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Case Comprehensive Cancer Center Newsletter

March 12, 2012

MESSAGE FROM THE DIRECTOR

New Faculty

Please join me in welcoming three new faculty members who were recently recruited to the Cancer Center:

Dr. Harris

Lyndsay Harris, MD
Co-Leader, Case CCC Breast Cancer Research Program in Development
Medical Director, Breast Cancer Program at Seidman Cancer Center
Professor, Division of Hematology and Oncology

Dr. DiFeo

Analisa DiFeo, PhD
Assistant Professor, Division of General Medical Sciences-Oncology

Dr. Narla

Goutham Narla, MD, PhD
Assistant Professor, Medicine and Transformative Molecular Medicine

A reception will be held today, Monday, March 12 at 5 pm in Wolstein Research Building 1-203, which is the carpeted area on the first floor. I hope you will attend and greet your new colleagues.

Stan Gerson, MD
Director, Case CCC


CASE CCC IN THE NEWS

Medical Researchers Up in Arms About Delayed Cures and Shuttered Labs as Obama Proposes Flat Research Grant Budget
Albany Times Union - March 12, 2012
The biomedical research budget of China is $4.3 trillion annually," says Dr. Charis Eng of the Cleveland Clinic. Her work is aimed at understanding how ...

Cuyahoga County Provides Extensive Review of State of Cancer in the County
Plain Dealer - Mar 11, 2012
"This can help us save lives and save money," said Dr. Stanton Gerson, director of University Hospitals Seidman Cancer Center and of the Case Comprehensive Cancer Center ...... agencies and community residents, said Susan Flocke, associate professor of family medicine and community health at Case Western Reserve University.

The Elusive Nature Of Cancer
ABC News- Mar 7, 2012
Dr. Neal Meropol of University Hospitals Seidman Cancer Center and other doctors discuss cancer and the reasons why it has been so difficult to treat.


MARK YOUR CALENDARS

Cancer Center Seminar Series: The Chemoprevention of Colorectal Cancer: the long saga of difluoromethyornithine (1980-?2016)
Dr. Meyskens

Friday, March 16
12 pm
BRB 105

Please join us March 16 for the next Cancer Center Seminar Series where Dr. Frank Meyskens, Jr., Director of the Chao Family Comprehensive Cancer Center at the University of California Irvine, will present The Chemoprevention of Colorectal Cancer: the long saga of difluoromethyornithine (1980-?2016).

Over the past 30 years, Dr. Meyskens has been involved with and PI of multiple treatment and prevention phase II and III trials. He has been Associate Director of Cancer Control and Prevention for SWOG since 2007. His prevention and control research has been funded by the NIH/NCI, and led to a very successful randomized placebo-controlled trial of the combination of difluoromethylornithine + sulindac in which advanced adenomas were reduced over 90% in at risk population. Subsequently, Dr. Meyskens co-founded Cancer Prevention Pharmaceuticals to move these findings to a registration trial and clinical benefit. His lab remains active and fully equipped for modern molecular research, and in the last five years has taken on the difficult task of developing a mechanistic basis for the chemoprevention of cutaneous melanoma.


FUNDING OPPORTUNITIES

Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE)

All Faculty members are invited to submit outlines for pilot projects to be funded by the NIH P50 GI SPORE. Proposals must be submitted through CTSC Webgrants. Please note that a SPORE project must be directed toward translational research of a GI malignancy. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples.

More information on grant application is available at http://webgrants.case.edu or through John Pounardjian, hxp125@case.edu, 368-1976. Information is also posted on the CWRU GI SPORE website.

Deadline: April 2

AACR Calls for Letters of Intent for a New Stand Up To Cancer-Cancer Research Institute Cancer Immunology Translational Research Dream Team

Stand Up To Cancer (SU2C) and the Cancer Research Institute (CRI), along with the American Association for Cancer Research (AACR), call upon the cancer research community to submit Letters of Intent for a new Dream Team — the SU2C-CRI Cancer Immunology Translational Research Dream Team. Significant scientific developments in the field of cancer immunology and the recent FDA approvals of two cancer immunotherapies highlight the field's potential to transform cancer treatment.

The SU2C-CRI Cancer Immunology Translational Research Dream Team Grant will provide funding of $6 million over a three-year period for translational cancer research projects that address laboratory and clinical efforts leading to the immunological treatment, control and prevention of cancer. Projects should also deliver near-term patient benefit through investigation by a multidisciplinary, multi-institutional, synergistic Dream Team of expert investigators.

LOI Deadline: April 9


ANNOUNCEMENTS

Cancer.gov Goes Mobile

The NCI announces the launch of its mobile website, m.cancer.gov. Designed specifically for mobile users on any mobile platform, the site offers much of the same high-quality information found on cancer.gov's desktop site. Available in English and Spanish, m.cancer.gov provides cancer patients, their loved ones, and their caregivers with easy access to the cancer information they need, when they need it.


