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Case Comprehensive Cancer Center Newsletter

November 21, 2011

gersonMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

Senators Sponsoring Resolution to Recognize the 40th Anniversary of the National Cancer Act of 1971: Show Your Support

Ohio Senator Sherrod Brown, along with Senators Jerry Moran (R-Kan.) and John Kerry (D-Mass.) are sponsoring a Congressional resolution recognizing the 40th anniversary of the National Cancer Act of 1971, reaffirming the national commitment to understanding and controlling cancer.

I ask that you relay your appreciation to Senator Brown's Office, and request you contact Senator Rob Portman to urge him to become a co-sponsor of this important resolution.


CASE CCC IN THE NEWS

FDA Revokes Approval of Avastin for Breast Cancer
Plain Dealer - Nov 18, 2011
Dr. Neal Meropol, chief of the division of hematology and oncology at UH Case Medical Center, said the decision was a difficult call, ... Dr. Joseph Baar, director of breast cancer research and the Breast Cancer Survivor Program at UH, is using Avastin in a Genentech-funded clinical trial to ...

Cleveland Clinic Expands West, Acquires Sandusky-based North Coast Cancer Care Inc.
Plain Dealer - Nov 16, 2011
Informal discussions about a possible merger started around a year ago, said Dr. Brian Bolwell, chairman of the Taussig Cancer Institute...

Melanin Research Creates a Skin Implant for Tanning
Daily Glow - Nov 15, 2011
Elma Baron, MD, a dermatologist at University Hospitals Care Medical Center in Cleveland, quoted at ABC News, said, "It's definitely novel. ...


MARK YOUR CALENDARS

Laser Capture Microdissection Service Replacement System Demonstrations

Molecular Machines and Industries (MMI) will be on campus to demo their Laser Capture Microdissection (LCM) system November 29-December 1. This is the last opportunity to pick up LCM slides and have them prepped in time for next week's LCM demo. Patrick Leahy, Director of the Laser Capture Microdissection Service, has a few brand-specific frame slides for those wishing to try out the instrument on their own samples. The Leica LMD 6500 system will be demonstrated the week of December 5.

Please contact Patrick Leahy at (216)368-0761 or patrick.leahy@case.edu for more information.

Weekly Seminar Series on Applied Biostatistics in Clinical Research

Registration is now open for the Weekly Seminar Series on Applied Biostatistics in Clinical Research. The course will be held Wednesdays, January 1-March 7, 2012 from 4-5:30 pm in SOM E301.

The course is targeted to faculty, fellows, and others involved in clinical research at CWRU and its affiliated hospitals, and is meant to provide an introductory overview. Emphasis is non-mathematical, focusing on understanding what methods to use in what situations, and on how to interpret the results. It is not a credited course, and there will not be a formal examination. Individuals are welcome to attend some or all lectures, depending on their particular interest. There is no registration fee, and handouts of slides will be provided.

Please contact course instructor Dr. Mark Schluchter with any questions.


FUNDING OPPORTUNITIES

NIH Director's Early Independence Award

The NIH Director's Early Independence Awards provide an opportunity for exceptional junior scientists, who have already established a record of innovation and research productivity, to have an accelerated entry into an independent research career. It is also an opportunity for research intensive institutions to invigorate their research departments by recruiting outstanding, early career scientists. Exceptional graduate students or clinicians nearing the completion of their PhD (or equivalent) or for clinicians (MD or equivalent) the end of their medical residency may contact appropriate Institutional scientific leaders to seek an appointment as an independent research scientist. Limit of TWO applications per institution.

Internal Deadline: December 5
External Deadline: December 30

Beez Foundation Proposals for Pediatric Brain Cancer Research, Education or Patient Services

The Beez Foundation is soliciting Proposals for Pediatric Brain Cancer Research, Education or Patient Services. The primary goal of the foundation is to annually identify and target key areas in the field of children's brain cancer research and patient services that are presently underfunded.

Grants are provided for:

  • Brain cancer research projects or studies that are designed to advance the treatment, cure, outcome, and etiology of pediatric brain cancer. The foundation's particular interest is in the initial funding of projects that are likely to generate data that can be used in larger-scale projects or studies.
  • Patient services that are focused on making the lives of children with cancer and their families a little easier, with emphasis on pediatric cancer-related requests.
  • Educational tools designed to raise the awareness of brain cancer and increase knowledge of patient treatment or options.

