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Case Comprehensive Cancer Center Newsletter

April 25, 2011

MESSAGE FROM THE DIRECTOR

Case Comprehensive Cancer Center Renewal – Countdown to May 2012

We are currently in the fifth year of our six-year CCSG award. I remind you that we were awarded a sixth year based on the "Outstanding" review of our last competitive renewal application.

Over the next year all of you, as members, will participate in our efforts to renew our award. We submit our fifth competitive renewal in May 2012, which will take a full year of concerted effort on the part of our more than 300 members. We have established a timeline for this effort. Keeping to this timeline will take considerable expertise and thoughtful coordination by the program leaders and the focus area leaders for each scientific program. The core leaders and the core group cluster leaders will be working with you as well to develop strong descriptions of our core facilities emphasizing the importance that they have in your individual research programs.

The first phase (due end of May 2011) of this renewal effort will be the initial draft of the scientific programs. These will be written by the program leaders, with support of the scientific focus group leaders, and will describe the overall scope of the program, its scientific focus areas, and the scientific highlights and accomplishments of the program membership.

The second phase (due June 2011) will be the descriptions of the shared resources of the Cancer Center and their use by Cancer Center members.

The third phase (July 2011) includes a comprehensive assessment of all the active and recent clinical trials to highlight both the scientific goals of these trials and the accrual that we have made to these clinical investigations. Most important will be our focus on investigator-initiated clinical trials, and clinical trials that emerge from our scientific programs and have laboratory correlative efforts within our scientific program areas.

At each point along the way, we will have extensive internal and external reviews. We will rely on our institutional internal advisory board, program leaders, and senior leaders to review the program and shared resource written descriptions, and we will review progress at our retreat in July.

As we move into the third draft of our programs in the fall of 2011, we will have formal external reviews of each of the scientific programs based on the written program descriptions. This very important review phase provides the most precise and concentrated review effort of the reapplication process. This extensive effort beforehand is to make sure we have provided the best descriptions of our programs by the time they go for external review. In my experience, this may well ensure that each of our programs scores in the outstanding to exceptional range.

As I noted, each of you will play an important role as you interact within your program and with program leaders to describe the exceptional work you have been doing. I look forward to your involvement and your feedback during this most important renewal year.

Thank you for your support and ongoing commitment to the Case Comprehensive Cancer Center.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center

 

CCSG Renewal Timeline

  • May 9, 2011: Cancer Center Leadership Strategic Planning Retreat
  • May 23, 2011: First draft of program descriptions due
  • June 6, 2011: First draft of shared resources descriptions due
  • June 20, 2011: Institutional Advisory Board meeting
  • July 8-9, 2011: Cancer Center Scientific Retreat
  • July 11-15, 2011: Alignment of clinical trials to programs
  • August 22, 2011: Second draft of program descriptions due
  • September 6, 2011: Second draft of shared resources descriptions due
  • October 3, 2011: Third draft of program descriptions due
  • October 10, 2011: Third draft of shared resources descriptions due
  • October, 2011: External reviews of programs and cores
  • October 27, 2011: External Advisory Board Meeting
  • November 10-December 5, 2011: Teleconferences with ad hoc external reviewers of all programs and cores
  • March 1, 2012: Final version of programs and cores due
  • April 1, 2012: Review of all sections completed
  • April-May, 2012: Application compiled
  • May 25, 2012: Application due at NCI

CASE CCC IN THE NEWS

Middle-Aging and Cancer
WCPN-FM - Apr 18, 2011
..."Cancer is a disease of genetic mutations, and the longer we go, the more our cells divide, the more likely we are to acquire genetic mutations," explained Nathan Berger, director of the Center for Science, Health & Society at Case Western Reserve University School of Medicine...


MARK YOUR CALENDARS

Cancer Center Seminar Series: Dissecting the Paths of Ovarian Cancer Development and Chemotherapy Resistance
difeo

Friday, April 29
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, April 29 at the next Cancer Center Seminar Series featuring Analisa DiFeo, PhD. Dr. DiFeo, Instructor of Genetics and Genomic Sciences at the Mount Sinai School of Medicine, will present Dissecting the Paths of Ovarian Cancer Development and Chemotherapy Resistance.

