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Case Comprehensive Cancer Center Newsletter

February 20, 2012


Secondary Appointments in the Cancer Center

The Case CCC Executive Committee is recommending a formal secondary appointment in the Division of General Medical Sciences (Oncology) for all full members of the Cancer Center. Our center has academic status, and this more formal appointment will provide the rights and responsibilities of faculty members of the School of Medicine. There is no additional obligation, and the appointment will be retained for the duration of membership in the Cancer Center.

To complete the secondary appointment process, the Cancer Center will make a formal request to the dean with the approval of the department chair on behalf of the full member. The secondary appointment will be rank equivalent, and will be recognized by a letter from the dean and myself.

Please contact Gillian Todd with any questions.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center


Beyond Increased Risk: Obesity Complicates Cancer Diagnosis, Treatment
Endocrine Today - Feb 20, 2012
The challenges related to screening and performing imaging on obese patients often lead to later diagnosis, said Dale R. Shepard, MD, PhD, an associate ...

After Denying Son Cancer Treatment But Treating their Dog for Fleas, Ohio Couple Gets 8 Years in Prison
Fox News - Feb 16, 2012
Dr. Stanton L. Gerson, director of the Case Comprehensive Cancer Center at Case Western Reserve University, said parents should watch for glands that are ...

Cervical Stitch Saves Baby and Mom
WKYC-TV - Feb 14, 2012
Cervical cancer is a terrifying diagnosis for any woman. ... Katie's doctor, Gynecological Oncologist Steven Waggoner knew it was ...

Cleveland Clinic Forms Adult Oncology Affiliation with Chicago-area Hospital
Crain's Cleveland Business - Feb 14, 2012
... the latest treatments available, along with greater access to clinical trials," said Dr. Brian J. Bolwell, chairman of Taussig, in a statement.

Cleveland Clinic Offers New AutoLITT Laser Technology to Treat Previously Inoperable Brain Tumors
PR Web (press release) - Feb 14, 2012
This is much less invasive than even our most minimally invasive open operations, said Dr. Gene Barnett, MD, Director of the Burkhardt Brain Tumor Center.


Cancer Center Seminar Series: Barrett's Esophagus: is it one step forward, two steps back?
Dr. Lynch

Friday, February 24
12 pm
BRB 105

Please join us Friday, February 24 for the next Cancer Center Seminar Series where Dr. John Lynch, Assistant Professor of Medicine at the University of Pennsylvania, will present Barrett's Esophagus: is it one step forward, two steps back?.

Dr. Lynch's research is focused on investigating the molecular mechanisms underpinning the establishment of Barrett's metaplasia and its progression to cancer. His laboratory has created experimental organotypic cultures for studying ectopic expression of intestine-specific transcription factors that are characteristic of Barrett's. Homeodomain transcription factor CDX2 is an important regulator of intestine-specific gene expression. It is expressed ectopically in BE, but its role is unknown. Dr. Lynch's research has investigated the role of CDX2 in esophageal metaplasia. They have hypothesized that ectopic CDX2 expression synergizes with acid reflux, COX-2 overexpression, autophagy activation, tumor-suppressor p53 mutations, and/or alterations in DNA methylation patterns to reprogram keratinocyte cells to promote intestinal transdifferentiation. This and other hypotheses are being tested by developing cell-culture and transgenic mouse models for intestinal metaplasia.

Midwest Blood Club Symposium

The Midwest Blood Club will hold its 10th Annual Symposium at Indiana University School of Medicine, March 15-16. Since 2003, this meeting has been organized to foster greater communication between hematology/oncology investigators within the Midwest region by creating a forum where researchers can meet and share ideas and data on stem cell biology, transplantation, cell/gene therapy, leukemogenesis, and immunotherapy. The meeting will be composed of both senior and junior investigators, with a decided focus towards students, postdoctoral/clinical fellows, and newly independent investigators serving as speakers.


Cellular Molecular Imaging of Cancer: Cancer Microenvironment Pilot Awards

The Case CCC awarded seed funding to three investigative interdisciplinary teams on the topic of Cellular Molecular Imaging of Cancer: Cancer Microenvironment.

