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Case Comprehensive Cancer Center Newsletter

April 2, 2012

CASE CCC IN THE NEWS

Eyes on Cancer
Scientist - Apr 1, 2012
Justin Lathia, assistant professor of cell biology at the Cleveland Clinic in Ohio...In collaboration with Jeremy Rich at the Clinic and Alex Huang at Case Western Reserve University, Lathia studies how cancer stem cells drive tumor growth

New Clinical Trial Explores Novel Non-Invasive Colon Cancer Screening Test
PR Newswire - Mar 30, 2012
Developed in the laboratory of Sanford Markowitz, MD, PhD, ... but is a preventable disease," says Gregory Cooper, MD, Co-Program Leader for Cancer Prevention... a discovery from the laboratory to the patient care setting," says Li Li, MD, PhD, the study's basic investigator... advancements and practices to deliver superior clinical outcomes for our patients," said Stanton Gerson, MD, Director, UH Seidman Cancer Center and Case Comprehensive Cancer Center...

Cleveland Clinic Gamma Knife Center Offers State-of-the-Art Alternative To Invasive Brain Tumor Surgery
Albany Times Union - Mar 29, 2012
... it that matters," said Michael Vogelbaum, MD, PhD, Associate Director of Cleveland Clinic's Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center.

Ford Demonstrates Virtual Reality Tools to Case Western Reserve Students
Plain Dealer - Mar 29, 2012
Jeffery Duerk, dean of the CWRU School of Engineering, stopped by the demonstration lab and said he was pleased to see his students so engaged, asking tough ...

University of Akron Research Team Gets National GE Innovation Award for Breast Cancer Research
Plain Dealer - Mar 27, 2012
The risk of infection from silicone breast implants is exceedingly low, says Dr. Julian Kim, a surgical oncologist and chief medical officer of University ...


NEWS FROM THE NCI

NCI Releases Annual Report to the Nation on the Status of Cancer

Death rates from all cancers combined for men, women, and children continued to decline in the United States between 2004 and 2008, according to the Annual Report to the Nation on the Status of Cancer, 1975-2008. The overall rate of new cancer diagnoses, also known as incidence, among men decreased by an average of 0.6 percent per year between 2004 and 2008. Overall cancer incidence rates among women declined 0.5 percent per year from 1998 through 2006 with rates leveling off from 2006 through 2008.

The report is co-authored by researchers from the Centers for Disease Control and Prevention, the North American Association of Central Cancer Registries, the National Cancer Institute, and the American Cancer Society. It appeared early online on March 28, 2012, in the journal CANCER.

The special feature section highlights the effects of excess weight and lack of physical activity on cancer risk. Esophageal adenocarcinoma, cancers of the colon and rectum, kidney cancer, pancreatic cancer, endometrial cancer, and breast cancer among postmenopausal women are associated with being overweight or obese. Several of these cancers also are associated with not being sufficiently physically active. [More]


MARK YOUR CALENDARS

Cancer Center Seminar Series: cAMP signaling and the ATM-dependent DNA damage response
Dr. Tibbetts

Friday, April 6
12 pm
BRB 105

Please join us April 6 for the next Cancer Center Seminar Series where Dr. Randal S. Tibbetts, Associate Professor, Human Oncology at University of Wisconsin-Madison, will present cAMP signaling and the ATM-dependent DNA damage response.

Research in the Tibbetts' lab is broadly focused on mechanisms of signal transduction and posttranscriptional regulation in cancer and neurodegenerative disease. One aspect of the lab is focused on understanding on how the cAMP second messenger system interfaces with the ATM-regulated DNA damage response and how this functional interface impacts both tumor suppression and metabolic control in vivo. In other studies, they are attempting to identify pathways that ameliorate motor neuron death in ALS/Lou Gehrig's disease using Drosophila and cell culture models.

This seminar is hosted by the Cell Death Regulation Program, led by Drs. Clark Distelhorst, Nancy Oleinick and Alex Almasan.

NCI Research to Reality Cyber Seminar Series: The Potentially Transformative Effect of Measuring the Health of a Community

Registration is open for the NCI Research to Reality Cyber Seminar Series: The Potentially Transformative Effect of Measuring the Health of a Community, April 10 at 2 pm.

