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Case Comprehensive Cancer Center Newsletter

February 13, 2012

CASE CCC IN THE NEWS

Skin Cancer Drug Quickly Reverses Alzheimer's Symptoms in Mice
Medicus- Feb 9, 2012
Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show that use of a drug in mice appears to quickly reverse the pathological, cognitive and memory deficits caused by the onset of Alzheimer's. The results point to the significant potential that the medication, bexarotene, has to help the roughly 5.4 million Americans suffering from the progressive brain disease....

Alzheimer's disease arises in large part from the body's inability to clear naturally-occurring amyloid beta from the brain. In 2008 Case Western Reserve researcher Gary Landreth, PhD, professor of neurosciences, discovered that the main cholesterol carrier in the brain, Apolipoprotein E (ApoE), facilitated the clearance of the amyloid beta proteins. Landreth, a professor of neurosciences in the university's medical school, is the senior author of this study as well.

Comparing Prostate Cancer Treatments Shows Newer Isn't Always Better
NCI Cancer Bulletin - Feb 7, 2012
In another study Exit Disclaimer, Dr. Jay Ciezki of the Cleveland Clinic and his colleagues used SEER-Medicare data to compare the benefits and harms of external-beam radiation therapy, brachytherapy, and surgery for prostate cancer. The researchers found that external-beam radiation therapy was the most toxic, most expensive, and most commonly used of these techniques.

Brachytherapy, although it was the least toxic and the least expensive, was used in only 12 percent of the patients. The limited use of brachytherapy may be due to the fact that it was initially thought to be suitable only for a small subset of men, but "I think people have gotten to the point where they're more comfortable offering [brachytherapy]," said Dr. Ciezki.

Kidney Cancer Patients May Need Higher Axitinib Dose
The Oncology Report - Feb 7, 2012
... well enough to advance to a higher one — up to twice as high — lead investigator Dr. Brian I. Rini reported at the Genitourinary Cancers Symposium here.


MARK YOUR CALENDARS

Cancer Center Seminar Series: Personalized Lung Cancer Targeted Therapy – Why it works and why it doesn't
Dr. Ma

Friday, February 17
12 pm
BRB 105

Please join us Friday, February 17 for the next Cancer Center Seminar Series where Dr. Patrick Ma, Assistant Professor of Translational Hematology and Oncology Research and Director of Aerodigestive Oncology Translational Research at the Cleveland Clinic, will present Personalized Lung Cancer Targeted Therapy – Why it works and why it doesn't.

Dr. has a special interest in thoracic malignancies including lung cancer, mesothelioma, and neuroendocrine tumors. He leads laboratory-based translational and clinical research in aerodigestive oncology, with an emphasis on cancer genomics, cancer metabolomics and personalized molecularly-targeted therapies. Dr. Ma's particular research focus is on the mutational analysis and profiling of molecular therapeutic targets of lung cancer. He has considerable expertise in MET targeting therapy in lung cancer.

Special Genomics Lecture

The NCI Center for Cancer Genomics is hosting a special genomics lecture on Tuesday, February 14 at 1 pm featuring Dr. Kevin P. White, Director of the Institute for Genomics & Systems Biology at The University of Chicago and Argonne National Laboratory. Dr. White will present Genomic Networks in Development and Cancer: Resolving Biomarkers and Therapeutic Targets from a Cloud of Data. The lecture can be viewed live at videocast.nih.gov.

Dr. White is a pioneer in combining experimental and computational techniques to understand the factors that control biological systems during development and evolution. He will talk about how his lab uses systems-level approaches to construct abstract molecular networks to make predictions about genetic and biochemical functions in cells, organisms, and disease states. The team is mining data from The Cancer Genome Atlas and the Chicago Cancer Genomes Project using the Bionimbus Cloud to identify new tumor suppressor genes and panels of genetic markers.

Ca-PRI Annual Meeting: Learning from Our Differences

Registration is open for the Cancer and Primary Care Research International Network (Ca-PRI) annual meeting, June 5-7 in Cleveland.

