November 28, 2011

CASE CCC IN THE NEWS

Explore Your Health Roots at the Holidays With a Family Health Tree
Plain Dealer - Nov 21, 2011
Dr. Charis Eng, chair of the Cleveland Clinic's Genomic Medicine Institute, knows that having such family discussions isn't always easy. ...

MARK YOUR CALENDARS

Cancer Center Seminar Series: Nanoparticle-Mediated p53 Gene Delivery for Cancer Therapy

Friday, December 2
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, December 2 at the next Cancer Center Seminar Series featuring Vinod Labhasetwar, PhD. Dr. Labhasetwar, Professor of Biomedical Engineering and Taussig Cancer Institute at CWRU/Cleveland Clinic, will present Modeling the Genesis and Progression of Human Melanoma in the Mouse.

Mutation of the p53 tumor suppressor gene is the most common genetic alteration in human cancers and results in more aggressive disease and increased resistance to conventional cancer therapies. In this presentation, Dr. Labhasetwar will describe the characteristics of biodegradable nanoparticles (NPs) as a sustained gene delivery system in cancer therapy. He will present data on the in vivo efficacy of p53 gene-loaded NPs (p53NPs) in prostate and breast cancer models. It was demonstrated that tumors treated with p53NPs show upregulation of thrombospondin-1, a potent antiangiogenic factor, and a decrease in microvessel density compared to controls (saline, p53 DNA alone, and control NPs). The mechanisms by which p53NPs inhibit tumor growth are disruption of tumor angiogenesis, apoptosis of cancer cells, and inhibition of the progression of tumor metastasis. It was also shown that p53NPs sensitize cancer cells with p53 mutation to cancer chemotherapeutic agents. The efficacy of NPs has been attributed to safe and sustained gene transfection. Dr. Labhasetwar laboratory’s recent investigations include biophysical interaction of NPs with cell membrane lipids and understanding how these interactions influence cellular uptake of NPs, their pharmacokinetics of biodistribution and tumor localization. A summary of these studies will be presented.

Laser Capture Microdissection Service Replacement System Demonstrations

Molecular Machines and Industries (MMI) will be on campus to demo their Laser Capture Microdissection (LCM) system November 29-December 1. This is the last opportunity to pick up LCM slides and have them prepped in time for next week's LCM demo. Patrick Leahy, Director of the Laser Capture Microdissection Service, has a few brand-specific frame slides for those wishing to try out the instrument on their own samples. The Leica LMD 6500 system will be demonstrated the week of December 5.

Please contact Patrick Leahy at (216)368-0761 or patrick.leahy@case.edu for more information.

Weekly Seminar Series on Applied Biostatistics in Clinical Research

Registration is now open for the Weekly Seminar Series on Applied Biostatistics in Clinical Research. The course will be held Wednesdays, January 1-March 7, 2012 from 4-5:30 pm in SOM E301.

The course is targeted to faculty, fellows, and others involved in clinical research at CWRU and its affiliated hospitals, and is meant to provide an introductory overview. Emphasis is non-mathematical, focusing on understanding what methods to use in what situations, and on how to interpret the results. It is not a credited course, and there will not be a formal examination. Individuals are welcome to attend some or all lectures, depending on their particular interest. There is no registration fee, and handouts of slides will be provided.

Please contact course instructor Dr. Mark Schluchter with any questions.

FUNDING OPPORTUNITIES

AACI Translational Cancer Research Fellowship

The Case CCC is accepting nominations for the AACI Translational Cancer Research Fellowship. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline. The AACI fellowship will provide a one-year non-renewable grant to support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution.

Interested candidates should forward a letter of support from their mentor and their biosketch to Gillian Todd by Monday, December 12. We may nominate ONE candidate from CWRU/UH, and ONE from the Cleveland Clinic.

Internal Deadline: December 12
External Deadline: February 1, 2012

Damon Runyon Clinical Investigator Award

The Case CCC is accepting nominations for the Damon Runyon Clinical Investigator Award, which supports young physician-scientists conducting patient-oriented cancer research. The goal is to increase the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments. The Clinical Investigator Award program is specifically intended to provide outstanding young physicians with the resources and training structure essential to becoming successful clinical investigators.

Interested candidates should forward a one-page letter of intent of proposal and their biosketch to Gillian Todd by Wednesday, December 14.

Internal Deadline: December 14
External Deadline: February 12, 2012

Fight Colorectal Cancer-AACR Career Development Award, in memory of Lisa Dubow

The Fight Colorectal Cancer-AACR Career Development Award, in memory of Lisa Dubow is open to junior faculty who are in the first 4 years of a faculty appointment at the start of the grant term on July 1, 2012. Research projects are restricted to translational or clinical cancer research that has an ultimate goal of developing or improving therapeutic interventions for patients with metastatic colorectal cancer.

Deadline: January 17, 2012

ANNOUNCEMENTS

Take the Clinical Research Education Needs Assessment Survey

In support of the Clinical and Translational Science Collaborative's (CTSC) goal of strengthening the training and career pathways for all clinical and translational research team members, a survey has been developed. We invite you to take the survey, which will help to assess interest in a certificate program in clinical research fundamentals that would demonstrate standard competency among our partner institutions. Your responses will be anonymous; please be candid. Results will help CTSC's leadership identify and respond to the educational needs of the research community. If you have not done so already, please complete the survey.

