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Case Comprehensive Cancer Center Newsletter

May 2, 2011

CASE CCC IN THE NEWS

Comparing Cancer Care: How Can You Tell Who Has the Best?
Plain Dealer - May 2, 2011
"The challenge is that there are so many vagaries of specific types of cancer that a cancer center sees that it's hard to come up with a simple survival rate," said Dr. Stanton Gerson, director of University Hospitals Seidman Cancer Center. ... It's about transparency, says Dr. Brian Bolwell, interim chairman of the Clinic's Taussig Cancer Institute, seen as a pioneer in outcomes reporting. "We were the first," he said. "I think many other organizations were surprised that we were willing to ...

Cleveland Clinic Researchers Link Hypertension with Improved Survival in Advanced Kidney Cancer
HealthCanal.com - Apr 29, 2011
"These findings support the hypothesis that high blood pressure may act as a biomarker of a medication's anti-tumor effectiveness," said Brian Rini, MD, a staff physician in Cleveland Clinic's Taussig Cancer Institute. ...


MARK YOUR CALENDARS

Cancer Center Seminar Series: MRI Contrast Agents for Imaging Tumor Microenvironment
lu

Friday, May 6
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, May 6 at the next Cancer Center Seminar Series featuring Zheng-Rong Lu, PhD. Dr. Lu, Professor of Biomedical Engineering at CWRU, will present MRI Contrast Agents for Imaging Tumor Microenvironment.

Dr. Zheng-Rong Lu is the M. Frank and Margaret Domiter Rudy Professor of Biomedical Engineering at the Department of Biomedical Engineering, Case School of Engineering, Case Western Reserve University. Dr. Lu received his BS and MS in Chemistry from Lanzhou University, and PhD in Chemistry from Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences at Lanzhou, China. Dr. Lu was an Associate Professor of Chemistry in 1992 and Professor of Chemistry in 1994 at Wuhan University in China. In 2002, Dr. Lu was appointed to Assistant Professor in the Department of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah. Dr. Lu was promoted to a tenured Associate Professor in 2006.

Dr. Lu's research involves molecular imaging, MRI contrast agents, image-guided photodynamic therapy, non-invasive methods for cancer treatment assessment, polymeric drug delivery systems for retinal diseases and multifunctional delivery systems for nucleic acids. He has over 100 peer-reviewed scientific publications, five book chapters, 70 abstracts, and four US patents. He is a Principal Investigator of major grants from the NIH. Dr. Lu serves on the scientific advisory board of Pharmaceutical Research and Molecular Pharmaceutics. Currently, Dr. Lu serves as a member of the NIH Clinical Molecular Imaging and Probe Development Study Section.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


ANNOUNCEMENTS

Court of Appeals Stem Cell Ruling

Message from Tony Mazzaschi, Association of American Medical Colleges

In a 2-1 decision issued by a Federal Appeals Court, the preliminary injunction blocking federal funding of human embryonic stem cell research was lifted, allowing NIH funding for such research to continue. The majority said that "We conclude the plaintiffs are unlikely to prevail because Dickey-Wicker is ambiguous and the NIH seems reasonably to have concluded that, although Dickey-Wicker bars funding for the destructive act of deriving an ESC from an embryo, it does not prohibit funding a research project in which an ESC will be used. We therefore vacate the preliminary injunction." A trial on the merits of the case is still possible, as are further appeals by opponents of human embryonic stem cell research.

Release of the President's Cancer Panel Report

The President's Cancer Panel is pleased to announce the release of the final report, "America's Demographic and Cultural Transformation: Implications for Cancer."

The Panel's report states that knowledge of cancer risk, incidence, progression, and outcomes is based largely on studies of non-Hispanic white populations. The current understanding of risk factors, screening guidelines, and treatment may therefore not be appropriate for individuals of non-European descent. The Panel also calls for higher standards of "cultural competence" among healthcare professionals to better address cultural and language barriers that can negatively impact the quality of patient care.

Because cancer incidence among minority populations is projected to nearly double between 2010 and 2030, the Panel calls for a more accurate assessment of the effects that a changing demographic will continue to have on cancer incidence and mortality in the coming decades.

The report includes an addendum, "How the Patient Protection and Affordable Care Act and Other Recent Legislative Activity May Impact the Panel's Recommendations." This supplement provides guidance for policymakers and the public regarding the ways in which this landmark legislation might address some of the challenges associated with providing optimal health care to an increasingly diverse population.