This cyber-seminar will explore tools and resources, such as the County Health Rankings, to measure the health of a community and ways that have the potential to stimulate this multistakeholder engagement, and to serve as a focus for ongoing efforts to improve community health and health equity. Dr. Kurt Stange will highlight models of how measuring the health of a community and how this knowledge, generated and followed over time, can empower multi-stakeholder groups to take responsibility for working together to improve health, its determinants, and equity. Terry Allen and Paul Jarris will join the seminar to share their experiences in working across sectors to measuring community health at the local and national levels, and will engage participants in sharing their experiences and lessons learned, and thoughts on how other communities can use this approach to improve health and equity.

Case GI Cancers SPORE Retreat

The Case GI Cancers SPORE Retreat will be held on Friday, May 4 in Dively Building on Case campus. Topics will include colon cancer, Barrett's Esophagus, cancer metastasis and prevention and cancer in minorities. Faculty, fellows and students in the Cancer Center community are encouraged to attend and learn more about exciting findings from researchers in the specialized program of research excellence. Postdoc, graduate and clinical fellows are encouraged to submit poster abstracts. There will be a cash prize for best poster! The Retreat begins at 8:30 am, with the poster session at noon.

Advance registration is required. Contact John Pounardjian with any questions.


ANNOUNCEMENTS

CTSC Core Utilization Grants

Congratulations to the following Cancer Center members who received CTSC Core Utilization Grant Funding:

  • Sudha Iyengar, PhD: Using next-generation sequencing to comprehend transcription regulation of CFH in the retina
  • Ofer Reizes, PhD: Leptin and leptin receptor gene signature in breast cancer stem cells
  • Lisa Rogers, DO: Comparison of MRI morphologic characteristics in surgically proven radiation necrosis versus recurrent brain tumor and correlation with histologic profiles
Race for the Place

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 3 at Beachwood Place Mall. The Case CCC is putting together a "trainee team" for the Race but would like to judge interest before officially registering the team. Any fellow or trainee who is interested in participating should contact Lyn Haselton, Case CCC Training Program Manager, at 216.844.5375 or lyn.haselton@case.edu.


FUNDING OPPORTUNITIES

GI SPORE Pilot Funding

All Faculty members are invited to submit outlines for pilot projects of up to $50,000 to be funded by the NIH P50 GI SPORE. Deadline for submission has been extended to April 13 with funding expected to begin September 2012. Award budget limited to $50,000.

EVENTS

calendar

**All events are open to anyone interested in attending

April 2

Physiology and Biophysics Seminar
Holger Sondermann, PhD
Associate Professor, Life Science & Technology
Department of Molecular Medicine
Cornell University
Topic: Molecular Mechanisms of Membrane Deformation
4 pm SOM E501

Cancer Imaging Program Meeting
Julian Kim, MD
Professor, Surgical Oncology
CWRU/UH
Topic: Imaging T-cell After Adoptive Immunotherapy
4:30 pm Wearn B37


April 3

Immunology Seminar Series
Warren Shlomchik, MD
Associate Professor, Medicine and Immunobiology
Yale University
Topic: Mechanisms of Graft-versus-Host Disease and Graft-versus-Leukemia
12 pm WRB 1-413

Pharmacology Seminar
Derek Radisky, PhD
Assistant Professor, Cancer Biology
Mayo Clinic
Topic: Matrix-metalloproteinase-induced Epithelial-mesenchmal Transition in Breast and Lung Cancer
12 pm SOM W331


April 4

Hematology and Oncology Division Research Conference
Cheng-Kui Qu, MD, PhD
Associate Professor, Medicine- Div. of Hem/Onc
CWRU/UH
Topic: A Differentiation Checkpoint in Hematopoietic Stem Cells Activated by Bioenergetic Stress
8 am Lerner Tower B-151

Case CCC Clinical Research Retreat
5:30-8:30 pm Dively Building
Agenda
Registration


April 5

Molecular Biology and Microbiology Seminar
Yong Gao, PhD
Arts Lab, Molecular Biology and Microbiology
CWRU
Topic: A Way Possibly Leading to Broadly Effective Anti-HIV Vaccines
AND
Bernard Bagaya
Arts Lab, Molecular Biology and Microbiology
CWRU
Topic: Prime-boost Immunization with Progressively Varying Polyvalent HIV-1 Envelope Glycoproteins to Broaden Humoral Immune Responses
1 pm SOM W203

NCRM Seminar
Demin Wang, PhD
Professor and Senior Investigator
Blood Center of Wisconsin
Topic: Signal Regulation of Hematopoiesis and B Lymphopoiesis
1 pm WRB 2-136


April 6

Taussig Cancer Institute Grand Rounds canceled

Informatics Symposium
7 am - 2:30 pm WRB
Pre-Registration Required

Hematology/Oncology Fellows
Andrew Parchman, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Prostate Cancer: A Review of Current Treatment Strategies
8 am Wearn 137

