Case Comprehensive Cancer Center: Weekly Newsletter

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December 5, 2011
CASE CCC IN THE NEWS University Hospitals Seidman Cancer Center Tests Novel Drug That Makes Brain Tumors Glow Hot Pink EurekAlert - Dec 1, 2011 ... Seidman Cancer Center at University Hospitals (UH) Case Medical Center, where Andrew Sloan, MD, diagnosed her with Stage 4 glioblastoma, the most aggressive form of brain cancer and the most difficult to treat...Dr. Sloan, lead investigator of the study looking at the effects of varying 5-ALA dose levels, is collaborating with David Dean, PhD, Associate Professor and Director of the Imaging Laboratory in ... MedWorks Clinic Spotted Cancer, Saved Life: Holiday Spirit Plain Dealer (blog) - Nov 30, 2011 Rob Corbett, right, listens to Dr. Lee Ponsky talk about Corbett's successful battle with cancer. Corbett was at University Hospitals for a follow-up exam in April. Lee Ponsky's father, Dr. Jeffrey Ponsky, found Corbett's cancerous tumor during a MedWorks clinic... MARK YOUR CALENDARS Cancer Center Seminar Series: Defining Novel Tumor Suppressor-Oncogene Interactions in Mammary Cell Transformation Friday, December 9 12-1 pm Frohring Auditorium - BRB 105 Please join us Friday, December 9 at the next Cancer Center Seminar Series featuring Mark W. Jackson, PhD. Dr. Jackson, Assistant Professor of Pathology at CWRU, will present Defining Novel Tumor Suppressor-Oncogene Interactions in Mammary Cell Transformation. The Jackson laboratory focuses on genetic events that contribute to breast hyperplasia. They have developed a breast cancer model that starts with normal human mammary epithelial cells (HMECs), and utilizes genetic alterations associated with breast cancer to transform the HMEC to a cancerous state. Using this model, they can interrogate the contribution of breast specific tumor-suppressive signaling and define how oncogene activation dismantles these suppressive signals to drive breast cancer development and progression. Current areas of focus include identifying novel endogenous regulators of HMEC transformation, and how exogenous microenvironmental factors (TGF-beta, Oncostatin M, and Interferon signaling) influence the transformed phenotype. Laser Capture Microdissection Service Replacement System Demonstrations The second Laser Microdissection demonstration takes place Tuesday, December 6 and Wednesday, December 7. Leica will demonstrate their LMD 6500 system. All are welcome to drop by any time between 9 am and 5 pm to check out the system. Exclusive blocks of one-hour, hands-on time with the Leica trainer may be scheduled by contacting Patrick Leahy at patrick.leahy@case.edu or (216)368-0761. ANNOUNCEMENTS ASH Annual Meeting The upcoming American Society of Hematology (ASH) Annual Meeting, December 10-13, will feature updates on groundbreaking research. We are pleased to have research conducted by Case CCC members well represented at the poster sessions. In addition, Drs. Jaroslaw Maciejewski and Clark Distelhorst are invited speakers, and Drs. Raymond Tiu, Yogen Saunthararajah, Hillard Lazarus, Anjali Advani, Brian Bolwell, Mikkael Sekeres, and Alvin Schmaier will be serving as session moderators. Click here to view a listing of all Cancer Center presentations and abstracts. Congratulations to all participants. FUNDING OPPORTUNITIES AACI Translational Cancer Research Fellowship The Case CCC is accepting nominations for the AACI Translational Cancer Research Fellowship. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline. The AACI fellowship will provide a one-year non-renewable grant to support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution. Interested candidates should forward a letter of support from their mentor and their biosketch to Gillian Todd by Monday, December 12. We may nominate ONE candidate from CWRU/UH, and ONE from the Cleveland Clinic. Internal Deadline: December 12 External Deadline: February 1, 2012 Mary Kay Foundation: Innovative/Translational Cancer Research The Case CCC is accepting nominations for the Mary Kay Foundation Translational Cancer Research Program, which offers innovative grants for translational research in ovarian, uterine, breast, or cervical