Case Comprehensive Cancer Center: Weekly Newsletter

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April 4, 2011
MESSAGE FROM THE DIRECTOR Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System According to the recently released Annual Report to the Nation on the Status of Cancer, there has been a decrease in the rate of deaths from all cancers. Lung cancer continues to take more lives than any other cancer, despite a continued decrease in lung cancer deaths in men and a first-time decrease in in women. New cancer diagnoses for adults have also dropped slightly, though childhood cancer incidence rates have increased. The Report also includes a special section on brain tumors and other nervous system cancers. Of special note, researchers found non-malignant tumors were about twice as common as malignant tumors in adults. Brain tumors were much more common among adults than children, but if a child was diagnosed with a brain tumor it was more likely to be malignant. The Report appeared online March 31 in the "Journal of the National Cancer Institute", and will be available in print on May 4. A summary of report highlights is available on the NCI website. Stan Gerson, MD Director, Case Comprehensive Cancer Center CASE CCC IN THE NEWS Komen Founder and CEO Wraps up Cleveland Visit with UH Tour, City Club Speech Plain Dealer (blog) - Apr 1, 2011 In 2010 UH oncologist Dr. Cynthia Owusu received a three-year, $500000 grant from the national Komen group to fund a study aimed at improving outcomes for older women with newly diagnosed breast cancer. Wanting to put a face with the name, ... Case Western Reserve's Medical School Wins $1.6 Million Cancer Research Grant Crain's Cleveland Business - Mar 31, 2011 With the support of the five-year grant, Dr. Alex Y. Huang, an assistant professor at CWRU and a hematologist and oncologist at Rainbow Babies & Children's Hospital, will lead a team of researchers examining why the immune system doesn't fend off these ... MARK YOUR CALENDARS Case CCC Scientific Series The next installment of the Case CCC Scientific Series is scheduled for Thursday, April 21 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413). Drs. Anton Gorbachev, Neetu Gupta and Alex Huang will discuss the topic of Immunology. Presentations will be followed by a short receptions. All are encouraged to attend. Case CCC Annual Scientific Retreat The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon. FUNDING OPPORTUNITIES Strategic Partnering to Evaluate Cancer Signatures [SPECS II] The cancer center leadership encourages consideration of this grant opportunity especially in the context of our disease based research initiative and strategic plan. Please direct comments to Dr. Stan Gerson and he will facilitate dialogue with other cancer center member investigators. This message is to alert you to a new funding opportunity announcement: Strategic Partnering to Evaluate Cancer Signatures [SPECS II] (PAR-11-151). There will be one receipt date in 2011 for this competition. Please note this is a re-issue of PAR-10-126. New in 2011: electronic application submission and a cap on requested budgets. This FOA encourages the submission of grant applications for support of the clinical application of multi-analyte molecular signatures derived from comprehensive molecular annotation of tumors. The NCI invites investigators to form strategic partnerships that will bring together the multi-disciplinary expertise and resources needed to determine how the information derived from comprehensive molecular analyses can be used to improve patient care and, ultimately, patient outcomes. ANNOUNCEMENTS George Stark Named Honored with American Society for Biochemistry and Molecular Biology's (ASBMB) 2011 Herbert Tabor/Journal of Biological Chemistry Lectureship Congratulations to Dr. George Stark who was awarded the 2011 Herbert Tabor/Journal of Biological Chemistry Lectureship by the American Society for Biochemistry and Molecular Biology (ASBMB). Dr. Stark will present his award lecture the ASBMB's annual meeting on April 9 in Washington, DC. AACR Annual Meeting The following Cancer Center