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Case Comprehensive Cancer Center Newsletter

May 7, 2012

CASE CCC IN THE NEWS

Bainbridge: Tanning Can be a Hard Habit to Break
WKYC-TV - May 3, 2012
Dr. Kord Honda, a dermatologist at University Hospitals, says there is no known number of sessions it takes for tanning to cause serious skin damage, ...

Turning Plant Virus into Cancer Weapon
WKYC-TV - May 2, 2012
Inside the Biomedical Engineering building at Case Western Reserve University, Nicole Steinmetz, Ph.D. and her team are taking the virus that attacks your ...

Cleveland Clinic Researcher's Breast Cancer Vaccine gets Attention, Financial Boosts
Plain Dealer - April 30, 2012
In May 2010, when results of his years-long research were published in the scientific journal Nature Medicine, Vincent Tuohy was hopeful that the ensuing attention...


MARK YOUR CALENDARS

Cancer Center Seminar Series: Targeting the Bcl-2 family in cancer therapy: Discovery of selective Mcl-1 inhibitors
Dr. Wang

Friday, May 11
12 pm
BRB 105

Please join us May 11 for the next Cancer Center Seminar Series where Dr. Hong-Gang Wang, Professor of Pharmacology at Penn State University, will present Targeting the Bcl-2 family in cancer therapy: Discovery of selective Mcl-1 inhibitors.

The Bcl-2 family of proteins plays a pivotal role in apoptosis by regulating mitochondrial function. High levels of the anti-apoptotic Bcl-2 family proteins (Bcl-2, Bcl-XL, and Mcl-1) are associated with the pathogenesis of cancer and resistance to therapy. To date, several small-molecule Bcl-2 inhibitors have been synthesized as BH3 mimetics, and three of the molecules (ABT-737/ABT-263, Obatoclax, and Gossypol/AT-101) have entered clinical trials. However, none of these Bcl-2 inhibitors are specific for Mcl-1. At this seminar, Dr. Wang will discuss the need and development of Mcl-1-specific inhibitors for the treatment of cancer as a single agent or in combination therapy.


FUNDING OPPORTUNITIES

DOD Peer Reviewed Cancer Research Program

Applications for the Peer Reviewed Cancer Research Program (PRCRP) are being solicited by the Assistant Secretary of Defense for Health Affairs, Defense Health Program. The goal of the PRCRP is to improve quality of life by decreasing the impact of cancer on service members, their families, and the American public. The FY12 PRCRP fosters the next generation of cancer research by providing new and early career investigators opportunities to excel in groundbreaking cutting-edge research for the prevention, detection, and treatment of cancer.

  • The Visionary Postdoctoral Fellowship Award is intended to support exceptionally talented, recent medical or other doctoral graduates in their pursuit of cancer research during a postdoctoral fellowship with a focus on cutting-edge, innovative, high-risk/high-impact basic science or translational research that will have either short-term or long-term clinical impact.
    Pre-Application Deadline: June 19
    Application Deadline: September 12
  • The Career Development Award mechanism is being offered for the first time in FY12. This award is intended to support novel and innovative research projects with an emphasis on discovery. Preliminary data is not required. The proposed research project should include a well-formulated, testable hypothesis based on strong scientific rationale and study design.
    Pre-Application Deadline: June 19
    Application Deadline: September 12

ANNOUNCEMENTS

NIH Launches Collaborative Program with Industry and Researchers to Spur Therapeutic Development

The NIH unveiled a collaborative program that will match researchers with a selection of pharmaceutical industry compounds to help scientists explore new treatments for patients. NIH's new National Center for Advancing Translational Sciences (NCATS) has partnered initially with Pfizer, AstraZeneca, and Eli Lilly and Company which have agreed to make dozens of their compounds available for this initiative's pilot phase.

The initiative, Discovering New Therapeutic Uses for Existing Molecules, will direct researchers' attention to a part of the therapeutic pipeline that traditionally has been difficult for them to access: compounds that already have cleared several key steps in the development process, including safety testing in humans. The President's FY2013 budget proposed $575 million for NCATS, of which approximately $20 million total will be provided to support research grants of up to three years duration for pre-clinical and clinical feasibility studies. These studies will test more than 20 compounds from industry partners for their effectiveness against a variety of diseases and conditions. The companies will provide the researchers with access to the compounds and related data.

The pilot program incorporates innovative template agreements designed to streamline the legal and administrative process for participation by multiple organizations. These template agreements reduce time, cost, and effort, as well as allow greater participation than traditional partnerships.

American Academy of Neurology Annual Meeting

In April, Dr. Lisa Rogers co-directed the Highlights in Neuro-oncology session at the American Academy of Neurology Annual Meeting in New Orleans. Dr. Rogers is the immediate Past President of the Neuro-oncology Section of the American Academy of Neurology.

Cancer Center presentations at the Annual Meeting included:

  • Frequency of the Metabolic Syndrome and Association with Survival in Newly Diagnosed Glioblastoma Patients: A Retrospective Review
    Lisa Rogers, Jaime Vengoechea, Quinn Ostrom, Yanwen Chen, Perica Davitkov, Kyle Strodtbeck, Warren Selman, Stanton Gerson, Charles Nock, Mitchell Machtay, Simon Lo, Andrew Sloan, Jill Barnholtz-Sloan
  • Results of Bevacizumab Therapy on Hearing Loss Associated with Vestibular Schwannomas in NF2
    Pichet Termsarasab, Cliff Megerian, Maroun Seeman, Kristine Blackham, Patrice Walker, Nicholas Bambakidis, Lisa R Rogers
Race for the Place- Join Our Team!

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 3 at Beachwood Place Mall. The Case CCC has created a CaseCCC Trainees team. Click here to join the team or to show your support by making a donation. Contact Lyn Haselton, Case CCC Training Program Manager, at 216.844.5375 or lyn.haselton@case.edu for more information.


NCI Cancer Bulletin

News
Featured Article: Chemoradiation May Help Some Patients with Bladder Cancer Avoid Radical Surgery

Type of Surgery Affects Long-Term Survival in Early-Stage Kidney Cancer

Survival Differences Persist Between Black and White Children with Cancer

Hispanics Have Lower Death Rates for Common Lung Cancer

Women at High Risk for Breast Cancer May Benefit from Starting Mammography at Age 40

Combination Targeted Therapy for Liver Cancer Shows Promise in Mice

Also in the Journals: New Diet and Exercise Guidelines for Cancer Survivors

Also in the Journals: Prostate Cancer Screening Rates in Elderly Men Unchanged Despite 2008 Recommendations

In Depth
A Transfer of Power: Harnessing Patients' Immune Cells to Treat Their Cancer

Crunching Numbers: What Cancer Screening Statistics Really Tell Us

Featured Clinical Trial: Surgical and Radiation Therapies for High-Risk Early Lung Cancer

The Leading Edge: Small Businesses Bring Novel Cancer Technologies to Market

Updates
FDA Update: FDA Approves New Drug for Advanced Soft Tissue Sarcoma

Cancer.gov Update: NCI Report Features Cancer Statistics through 2009

Notes

EVENTS

calendar

**All events are open to anyone interested in attending

May 7

Pathology Research Seminar Series
Herbert Lin, MD, PhD
Associate Professor, Medicine
Harvard University
Topic: Novel Treatment Strategies for Anemia of Chronic Disease
12 pm WRB 1-413

Cancer Imaging Program Meeting
Samuel Chao, MD
Assistant Professor and Staff, Brain Tumor and Neuro-Oncology Center, Radiation Oncology
CWRU/Cleveland Clinic
Topic: The New Strategies for Radiation Treatment
4:30 pm Wearn B37


May 8

Cancer Biology Seminar
Steven Rosenfeld, MD, PhD
Professor, Cancer Biology
CWRU/Cleveland Clinic
Topic: Myosins in Glioma Invasion and Angiogenesis
11 am NC1-202 Cleveland Clinic

Pharmacology Seminar
Rakesh Kumar, PhD
Professor and Chairman, Biochemistry and Molecular Biology
George Washington University
Topic: MTA1 Master Coregulator in Cancer
12 pm SOM W331

Molecular Biology and Microbiology Seminar
Michael Shthtman, PhD
Assistant Professor, Pharmaceutical and Biomedical Sciences
University of South Carolina/Hollings Cancer Center
Topic: Drug Targets Discovery Through Functional Genomics; Technical Findings
1 pm SOM W203


