research Highlights Move Toward Personalized Treatment in AML HemOnc Today - Sep 25 "Dr. Grimwade has given us a nice summary of different prognostic markers," Matt Kalaycio, MD, director of the Bone Marrow Transplant Program at Taussig Cancer Institute at Cleveland Clinic, told HemOnc Today... Pediatric regimens may provide insight into treatment of adult ALL HemOnc Today - Sep 25 "The pediatric regimens included more vincristine, steroids and asparaginase," Anjali Advani, MD, staff physician in hematologic oncology and blood disorders... FUNDING OPPORTUNITIES Doris Duke Clinical Scientist Development Award The Doris Duke Clinical Scientist Development Award provides grants to junior physician-scientists to facilitate their transition to independent clinical research careers. Pre-proposals are being sought from junior physician scientist faculty conducting clinical research in any disease area. It is recommended that applicants have significant research experience and strong publication records. The Clinical Scientist Development Award will not require institutional nomination in 2013. Pre-Proposal Deadline: October 29 Full Proposal Deadline: February 20, 2013 Call for Ideas: Stand Up To Cancer-St. Baldrick's Pediatric Translational Cancer Research Dream Team Stand Up To Cancer (SU2C) and the St. Baldrick's Foundation, along with the American Association for Cancer Research (AACR), call upon members of the cancer community to contribute their ideas to the groundbreaking SU2C-St. Baldrick's Pediatric Translational Cancer Research Dream Team. Investigators are invited to submit ideas for translational cancer research projects that would address laboratory and clinical efforts that will lead to the therapeutic interventions for childhood cancers and deliver near-term patient benefit through investigation by a multidisciplinary, multi-institutional, synergistic Dream Team of expert investigators. The ideas should be based on perceived opportunities for success as well as high-priority areas with a critical need for rapid progress beyond current medical care. The collective ideas for Dream Team translational research projects suggested by the cancer community will assist the SU2C-St. Baldrick's Joint Scientific Advisory Committee in selecting the most promising ideas to be submitted as full research proposals. The committee will select a SU2C-St. Baldrick's Pediatric Translational Cancer Research Dream Team from the invited proposals. Please note that in this call for ideas the AACR and St. Baldrick's are not accepting research proposals for grant funding. Rather, the AACR and St. Baldrick's are inviting ideas to be submitted in a Letter of Intent for the SU2C-St. Baldrick's Pediatric Dream Team Translational Cancer Research Grant. A subset of ideas will be selected for submission of full research proposals for further consideration. Deadline: November 1 Limited Submission: Rita Allen Foundation Scholars Program The Rita Allen Foundation Scholars Program provides grants to leading medical research institutions selected by the Rita Allen Foundation Scientific Advisory Committee and confirmed by the Rita Allen Foundation Board of Directors. The Scholars program supports research scientists in the early stages of their careers. Fields of research are analgesics, cancer, immunology and neurosciences. Candidates must have completed their training and provided persuasive evidence of distinguished achievement or extraordinary promise in research in of the relevant fields. Each institution may nominate ONE candidate. Internal Deadline: November 26 External Deadline: January 25, 2013 DOD Breast Cancer Research Program The Department of Defense Breast Cancer Research Program is accepting applications for the Postdoctoral Fellowship Award. This award supports exceptionally talented recent doctoral or medical graduates in their pursuit of innovative, high-impact breast cancer research during their postdoctoral training and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research. These individuals should be exceptionally talented scientists who have demonstrated that they are the "best and brightest" of their peers. Applicants for this award must exhibit a strong desire to pursue a career in breast cancer research. Pre-Application Deadline: December 4 Application Deadline: December 18 MARK YOUR CALENDARS National GvHD Health Symposium The Meredith A. Cowden Foundation, in collaboration with the Case CCC, Seidman Cancer Center, and Taussig Cancer Institute, presents the 2012 National GvHD Health Symposium at the Embassy Suites Cleveland-Rockside on November 2. This unique one-day conference, will consist of two-tracks- one designed for physicians and other health care professionals and one for bone-marrow transplant (BMT) survivors, their families and their caregivers. Both tracks will focus on cutting edge research and new treatments. This year's conference will feature a poster session. The deadline submit abstracts has been extended to Tuesday, October 11, 2012 at 11:59 pm. Abstracts should be emailed to cmr4@case.edu. You will be notified October 20 whether your poster has been selected. The registration fee for invited presenters is complimentary, but advance registration is required. NCI CANCER BULLETIN October 2, 2012 News Featured Article: Targeted Drug Benefits Some Patients with Advanced Lung Cancer Drug Combination More Effective than Single Drug for Advanced Melanoma Health Care Costs a Major Barrier for Young Adult Cancer Survivors Many Women whose Tumors Disappear after Chemotherapy Have Mastectomies Commentary Statement from HHS Secretary Kathleen Sebelius on Breast Cancer Awareness Month Multimedia NIH Research Radio: Building a Biobank In Depth Turning Genes Up, Not On: A New View of the Myc Protein With CellMiner, Researchers Prospect for Cancer Discoveries New Tools Enhance Molecular Portraits of Breast Cancers Featured Clinical Trial: Comparing Radiation Therapy Regimens for Early-Stage Breast Cancer Updates Legislative Update FDA Update Notes	EVENTS October 8 Cancer Genetics Faculty Candidate