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Case Comprehensive Cancer Center Newsletter

October 8, 2012

gersonMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

We are two weeks away from the site visit and it is a buckle-down time for program leaders and core directors. More than 70 members and staff are directly involved in slides, updated databases and documents, logistics, and rehearsals. Our preparation will yield a very solid presentation of our center, programs and shared resources. Our review team is informed, and balanced. I expect a careful assessment and a fair review. If you have been asked to participate, you will receive instructions on agenda, decorum, and choreography next week.

Before I get back to work on the details and planning for the site visit, I would like to share two forward-looking thoughts. First, please consider applying to the Provocative Questions RFA that was recently reissued. Many of us are ideal respondents. Harold Varmus places a good deal of emphasis on this process, and as a center we will do well with a number of applications and perhaps a few awards. These topics represent a consensus of important areas of research. The links are below.

Second, I was recently asked about potential topics for the NCI to consider. These often lead to NCI workshops and even RFAs. I have four (derived from recent insights from program leaders) and would like your suggestions. My suggestions are:

  • Clinical trial design in the genomic era with particular attention to clinical decision making
  • Validated mouse lines and human primary tumor xenografts in drug development
  • New imaging modalities as clinical trial endpoints – imaging drug delivery, PET-MR, PET endpoints
  • Genomic targeted drug development – identifying novel mutations

* * * * * * *

Provocative Questions links:

Group A: Cancer Prevention and Risk
(R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-015.html
(R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-016.html

Group B: Mechanisms of Tumor Development or Recurrence
(R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-017.html
(R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-018.html

Group C: Tumor Detection, Diagnosis, and Prognosis
(R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-019.html
(R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-020.html

Group D: Cancer Therapy and Outcomes
(R01) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-021.html
(R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-022.html

Provocative Questions homepage: http://provocativequestions.nci.nih.gov/


CASE CCC IN THE NEWS

Minority Women with Breast Cancer
Cleveland Fox 8-Sep 27, 2012
Dr. Sonja Harris-Haywood, a physician with University Hospitals, shared some important statistics with Fox 8 News viewers Thursday morning.

Research Highlights Move Toward Personalized Treatment in AML
HemOnc Today - Sep 25
"Dr. Grimwade has given us a nice summary of different prognostic markers," Matt Kalaycio, MD, director of the Bone Marrow Transplant Program at Taussig Cancer Institute at Cleveland Clinic, told HemOnc Today...

Pediatric regimens may provide insight into treatment of adult ALL
HemOnc Today - Sep 25
"The pediatric regimens included more vincristine, steroids and asparaginase," Anjali Advani, MD, staff physician in hematologic oncology and blood disorders...


FUNDING OPPORTUNITIES

Doris Duke Clinical Scientist Development Award

The Doris Duke Clinical Scientist Development Award provides grants to junior physician-scientists to facilitate their transition to independent clinical research careers. Pre-proposals are being sought from junior physician scientist faculty conducting clinical research in any disease area. It is recommended that applicants have significant research experience and strong publication records. The Clinical Scientist Development Award will not require institutional nomination in 2013.

Pre-Proposal Deadline: October 29
Full Proposal Deadline: February 20, 2013

Call for Ideas: Stand Up To Cancer-St. Baldrick's Pediatric Translational Cancer Research Dream Team

Stand Up To Cancer (SU2C) and the St. Baldrick's Foundation, along with the American Association for Cancer Research (AACR), call upon members of the cancer community to contribute their ideas to the groundbreaking SU2C-St. Baldrick's Pediatric Translational Cancer Research Dream Team. Investigators are invited to submit ideas for translational cancer research projects that would address laboratory and clinical efforts that will lead to the therapeutic interventions for childhood cancers and deliver near-term patient benefit through investigation by a multidisciplinary, multi-institutional, synergistic Dream Team of expert investigators. The ideas should be based on perceived opportunities for success as well as high-priority areas with a critical need for rapid progress beyond current medical care. The collective ideas for Dream Team translational research projects suggested by the cancer community will assist the SU2C-St. Baldrick's Joint Scientific Advisory Committee in selecting the most promising ideas to be submitted as full research proposals. The committee will select a SU2C-St. Baldrick's Pediatric Translational Cancer Research Dream Team from the invited proposals.