Primary care remains at the forefront of cancer prevention, early diagnosis and management. The fifth annual Ca-PRI meeting will be a showcase of primary care and cancer research. Plenary speakers will highlight the broad scope of primary care and cancer research, and explore the potential of primary care to improve cancer outcomes from a clinical, public health and international perspective. The meeting will highlight international differences in the role of primary care and will provide unique opportunities for delegates from broad and multi-disciplinary backgrounds to exchange ideas.


ANNOUNCEMENTS

Summer Volunteers: Placements Needed

It's that time of year again where we receive requests from students inquiring about summer research positions. If you have room in your lab for a summer student, please send an email to Lyn Haselton, Cancer Center Training Program Manager. We will add your name to a list and will send you resumes if we receive them.


NCI CANCER BULLETIN

February 7, 2012

News
Clinical Trials Point to New Options for Advanced Prostate Cancer

Additional Surgery after Breast-Conserving Surgery Varies Widely

Comparing Prostate Cancer Treatments Shows Newer Isn't Always Better
**featuring research conducted by Dr. Jay Ciezki

Oral HPV Infections May Help Explain Why Some Head and Neck Cancers are More Common in Men

Cancer Screening Rates Lag Behind National Target Levels

HPV Testing with Self-Collected Samples May Be Valid Cervical Cancer Screening Method

Genetic Studies Uncover Clues to Childhood Brain Cancers

Also in the Journals: CDC Advisory Committee Strengthens Recommendation for HPV Vaccination in Males

Commentary
Global Health through Collaboration and Leadership by Dr. Nils Daulaire

A Conversation with Drs. Christopher Kinsinger and Henry Rodriguez about Sharing Proteomics Data

In Depth
Studies Highlight Complexities of Treating Advanced Head and Neck Cancer

Connecting the Dots: Network Analysis Helps Public Health Researchers Get the Big Picture

Featured Clinical Trial: Cetuximab and Radiotherapy for HPV-Associated Oropharynx Cancer

Updates
FDA Update

Notes

EVENTS

calendar

**All events are open to anyone interested in attending

February 13

Pathology Research Seminar Series
Duncan Stearns, PhD
Assistant Professor, Pediatrics- Hem/Onc
CWRU/UH
Topic: Modeling Anaplastic Medulloblastoma
12 pm WRB 1-413

SDIG Meeting
Shuying Sun, PhD
Assistant Professor, General Medical Sciences-Oncology
CWRU/UH
Topic: TBD
2:30 pm WRB 1-402

Physiology and Biophysics Seminar
Jeffrey Brodsky, PhD
Professor and Chair, Biological Sciences
University of Pittsburgh
Topic: Molecular Chaperones, Protein Quality Control, and Conformational Diseases
4 pm SOM E501


February 14


February 15

Hematology and Oncology Division Research Conference
Henry Koon, MD
Assistant Professor, Medicine-Hem/Onc
CWRU/UH
Topic: TBD
8 am Lerner Tower B-151

Cancer Center Faculty Candidate Seminar
David MacPherson, PhD
Staff Associate, Embryology
Carnegie Institution
Topic: Rb Collaborators in Cancer
11 am WRB 3-136

Immunology Students/Fellows Research in Progress Seminar Series
Shyamasree Datta, PhD
Research Associate, Hamilton Lab
CWRU
Topic: The Interface of Cellular Stress and Inflammation
AND
Ronald Charles, MD
Fellow, Lu Lab
CWRU
Topic: Human Hepatic Stellate Cells Inhibit T-cell Response Through B7-H1 Pathway
12 pm NC1-202 Cleveland Clinic

Cell Death Regulation Program Meeting
Junran Zhang, MD, PhD
Assistant Professor, Radiation Oncology
CWRU/UH
Topic: The Role of Homologous Recombination in Genomic Stability and Cancer Therapy
AND
Matthew Summers, PhD
Assistant Staff, Cancer Biology
Cleveland Clinic
Topic: New Insight into Spindle Assembly Checkpoint Antagonism by p31-Comet
4 pm College Club


February 16


February 17

Hem/Onc Fellows Conference
Ashley Rosko, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Stephan Moll, MD
Associate Professor, Medicine- Hem/Onc
University of North Carolina
Topic: Thrombophilia- Clinical Update 2012
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Patrick Ma, MD, MSc
Assistant Professor, Translational Hematology and Oncology Research
Director, Aerodigestive Oncology Translational Research
CWRU/Cleveland Clinic
Topic: Personalized Lung Cancer Targeted Therapy – Why it works and why it doesn't
12 pm BRB 105