cancer. Applications must be submitted by one Principal Investigator, selected by the Institution. Only ONE grant application will be accepted from each accredited medical school and schools of public health in the United States. Interested candidates should forward a one-paragraph description and their biosketch to Gillian Todd by Tuesday, December 13. Internal Deadline: December 13 External Deadline: February 3, 2012 Damon Runyon Clinical Investigator Award The Case CCC is accepting nominations for the Damon Runyon Clinical Investigator Award, which supports young physician-scientists conducting patient-oriented cancer research. The goal is to increase the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments. The Clinical Investigator Award program is specifically intended to provide outstanding young physicians with the resources and training structure essential to becoming successful clinical investigators. Interested candidates should forward a one-page letter of intent of proposal and their biosketch to Gillian Todd by Wednesday, December 14. Internal Deadline: December 14 External Deadline: February 12, 2012 National Center for Regenerative Medicine Stem Cell-related Pilot Projects The National Center of Regenerative Medicine (NCRM) is accepting proposals for funding of Stem Cell-related Pilot Projects. NCRM can provide two $35,000 grants this year to promote new projects in stem cell research and an additional $10,000 can be requested from the CTSC to use one of their approved facilities. In addition to providing seed money for new research ideas, priority will be given to projects that involve multiple institutions, have robust experimental plans and when completed lead to additional funding opportunities. Projects must have a clinical and/or commercial direction though it may be more rudimentary. Deadline: December 21 Society of Surgical Oncology 2012 Clinical Investigator Awards The Society of Surgical Oncology (SSO) is now accepting applications for its 2012 Clinical Investigator Awards. The purpose of these awards is to promote patient-oriented research conducted by surgical oncologists in clinical and translational science. Applicants must be surgical oncologists within 10 years of completion of training and be full SSO members. Deadline: January 9, 2012 AACR-Genentech BioOncology Fellowship for Cancer Research on the HER Family Pathway The AACR-Genentech BioOncology Fellowship for Cancer Research on the HER Family Pathway represents a joint effort to encourage and support postdoctoral and clinical research fellows who are in the first 5 years of their fellowship training (at the start of the grant term) to conduct cancer research on the HER family pathway and establish successful career paths in this field. Proposed research projects are restricted to basic, translational, clinical, or epidemiological projects that substantially advance the field of cancer research on the HER family pathway. Deadline: January 10, 2012 AACR Clinical and Translational Cancer Research Fellowships The AACR Clinical and Translational Cancer Research Fellowships are open to Postdoctoral and Clinical Research Fellows working at an academic, medical, or research institution who will be in the first 5 years of their postdoctoral training at the start of the grant term. Proposed research projects may be in any area of clinical and/or translational cancer research. Deadline: January 11, 2012 Support of the Cancer Genome Atlas Program SAIC-Frederick is pleased to announce a new solicitation available in support of The Cancer Genome Atlas (TCGA) Program. The Cancer Genome Atlas is a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. This funding is made available under Congressional appropriated funding and also the American Recovery and Reinvestment Act of 2009 (Recovery Act), Pub. L. No. 111-5. SAIC Frederick hopes to receive proposals from institutions and established network sites that currently collect high quality biospecimens. TCGA TSS awardees will either have an on-site biorepository (located in the same institution as the specimen collection) or demonstrate capability to collect, short-term store, and ship high quality biospecimens to an appropriate