NCI CANCER BULLETIN

March 6, 2012

News
Featured Article: Heavy Diesel Exhaust Linked to Lung Cancer Deaths in Miners

Vemurafenib Improves Survival for Patients with Metastatic Melanoma

Less-Invasive Colorectal Screening Test May Detect Cancer as Effectively as Colonoscopy

Chemotherapy Can Impair Cognition More than Two Decades Later

Gene Mutation Implicated in Heightened Breast Cancer Risk in Some Families

Study Details Cancer-Promoting Activity of mTOR Protein

Also in the News: Judge Rules against Graphic Warnings on Cigarette Packages

Also in the Journals: Questioning the Use of Progression-Free Survival as a Clinical Trial Endpoint

Commentary
A Conversation with The Who's Roger Daltrey about Teen Cancer Centers

In Depth
Colonoscopy Reduces Risk of Death from Colorectal Cancer in High-Rick Patients

Featured Clinical Trial: Exploring the Anticancer Potential of Valproic Acid in Advanced Thyroid Cancer

Updates
Cancer.gov

Notes

EVENTS

calendar

**All events are open to anyone interested in attending

March 12

SDIG Seminar
Nicholas Beckloff, PhD
Instructor, Genetics
CWRU
Topic: State of the Genome: Past, Present and Future of the Field of NGS
2:30 pm WRB-1402

New Case CCC Faculty Welcome Reception
5 pm WRB 1-203


March 13

Immunology Invited Speaker Seminar Series
Yinling Hu, PhD
Laboratory of Experimental Immunology, Head, Inflammation and Tumorigenesis Section
NCI-Frederick
Topic: IKKalpha: From a Master Keratinocyte Regulator to the Suppressor of Skin and Lung Squamous Cell Carcinomas
11 am NA1-140 Cleveland Clinic

Department of Cancer Biology Invited Speaker Seminar
Nicholas Beckloff, PhD
Instructor, Genetics
CWRU
Topic: State of the Genome: Past, Present and Future of the Field of NGS
11 am NC1-202 Cleveland Clinic

NCI Office of Cancer Centers Learning Series Webinar
Topic: The Clinical Assay Development Program – A Resource for Assay Validation
2 pm Webinar Site

Cancer Cell Signaling Program Meeting of the Cytokine Signaling, Inflammation, and Cancer Focus Group
Yinling Hu, PhD
Laboratory of Experimental Immunology, Head, Inflammation and Tumorigenesis Section
NCI-Frederick
Topic: Role of IKKalpha in skin and lung squamous cell carcinomas
AND
George R. Stark, PhD
Emeritus Professor of Genetics
CWRU/Cleveland Clinic
Topic: Mechanisms of NFκB Activation and Function in Lung Cancer
3-5 pm The College Club of Cleveland
Pre-registration to Tracy Rehl required


March 14

Hematology and Oncology Division Research Conference
Dr. Peter Naturi Mwamba
Lecturer in Hematology and Blood transfusion, Hematology and Pediatric Oncology
University of Nairobi
Topic: Cancer in East Africa
8 am Lerner Tower B-151

Skeletal Research Center Seminar
Eric Hesse MD, PhD
Heisenberg-Professor and Director, Experimental Trauma Surgery
Department of Trauma-, Hand-, and Reconstructive Surgery
University Medical Center Hamburg-Eppendorf
Topic: Novel Insights into Osteoblast-Dependent Control of Bone Integrity and Tumor Cell Dormancy
4 pm Millis 123

Cell Death Regulation Program Meeting
Alex Almasan, PhD
Associate Professor, Cancer Biology, Radiation Oncology
CWRU/Cleveland Clinic
AND
Brian Hill, MD, PhD
Associate Staff, Hematologic Oncology and Blood Disorders
Cleveland Clinic
Topic: Recent Research and Advances in CLL
4-6 pm The College Club of Cleveland


March 15

CWRU Office of Research Compliance Webinar
Topic: Ethical Internet Research: Informed Consent Regulations and Realities
1-2:30 pm
Registration

National Center for Regenerative Medicine Seminar
Wouter van't Hof, PhD
Senior Director, Regenerative Medicine Program
Athersys, Inc
Topic: Evaluation of MultiStem, an Adult Bone Marrow Derived Cell Product, as an Adjunct in Prevention of GVHD after Allo HSCT
1 pm WRB 1-403


March 16

Hematology/Oncology Fellows
Nathan Langer
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Walter Stadler, MD
Professor, Medicine and Surgery
University of Chicago
Topic: Renal Cancer: Now What?
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Frank Meyskens, Jr., MD
Director, Chao Family Comprehensive Cancer Center
University of California Irvine
Topic: The Chemoprevention of Colorectal Cancer: the long saga of difluoromethyornithine (1980-?2016)
12 pm BRB 105

Molecular Biology and Microbiology Thesis Defense
Benjamin Dickerman
Sen Lab, Molecular Genetics
Cleveland Clinic
Topic: The Physiological Function of dsRNA-Binding Protein PACT/RAX Protein Activator of PKR and Its Role in Mouse Development
1 pm NC1-202 Cleveland Clinic

Cancer Center Research in Progress Seminar
Eric Lam
Graduate Student, Letterio Lab, Div. of Hem/Onc
CWRU/UH
Topic: Cdk5: A Novel Role for a Unique Kinase in T Cell Function and Gene Expression
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case CCC Clinical Research Retreat
April 4
5:30-8:30 pm Dively Building
Agenda
Registration

Breast Cancer 2012: Risk Assessment through Survivorship
May 18
Brochure
Registration

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7 InterContinental Hotel
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

NCI Second Symposium on Translational Genomics
March 15-16
NIH, Bethesda, Maryland
Registration

Midwest Blood Club Symposium
March 15-16
Indiana University School of Medicine
Details

Sternlicht Memorial Lectureship in Cancer Biology and Pharmacology
March 22
Gordon Shore, PhD
Professor, Biochemistry
McGill University
Topic: Targeting Mcl-1 for Synthetic Lethality in Cancer Therapy
4 pm WRB 1-413

Grant Writing and Reviewing Workshop
March 29
Alan L. Willard, PhD
Deputy Director, Division of Extramural Research
NIH/NINDS
Topic Writing and Reviewing Grants: Negotiating the NIH Grant System
10 am - 12 pm WRB 1-413
AND Job Opportunities in Health Research Administration at the NINDS
1-2 pm WRB 1-413

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Childhood Brain Tumor Foundation (CBTF)
Deadline: March 12

James S. McDonnell Foundation Research Award in Brain Cancer Research
Deadline: March 14

James S. McDonnell Foundation Scholar Awards in Complex Systems Science
Deadline: March 14

Alex's Lemonade Stand Pediatric Oncology Student Training (POST) Program
Deadline: March 15

Damon Runyon Cancer Research Foundation Fellowship Award
Deadline: March 15

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 15

American Society of Hematology(ASH) Trainee Research Award
Deadline: March 16

Prostate Cancer Foundation-Honorable A. David Mazzone Special Challenge Award Research Program 2012
Deadline: March 16

American Legacy Foundation Sybil G. Jacobs Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

American Legacy Foundation Christine O. Gregoire Youth/Young Adult Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

Multiple Myeloma Research Foundation 2012 Senior Research Award Program
Deadline: March 27

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 30

Irvington Institute Fellowship Program
Deadline: April 1

American Cancer Society Postdoctoral Fellowships
Deadline: April 1

Clinical and Translational Informatics Funding Opportunity
Deadline: April 2

DAISY Foundation 2012 Patient Care Research Grant Program for Nurses
LOI Deadline: April 2
Application Deadline: June 8

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: April 5
Application Deadline: April 19

DOD Breast Cancer Research Program Era of Hope Award
Pre-Application Deadline: April 5
Application Deadline: April 19

DOD Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: April 9
Application Deadline: July 18

DOD Peer Reviewed Medical Research Program Investigator-Initiated Research Award
Pre-Application Deadline: April 10
Application Deadline: July 31

DOD Ovarian Cancer Research Program Ovarian Cancer Academy Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Synergistic Translational Leverage Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Breast Cancer Research Program Idea Award Award
Pre-Application Deadline: April 26
Application Deadline: August 15

American Nurses Foundation Nursing Research Grants
Deadline: May 1

DOD Breast Cancer Research Program Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Innovator Award Award Award
Pre-Application Deadline: May 3
Application Deadline: August 2

DOD Breast Cancer Research Program Clinical Translational Research Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 3
Application: August 15

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Diet, Epigenetic Events, and Cancer Prevention (R01)(PA-09-234)

Diet, Epigenetic Events, and Cancer Prevention (R21)(PA-09-235)

Exploratory Cancer Prevention Studies Involving Molecular Targets for Bioactive Food Components (R21)(PA-10-088)

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)(PAR-10-169)

Paul Calabresi Career Development Award for Clinical Oncology (K12)(PAR-10-155)

Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis (R21)(PA-09-238)

Image-guided Drug Delivery in Cancer (R01)(PA-09-253)

National Cancer Institute (NCI) Cancer Education and Career Development Program (R25)(PAR-10-165)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.