Cancer Center Research in Progress Seminar
Ming-Jin Chang, PhD
Postdoctoral Fellow, Distelhorst Lab
CWRU/UH
Topic: Bcl-2 and IP3 Receptor: How Their Interaction Affect Life and Death of Cells
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Cancer Cell Signaling Program Retreat
February 29
6-8 at the College Club
RSVP to Tracy Rehl at tracy.rehl@case.edu

ADDITIONAL UPCOMING SEMINARS & EVENTS

NCI Second Symposium on Translational Genomics
March 15-16
NIH, Bethesda, Maryland
Registration

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Innovations for Health: Solutions that Cross Borders
Deadline: February 13

Advancing Health Services through System Modeling Research
Deadline: February 15

Leukemia Research Foundation New Investigator Grants
Deadline: February 15

Ohio Cancer Research Associates
Deadline: February 17

NSF Integrative Graduate Education and Research Traineeship Program (IGERT)
Internal Deadline: February 27

Robert Wood Johnson Foundation Clinical Scholars Program
Deadline: February 29

Cancer Research Institute Student Training and Research in Tumor Immunology (STaRT) Program
Deadline: March 1

New York Academy of Medicine David E. Rogers Fellowship Program
Deadline: March 1

Leukemia & Lymphoma Society Translational Research Program
LOI Deadline: March 1
Full Application Deadline: March 15

Childhood Brain Tumor Foundation (CBTF)
Deadline: March 12

James S. McDonnell Foundation Research Award in Brain Cancer Research
Deadline: March 14

James S. McDonnell Foundation Scholar Awards in Complex Systems Science
Deadline: March 14

Alex's Lemonade Stand Pediatric Oncology Student Training (POST) Program
Deadline: March 15

Damon Runyon Cancer Research Foundation Fellowship Award
Deadline: March 15

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 15

American Society of Hematology(ASH) Trainee Research Award
Deadline: March 16

Prostate Cancer Foundation-Honorable A. David Mazzone Special Challenge Award Research Program 2012
Deadline: March 16

American Legacy Foundation Sybil G. Jacobs Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

American Legacy Foundation Christine O. Gregoire Youth/Young Adult Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

Multiple Myeloma Research Foundation 2012 Senior Research Award Program
Deadline: March 27

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 30

Irvington Institute Fellowship Program
Deadline: April 1

American Cancer Society Postdoctoral Fellowships
Deadline: April 1

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Notice of Change to Non-Allowable Costs for PA-10-071: NIH Support for Conferences and Scientific Meetings [Parent R13/U13] (NOT-OD-12-048)

Request for Information (RFI): Optimization of Information Technology for Biobanks Collecting Specimens from Clinical Trials Sponsored by the National Cancer Institute (NCI)(NOT-CA-12-008)

NCI Will Participate in RFA-AR-12-007, "Ancillary Domain Development Patient-Reported Outcomes Measurement Information System (PROMIS®) Studies (R01)" (NOT-CA-12-011)

Request for Information (RFI): Updating the National Institutes of Health Research Plan on Fragile X Syndrome and Associated Disorders (NOT-HD-12-012)

Ancillary Domain Validation Patient-Reported Outcomes Measurement Information System (PROMIS®) Studies (R01)(RFA-AR-12-007)

Basic Cancer Research in Cancer Health Disparities (U01)(PAR-12-095)

Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)(PAR-12-094)

Diet, Epigenetic Events, and Cancer Prevention (R01)(PA-09-234)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01)(PA-11-160)

Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21)(PAR-12-096)

Identifying Non-coding RNA Targets for Cancer Early Detection and Prevention (R01)(PA-09-199)

Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01)(PAR-11-150)

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)(PAR-10-169)

Image-guided Drug Delivery in Cancer (R01)(PA-09-253)

Studies of Energy Balance and Cancer in Humans (R01)(PA-09-148)

Biomarkers of Infection-Associated Cancers (R01)(PA-11-158)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.