Hard copies of the report and the addendum may be downloaded at http://pcp.cancer.gov. Additional hard copies can be requested by contacting the Panel at pcp-r@mail.nih.gov or at 301-451-9399.

ASCO Annual Meeting

The Cancer Center is attempting to track members who are part of the formal program or presenting a poster at the ASCO Annual Meeting, June 3-7 in Chicago. Please send information to gillian.irwin@case.edu.

Call for Participation- Hematopoietic Stem Cell Core Facility Survey

Message from Dr. David Wald, Scientific Director, Hematopoietic Stem Cell Core Facility
The Case Comprehensive Cancer Center is gathering information about anticipated research needs for the Hematopoietic Stem Cell Core Facility. Your responses will help us build a core facility that reflects the collective needs of cancer center members. Please visit http://www.zoomerang.com/Survey/WEB22C22WB5KZ7/ and complete the short survey.

We appreciate your participation!


FUNDING OPPORTUNITIES

DOD CDMRP Ovarian Cancer Research Program (OCRP)

Applications are now being accepted for the following funding opportunities from the Ovarian Cancer Research Program (OCRP):

Pilot Award
Supports conceptually innovative, high-risk/high-reward research that could ultimately lead to critical discoveries or major advancements that will drive the field of ovarian cancer research forward.
Pre-Application Deadline: June 8
Application Deadline: August 18

Translational Pilot Award
Supports innovative translational research addressing a critical problem or question in ovarian cancer that will accelerate the movement of promising ideas toward clinical applications. The proposed research should provide a catalyst to challenge or expand current thinking about and/or approaches to ovarian cancer. It must involve early-stage translation of an idea from the laboratory to the clinic, or from the clinic back to the laboratory.
Pre-Application Deadline: June 8
Application Deadline: August 18

Translational Leverage Award
Supports the leveraging of existing human-based ovarian cancer resources in translational research to address high-impact research ideas or unmet needs in ovarian cancer.
Pre-Application Deadline: June 8
Application Deadline: August 18

Teal Innovator Award
Supports the recruitment of a visionary individual from any field principally outside of, but not exclusive of, ovarian cancer to focus his/her creativity, innovation, and leadership on ovarian cancer research. This individual must have experience in guiding a research team and demonstrate that he/she is committed to investigating paradigm-shifting ideas in ovarian cancer.
Pre-Application Deadline: June 8
Application Deadline: August 18

Pilot Project Grants: American Cancer Society IRG Awards

The Case CCC is currently accepting applications for American Cancer Society Institutional Research Grant (IRG) awards. Pilot funding is available for projects in basic, clinical, prevention and control, behavioral, health services, and epidemiology cancer research with awards up to $30,000 for one-year cancer research projects that provide the basis for future independent grants.

Instructions, frequently asked questions, and application forms are available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration (844-7252, tld6@case.edu) for more information.

LOI Deadline: June 13
Application Deadline: July 5, 2011

EVENTS

calendar

**All events are open to anyone interested in attending

May 2

Physiology and Biophysics Seminar
David Essig, PhD
Associate Professor, Biology
Geneva College
Topic: Introducing Physiology Through Genomic Annotation
4 pm SOM E501


May 3

Cancer Biology Invited Speaker Seminar
Ruth Keri, PhD
Associate Professor and Vice Chair, Pharmacology
CWRU
Topic: Identification of Novel Pathways Involved in Breast Development and Cancer
11 am NC1-202 Cleveland Clinic

Immunology Seminar
M. Edward Medof, MD, PhD
Professor, Pathology
CWRU/UH
Topic: Why Cell Biology and Immunology Textbooks Are Out of Date
12 pm WRB 1-413


May 4

Hematology and Oncology Division Research Conference
Rom Leidner, MD
Instructor, Div. of Hem/Onc
CWRU/UH
Topic: NextGen Sequencing and Epigenetic Biomarker Development
8 am Lerner B-151

Immunology Students/Fellows Research In Progress Series
Ken Matsui, PhD
Postdoctoral Fellow, Gupta Lab
Cleveland Clinic
Topic: Exploring the Role of Ezrin in B Cell Immune Responses
12 pm NC1-202 Cleveland Clinic