Chalk Talk Dong Shen, MD, PhD Staff Scientist, The Genome Institute Washington University 12 pm WRB 3-136 Sequencing Data Interest Group (SDIG) Meeting Dan Savel PhD Student, Electrical Engineering and Computer Science CWRU Topic: Pluribus: Correcting Errors in Next Generation Sequencing Data 2:30 pm WRB 1-402 October 9 Radiation Oncology Grand Rounds Chandan Guha, MD Professor and Vice Chair, Radiation Oncology Albert Einstein College of Medicine Topic: Immunomodulation of Radiation Oncology 8:10 am Lerner B-151 October 10 Hematology and Oncology Special Presentation Yanis Boumber, MD, PhD Fellow, Div. of Hem/Onc MD Anderson Cancer Center Topic: The Role of DNA Methylation and Stem Cell Factors in Leukemia and Beyond 8 am Lerner B-151 Innovative Science Discussion Group Topic: TBD 12:15 pm WRB 3-136 October 11 October 12 Hematology/Oncology Fellows Conference/Curriculum Series Charles Wellman Chief Medical Officer Hospice of the Western Reserve Topic: Pain Management 8 am Wearn 137 Taussig Cancer Institute Grand Rounds: Annual Bruell Lecture D. Ross Camidge, MD Associate Professor, Div. of Medical Oncology University of Colorado Topic: The Road to Hope: Turning Lung Cancer into a Chronic Disease 8 am R3/002-003 Cleveland Clinic Cancer Center Seminar Series Goutham Narla, MD, PhD Assistant Professor, Medicine and Transformative Molecular Medicine CWRU/UH Topic: Small molecule therapies for the treatment of cancer 12 pm Frohring Auditorium – BRB 105 Molecular Biology and Microbiology Thesis Presentation Annette Ratcliff Arts Lab, Molecular Biology and Microbiology CWRU Topic: Mechanisms of CCR5 agonist/antagonist inhibition of HIV-1 entry and in vitro selection of virus resistant to Maraviroc 1 pm Wood Bldg, W203 Cancer Center Research in Progress Yulan Qing, PhD Senior Research Associate, Gerson Lab, Div. of Hem/Onc CWRU/UH Topic: Rescue of the HSC maintenance defects in Ku70-deficient mice by overexpression of Bcl2 reveals a novel role of Bcl2 in HSC 4 pm WRB 3-136 Case CCC Calendar LRI Calendar UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS National GvHD Health Symposium November 2 Embassy Suites Cleveland-Rockside Details Registration Deadline to submit abstracts: October 11 ADDITIONAL UPCOMING SEMINARS & EVENTS Ninth International Conference of the Society for Integrative Oncology October 8-10 Albuquerque, NM Details Biennial Science of Global Prostate Cancer Disparities conference November 1-4 Nassau, The Bahamas Details The Cancer Genome Atlas 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA November 27-28 Crystal City, Virginia Details American Society of Hematology (ASH) Annual Meeting December 8-11 Atlanta, Georgia Details Pacific Symposium on Biocomputing 2013 January 3-7, 2013 Fairmont Orchid, Hawaii Details

PREVIOUSLY ANNOUNCED OPPORTUNITIES
American Cancer Society Area of Special Interest: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment Deadline: October 15 American Cancer Society Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families Deadline: October 15 American Cancer Society Priority Focus in Cancer Control and Prevention Research Program: Health Disparities Research Deadline: October 15 Bonnie J. Addario Lung Cancer Foundation Research Grants Deadline: October 15 Robert Wood Johnson Foundation Scholars in Health Policy Research program Deadline: October 16 CTSC KL2 Training Program Deadline: October 22 AACR–American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention Nomination Deadline: September 26 AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research Nomination Deadline: September 26 AACR Award for Lifetime Achievement in Cancer Research Nomination Deadline: September 26 AACR Princess Takamatsu Memorial Lectureship Nomination Deadline: September 26 AACR Award for Outstanding Achievement in Chemistry in Cancer Research Nomination Deadline: October 3 AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship Nomination Deadline: October 3 AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Nomination Deadline: October 3 Melanoma Research Alliance-Prostate Cancer Foundation Team Science Partnership Award Deadline: October 15 NCI Clinical Assay Development Program (CADP) Deadline: October 15 Conquer Cancer Foundation Advanced Clinical Research Award (ACRA) LOI Deadline: October 22 Full Application Deadline: December 5 Alex's Lemonade Stand Foundation Springboard Grant Deadline: October 29	Leukemia & Lymphoma Society Specialized Center of Research Program Deadline: November 1 DeGregorio Foundation Award for Cancers of the Upper GI Tract Deadline: November 5 Limited Submission: NIH Director's Early Independence Award Internal Deadline: November 26 LOI Deadline: December 30 Full Application: January 30, 2013 AACR-Women in Cancer Research Scholar Awards Deadline: November 30 Alex's Lemonade Stand Foundation Innovation Grants Deadline: December 3 Alex's Lemonade Stand Foundation Epidemiology Awards Deadline: December 17 Alex's Lemonade Stand Foundation Young Investigator Awards Deadline: December 17 Association for Research of Childhood Cancer Deadline: January 1, 2013 Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC) Deadline: Open AACR Scholar-in-Training Awards - Other Conferences and Meetings Deadline: Open Case CCC Protocol Specific Research Support (PSRS) Deadline: Open International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships Application Deadline: Open International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program Application Deadline: Open SAIC-Frederick Support of the Cancer Genome Atlas Program Application Deadline: Open Solving Kids' Cancer Therapeutic Development Initiative Application Deadline: Open NCI Short-Term Scientist Exchange Program Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities National Cancer Institute Program Project (P01) Applications (PAR-12-005) Cancer Education Grants Program (R25)(PAR-12-049)
Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216.844.8317 phone 216.844.7832 fax gillian.irwin@case.edu	HELP US HELP YOU! If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu.