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Case Comprehensive Cancer Center Newsletter

April 16, 2012

gersonMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

Summer Plans

We are the final throes of the NCI renewal application due at the end of May. Preparation for this application has involved more than 65 faculty and another 80 staff who have active roles in Cancer Center programs and shared resources. I am happy to say the contributions of ALL of our 326 members are noted. Having reviewed every page and word so far, I am confident this submission will reflect the powerful impact our Cancer Center makes to shift the paradigms of cancer biology, change cancer treatment, and reduce the risk of cancer by population studies and early detection.

This year, our usual summer scientific retreat will be restricted to a focus on the October NCI site visit. We ask all of the Cancer Center leadership, program leaders, core directos, and members of the clinical research office and units to participate. This retreat will be held at the time normally reserved for the scientific retreat (date TBD). For this reason, this summer we will not attempt to also hold a normal retreat as we prepare for the site visit. During this time, however, the Cancer Center and programs will continue to hold conferences, small retreats, project initiatives, and other activities that the Cancer Center will support.

Many of you will be called upon to give input for program and core facility preparations for the site visit. Speaking for the entire leadership team of the Cancer Center, I appreciate the time and effort that has gone into the core grant renewal. We have a great consortium cancer center, and your discoveries and efforts are reflected in our grant submission.


CASE CCC IN THE NEWS

Breakthrough Discovery Unveils "Master Switches" in Colon Cancer
Science Daily - Apr 12, 2012
A team of researchers at Case Western Reserve University School of Medicine have identified a new mechanism by which colon cancer develops. By focusing on segments of DNA located between genes, or so-called "junk DNA," the team has discovered a set of master switches, i.e., gene enhancer elements, that turn "on and off" key genes whose altered expression is defining for colon cancers. They have coined the term Variant Enhancer Loci or "VELs," to describe these master switches.... despite the fact that the tumors arose in different individuals and are at different stages of the disease," says Peter Scacheri, PhD, senior author of ...... to identify genes that are direct targets of alterations on chromosomes," says Sanford Markowitz, MD, PhD, Ingalls Professor of Cancer Genetics in the ...

Study Links Dental X-rays to Brain Tumors
Plain Dealer - Apr 11, 2012
It's well known that radiation is associated with meningioma, said Dr. Andrew Sloan, director of the Brain Tumor and Neuro-Oncology Center at University ...

Battling the Odds in RCC: An Interview With Brian Rini, MD
OncLive - Apr 11, 2012
Ask Brian Rini, MD, and he'll tell you his contributions to the battle against kidney cancer amount to a series of small victories in a war whose end is nowhere in sight...


MARK YOUR CALENDARS

Tumor Microenvironment Meeting

At least four of the programs of the Case CCC Programs– Cancer Signaling, GU Malignancies, Developmental Therapeutics, and Cancer Imaging - have themes or aims related to the tumor microenvironment: angiogenesis and endothelial cells, immune effectors and immunotherapy, and the matrix, adhesion, and stroma. Discussion sessions were started in 2011 by Dr. Danny Manor for Signaling and have been extended in 2012 to include imaging, angiogenesis, and invasion. We anticipate continuing these sessions approximately monthly through 2012 and 2013. We hope that these talks will lead eventually to basic/translational projects and/or collaborative grants, and maybe down the road enough commonality to plan towards P01s in the topic areas of focus.

The next session will be on immune effector mechanisms and interventions and will be held April 18 from 5-7:30pm at the Taussig Cancer Institute R3-027 with light dinner fare, including wine and cheese. Talks will be 20-25 minutes followed by discussion. Presentations will be as follows:

  • Dr. Thomas Hamilton: Chemokines and their regulation
  • Dr. Vince Tuohy: A vaccine to a mammary protein: plans toward clinical trials
  • Dr. Joseph Baar: A MUC-1 vaccine for breast carcinoma: its rationale and evaluation
  • Dr. Pierre Triozzi: Clinical and biomarker IND therapeutics from the NCI Immunotherapy Network
Cancer Center Seminar Series: Molecular and Functional Imaging of Cancer: Windows into an Impenetrable Disease
Dr. Bhujwalla

Friday, April 20
12 pm
BRB 105

Please join us April 20 for the next Cancer Center Seminar Series where Dr. Zaver M. Bhujwalla, Professor of Radiology & Radiological Science and Oncology and Director of the In Vivo Cellular Molecular Imaging Center at Johns Hopkins University, will present Molecular and Functional Imaging of Cancer: Windows into an Impenetrable Disease.