Pathology Graduate Student Seminar
Gregory Adams
Schmaier Lab, Div. of Hem/Onc
CWRU/UH
Topic: Murine Prolylcarboxypeptidase Depletion Induces Vascular Dysfunction With Hypertension and Faster Arterial Thrombosis
12 pm WRB 1-413

NCRM and Cardiovascular Research Institute Seminar
Ed Morrisey, PhD
Professor, Medicine and Cell Developmental Biology
Scientific Director, Penn Institute of Regenerative Medicine
University of Pennsylvania
Topic: Epigenetic Mechanisms of Stem Cell Programming and Reprogramming
4 pm WRB 1-413


May 5

Department of Stem Cell Biology and Regenerative Medicine Seminar
Wang Min, PhD
Associate Professor, Pathology
Yale University
Topic: AIP1: A Novel Tumor Metastasis Suppressor Gene
1 pm NE1-205

Aging-Cancer-Energetics Seminar
Jung-won Lim, PhD
Assistant Professor, Mandel School for Applied Social Sciences
CWRU
Topic: Communication and Coping in Asian American Families with Breast Cancer Survivors
4 pm BRB 732


May 6

Hematology/Oncology Fellows
Ashley Rosko, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Julie Vose, MD
Professor, Internal Medicine- Hem/Onc
University of Nebraska Medical Center
Topic: T-Cell Lymphoma
8 am R3/002-003 Cleveland Clinic

Pathology Graduate Student Defense Seminar
Daimon Simmons
Harding Lab
CWRU/UH
Topic: Effects of Toll-Like Receptors and Type I Interferon on Dendritic Cell Maturation and Activation of T Cells
12 pm WRB 6-136

Cancer Center Seminar Series
Zheng-Rong Lu, PhD
Professor, Biomedical Engineering
CWRU
Topic: MRI Contrast Agents for Imaging Tumor Microenvironment
12 pm BRB 105

Cancer Center Research in Progress Seminar
Lachelle Weeks
Graduate Student, Liu Lab
CWRU/UH
Topic: The Role of Genomic Uracil Accumulation and Uracil DNA Glycosylase (UDG) in Pemetrexed Sensitivity
4 pm WRB 3-136

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East
Brochure

ASCO Review 2011
June 30
InterContinental Hotel and Bank of America Conference Center
Details

Case CCC Annual Scientific Retreat
July 8-9
Details to follow

ADDITIONAL UPCOMING SEMINARS & EVENTS

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati
Details

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City
Details

2nd Annual Department of Medicine Research Day
May 16
12-5 pm
Wolstein Research Building auditorium and lobby
Details

Race for the Place
June 5
Beachwood Place Mall
Details

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada
Details

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland
Details

8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland
Details


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Ovarian Cancer Research Fund Program Project Development Grants
LOI Deadline: May 9

Ovarian Cancer Research Fund Liz Tilberis Scholars
LOI Deadline: May 9

Ovarian Cancer Research Fund Ann Schreiber Research Training Programs of Excellence
LOI Deadline: May 9

DOD CDMRP Prostate Cancer Research Program Collaborative Undergraduate HBCU Student Summer Training Program Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Exploration: Hypothesis Development Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Health Disparity Training Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Population-Based Research Award
Pre-Application Deadline: May 18
Application Deadline: June 8

DOD CDMRP Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: May 18
Application Deadline: June 8

Robert Wood Johnson Foundation Public Health Services and Systems Research Grant
Proposal Deadline: May 24

DOD CDMRP Breast Cancer Research Program Idea Award
Pre-Application Deadline: May 31
Application (Invited) Deadline: August 25

DOD CDMRP Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 31
Application (Invited) Deadline: August 25

Damon Runyon-Rachleff Innovation Award
Pre-Proposals Deadline: June 1
Full Proposal Deadline: September 2

DOD CDMRP Prostate Cancer Research Program Idea Development Award
Pre-Application Deadline: June 2
Application Deadline: August 23

DOD CDMRP Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application Deadline: June 2
Application Deadline: August 23

DOD CDMRP Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Breast Cancer Research Program Innovator Award
Pre-Application Deadline: June 7
Application Deadline: June 21

DOD CDMRP Breast Cancer Research Program Era of Hope Scholar Award
Pre-Application Deadline: June 7
Application Deadline: June 21

Damon Runyon Fellowship Award
Application Deadline: August 15

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Center for Inherited Disease Research (CIDR) High Throughput Genotyping and Sequencing Resource Access (X01) (PAR-11-210)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.