Deadline: January 10, 2012

Lasker Foundation

The Lasker Foundation is accepting nominations for the 2012 Lasker Awards:

  • The Albert Lasker Basic Medical Research Award honors scientists whose fundamental investigations have provided techniques, information, or concepts contributing to the elimination of major causes of disability and death.
  • The Lasker-DeBakey Clinical Medical Research Award honors investigators whose contributions have improved the clinical treatment of patients.
  • The Lasker-Koshland Special Achievement Award in Medical Science honors scientists whose contributions to research are of unique magnitude and have immeasurable influence on the course of science, health, or medicine, and whose professional careers have engendered within the biomedical community the deepest feelings of awe and respect.

Deadline: February 1, 2012

James S. McDonnell Foundation 21st Century Research Awards

James S. McDonnell Foundation 21st Century Research Awards are designed to support research projects with a high probability of generating new knowledge and insights. Projects submitted for funding consideration should be at an early, even preliminary stage of development, and should be intended to break new ground or to revisit commonly-held assumptions. Projects submitted should be sufficiently cross-disciplinary or heterodox to have a strong likelihood of influencing the development of new ways of thinking about important problems.

Deadline: March 14, 2012

Case CCC Clinical Trials Funding Opportunity

The Case CCC is announcing the availability of Protocol Specific Research Support (PSRS) funding for Year 2011. The budgeted funds are for the conduct of early phase clinical trial and restricted to support research nurses and data managers directly involved in the conduct of these clinical trials. Studies developed jointly between UH and CCF with planned accrual at both institutions will be prioritized. Please direct questions and requests for information about the funding process to Katarzyna Karelus, Administrative Director, Case CCC Clinical Research Office, at (216)844-4176 or katarzyna.karelus@case.edu.


ANNOUNCEMENTS

Duerk Named as Dean of Case School of Engineering
duerk

Dr. Jeffrey Duerk was recently named as dean of the Case School of Engineering, effective January 1, 2012. Since earning his doctorate in Biomedical Engineering from CWRU in 1987, Dr. Duerk has filled several leadership roles at CWRU and at the Cancer Center. He is currently the Chair of the Department of Biomedical Engineering.

Auletta Recognized by American Red Cross
auletta

Last week, Dr. Jeffery Auletta received a Hero award in the medical category from the Cleveland Chapter of the American Red Cross. Dr. Auletta was recognized as a "medical professional who extends his touch beyond exceptional treatment to help individuals in our community avoid or work through medical problems".

According to the "Strongsville Patch", Dr. Auletta also received the People's Choice award in the medical category by receiving over 1,500 votes, more than anyone in any category ever.

Updated Case CCC SOP Manual and Protocol Templates Now Available

The updated Case CCC Standard Operating Procedures (SOP) Manual and protocol templates are available on the Case CCC webpages for the Clinical Research Administrative Office and Clinical Trials Core Facility. Investigators are encouraged to use Case CCC protocol templates when developing investigator-initiated studies.

If you have any questions about the SOPs and/or protocol templates, please contact Katarzyna Karelus at katarzyna.karelus@case.edu.


NEWS FROM NIH

Independent Panel to Present Findings on Role of Active Surveillance in the Management of Localized Prostate Cancer

To better understand the benefits and risks of active surveillance and other observational management strategies for PSA-screening-detected, low-grade, localized prostate cancer, the NIH is convening a State-of-the-Science Conference, December 5-7, to assess the available scientific evidence. An impartial, independent panel will hold a press telebriefing after the conference to discuss their findings and implications for the public. The panel's statement will incorporate their assessment of the available evidence from a systematic literature review, expert presentations, and audience input to inform public and provider decisions regarding active surveillance and other observational management strategies for localized prostate.

Presentation and discussion of the panel's draft statement will be Wednesday, December 7 at 9 am and will be available via live webcast.

NCI Releases Workbook That Offers Strategies for Communicating Data to Lay Audiences

The NCI recently released a free guide to communicating data to lay audiences. Making Data Talk: A Workbook, can help present scientific and health data in engaging and effective ways. The workbook, based on the ground-breaking book "Making Data Talk: Communicating Public Health Data to the Public, Policy Makers, and the Press" written by NCI communication researchers, provides key information, practical suggestions, and examples that can be applied to many public health issues. The content provides recommendations about selecting and presenting data, including tips for using visual symbols, and introduces the OPT-IN (Organize, Plan, Test, Integrate) framework which guides public health practitioners on how to present health data to lay audiences. Many chapters also include practice exercises that use real-world examples to reinforce key concepts and help you apply what you have learned.

