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Case Comprehensive Cancer Center Newsletter

May 23, 2011


Experts Discuss Emerging Treatments and Multi-Disciplinary Approaches to Prostate Cancer Care
Sacramento Bee - May 20, 2011
"The development of stereotactic radiosurgery capabilities has opened up new possibilities for the non-invasive treatment of kidney and prostate cancer," said Lee E. Ponsky, MD, director of the Center for Urologic Oncology and Minimally Invasive ...

Seidman Cancer Center to Offer Cutting Edge Technology
Cleveland News - Fox 8 - May 17, 2011
"Proton technology is a remarkable type of new radiation technology that will impact the way we treat patients with radiation," said Dr. Nathan Levitan, president of the Seidman Cancer Center...."This is heavier particle that delivers all of its energy wherever we tell it to, and the computers simulate it to do so," said Dr. Stan Gerson, director of the Seidman Cancer Center. "And so much greater percentage of the energy goes directly into the ...

University Hospitals Plans $30 Million Proton Therapy Center
Plain Dealer - May 17, 2011
About half of all cancer patients receive radiation as part of their treatment, said Dr. Mitch Machtay, chairman of radiation oncology at UH Case Medical Center and Case Western Reserve University School of Medicine. Proton therapy isn't the automatic ...


Cancer Center Seminar Series: Personalized Medicine in Clinical Trials

Friday, May 27
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, May 27 at the next Cancer Center Seminar Series featuring Donald A. Berry, PhD, Head of Division of Quantitative Sciences and Professor and Chair of Biostatistics- Quantitative Sciences at the University of Texas MD Anderson Cancer Center. Dr. Berry will present Personalized Medicine in Clinical Trials.

Donald Berry is a research professor in the Department of Biostatistics of the University of Texas MD Anderson Cancer Center. He was founding Chair of this department in 1999. Since 1990, he has served as a faculty statistician on the Breast Cancer Committee of the Cancer and Leukemia Group B (CALGB), a national oncology group. In this role, he has designed and supervised the conduct of many large U.S. intergroup trials. Through Berry Consultants, LLC he has consulted with many pharmaceutical and medical device companies on clinical trial design and analysis issues. He is well known as a developer of Bayesian adaptive designs that minimize sample size while increasing the likelihood of detecting drug activity, efficiently using information that accrues over the course of the trial. Since 1999, the Department of Biostatistics has designed over 300 clinical trials that take a Bayesian approach. He is co-developer (with Giovanni Parmigiani) of BRCAPRO, a widely used program that provides individuals' probabilities of carrying mutations of breast/ovarian cancer susceptibility genes BRCA1 and BRCA2.

Dr. Berry received his PhD in statistics from Yale University, and previously served on the faculty at the University of Minnesota and Duke University. He has held endowed positions at Duke University and MD Anderson. Dr. Berry is the author of several books on biostatistics and over 300 published articles, including first-authored articles in the New England Journal of Medicine, Journal of the American Medical Association, and Nature. Dr. Berry has been the principal investigator for numerous research grants from the National Institutes of Health and the National Science Foundation. He is a Fellow of the American Statistical Association and of the Institute of Mathematical Statistics.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


Pilot Project Grants: American Cancer Society IRG Awards

The Case CCC is currently accepting applications for American Cancer Society Institutional Research Grant (IRG) awards. Pilot funding is available for projects in basic, clinical, prevention and control, behavioral, health services, and epidemiology cancer research with awards up to $30,000 for one-year cancer research projects that provide the basis for future independent grants.

Instructions, frequently asked questions, and application forms are available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration (844-7252, tld6@case.edu) for more information.

LOI Deadline: June 13
Application Deadline: July 5, 2011

AACR Research Grant Funding

The AACR is accepting applications for the following opportunities:

Breast Cancer Research Foundation-AACR Grants for Translational Breast Cancer Research
These two-year Grants will provide up to $150,000 over the grant term ($75,000 per year) for innovative cancer research projects designed to accelerate the discovery, development, and application of new agents to treat breast cancer and/or for pre-clinical research with direct therapeutic intent.
LOI Deadline: June 13

AACR-Aflac, Inc. Career Development Award for Pediatric Cancer Research
This two-year grant of $100,000 ($50,000 per year) is open to junior faculty who are in the first 4-years of a faculty appointment (at the start of the grant term). The research proposed for funding may be basic, translational, clinical or epidemiological in nature and must have direct applicability and relevance to pediatric cancer.
Application Deadline: June 20

Case CCC Clinical Trials Funding Opportunity

The Case Comprehensive Cancer Center is announcing the availability of Protocol Specific Research Support (PSRS) funding for Year 2011. The budgeted funds are for the conduct of early phase clinical trial and restricted to support research nurses and data managers directly involved in the conduct of these clinical trials. Studies developed jointly between UH and CCF with planned accrual at both institutions will be prioritized. Please direct questions and requests for information about the funding process to Katarzyna Karelus, Administrative Director, Case Comprehensive Cancer Center Clinical Research Office, at (216) 368-6287 or katarzyna.karelus@case.edu.


PNAS Publication

Cancer Center Members Drs. David Danielpour and Mark Jackson along with Rocky Cipriano, Charlene Kan, James Graham, and Martha Stampfer, co-authored the publication TGF-β signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells, which was published in the May 17 issue of "PNAS". This paper was edited by Dr. George Stark.

ASCO Annual Meeting

The Cancer Center is attempting to track members who are part of the formal program or presenting a poster at the ASCO Annual Meeting, June 3-7 in Chicago. Please send information to gillian.irwin@case.edu.


May 17, 2011

Featured Article: Chemotherapy Regimen Extends Survival in Advanced Pancreatic Cancer Patients

Study Finds Colonoscopy Screening Overused in Medicare Beneficiaries

Prostate Cancer Study Provides More Data on Surgery versus Watchful Waiting

Breast Cancers Arising between Mammograms Have Aggressive Features

Patient Reports of Family Cancer History Are Often Inaccurate

In Depth
In Rare Skin Cancer, Virus Emerges as Target and Tool

Straight from the Source: Electronic Patient-Reported Outcomes

Combining Targeted Cancer Therapies: Much Promise, Many Hurdles

Featured Clinical Trial: Lenalidomide and Radiation for Children with Brain Cancers

FDA Update

Legislative Update




**All events are open to anyone interested in attending

May 23

May 24

Center for Global Health and Diseases Special Seminar
Deborah Lehmann, MBBS, MSc
Senior Researcher
Telethon Institute for Child Health Research
Topic: Pneumococcal Vaccine Trials in Papua New Guinea
9:45 am WRB 4-136

Cancer Biology Invited Speaker Seminar
Jan Van Deursen, PhD
Professor, Pediatrics and Adolescent Medicine, and Biochemistry
Mayo Clinic
Topic: Mitotic Checkpoint Control in Cancer and Aging
11 am NC1-202 Cleveland Clinic

Center for Global Health and Diseases Special Seminar
Michael Alpers, MD
Professor, International Health
Curtin University of Technology of Western Australia
Topic: Kuru: Clinical and Aetiological Aspects
11 am WRB 4-136

May 25

Hematology and Oncology Division Research Conference
Lili Liu, PhD
Associate Professor, Medicine-Hem/Onc
Topic: Impact of Uracil-DNA Glycosylase on Cytotoxicity of Pemetrexed: Identifying a Potential Target for New Drug Development

Immunology Invited Speaker Seminar Series
Christopher King, MD
Professor, International Health, Medicine and Pathology
Center for Global Health and Disease
Topic: Natural Acquired Immunity to Malaria
12 pm NC1-202 Cleveland Clinic

School of Dental Medicine Seminar
Maura Gillison, MD, PhD
Professor, Medicine, Epidemiology and Otolaryngology
Chair of Cancer Research, Div. of Medical Oncology
Ohio State University
Topic: Oral HPV Infection and Disease in Immunocompetent and Immunosupressed Populations
12 pm SOM W203

Cancer Imaging Program (CIP) Meeting: Cancer Imaging at the Cleveland Clinic
Steve Huang, MD, PhD
Assistant Professor, Nuclear Medicine
CWRU/ Cleveland Clinic
Topic: Developing PSMA Targeting Tracers
Gordon McLennan, MD
Staff Physician, Diagnostic Radiology
Cleveland Clinic
Topic: Local Delivery of NAD Analogs for Treatment of Cancer
Shyam Srinivas, MD, PhD
Vice Chair, Nuclear Medicine
Cleveland Clinic
Topic: New Applications for PET Imaging in Cancer- It's Not Just FDG Anymore
2 pm Wearn B37

May 26

Stem Cell Biology and Regenerative Medicine Seminar
Guoqiang Gu, PhD
Associate Professor, Cell and Developmental Biology
Vanderbilt Medical Center
Topic: Ngn3 Directs Islet Cell Production by Regulating Both Positive and Negative Regulators
1 pm NE1-205 Cleveland Clinic

May 27

Taussig Cancer Institute Grand Rounds canceled

Hematology/Oncology Fellows canceled

Cancer Center Seminar Series
Donald A. Berry, PhD
Head, Division of Quantitative Sciences
Professor and Chair, Biostatistics- Quantitative Sciences
University of Texas MD Anderson Cancer Center
Topic: Personalized Medicine in Clinical Trials
12 pm BRB 105

Immunology Seminar
Sulie Chang, PhD
Professor, Biological Studies
Director, Institute of NeuroImunne Pharmacology
Seton Hall University
Topic: Morphine Modulation of the Neuroimmune Circuit
12 pm NC1-202 Cleveland Clinic

Cancer Center Research in Progress Seminar
Snehal Dabir, MD, PhD
Postdoctoral Scholar, Dowlati Lab, Div. of Hem/Onc
Topic: PIAS3- Potential Role in Mesothelioma and Interaction with p53
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


ASCO Review 2011
June 30
InterContinental Hotel and Bank of America Conference Center

Case CCC Annual Scientific Retreat
July 8-9
Details to follow


Race for the Place
June 5
Beachwood Place Mall

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland

8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland


Robert Wood Johnson Foundation Public Health Services and Systems Research Grant
Proposal Deadline: May 24

STERIS Corporation Infectious Diseases Research Support Grant
Application Deadline: May 27
Contact Martha Salata at mks18@case.edu for more information.

DOD CDMRP Breast Cancer Research Program Idea Award
Pre-Application Deadline: May 31
Application (Invited) Deadline: August 25

DOD CDMRP Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 31
Application (Invited) Deadline: August 25

Damon Runyon-Rachleff Innovation Award
Pre-Proposals Deadline: June 1
Full Proposal Deadline: September 2

DOD CDMRP Prostate Cancer Research Program Idea Development Award
Pre-Application Deadline: June 2
Application Deadline: August 23

DOD CDMRP Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application Deadline: June 2
Application Deadline: August 23

DOD CDMRP Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Breast Cancer Research Program Innovator Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Breast Cancer Research Program Era of Hope Scholar Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Ovarian Cancer Research Program Translational Pilot Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Ovarian Cancer Research Program Translational Leverage Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Prostate Cancer Research Program Clinical Trial Award
Pre-Application (Preproposal) Deadline: June 10
Application Deadline: September 1

Society of Surgical Oncology Clinical Investigator Award in Breast Cancer Research
Deadline: July 8

DOD CDMRP Prostate Cancer Research Program Impact Award
Pre-Application Deadline: June 10
Application Deadline: September 1

DOD CDMRP Prostate Cancer Research Program Laboratory - Clinical Transition Award (Modified)
Pre-Application Deadline: June 10
Application Deadline: September 1

James S. McDonnell Foundation 21st Century Science Initiative 2011
Deadline: July 15

International Myeloma Foundation Brian D. Novis Research Grant program
Deadline: August 1

Mesothelioma Applied Research Foundation
Deadline: August 5

Damon Runyon Fellowship Award
Application Deadline: August 15

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Clarification of NIH Fiscal Policy for Grant Awards FY 2011 (NOT-OD-11-077) National Institutes of Health

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.