Dr. Analisa DiFeo is an Instructor in the Department of Genetics and Genomic Sciences at Mount Sinai School of Medicine in New York. Her initial research studies were focused on uncovering the role of the KLF6 tumor suppressor gene in ovarian cancer. She played a central role in defining KLF6 and its novel oncogenic splice variant, KLF6-SV1, as a key regulator of a number of human malignancies, but mainly focused on epithelial ovarian cancer (EOC). Her findings were the first to demonstrate that a majority of ovarian cancer tumors have increased expression of the oncogenic KLF6-SV1 isoform, and that this variant is a novel anti-apoptotic protein which regulates chemotherapy response.

Currently, Dr. DiFeo's laboratory os working toward better understanding the mechanism by which small noncoding RNAs (microRNAs) are involved in ovarian tumor biology and the development of chemoresistance. Work in her laboratory is focused on microRNAs that may serve both as potential predictive markers for individualized therapy and novel therapeutic targets.

Dr. DiFeo has received numerous awards, including the Liz Tilberis Scholar Award from the Ovarian Cancer Research Fund, the AstraZeneca Scholar-in-Training Award from the American Association of Cancer Research, and the Doctoral Dissertation Award from Mount Sinai School of Medicine.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


FUNDING OPPORTUNITIES

Damon Runyon Cancer Research Foundation

The Damon Runyon Cancer Research Foundation is accepting applications for the following funding opportunities:

The Damon Runyon Fellowship Award is the Foundation's oldest and most well recognized award. It is one of the highest accolades an early career scientist can receive. The grant is designed to give the nation's top minds the resources to further hone their cancer research skills and explore their own innovative ideas, while working with mentors in top universities and cancer research centers. Candidates must apply for the fellowship under the guidance of a Sponsor-a scientist (tenured, tenure-track or equivalent position) capable of providing mentorship to the Fellow. Only one fellowship application will be accepted from a Sponsor or Fellow per review session; there is no limit, however, to the number of applications from an institution.

Application Deadline: August 15

The Damon Runyon-Rachleff Innovation Award funds cancer research by exceptionally creative thinkers with "high-risk/high-reward" ideas- ideas that have the potential to significantly impact cancer, but lack sufficient preliminary data to obtain traditional funding. Institutional nominations are not required and there is no limit to the number of applications that can be received from a particular institution.

Pre-Proposals Deadline: June 1
Full Proposal Deadline: September 2

DOD CDMRP Breast Cancer Research Program (BCRP)

Applications are now being accepted for the following funding opportunities from the Breast Cancer Research Program (BCRP):

Postdoctoral Fellowship Award
Supports exceptionally talented recent doctoral or medical graduates in their pursuit of innovative, high-impact breast cancer research during their postdoctoral training, and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research
Pre-Application Deadline: June 7
Application Deadline: June 21

Innovator Award
Supports visionary individuals who have demonstrated creativity, innovative work, and leadership in any field including, but not limited to, breast cancer.
Pre-Application Deadline: June 7
Application Deadline: June 21

Era of Hope Scholar Award
Supports individuals who are early in their careers and have high potential for innovation in breast cancer research.
Pre-Application Deadline: June 7
Application Deadline: June 21

Idea Award
Supports promising research that has extraordinary potential to yield highly impactful data and new avenues of investigation.
Pre-Application Deadline: May 31 Application (Invited) Deadline: August 25

Transformative Vision Award
Supports research projects to realize an extraordinary vision for dramatically affecting the prevention or treatment of breast cancer, and a plan to test and achieve the vision as quickly as possible through the translation of these ideas into patients.
Pre-Application Deadline: May 31 Application (Invited) Deadline: August 25

DOD CDMRP Prostate Cancer Research Program (PCRP)

Applications are now being accepted for the following funding opportunities from the Prostate Cancer Research Program (PCRP):