Cancer Center Seminar Series
Randal S. Tibbetts, PhD
Associate Professor, Human Oncology
University of Wisconsin
Topic: cAMP Signaling and the ATM-dependent DNA Damage Response
12 pm BRB 105

Cancer Center Research in Progress Seminar
Damian Junk, PhD
Postdoctoral Scholar, Jackson Lab, Pathology
CWRU
Topic: Spontaneous EMT During Human Mammary Epithelial Cell Transformation Generates a Population of Tumor Initiating Cells
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case CCC Scientific Series: Stem Cells
April 12
Alex Huang, MD
Topic: Longitudinal tracking of in vivo tumor microenvironment in high definition
Jeongwu Lee, PhD
Topic: C-MET signaling in GBM stem cells and treatment resistance
Ofer Reizes, PhD
Topic: Obesity tips the scales on breast cancer: a role for the fat hormone leptin in cancer stem cells
Reception and presentations, 4-6 pm BRB 105

Breast Cancer 2012: Risk Assessment through Survivorship
May 18
Brochure
Registration

Case CCC Scientific Series: Imaging Research
May 31
Jim Basilion, PhD
Topic: Introduction
Chris Flask, PhD
Topic: Development of PARACEST-MRI Imaging Agents for In Vivo Assessment of Autophagy OR Magnetic Resonance Imaging as an Early-Stage Biomarker
Cheryl Thompson, PhD
Topic: Variation in Breast Tissue Gene Expression by Mammographic Density
Reception and presentations, 4-6 pm WRB 1-413

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7 InterContinental Hotel
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Irvington Institute Fellowship Program
Deadline: April 1

American Cancer Society Postdoctoral Fellowships
Deadline: April 1

Clinical and Translational Informatics Funding Opportunity
Deadline: April 2

DAISY Foundation 2012 Patient Care Research Grant Program for Nurses
LOI Deadline: April 2
Application Deadline: June 8

Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE)
Deadline Extended: April 13

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: April 5
Application Deadline: April 19

DOD Breast Cancer Research Program Era of Hope Award
Pre-Application Deadline: April 5
Application Deadline: April 19

DOD Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: April 9
Application Deadline: July 18

SU2C-CRI Cancer Immunology Translational Research Dream Team
LOI Deadline: April 9

DOD Peer Reviewed Medical Research Program Investigator-Initiated Research Award
Pre-Application Deadline: April 10
Application Deadline: July 31

DOD Ovarian Cancer Research Program Ovarian Cancer Academy Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Synergistic Translational Leverage Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Prostate Cancer Research Program Idea Development Award
Pre-Application Deadline: April 24
Application Deadline: August 9

DOD Breast Cancer Research Program Idea Award Award
Pre-Application Deadline: April 26
Application Deadline: August 15

American Nurses Foundation Nursing Research Grants
Deadline: May 1

Howard Hughes Medical Institute Investigator Program
Deadline to establish eligibility: May 1
Application Deadline: June 13

DOD Breast Cancer Research Program Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Innovator Award Award Award
Pre-Application Deadline: May 3
Application Deadline: August 2

DOD Breast Cancer Research Program Clinical Translational Research Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 3
Application: August 15

DOD Prostate Cancer Research Program Biomarker Development Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Clinical Exploration Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Laboratory - Clinical Transition Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Transformative Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application Deadline: May 3
Application Deadline: August 9

Barrett's Esophagus Translational Research Network (BETRNet) pilot projects
Deadline: May 18

Doctors Cancer Foundation, Inc.
Deadline: May 31

DOD Prostate Cancer Research Program Exploration - Hypothesis Development Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: July 26
Application Deadline: August 9

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

NCI Exploratory/Developmental Research Grant Program (NCI Omnibus R21)(PAR-12-145)

NCI Small Grants Program for Cancer Research (NCI Omnibus R03)(PAR-12-144)

Mechanisms of Alcohol-associated Cancers (R01)(PA-12-146)

Mechanisms of Alcohol-associated Cancers (R21)(PA-12-147)

Role of the Microflora in the Etiology of Gastro-Intestinal Cancer (R01)(PAR-12-140)

NSF-NIH Interagency Initiative: Core Techniques and Technologies for Advancing Big Data Science and Engineering (BIGDATA)(NOT-GM-12-109)

Cancer Target Discovery and Development (CTDD) Network (U01)(RFA-CA-12-006)

A Data Resource for Analyzing Blood and Marrow Transplants (Limited Competition U24)(RFA-CA-12-503)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.