Dr. Bhujwalla's main research interests involve understanding the role of the physiological environment and vascularization in tumor progression, invasion and metastasis. The Bhujwalla laboratory employs both in vivo and isolated perfused cell systems. They mainly use multinuclear Magnetic Resonance (MR) Imaging (I) and Spectroscopy (S) for studying cancer cell physiology and metabolism. Research studies are performed on established human breast cancer and prostate cancer lines. Another area of research is detecting the response of tumors to radiation and chemotherapy with MR methods. They also use multinuclear MR methods for pharmokinetic and pharmodynamic studies.

Case GI SPORE Retreat

The Case Gastrointestinal Cancers SPORE Retreat will be held Friday, May 4 in Dively Hall on Case campus. Topics will include colon cancer, Barrett's Esophagus, cancer metastasis and prevention and cancer in minorities. Faculty, fellows and students in the Cancer Center community are encouraged to attend and learn more about exciting findings from researchers in the specialized program of research excellence.

The retreat will also feature a lunchtime poster session that starts at 12 pm. Postdoc, graduate and clinical fellows are encouraged to submit poster abstracts. Send poster abstracts to John Wang, PhD by today, April 16. A cash prize will be awarded for best poster.

Advance registration is required. Contact John Pounardjian with any questions.


FUNDING OPPORTUNITY

BETRNet Pilot Funding

Faculty members with an appointment at the Assistant Professor level or higher at participating institutions are invited to submit applications for individual and/or cross Barrett's Esophagus Translational Research Network (BETRNet) pilot projects. Participating institutions include CWRU, University of Pennsylvania, Fred Hutchinson Cancer Research Center, Johns Hopkins, University North Carolina, Washington University, and Mayo Clinic. BETRNet projects must be directed toward translational research related to Barrett's Esophagus or Esophageal Adeno Cardinoma. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples.

Deadline: May 18


ANNOUNCEMENTS

eBioscience Support for TRCCC

All members of the Case CCC are now entitled to substantial discounts from eBioscience for many of their products. This arrangement has been made recently as part of eBiosciences commitment to support the Translational Research Cancer Centers Consortium (TRCCC) and their annual meeting in Seven Springs, PA.

These discounts are outlined in the this flyer and include:

  • 30% off Flow Cytometry Reagents
  • 25% off Additional Reagents (ELISA's, Antibodies, Proteins, Growth Factors, Cytokines, IHC/ICC Reagents)
  • 10% off InstantOne™ Phospho ELISA Assays
  • 2% of 2012 sales donated to the 2013 TRCCC Annual Meeting

The discounts are valid for participating members of the Translational Research Cancer Centers Consortium (TRCCC) until December 31, 2012.

Please setup sales quotations with local account manager, Keith Olszens at keith.olszens@ebioscience.com.

EVENTS

calendar

**All events are open to anyone interested in attending

April 16

Frontiers in Molecular Medicine Symposium Series
Darrell Irvine, PhD
Associate Professor, Materials Science Engineering and Biological Engineering
Howard Hughes Medical Institute
Massachusetts Institute of Technology
Topic: New Materials and New Methods for Cancer Immunotherapy and Vaccine Delivery
4 pm WRB 1-413

Physiology and Biophysics Seminar
P. Darrell Neufer, PhD
Associate Professor, Exercise & Sport Sciences and Physiology
East Carolina University
Topic: Linking Mitochondrial Bioenergetics to the Etiology of Insulin Resistance
4 pm SOM E-501

Skeletal Research Center Seminar
Jean Welter, MD, PhD
Research Associate Professor, Biology, Skeletal Research Center
CWRU
Topic: Poking Around in the Viscosupplementation Morass
4 pm Millis 123


April 17

Cancer Biology Candidate Seminar
Philip Howe, PhD
Professor, Biochemistry and Molecular Biology
Associate Director of Basic Science
Hollings Cancer Center/Medical University of South Carolina
Topic: Translational Regulation of EMT/Metastasis
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
M. Edward Medof, MD, PhD
Professor, Pathology
CWRU/UH
Topic: Similarities Between iTregs and nTregs. Is the Nomenclature Correct?
12 pm WRB 1-413


April 18

Hematology and Oncology Division Research Conference
Rami Manochakian, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Research: Metformin and Cancer
8 am Lerner Tower B-151

OnCore Clinical Trials Management System Training Class
Topic: Documents Tab of Main Console
12 pm Wearn 137