Collaborative Undergraduate HBCU Student Summer Training Program Award
Supports new or existing summer training programs for undergraduate HBCU students at host institutions with thriving prostate cancer research programs.
Pre-Application Deadline: May 18
Application Deadline: June 8

Exploration: Hypothesis Development Award
Supports the exploration of highly innovative, untested, potentially groundbreaking concepts.
Pre-Application Deadline: May 18
Application Deadline: June 8

Health Disparity Research Award
Supports new ideas for prostate cancer health disparity research that have the potential to make an important contribution to reducing and ultimately eliminating disparities in prostate cancer incidence, morbidity, and mortality.
Pre-Application Deadline: May 18
Application Deadline: June 8

Health Disparity Training Award
Supports training in prostate cancer health disparity research for individuals in early stages of their careers.
Pre-Application Deadline: May 18
Application Deadline: June 8

Physician Research Training Award
Supports training of physicians with clinical duties for careers in prostate cancer research.
Pre-Application Deadline: May 18
Application Deadline: June 8

Population-Based Research Award
Supports high-impact approach to prostate cancer research from the perspective of population-based studies that will, if successful, significantly accelerate the elimination of death and suffering from prostate cancer.
Pre-Application Deadline: May 18
Application Deadline: June 8

Postdoctoral Training Award
Supports postdoctoral training in prostate cancer research for recent doctoral graduates.
Pre-Application Deadline: May 18
Application Deadline: June 8

Idea Development Award
Supports new ideas that represent innovative, high-risk/high-gain approaches to prostate cancer research, and have the potential to make an important contribution to eliminating death and suffering from prostate cancer.
Pre-Application Deadline: June 2
Application Deadline: August 23

Synergistic Idea Development Award
Supports new or existing partnerships between two or three independent investigators to address a central innovative question or problem in prostate cancer that may include high risk, provided there is a potential for significant impact.
Pre-Application Deadline: June 2
Application Deadline: August 23

Pilot Project Grants: American Cancer Society IRG Awards

The Case CCC is currently accepting applications for American Cancer Society Institutional Research Grant (IRG) awards. Pilot funding is available for projects in basic, clinical, prevention and control, behavioral, health services, and epidemiology cancer research with awards up to $30,000 for one-year cancer research projects that provide the basis for future independent grants.

Instructions, frequently asked questions, and application forms are available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration (844-7252, tld6@case.edu) for more information.

LOI Deadline: June 13
Application Deadline: July 5, 2011


ANNOUNCEMENTS

Message from Dr. David Wald, Scientific Director, Hematopoietic Stem Cell Core Facility
The Case Comprehensive Cancer Center is gathering information about anticipated research needs for the Hematopoietic Stem Cell Core Facility. Your responses will help us build a core facility that reflects the collective needs of cancer center members. Please visit http://www.zoomerang.com/Survey/WEB22C22WB5KZ7/ and complete the short survey.

We appreciate your participation!

EVENTS

calendar

**All events are open to anyone interested in attending

April 25

Pathology Research Seminar
Lan Zhou, MD, PhD
Assistant Professor, Pathology
CWRU
Topic: O-fucose Regulates Notch Signaling in Hematopoiesis
12 pm WRB 1-413

Physiology and Biophysics Seminar
Laura Nagy, PhD
Professor, Molecular Medicine
Staff, Patholobiology and Gastroenterology
Cleveland Clinic
Topic: Innate Immunity and Alcoholic Liver Disease
4 pm SOM E501


April 26

Cancer Biology Invited Speaker Seminar
Bing-Cheng Wang, PhD
Professor, Medicine and Pharmacology
CWRU/ MetroHealth
Topic: EphA2 Kinase in Tumor Invasion and Metastasis: Tale of an Unwitting Partner
11 am NC1-202 Cleveland Clinic

Immunology Seminar
Jeffrey Ravetch, MD, PhD
Theresa and Eugene M. Lang Professor
Leonard Wagner Laboratory of Molecular Genetics and Immunology
Rockefeller University
Topic: The Antibody Paradox
12 pm WRB 1-413

Stem Cell Biology and Regenerative Medicine
Eric Holland, MD, PhD
Director, Brain Tumor Center
Memorial Sloan Kettering Cancer Center
Topic: The Biology of Therapeutic Response in Gliomas
2 pm NC1-202


April 27

Hematology and Oncology Division Research Conference
Brenda Cooper, MD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: FLT-3 Inhibitors in AML
8 am Lerner B-151

Cellular and Molecular Biology of Disease Symposium Series
Douglas Golenbock, MD
Professor, Medicine and Infectious Diseases
Chief, Division of Infectious Diseases and Immunology
University of Massachusetts Medical School
Topic: Innate Immunity and Human Disease
10:30 am WRB 1-413

Immunology Invited Speaker Seminar Series
Ann Marshak-Rothstein, PhD
Professor, Rheumatology
University of Massachusetts
Topic: sTrolling Down the Road to SLE and into the Fas Lane
12 pm NC1-202 Cleveland Clinic

Cellular and Molecular Biology of Disease Symposium Series
Douglas Golenbock, MD
Professor, Medicine and Infectious Diseases
Chief, Division of Infectious Diseases and Immunology
University of Massachusetts Medical School
Topic: DNA Drives the Inflammatory Response During Malaria
4 pm WRB 1-413


April 28


April 29

Taussig Cancer Institute Grand Rounds canceled

Hematology/Oncology Fellows
Lalitha Nayak, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Wearn 137

Cell Biology Seminar
Charlotte Kuperwasser, PhD
Associate Professor, Anatomy and Cellular Biology
Tufts University
Topic: Embryonic Development, Stem Cells and Cancer: The Cellular, Molecular and Genetic Contributors to Human Breast Cancer Pathogenesis
10 am NC1-202 Cleveland Clinic

Pathology Graduate Student Defense Seminar
Jason Molitoris
Distelhorst Lab, Div. of Hem/Onc
CWRU/UH
Topic: Mechanistic Insights into Glucocorticoid-Induced Apoptosis and Autophagy in Lymphoid Malignancies
11 am WRB 6-136

Cancer Center Seminar Series
Analisa DiFeo, PhD
Instructor, Genetics and Genomic Medicine
Mount Sinai School of Medicine
Topic: Dissecting the Paths of Ovarian Cancer Development and Chemotherapy Resistance
12 pm BRB 105

Cancer Center Research in Progress Seminar
Duncan Stearns, MD
Assistant Professor, Pediatrics- Hem/Onc
CWRU/UH
Topic: Examining the Role of Tumor Derived Extracellular Matrix in Medulloblastoma
4 pm WRB 3-136

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East
Brochure

Case CCC Annual Scientific Retreat
July 8-9
Details to follow

ADDITIONAL UPCOMING SEMINARS & EVENTS

2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29
Omni Shoreham in Washington, DC
Details

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati
Details

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City
Details

2nd Annual Department of Medicine Research Day
May 16
12-5 pm
Wolstein Research Building auditorium and lobby
Details

Race for the Place
June 5
Beachwood Place Mall
Details

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada
Details

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland
Details

8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland
Details


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Ovarian Cancer Research Fund Program Project Development Grants
LOI Deadline: May 9

Ovarian Cancer Research Fund Liz Tilberis Scholars
LOI Deadline: May 9

Ovarian Cancer Research Fund Ann Schreiber Research Training Programs of Excellence
LOI Deadline: May 9

Robert Wood Johnson Foundation Public Health Services and Systems Research Grant
Proposal Deadline: May 24

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Clarification of the Scope and Requirements of PAR-11-150, Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01) (NOT-CA-11-011)

Request for Information (RFI) Related to a Planned Funding Opportunity for Support of Basic and Translational Research in the Area of Tumor Glycomics (NOT-CA-11-012)

Notice of Correction in Key Dates for RFA-ES-11-002: Dietary Influence on the Human Health Effects of Environmental Exposures (R21) (NOT-ES-11-008)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.