EVENTS

calendar

**All events are open to anyone interested in attending

November 21

Stem Cell Biology and Regenerative Medicine Seminar
Donna Hansel, MD, PhD
Associate Professor, Pathology and Laboratory Medicine
CWRU/Cleveland Clinic
Topic: mTORC2: Bladder Cancer on the Move
10 am NC1-202 Cleveland Clinic

SDIG Meeting
Ram Podicheti
Graduate Student, Informatics
Indiana University
Topic: Characterization and Analysis of Genetic Polymorphisms in Highthroughput Genomics
2:30 pm WRB 1-402

Physiology and Biophysics Seminar
Aurelio Galli, PhD
Associate Professor, Molecular Physiology and Biophysics
Vanderbilt University
Topic: How the Big GULP Cures the Fat Brain: Striatal Insulin Resistance and GLP-1 Signaling
4 pm Millis 123


November 22


November 23

Hematology and Oncology Division Research Conference canceled


November 24

Happy Thanksgiving!


November 25

Cancer Center Research in Progress Seminar canceled

Cancer Center Seminar Series canceled

Hematology/Oncology Fellows Conference canceled

Taussig Cancer Institute Grand Rounds canceled

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Affymetrix Seminar
Synergies of Next Gen Sequencing and Microarrays: Understanding when to use each technology to get the most from your study
December 2
10 am - 12 pm WRB 1-413
To register, contact Bill Warble, Affymetrix Account Manager, (412)651-0112
*Hosted by the Gene Expression and Genotyping Core Facility

ADDITIONAL UPCOMING SEMINARS & EVENTS

Office of Cancer Centers Learning Series Webinar: Opportunity for CTSU Support for Collaborative Multi-Center Phase 2 Trials Led by NCI-Designated Cancer Centers and SPOREs
December 5
2-3:30 pm
Registration


NCI CANCER BULLETIN

November 15, 2011- Special Issue: Obesity and Cancer Research

Commentary
Guest Commentary by Dr. Rachel Ballard-Barbash: The Emerging Evidence about the Role of Obesity in Cancer

Features
Uncovering the Mechanisms Linking Obesity and Cancer Risk
**Dr. Li Li is quoted discussing his TREC-supported research

Searching for Clues to Obesity among the Body's Many Microbes

Bridging Disciplines to Study Possible Cancer-Obesity Links

The Right Balance: Helping Cancer Survivors Achieve a Healthy Weight

Learn More: Additional Information and Resources

News Highlights
Protein May Regulate Hormone Sensitivity in Breast Cancer

Epigenetic Therapy Shows Potential in Advanced Lung Cancer

Treatment Uses Antibodies and Light to Target Cancer Cells

Genetic Mutation that Raises Melanoma Risk Identified

Updates
FDA Update

Notes

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Cellular Molecular Imaging of Cancer Pilot Funding: Cancer Microenvironment
Deadline Extended: November 22

Robert Wood Johnson Foundation Community Health Leaders
Deadline: November 28

SU2C-PCF Prostate Dream Team Translational Cancer Research Grant
LOI Deadline: November 28

Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant
Extended Deadline: November 29

Burroughs Wellcome Fund Collaborative Research Travel Grants
Deadline: December 1

CTSC Core Utilization pilot program
Deadline: December 1

Kimmel Scholar Award
Deadline: December 1

Kimmel Translational Science Award
Deadline: December 1

American Medical Association Seed Grant Research Program
Deadline: December 5

2012 NIH Director's Transformative Research Awards
LOI Deadline: December 12
Application Deadline: January 12, 2012

L'Oréal USA Fellowships For Women In Science
Deadline: December 15

Lymphatic Research Foundation (LRF) Postdoctoral Fellowship Program
Deadline: January 10, 2012

HHMI Medical Research Fellows Program
Deadline: January 11, 2012

2012 CTSC Annual Pilot Grant Funding
Mandatory LOI Deadline: January 15, 2012

Oncology Nursing Society Foundation Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award
Deadline: January 15, 2012

Robert Wood Johnson Foundation Executive Nurse Fellows
Deadline: January 18, 2012

Innovations for Health: Solutions that Cross Borders
Deadline: February 13, 2012

Robert Wood Johnson Foundation Clinical Scholars Program
Deadline: February 29, 2012

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

NIH Director's Early Independence Awards (DP5)(RFA-RM-11-007)

Validation of Molecular Diagnostics to Predict Patient Outcomes Using Specimens from Multi-Site Cancer Trials (R21) (PA-12-014)

Validation of Molecular Diagnostics to Predict Patient Outcomes Using Specimens from Multi-Site Cancer Trials (R01) PA-12-013

NIH Announces FCOI Webinar: What NIH Grantees Need to Know about the 2011 Revised Financial Conflict of Interest Regulation (NOT-OD-12-012)

Lasker Clinical Research Scholars Program (Si2) (RFA-OD-12-001)

Practical Interventions to Improve Medication Adherence in Primary Care (R01) (PA-12-022)

Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01) (PA-12-024)

Shared Instrumentation Grant Program (S10) (PAR-12-017)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.