EVENTS

**All events are open to anyone interested in attending

November 28

Pathology Research Seminar Series
Zhenghe John Wang, PhD
Assistant Professor, Genetics
CWRU
Topic: TBD
12 pm WRB 1-413

Physiology and Biophysics Seminar
Martin Young, DPhil
Associate Professor, Medicine- Cardiovascular Diseases
University of Alabama at Birmingham
Topic: Timing is Everything- Emerging Roles for the Cardiomyocyte Circadian Clock
4 pm SOM E501

Skeletal Research Center
Vincent Hascall, PhD
Staff, Biomedical Engineering
Cleveland Clinic
Topic: Bone Marrow Stromal Cells That Divide in Hyperglycemic Medium Initiate Hyaluronan Synthesis in Intracellular Compartments and Undergo Pathological Adipogenesis
4 pm Millis 123

November 29

Cancer Biology Staff Candidate Seminar
Roya Khosravi-Far, PhD
Associate Professor, Pathology
Harvard University
Topic: Mechanisms of Malignant Progression and Challenges in Therapy
11 am NC1-202 Cleveland Clinic

November 30

Hematology and Oncology Division Research Conference
Clark Distelhorst, MD
Professor, Medicine- Hem/Onc
CWRU/UH
Topic: CLL Research
8 am Lerner Tower B-151

Center for AIDS Research
David Metzger, PhD
Research Professor, Social Policy in Psychiatry
University of Pennsylvania
Topic: Drug Treatment as HIV Prevention: Integrating Behavioral and Biological Methods
10 am SOM W203

Immunology Research in Progress Seminar Series
Caini Liu, PhD
Research Associate, Immunology
Cleveland Clinic
Topic: Act1 at the Crossroads of IL-17 Receptor Signaling
12 pm NC1-202 Cleveland Clinic

December 1

December 2

Hematology/Oncology Fellows Conference
Greg Manson, MD
Fellow, Div. of Hematology/Oncology
CWRU/UH
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds Topic: TBD
8 am R3/002-003 Cleveland Clinic

Affymetrix Seminar
Topic: Synergies of Next Gen Sequencing and Microarrays: Understanding When to Use Each Technology to Get the Most From Your Study
10 am WRB 1-413
To register, contact Bill Warble, Affymetrix Account Manager, (412) 651-0112

Cancer Center Seminar Series
Vinod Labhasetwar, PhD
Professor, Biomedical Engineering and Taussig Cancer Institute
CWRU/Cleveland Clinic
Topic: Nanoparticle-Mediated p53 Gene Delivery for Cancer Therapy
12 pm BRB 105

Cancer Center Research in Progress Seminar
David Wald, MD, PhD
Assistant Professor, Pathology
CWRU/UH
Topic: Targeting GSK3 in AML
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar

UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Affymetrix Seminar
Synergies of Next Gen Sequencing and Microarrays: Understanding when to use each technology to get the most from your study
December 2
10 am - 12 pm WRB 1-413
To register, contact Bill Warble, Affymetrix Account Manager, (412)651-0112
*Hosted by the Gene Expression and Genotyping Core Facility

ADDITIONAL UPCOMING SEMINARS & EVENTS

Office of Cancer Centers Learning Series Webinar: Opportunity for CTSU Support for Collaborative Multi-Center Phase 2 Trials Led by NCI-Designated Cancer Centers and SPOREs
December 5
2-3:30 pm
Registration

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Robert Wood Johnson Foundation Community Health Leaders
Deadline: November 28

SU2C-PCF Prostate Dream Team Translational Cancer Research Grant
LOI Deadline: November 28

Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant
Extended Deadline: November 29

Burroughs Wellcome Fund Collaborative Research Travel Grants
Deadline: December 1

CTSC Core Utilization pilot program
Deadline: December 1

Kimmel Scholar Award
Deadline: December 1

Kimmel Translational Science Award
Deadline: December 1

American Medical Association Seed Grant Research Program
Deadline: December 5

NIH Director's Early Independence Awards
Internal Deadline: December 5
External Deadline: December 30

2012 NIH Director's Transformative Research Awards
LOI Deadline: December 12
Application Deadline: January 12, 2012

L'Oréal USA Fellowships For Women In Science
Deadline: December 15

Beez Foundation
Deadline: January 10, 2012

Lymphatic Research Foundation (LRF) Postdoctoral Fellowship Program
Deadline: January 10, 2012

HHMI Medical Research Fellows Program
Deadline: January 11, 2012

2012 CTSC Annual Pilot Grant Funding
Mandatory LOI Deadline: January 15, 2012

Oncology Nursing Society Foundation Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award
Deadline: January 15, 2012

Robert Wood Johnson Foundation Executive Nurse Fellows
Deadline: January 18, 2012

2012 Lasker Awards
Deadline: February 1, 2012

Innovations for Health: Solutions that Cross Borders
Deadline: February 13, 2012

Robert Wood Johnson Foundation Clinical Scholars Program
Deadline: February 29, 2012

James S. McDonnell Foundation 21st Century Research Awards
Deadline: March 14, 2012

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

The NIH Operates Under a Continuing Resolution (NOT-OD-12-017)

Notice of Intent to Publish a Funding Opportunity Announcement for the NHLBI Centers for Accelerated Innovations (NOT-HL-11-157)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.