biorepository. SAIC-Frederick is hopeful that many sites will meet the qualifications and would find it attractive to participate in the specimen collection portion of TCGA. Deadline: January 13, 2012 Caring for Carcinoid Foundation-AACR Grants for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research The Caring for Carcinoid Foundation-AACR Grants for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research represent a joint effort to promote and support innovative cancer research. These grants are available to independent junior and senior investigators to develop and study new ideas and approaches that have direct application and relevance to carcinoid tumors or pancreatic neuroendocrine tumors. Proposed research may be in any discipline of basic, translational, clinical or epidemiological cancer research. Deadline: January 17, 2012 Children's Tumor Foundation Young Investigator Awards Through its Young Investigator Award Program, the Children's Tumor Foundation seeks scientific and clinical research applications that apply novel and innovative research ideas aimed at accelerating progress toward improved management of individuals affected with NF1, NF2 and schwannomatosis. Pre-Application Deadline: January 27, 2012 Application Deadline: April 2, 2012 Advancing Health Services through System Modeling Research NSF, in collaboration with the Health Information Technology (IT) Portfolio at the Agency for Healthcare Research and Quality (AHRQ), will accept and review investigator-initiated proposals that address systems modeling in health services research. The Service Enterprise Systems program in the Civil, Mechanical, and Manufacturing Innovation (CMMI) division of the Engineering Directorate will be the lead program on this interdisciplinary topic. Through this partnership, NSF and AHRQ look to foster new collaborations among health services researchers and industrial and systems engineers with a specific emphasis on the supportive role of health IT. Deadline: February 15, 2012 Leukemia & Lymphoma Society Translational Research Program The Leukemia & Lymphoma Society (LLS) funds new and innovative research that shows high promise for translating basic biomedical knowledge to clinical application. The Translational Research Program (TRP) puts you on the bench-to-bedside fast track when it comes to finding better treatment and cures for leukemia, lymphoma and myeloma. The goal of translational research is to reduce the time between laboratory findings and actual treatment. LOI Deadline: March 1, 2012 at 3 pm Full Application Deadline: March 15, 2012 at 3 pm	EVENTS All events are open to anyone interested in attending December 5 Skeletal Research Center Nora G. Singer, MD Professor, Medicine and Pediatrics, Div. of Rheumatology CWRU/MetroHealth Topic:** MSCs as Future Therapy for Inflammatory Arthritis 4 pm Millis 123 December 6 Skeletal Research Center Ira M. Herman, PhD Professor, Molecular Physiology & Pharmacology Tufts University Topic: Pericyte-Endothelial Interactions and Microvascular Dysfunction: Insights into the Angiogenic Switch 9:30 am Millis 123 Cancer Biology Special Seminar Raphael Kopan, PhD Professor, Molecular Biology & Pharmacology and Medicine- Dermatology Washington University Topic: Notch as a Tumor Suppressor 11 am NC1-202 Cleveland Clinic December 7 Hematology and Oncology Division Research Conference Sanford Markowitz, MD Professor, Medicine- Hem/Onc CWRU/UH Topic: GI SPORE – Translational Research Topics in GI Cancers 8 am Lerner Tower B-151 Immunology Invited Speaker Seminar Series Gregg J. Silverman, MD Professor, Medicine and Pathology Co-Director of the Musculoskeletal Center of Excellence New York University Topic: Natural Antibody Regulation of Innate Immune Responses 12 pm NC1-202 Cleveland Clinic December 8 Hematology and Oncology Research Conference Special Presentation Marcos de Lima, MD Professor, Stem Cell Transplantation and Cellular Therapy- Cancer Medicine University of Texas MD Anderson Cancer Center Topic: Allogeneic Transplantation for Myeloid Leukemias 8 am Lerner B-151 December 9 Cancer Center Research in Progress Seminar canceled Hematology/Oncology Fellows Conference canceled Taussig Cancer Institute Grand Rounds canceled Cancer Center Seminar Series Mark W. Jackson, PhD Assistant Professor, Pathology CWRU Topic: Defining Novel Tumor Suppressor-Oncogene Interactions in Mammary Cell Transformation 12 pm BRB 105 Case CCC Calendar LRI Calendar UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS ADDITIONAL UPCOMING SEMINARS & EVENTS Office of Cancer Centers Learning Series Webinar: Opportunity for CTSU Support for Collaborative Multi-Center Phase 2 Trials Led by NCI-Designated Cancer Centers and SPOREs December 5 2-3:30 pm Registration