The ability to identify and image key common pathways that control cellular or molecular aspects of cancer biology and/or exploit the microenvironment for tumor detection or drug delivery is critically important in the understanding and treatment of cancer.


Robert Wood Johnson Foundation: Building Evidence for Decision-Making

The Robert Wood Johnson Foundation Building Evidence for Decision-Making program Grants will support efforts to produce evidence that can inform public health practice and policy decisions by comparing systems with change in organizational structures, legal infrastructure, financing mechanisms, and service delivery strategies to systems without changes. Proposals are encouraged from researchers representing disciplines such as law, public policy, economics, business administration, organizational behavior, sociology, finance, urban planning, public administration, information and library science, and industrial and systems engineering.

Mandatory LOI Deadline: March 6
Application Deadline: March 27

Clinical and Translational Informatics Funding Opportunity

The purpose of the Clinical and Translational Science Collaborative (CTSC) informatics pilot funding opportunity is to innovate and develop informatics approaches for expanding the use of biomedical, behavioral or health data by addressing challenges in capturing, organizing, integrating, searching, analyzing, or visualizing such data. This may include methodological and measurement development, has a human behavioral social science focus, or applies unique technology and methods to a broad range of translational and clinical research topics. Successful applications will typically involve two or more disciplines, one of which must be translational bioinformatics or clinical research informatics.

Deadline: April 2

DAISY Foundation 2012 Patient Care Research Grant Program for Nurses

As part of its mission to honor the work of nurses on behalf of patients and their families, the DAISY (Diseases Attacking the Immune System) Foundation provides funding to nurses who wish to conduct nursing research and evidence-based practice projects designed to improve the treatment of patients with auto-immune diseases and cancer.

Two types of grants are available: research grants for studies that involve clinical research that directly benefits patients and/or families; and evidence-based practice project grants that use patient-focused data to study and develop improved nursing practices.

LOI Deadline: April 2
Application Deadline: June 8

American Nurses Foundation Nursing Research Grants

The American Nurses Foundation (ANF) Nursing Research Grants (NRG) Program provides funds to beginner and experienced nurse researchers to conduct studies that contribute toward the advancement of nursing science and the enhancement of patient care. Awards are given in all areas of nursing, including healthy patient outcomes, health care policy development, critical care, gerontology, women's health, community and family intervention.

Deadline: May 1



**All events are open to anyone interested in attending

February 20

Immunology Seminar Series
Gerardo Vasta, PhD
Professor, Microbiology and Immunology
University of Maryland
Topic: Structure, Function, and Evolution of Protein-Carbohydrate Interactions in Innate Immunity
12 pm WRB 1-413

Physiology and Biophysics Seminar
Charles Kunos, MD, PhD
Assistant Professor, Radiation Oncology
Topic: Ribonucleotide Redactase Inhibitors in Oncology
4 pm SOM E501

February 21

Prostate Cancer Endowed Chair Candidate Seminar
Gang Zeng, PhD
Associate Professor, Urology
University of California, Los Angeles
Topic: Harnessing Spontaneous Anti-Tumor Immunity for Prostate Cancer Diagnosis and Therapy
11 am NC1-202

Immunology Seminar Series
John Schreiber, MD, MPH
Professor, Pediatrics
Tufts University
Topic: Conjugate Vaccines: How Do They Work, How Do We Make Them Better?
12 pm WRB 1-413

February 22

Hematology and Oncology Division Research Conference
Panos Savvides, MD, PhD
Assistant Professor, Medicine-Hem/Onc
Topic: TBD
8 am Lerner Tower B-151

Immunology Faculty Research in Progress Seminar Series
Greg Plautz, MD
Professor, Pediatric Hematology and Oncology
CWRU/Cleveland Clinic
Topic: Immunotherapy of HER2 Positive Breast Cancer
12 pm NC1-202 Cleveland Clinic

February 23

Molecular Biology and Microbiology Seminar
Lora Hooper, PhD
Associate Professor, Immunology
UT Southwestern
Topic: Immune Defense of the Intestinal Epithelial Surface
1 pm SOM W203

February 24

Cancer Center Research in Progress Seminar canceled

Hem/Onc Fellows Conference
Greg Manson, MD
Fellow, Div. of Hem/Onc
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Thomas Shea, MD
Professor, Medicine- Hem/Onc
University of North Carolina
Topic: Update on Mantle Cell Lymphoma
8 am R3/002-003 Cleveland Clinic

Cell Biology Seminar Series
Andrew Dannenberg, MD
Professor, Medicine
Director, Weill Cornell Cancer Center
Cornell University
Topic: Obesity and Breast Inflammation: Implications for Cancer Prevention
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
John Lynch, MD, PhD
Assistant Professor, Medicine
University of Pennsylvania
Topic: Barrett's Esophagus: is it one step forward, two steps back?
12 pm BRB 105

Cancer Center Faculty Candidate Seminar
Yusuke Shiozawa, MD, PhD
Research Investigator, Periodontics and Oral Medicine
University of Michigan
Topic: The Hematopoietic Stem Cell Niche is the Target of Metastatic Cells from Solid Tumors
2 pm WRB 3-136



Case CCC Calendar

LRI Calendar


Cancer Cell Signaling Program Retreat
February 29
6-8 College Club
RSVP to Tracy Rehl at tracy.rehl@case.edu

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7 InterContinental Hotel


NCI Second Symposium on Translational Genomics
March 15-16
NIH, Bethesda, Maryland

Sternlicht Memorial Lectureship in Cancer Biology and Pharmacology
March 22
Gordon Shore, PhD
Professor, Biochemistry
McGill University
Topic: Targeting Mcl-1 for Synthetic Lethality in Cancer Therapy
4 pm WRB 1-413

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


NSF Integrative Graduate Education and Research Traineeship Program (IGERT)
Internal Deadline: February 27

Robert Wood Johnson Foundation Clinical Scholars Program
Deadline: February 29

Cancer Research Institute Student Training and Research in Tumor Immunology (STaRT) Program
Deadline: March 1

New York Academy of Medicine David E. Rogers Fellowship Program
Deadline: March 1

Leukemia & Lymphoma Society Translational Research Program
LOI Deadline: March 1
Full Application Deadline: March 15

Childhood Brain Tumor Foundation (CBTF)
Deadline: March 12

James S. McDonnell Foundation Research Award in Brain Cancer Research
Deadline: March 14

James S. McDonnell Foundation Scholar Awards in Complex Systems Science
Deadline: March 14

Alex's Lemonade Stand Pediatric Oncology Student Training (POST) Program
Deadline: March 15

Damon Runyon Cancer Research Foundation Fellowship Award
Deadline: March 15

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 15

American Society of Hematology(ASH) Trainee Research Award
Deadline: March 16

Prostate Cancer Foundation-Honorable A. David Mazzone Special Challenge Award Research Program 2012
Deadline: March 16

American Legacy Foundation Sybil G. Jacobs Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

American Legacy Foundation Christine O. Gregoire Youth/Young Adult Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

Multiple Myeloma Research Foundation 2012 Senior Research Award Program
Deadline: March 27

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 30

Irvington Institute Fellowship Program
Deadline: April 1

American Cancer Society Postdoctoral Fellowships
Deadline: April 1

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

New Electronic Submission Process Now Available for Administrative Supplement Requests (NOT-OD-12-043)

Notice of Change of Participation of NIH Institutes and Centers in PA-11-335 Lab to Marketplace: Tools for Biomedical and Behavioral Research (SBIR [R43/R44])(NOT-OD-12-053)

Notice of Intent to Publish a Request for Applications for Centers of Excellence for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (P50) (NOT-DA-12-007)

Correction and Clarification of PAR-12-068 Fogarty HIV Research Training Program for Low- and Middle-Income Country Institutions (D43) (NOT-TW-12-005)

Administrative Supplements to Existing NIH Grants and Cooperative Agreements(Parent Admin Supp)(PA-12-100)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.