May 9

Hematology and Oncology Division Research Conference
Jennifer Eads, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Lerner Tower B-151

Cancer Pharmacology Training Program Symposium
11 am - 4:30 pm SOM W331

Immunology Faculty Research in Progress Series
Jim Finke, PhD
Professor, Immunology
CWRU/Cleveland Clinic
Topic: Function and Regulation of Granulocytic MDSC in Tumor Bearing Host
12 pm NC1-202 Cleveland Clinic


May 10

Department of Neurosciences Guest Speaker Series
Brian Davis, PhD
Professor, Medicine
Associate Division Chief of Research, Div. of Gastroenterology, Hepatology and Nutrition
University of Pittsburgh
Topic: Growth Factors and TRP Channels Collaborate in Inflammatory Disease and Cancer
10 am NE1-205 Cleveland Clinic

Sequence-Palooza: What Can Next Gen Sequencing Do For You?
11 am - 3 pm BRB 105

NCRM Lunch and Learn
Stephen Fischer, PhD
Scientist, Research and Development
Arteriocyte
Topic: Nanofiber Based Ex Vivo Expansion of Stem Cells for Pre-clinical and Clinical Application
11:30 am - 1:30 pm WRB 2-136


May 11

Hematology/Oncology Fellows
Santosh Rao, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: An Integrative Oncology Observership
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Anthony Back, MD
Professor, Oncology Division
Adjunct Associate Professor, Medical History and Ethics
University of Washington/Fred Hutchinson Cancer Research Center
Topic: Improving Communication between Oncologists and Patients
8 am R3/002-003 Cleveland Clinic

Biomedical Engineering Seminar
Maciej Zborowski, PhD
Associate Professor, Biomedical Engineering
CWRU/Cleveland Clinic
Topic: Magnetic Weight Watching, One Cell at a Time
11 am NE1-205 Cleveland Clinic

Cancer Center Seminar Series
Hong-Gang Wang, PhD
Professor, Pharmacology
Penn State University
Topic: Targeting the Bcl-2 family in cancer therapy: Discovery of selective Mcl-1 inhibitors
12 pm BRB 105

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Breast Cancer 2012: Risk Assessment through Survivorship
May 18
Brochure
Registration

Case CCC Scientific Series: Imaging Research
May 31
Jim Basilion, PhD
Topic: Introduction
Chris Flask, PhD
Topic: Development of PARACEST-MRI Imaging Agents for In Vivo Assessment of Autophagy OR Magnetic Resonance Imaging as an Early-Stage Biomarker
Cheryl Thompson, PhD
Topic: Variation in Breast Tissue Gene Expression by Mammographic Density
Reception and presentations, 4-6 pm WRB 1-413

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7
InterContinental Hotel
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Comparative Effectiveness Research: From All Angles
May 21-22
CWRU SOM E401
Registration

Cleveland Clinic 2012 Personalized Healthcare Summit
May 31
InterContinental Hotel and Conference Center
Registration

Ninth International Conference of the Society for Integrative Oncology
October 8-10
Albuquerque, NM
Details

Biennial Science of Global Prostate Cancer Disparities conference
November 1-4
Nassau, The Bahamas
Details


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

AACR Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen for the Cure®
Deadline: May 16

AACR Distinguished Lectureship in Breast Cancer Research
Deadline: May 16

Barrett's Esophagus Translational Research Network (BETRNet) pilot projects
Deadline: May 18

DOD Lung Cancer Research Program Idea Development Award
Pre-Application Deadline: May 30
Application Deadline: September 20

DOD Lung Cancer Research Program Translational Research Partnership Award
Pre-Application Deadline: May 30
Application Deadline: September 20

Doctors Cancer Foundation, Inc.
Deadline: May 31

Damon Runyon-Rachleff Innovation Award
Deadline: June 1

DOD Prostate Cancer Research Program Exploration - Hypothesis Development Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

AACR-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research
Deadline: June 20

AACR Award for Distinguished Lecture on the Science of Health Disparities, funded by Susan G. Komen for the Cure®
Deadline: June 20

Society of Surgical Oncology Clinical Investigator Award in Breast Cancer Research
Deadline: July 9

DOD Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: July 26
Application Deadline: August 9

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.