NCI CANCER BULLETIN November 29, 2011 News Featured Article: Researchers Uncover New Mechanism of Resistance to Melanoma Drug Survey of Oncologists Suggests Lack of Progress in Cancer Pain Management Trial Confirms Efficacy of HPV Vaccine, Shows Cross-Protection Genetic Study Yields Clues to Neuroendocrine Prostate Cancer Commentary A Conversation with Dr. Mason Bond on Improving the Treatment of Patients with Ewing Sarcoma In Depth Study Raises Concerns about Using Cancer Cell Lines to Test Drug Resistance Unexpected Complications: Treating Cancer during Pregnancy Interpreting Risk: Direct-to-Consumer Genetic Testing Featured Clinical Trial: Novel Combination Chemotherapy for Localized Ewing Sarcoma Updates FDA Update Notes


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES
American Medical Association Seed Grant Research Program Deadline: December 5 NIH Director's Early Independence Awards Internal Deadline: December 5 External Deadline: December 30 2012 NIH Director's Transformative Research Awards LOI Deadline: December 12 Application Deadline: January 12, 2012 L'Oréal USA Fellowships For Women In Science Deadline: December 15 Beez Foundation Deadline: January 10, 2012 Lymphatic Research Foundation (LRF) Postdoctoral Fellowship Program Deadline: January 10, 2012 HHMI Medical Research Fellows Program Deadline: January 11, 2012 2012 CTSC Annual Pilot Grant Funding Mandatory LOI Deadline: January 15, 2012 Oncology Nursing Society Foundation Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award Deadline: January 15, 2012 Fight Colorectal Cancer-AACR Career Development Award, in memory of Lisa Dubow Deadline: January 17, 2012 Robert Wood Johnson Foundation Executive Nurse Fellows Deadline: January 18, 2012	2012 Lasker Awards Deadline: February 1, 2012 Innovations for Health: Solutions that Cross Borders Deadline: February 13, 2012 Robert Wood Johnson Foundation Clinical Scholars Program Deadline: February 29, 2012 James S. McDonnell Foundation 21st Century Research Awards Deadline: March 14, 2012 Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC) Deadline: Open AACR Scholar-in-Training Awards - Other Conferences and Meetings Deadline: Open Case CCC Protocol Specific Research Support (PSRS) Deadline: Open International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships Application Deadline: Open International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program Application Deadline: Open NCI Short-Term Scientist Exchange Program Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities Cancer Education Grants Program (R25)(PAR-12-049) UPDATE to American Reinvestment and Recovery Act (ARRA): AHRQ Grant Policy Notice Removing Expanded Authorities and No Cost Extensions for AHRQ ARRA Grants (NOT-HS-12-002) Research Centers in Primary Care Practice Based Research and Learning (P30)(RFA-HS-12-002) Small Grants Program for Cancer Epidemiology (R03)(PAR-12-039) Frequently Asked Questions for RFA-MH-12-130 - OppNet's Basic Research on Decision Making: Cognitive, Affective, and Developmental Perspectives (R01) (NOT-OD-12-019) Administrative Supplements for U.S. - China Biomedical Collaborative Research on Cancer, Mental Health, Allergy, Immunology, and Infectious Diseases including HIV/AIDS and its Co-morbidities (NOT-CA-12-002) Notice of Correction of Award Budget for PAR-12-010, NIH Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (R01) (NOT-CA-12-005) Limited Competition - Women's Interagency HIV Study (WIHS-V) (U01) (RFA-AI-12-002)
Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216-844-8317 phone 216-844-7832 fax gillian.irwin@case.edu	HELP US HELP YOU! If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu.