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Case Comprehensive Cancer Center Newsletter

May 16, 2011

CASE CCC IN THE NEWS

Smarter Treatment for Killer Infections
Newswise - May 13, 2011
"Currently, our therapies for sepsis are very limited," said Mukesh K. Jain, MD, Ellery Sedgwick Jr. Chair, director of the Case Cardiovascular Research ...

CWRU Researchers Call for Changing How Research is Done
PR Newswire - May 11, 2011
In a commentary for Science Translational Medicine, Ann S. Williams and Shirley M. Moore from the nursing school ask researchers to rethink participation ...

First-of-its-Kind Phase 2 Study Shows Oral Therapy is Viable Treatment Option
HealthCanal.com - May 10, 2011
A nationwide, multi-institutional research team, led by Mikkael Sekeres, MD, Director of the Leukemia Program at Cleveland Clinic's Taussig Cancer Institute ...


MARK YOUR CALENDARS

Cancer Center Seminar Series: The Ohio Brain Tumor Study: How to do BIG science in a RARE cancer
barnholtz-sloan

Friday, May 20
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, May 20 at the next Cancer Center Seminar Series featuring Jill Barnholtz-Sloan, PhD. Dr. Barnholtz-Sloan, Assistant Professor of General Medical Sciences- Oncology, will present The Ohio Brain Tumor Study: How to do BIG science in a RARE cancer.

Dr. Jill Barnholtz-Sloan has been at the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine since February 2007, with joint appointments in the Department of Epidemiology and Biostatistics and the Center for Proteomics and Bioinformatics. Dr. Barnholtz-Sloan is multi-disciplinary trained in biostatistics, population genetics and human genetics, and the main thrust of her research is in cancer genetic epidemiology and statistical estimation of genetic ancestry for studying racial/ethnic differences in cancer development and clinical outcomes. While the major focus of her independent research program is in brain tumors, she is also involved in funded studies of ovarian, breast, prostate and colon cancers.

Dr. Barnholtz-Sloan has successfully established a multi-center network within Ohio, the Ohio Brain Tumor Study (OBTS), to accrue newly diagnosed brain tumor patients and obtain biospecimens, correlative clinical information and active follow-up. Because of the success of this state-wide network, she was recently awarded a multi-site The Cancer Genome Atlas (TCGA) contract as PI, for OBTS to be one of the TCGA Networks of Tissue Source Sites. In addition, her team has recently been awarded local pilot funds to study methylation and proteomics in brain tumors. She is PI of subcontracts to CWRU for three different multi-center NCI funded studies of gliomas and ovarian cancer. Additionally, in 2009 she was elected Co-Vice President (US) of the Brain Tumor Epidemiology Consortium (BTEC) and will become the co-President (US) in 2012, and is the current President-Elect for the CWRU School of Medicine Faculty Council.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


FUNDING OPPORTUNITIES

Pilot Project Grants: American Cancer Society IRG Awards

The Case CCC is currently accepting applications for American Cancer Society Institutional Research Grant (IRG) awards. Pilot funding is available for projects in basic, clinical, prevention and control, behavioral, health services, and epidemiology cancer research with awards up to $30,000 for one-year cancer research projects that provide the basis for future independent grants.

Instructions, frequently asked questions, and application forms are available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration (844-7252, tld6@case.edu) for more information.

LOI Deadline: June 13
Application Deadline: July 5, 2011

Society of Surgical Oncology Clinical Investigator Award in Breast Cancer Research

The Society of Surgical Oncology (SSO) has released a call for applications for the Clinical Investigator Award in Breast Cancer Research funded by Susan G. Komen for the Cure®. The purpose of this award is to promote patient-oriented breast cancer research conducted by surgical oncologists in clinical and translational science. Applicants must be surgical oncologists within 10 years of completion of training and be full SSO members.

Deadline: July 8

International Myeloma Foundation Brian D. Novis Research Grant Program

The International Myeloma Foundation (IMF) is accepting applications from both junior and senior investigators for the Brian D. Novis Research Grant program. This program supports investigators conducting cutting-edge studies to provide better treatment, management, prevention, and ultimately, a cure for myeloma.

Deadline: August 1

Mesothelioma Research Grants

The Mesothelioma Applied Research Foundation announces the availability of its 2011 round of mesothelioma research grant funding. Continuing its efforts to stimulate translational research for the treatment of malignant mesothelioma, the Meso Foundation is again soliciting applications for funding of innovative projects that address issues for the treatment of the disease. Eligible projects may relate to benchwork, translational or clinical research and may be conducted through any not-for-profit academic, medical or research institution, in the U.S. or abroad.

Deadline: August 5

Case CCC Clinical Trials Funding Opportunity

The Case Comprehensive Cancer Center is announcing the availability of Protocol Specific Research Support (PSRS) funding for Year 2011. The budgeted funds are for the conduct of early phase clinical trial and restricted to support research nurses and data managers directly involved in the conduct of these clinical trials. Studies developed jointly between UH and CCF with planned accrual at both institutions will be prioritized. Please direct questions and requests for information about the funding process to Katarzyna Karelus, Administrative Director, Case Comprehensive Cancer Center Clinical Research Office, at (216) 368-6287 or katarzyna.karelus@case.edu.


ANNOUNCEMENTS

AACR: 2011 Joint Hill Day Summary and Highlights

Message from AACR

Last Wednesday we hosted, along with the Association of American Cancer Institutes, the American Society of Clinical Oncology and the Friends of Cancer Research, a Hill Day in which 80 scientists and cancer center leaders from across the country participated.

In total, nearly 150 meetings with representatives and senators from 32 states were held and the primary message was to support sustained, and ideally increased, funding for the National Institutes of Health (NIH). Leaders from all 4 organizations also had the opportunity to meet with key House and Senate leadership offices, and FDA appropriations were discussed with some offices. Other issues that came up in some meetings were cancer drug shortages and concerns about the scientific workforce.

We are still collecting meeting feedback forms, but in general, attendees reported that members of Congress and their staff were receptive to the message about the importance of NIH funding and cancer research; however, many – especially Republican offices – were noncommittal about funding increases for the agency, and some were candid about their support for flat funding at best.

We were pleased to host Erik Fatemi, Majority Clerk for the Senate Appropriations Subcommittee on Labor-Health and Human Services-Education, who spoke to attendees at Wednesday's breakfast. Erik reviewed the recent completion of the FY 2011 appropriations process and briefly discussed where things stand with respect to FY 2012. He pointed out that when inflation is accounted for, the recent $320 million cut to NIH is closer to a $1.3 billion cut. He spoke with great candor about the difficulty and uncertainty facing Congress with respect to the current budget discussion for FY 2012. Between the House budget resolution and several parallel efforts in the Senate, "no one knows where this is going to end up." He noted that given the pressure to address the debt limit and insistence by many on focusing the bulk of cuts on non-security, discretionary spending, he could not envision a scenario where NIH does not take some kind of cut, especially because it is a $30 billion line item (more than the entire budget of the Labor Department, for example). He did, however, emphasize that NIH continues to enjoy strong bipartisan support and that "no one wants to cut NIH." He pointed out that with limited funds, even popular programs and agencies are going to be hurt and are pitted against one another for funds.

Erik encouraged attendees to focus messages on NIH' s benefit to state and local economies, job creation potential, and importance to America's global competitiveness. He also encouraged members to focus on communicating with Members of Congress back in the home district at town halls, and through venues other than just on Capitol Hill. Lastly, he encouraged members to think in terms of the larger budget picture – not just that of NIH. In his opinion, what will truly help the NIH budget this year is a larger overall domestic discretionary budget, so that key programs are not competing against each other for such limited dollars.

The four organizations presented the 2011 Cancer Research Advocacy Award to Rep. Ed Markey (D-MA), for his steadfast support for NIH over many years in Congress. In recent years, Rep. Markey has spearheaded a Dear Colleague letter to House appropriators urging support for the agency. Unfortunately, Rep. Markey was unable to attend our reception at the last minute due to votes on the House floor coupled with a last minute Committee markup.

ASCO Annual Meeting

The Cancer Center is attempting to track members who are part of the formal program or presenting a poster at the ASCO Annual Meeting, June 3-7 in Chicago. Please send information to gillian.irwin@case.edu.

EVENTS

calendar

**All events are open to anyone interested in attending

May 16

Department of Medicine Research Day
12 -5 pm Wolstein Auditorium and Lobby

Physiology and Biophysics Seminar
Sichun Yang, PhD
Assistant Professor, Center for Proteomics and Pharmacology
CWRU
Topic: Integrative Approaches into Multidomain Protein Assemblies
4 pm SOM E501


May 17

Cancer Biology Fellow Seminar
Arindam Chakrabarti, PhD
Research Fellow, Silverman Lab
Cleveland Clinic
Topic: Involvement of Autophagy in the Antiviral Effect Mediated by the OAS/RNase L Pathway
11 am NC1-202 Cleveland Clinic

Eckel Lecture
Detlef Schlondorff, MD
Professor, Medicine- Nephrology
Mount Sinai School of Medicine
Topic: Toll-like Receptors as Mediators of Renal Disease
4 pm SOM E-501

LRI Showcase Seminar
Vince Tuohy, PhD
Professor, Immunology
CWRU/ Cleveland Clinic
Topic: Vaccine-Induced Prevention of Adult Diseases
4:30 pm NE1-205 Cleveland Clinic


May 18

Hematology and Oncology Division Research Conference
Tanyanika Phillips Towe, MD
Assistant Professor, Medicine-Hem/Onc
CWRU/UH
Topic: TBD
8 am Lerner B-151

Developmental Therapeutics Program Meeting
5 pm WRB 2-136


May 19

Tumor Microenvironment and Metastasis Focus Group Meeting
12 pm Wearn 137


May 20

Breast Cancer Detection and Management: Issues for 2011
8 am- 2:30 pm Hilton Cleveland East
Brochure

Hematology/Oncology Fellows
Waqas Rehman, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Jennifer Temel, MD
Assistant Professor, Medicine- Hem/Onc
Dana Farber/Harvard Cancer Center
Topic: Early Implementation of Palliative Care in the Management of Malignant Disease
8 am R3/002-003 Cleveland Clinic

Cell Biology Seminar Series
David Danielpour, PhD
Associate Professor, General Medical Sciences- Oncology
CWRU/ UH
Topic: Deregulation of TGFβ and BMP Signaling in Prostate Cancer: New Therapeutic Perspectives
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Jill Barnholtz-Sloan, PhD
Assistant Professor, General Medical Sciences- Oncology
CWRU/UH
Topic: The Ohio Brain Tumor Study: How to do BIG science in a RARE cancer
12 pm BRB 105

Cancer Center Research in Progress Seminar
Greg Adams
Graduate Student, Schmaier Lab
CWRU/UH
Topic: Murine Prolylcarboxypeptidase Depletion Induces Vascular Dysfunction with Hypertension and Faster Arterial Thrombosis
4 pm WRB 3-136

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

ASCO Review 2011
June 30
InterContinental Hotel and Bank of America Conference Center
Details

Case CCC Annual Scientific Retreat
July 8-9
Details to follow

ADDITIONAL UPCOMING SEMINARS & EVENTS

Race for the Place
June 5
Beachwood Place Mall
Details

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada
Details

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland
Details

8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland
Details


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

DOD CDMRP Prostate Cancer Research Program Collaborative Undergraduate HBCU Student Summer Training Program Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Exploration: Hypothesis Development Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Health Disparity Training Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Population-Based Research Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: May 18
Application Deadline: June 8

Robert Wood Johnson Foundation Public Health Services and Systems Research Grant
Proposal Deadline: May 24

STERIS Corporation Infectious Diseases Research Support Grant
Application Deadline: May 27
Contact Martha Salata at mks18@case.edu for more information.

DOD CDMRP Breast Cancer Research Program Idea Award
Pre-Application Deadline: May 31
Application (Invited) Deadline: August 25

DOD CDMRP Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 31
Application (Invited) Deadline: August 25

Damon Runyon-Rachleff Innovation Award
Pre-Proposals Deadline: June 1
Full Proposal Deadline: September 2

DOD CDMRP Prostate Cancer Research Program Idea Development Award
Pre-Application Deadline: June 2
Application Deadline: August 23

DOD CDMRP Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application Deadline: June 2
Application Deadline: August 23

DOD CDMRP Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Breast Cancer Research Program Innovator Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Breast Cancer Research Program Era of Hope Scholar Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Ovarian Cancer Research Program Translational Pilot Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Ovarian Cancer Research Program Translational Leverage Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: June 8
Application Deadline: August 18

DOD CDMRP Prostate Cancer Research Program Clinical Trial Award
Pre-Application (Preproposal) Deadline: June 10
Application Deadline: September 1

DOD CDMRP Prostate Cancer Research Program Impact Award
Pre-Application Deadline: June 10
Application Deadline: September 1

DOD CDMRP Prostate Cancer Research Program Laboratory - Clinical Transition Award (Modified)
Pre-Application Deadline: June 10
Application Deadline: September 1

James S. McDonnell Foundation 21st Century Science Initiative 2011
Deadline: July 15

Damon Runyon Fellowship Award
Application Deadline: August 15

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Notice of Opportunity for Fast Track Entry of Assay Projects for High Throughput Screening into the NIH Roadmap Molecular Libraries Probe Production Centers Network (NOT-RM-11-018)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.