Please note that in this call for ideas the AACR and St. Baldrick's are not accepting research proposals for grant funding. Rather, the AACR and St. Baldrick's are inviting ideas to be submitted in a Letter of Intent for the SU2C-St. Baldrick's Pediatric Dream Team Translational Cancer Research Grant. A subset of ideas will be selected for submission of full research proposals for further consideration.

Deadline: November 1

Limited Submission: Rita Allen Foundation Scholars Program

The Rita Allen Foundation Scholars Program provides grants to leading medical research institutions selected by the Rita Allen Foundation Scientific Advisory Committee and confirmed by the Rita Allen Foundation Board of Directors. The Scholars program supports research scientists in the early stages of their careers. Fields of research are analgesics, cancer, immunology and neurosciences. Candidates must have completed their training and provided persuasive evidence of distinguished achievement or extraordinary promise in research in of the relevant fields. Each institution may nominate ONE candidate.

Internal Deadline: November 26
External Deadline: January 25, 2013

DOD Breast Cancer Research Program

The Department of Defense Breast Cancer Research Program is accepting applications for the Postdoctoral Fellowship Award. This award supports exceptionally talented recent doctoral or medical graduates in their pursuit of innovative, high-impact breast cancer research during their postdoctoral training and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research. These individuals should be exceptionally talented scientists who have demonstrated that they are the "best and brightest" of their peers. Applicants for this award must exhibit a strong desire to pursue a career in breast cancer research.

Pre-Application Deadline: December 4
Application Deadline: December 18


MARK YOUR CALENDARS

National GvHD Health Symposium

The Meredith A. Cowden Foundation, in collaboration with the Case CCC, Seidman Cancer Center, and Taussig Cancer Institute, presents the 2012 National GvHD Health Symposium at the Embassy Suites Cleveland-Rockside on November 2. This unique one-day conference, will consist of two-tracks- one designed for physicians and other health care professionals and one for bone-marrow transplant (BMT) survivors, their families and their caregivers. Both tracks will focus on cutting edge research and new treatments.

This year's conference will feature a poster session. The deadline submit abstracts has been extended to Tuesday, October 11, 2012 at 11:59 pm. Abstracts should be emailed to cmr4@case.edu. You will be notified October 20 whether your poster has been selected. The registration fee for invited presenters is complimentary, but advance registration is required.


NCI CANCER BULLETIN

October 2, 2012

News
Featured Article: Targeted Drug Benefits Some Patients with Advanced Lung Cancer

Drug Combination More Effective than Single Drug for Advanced Melanoma

Health Care Costs a Major Barrier for Young Adult Cancer Survivors

Many Women whose Tumors Disappear after Chemotherapy Have Mastectomies

Commentary
Statement from HHS Secretary Kathleen Sebelius on Breast Cancer Awareness Month

Multimedia
NIH Research Radio: Building a Biobank

In Depth
Turning Genes Up, Not On: A New View of the Myc Protein

With CellMiner, Researchers Prospect for Cancer Discoveries

New Tools Enhance Molecular Portraits of Breast Cancers

Featured Clinical Trial: Comparing Radiation Therapy Regimens for Early-Stage Breast Cancer

Updates
Legislative Update

FDA Update

Notes

EVENTS

calendar

October 8

Cancer Genetics Faculty Candidate Chalk Talk
Dong Shen, MD, PhD
Staff Scientist, The Genome Institute
Washington University
12 pm WRB 3-136

Sequencing Data Interest Group (SDIG) Meeting
Dan Savel
PhD Student, Electrical Engineering and Computer Science
CWRU
Topic: Pluribus: Correcting Errors in Next Generation Sequencing Data
2:30 pm WRB 1-402


October 9

Radiation Oncology Grand Rounds
Chandan Guha, MD
Professor and Vice Chair, Radiation Oncology
Albert Einstein College of Medicine
Topic: Immunomodulation of Radiation Oncology
8:10 am Lerner B-151


October 10

Hematology and Oncology Special Presentation
Yanis Boumber, MD, PhD
Fellow, Div. of Hem/Onc
MD Anderson Cancer Center
Topic: The Role of DNA Methylation and Stem Cell Factors in Leukemia and Beyond
8 am Lerner B-151