Tumor Microenvironment Meeting
Thomas Hamilton, PhD
Topic: Chemokines and their regulation
Vince Tuohy, PhD
Topic: A vaccine to a mammary protein: plans toward clinical trials
Joseph Baar, MD, PhD
Topic: A MUC-1 vaccine for breast carcinoma: its rationale and evaluation
Pierre Triozzi, MD
Topic: Clinical and biomarker IND therapeutics from the NCI Immunotherapy Network
5-7:30 pm R3-027 Cleveland Clinic


April 19

Comparative Effectiveness Seminar Series
Sharon Meropol, MD, PhD
Assistant Professor, Pediatrics and Epidemiology and Biostatistics
CWRU/UH
Topic: What's Your Drug of Choice? Comparative Effectiveness Research in Pharmacoepidemiology
4 pm BRB 105

Frontiers in Chemistry
Robert Grubbs, PhD
2005 Nobel Prize Winner
Professor, Chemistry
California Institute of Technology
Topic: Synthesis of Molecules and Materials Using Olefin Metathesis Catalysts
4:30 pm Schmitt Lecture Hall


April 20

Hematology/Oncology Fellows
TBD
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Karyn Goodman, MD
Radiation Oncology
Memorial Sloan Kettering Cancer Center
Topic: Management of Pancreatic Cancer: Are We Entering a New Era?
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Zaver Bhujwalla, PhD
Professor, Radiology & Radiological Science and Oncology
Director, In Vivo Cellular Molecular Imaging Center
Johns Hopkins University
Topic: Molecular and Functional Imaging of Cancer: Windows into an Impenetrable Disease
12 pm BRB 105

Cancer Center Research in Progress Seminar
David N. Wald, MD, PhD
Assistant Professor, Pathology
CWRU
Topic: DNA Damage Signaling Triggers AML Differentiation
4 pm WRB 3-136

Dean's Distinguished Lecture
Jamie Grifo, MD, PhD
Director, Div. of Reproductive Endocrinology
Program Director, Fertility Center
Professor, Obstetrics and Gynecology
New York University
Topic: Lessons in Biology from Assisted Reproduction
4 pm WRB 1-413
RSVP to kathy.malone@case.edu

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case GI Cancers SPORE Retreat
May 4 Dively Building
Details and Agenda
Registration

Breast Cancer 2012: Risk Assessment through Survivorship
May 18
Brochure
Registration

Case CCC Scientific Series: Imaging Research
May 31
Jim Basilion, PhD
Topic: Introduction
Chris Flask, PhD
Topic: Development of PARACEST-MRI Imaging Agents for In Vivo Assessment of Autophagy OR Magnetic Resonance Imaging as an Early-Stage Biomarker
Cheryl Thompson, PhD
Topic: Variation in Breast Tissue Gene Expression by Mammographic Density
Reception and presentations, 4-6 pm WRB 1-413

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7 InterContinental Hotel
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

DOD Ovarian Cancer Research Program Ovarian Cancer Academy Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Synergistic Translational Leverage Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Prostate Cancer Research Program Idea Development Award
Pre-Application Deadline: April 24
Application Deadline: August 9

DOD Breast Cancer Research Program Idea Award Award
Pre-Application Deadline: April 26
Application Deadline: August 15

American Nurses Foundation Nursing Research Grants
Deadline: May 1

Howard Hughes Medical Institute Investigator Program
Deadline to establish eligibility: May 1
Application Deadline: June 13

DOD Breast Cancer Research Program Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Innovator Award Award Award
Pre-Application Deadline: May 3
Application Deadline: August 2

DOD Breast Cancer Research Program Clinical Translational Research Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 3
Application: August 15

DOD Prostate Cancer Research Program Biomarker Development Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Clinical Exploration Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Laboratory - Clinical Transition Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Transformative Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application Deadline: May 3
Application Deadline: August 9

Barrett's Esophagus Translational Research Network (BETRNet) pilot projects
Deadline: May 18

Doctors Cancer Foundation, Inc.
Deadline: May 31

DOD Prostate Cancer Research Program Exploration - Hypothesis Development Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: July 26
Application Deadline: August 9

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

NLM Administrative Supplements for Informationist Services in NIH-funded Research Projects (Admin Supp)(PA-12-158)

Basic Research on HIV Persistence (R01)(PA-12-161)

Basic Research on HIV Persistence (R21)(PA-12-162)

Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R21)(PAR-11-216)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.