Innovative Science Discussion Group
Topic: TBD
12:15 pm WRB 3-136


October 11


October 12

Hematology/Oncology Fellows Conference/Curriculum Series
Charles Wellman
Chief Medical Officer
Hospice of the Western Reserve
Topic: Pain Management
8 am Wearn 137

Taussig Cancer Institute Grand Rounds: Annual Bruell Lecture
D. Ross Camidge, MD
Associate Professor, Div. of Medical Oncology
University of Colorado
Topic: The Road to Hope: Turning Lung Cancer into a Chronic Disease
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Goutham Narla, MD, PhD
Assistant Professor, Medicine and Transformative Molecular Medicine
CWRU/UH
Topic: Small molecule therapies for the treatment of cancer
12 pm Frohring Auditorium – BRB 105

Molecular Biology and Microbiology Thesis Presentation
Annette Ratcliff
Arts Lab, Molecular Biology and Microbiology
CWRU
Topic: Mechanisms of CCR5 agonist/antagonist inhibition of HIV-1 entry and in vitro selection of virus resistant to Maraviroc
1 pm Wood Bldg, W203

Cancer Center Research in Progress
Yulan Qing, PhD
Senior Research Associate, Gerson Lab, Div. of Hem/Onc
CWRU/UH
Topic: Rescue of the HSC maintenance defects in Ku70-deficient mice by overexpression of Bcl2 reveals a novel role of Bcl2 in HSC
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

National GvHD Health Symposium
November 2
Embassy Suites Cleveland-Rockside
Details
Registration
Deadline to submit abstracts: October 11

ADDITIONAL UPCOMING SEMINARS & EVENTS

Ninth International Conference of the Society for Integrative Oncology
October 8-10
Albuquerque, NM
Details

Biennial Science of Global Prostate Cancer Disparities conference
November 1-4
Nassau, The Bahamas
Details

The Cancer Genome Atlas 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA
November 27-28
Crystal City, Virginia
Details

American Society of Hematology (ASH) Annual Meeting
December 8-11
Atlanta, Georgia
Details

Pacific Symposium on Biocomputing 2013
January 3-7, 2013
Fairmont Orchid, Hawaii
Details


PREVIOUSLY ANNOUNCED OPPORTUNITIES

American Cancer Society Area of Special Interest: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: October 15

American Cancer Society Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

American Cancer Society Priority Focus in Cancer Control and Prevention Research Program: Health Disparities Research
Deadline: October 15

Bonnie J. Addario Lung Cancer Foundation Research Grants
Deadline: October 15

Robert Wood Johnson Foundation Scholars in Health Policy Research program
Deadline: October 16

CTSC KL2 Training Program
Deadline: October 22

AACR–American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention
Nomination Deadline: September 26

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Nomination Deadline: September 26

AACR Award for Lifetime Achievement in Cancer Research
Nomination Deadline: September 26

AACR Princess Takamatsu Memorial Lectureship
Nomination Deadline: September 26

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Nomination Deadline: October 3

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Nomination Deadline: October 3

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Nomination Deadline: October 3

Melanoma Research Alliance-Prostate Cancer Foundation Team Science Partnership Award
Deadline: October 15

NCI Clinical Assay Development Program (CADP)
Deadline: October 15

Conquer Cancer Foundation Advanced Clinical Research Award (ACRA)
LOI Deadline: October 22
Full Application Deadline: December 5

Alex's Lemonade Stand Foundation Springboard Grant
Deadline: October 29

Leukemia & Lymphoma Society Specialized Center of Research Program
Deadline: November 1

DeGregorio Foundation Award for Cancers of the Upper GI Tract
Deadline: November 5

Limited Submission: NIH Director's Early Independence Award
Internal Deadline: November 26
LOI Deadline: December 30
Full Application: January 30, 2013

AACR-Women in Cancer Research Scholar Awards
Deadline: November 30

Alex's Lemonade Stand Foundation Innovation Grants
Deadline: December 3

Alex's Lemonade Stand Foundation Epidemiology Awards
Deadline: December 17

Alex's Lemonade Stand Foundation Young Investigator Awards
Deadline: December 17

Association for Research of Childhood Cancer
Deadline: January 1, 2013

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

National Cancer Institute Program Project (P01) Applications (PAR-12-005)

Cancer Education Grants Program (R25)(PAR-12-049)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.