members will be participating in the upcoming American Association for Cancer Research (AACR) Annual Meeting, April 2-6: Jill Barnholtz-Sloan, PhD Presentation, "How do I utilize ancestry estimates in my own study of cancer risk?" Session Chair, Methods Workshop: Population Stratification and Use of Genetic Ancestry to Assess Risk for Cancer Sat Apr 2, 8-10 am; Room W414 C/D, Orange County Convention Center Chair, Minisymposium: Host and Lifestyle Factors in Cancer Risk Sun Apr 3, 3:15-5:15 pm; Room W205, Orange County Convention Center Jorge A. Garcia, MD Presentation, "Bisphosphonates or RANK-ligand inhibitors: Options to reduce skeletal related events in Castraton-resistant Prostate cancer" New Concepts in Organ Site Research Session: NC24. Novel Therapeutic Strategies for the Treatment of Bone Metastases Tues Apr 5, 10:55-11:15 am; Room W224 A/B/E/F, Orange County Convention Center Donna Hansel, MD, PhD Presentation, Career Conversations: Choosing the Right Postdoctoral Fellowship/Clinical Fellowship for Research Careers in Academia, Industry, and Government Tues Apr 5, 1-2 pm; AACR Central, Associate Member Resource and Career Center, Exhibit Hall A4-C Michael Kattan, PhD Presentation, "Analysis and modeling" Methods Workshop: Design and Analysis of Cancer Prognosis Studies: Interface of Molecular Epidemiology and Clinical Research Sat Apr 2, 2:30-2:50 pm; Room W209, Orange County Convention Center Sanford Markowitz, MD, PhD Presentation, "DNA methylation markers for early cancer detection" Educational Session: Epigenetic Regulation and Cancer Sat Apr 2, 9-9:25 am; West Hall F5, Orange County Convention Center Jeremy Rich, MD Presentation, "The tumor microenvironment informs the tumor hierarchy" Session Chair, Educational Session: The Cancer Stem Cell Niche Sat Apr 2, 3:15-5:15 pm; West Hall F3/F4, Orange County Convention Center Session Chair, New Concepts in Organ Site Research: Stem Cells in the Brain: At the Crossroads of Development and Disease Tues Apr 5, 1-3 pm Room W311 E-H, Orange County Convention Center Brian Rini, MD Presentation, "Clinical applications of genomic classification of RCC" Session Chair, New Concepts in Organ Site Research Sessions: Molecular Insights in Renal Cell Carcinoma Sun Apr 3, 1-3 pm Room W315, Orange County Convention Center A full listing of all Cancer Center member presentations and abstracts is available on our website.	EVENTS All events are open to anyone interested in attending April 4 Pathology Research Seminar Marco Sardiello, PhD Assistant Professor, Molecular and Human Genetics Baylor University Topic:** Network Approaches to Study and Treat Neuronal Ceroid Lipofuscinoses 12 pm WRB 1-413 April 5 Immunology Seminar Eric Meffre, PhD Associate Professor, Immunobiology Yale University Topic: The Regulation of Early B Cell Tolerance Checkpoints in Humans 12 pm WRB 1-413 April 6 Hematology and Oncology Division Research Conference Scott Sommers, MD Fellow, Div. of Hem/Onc CWRU/UH Topic: Spontaneous Autologous GVHD in Plasma Cell Myeloma Autograft Recipients: Flow Cytometric Analysis of Hematopoietic Progenitor Cell Grafts 8 am Lerner Tower B-151 April 7 Aging-Cancer-Energetics Seminar Mary Step, PhD Assistant Professor, Family Medicine CWRU/UH Topic: A Communication Process Approach to Understanding Age-Related Patterns in Decision-Making 4 pm BRB 732 April 8 Hematology/Oncology Fellows Brad Clifford, MD Fellow, Div. of Hem/Onc CWRU/UH Topic: TBD 8 am Wearn 137 Taussig Cancer Institute Grand Rounds Thomas Buchholz, MD Professor, Radiation Oncology MD Anderson Cancer Center Topic: Radiation for Breast Cancer Treated with Neoadjuvant Chemotherapy 8 am R3/002-003 Cleveland Clinic Cancer Center Seminar Series Donna Hansel, MD, PhD Associate Professor, Anatomic Pathology CWRU/Cleveland Clinic Topic: Bladder Cancer on the Move: mTOR and Migration 12 pm BRB 105 LRI Graduate Student Association Seminar Vincent Tuohy, PhD Professor, Immunology CWRU/Cleveland Clinic Topic: Developing Immune Protection Against Adult Diseases 3 pm Bunts Auditorium Cleveland Clinic Cancer Center Research in Progress Seminar Peng Zhang Graduate Student, Wang Lab CWRU/UH Topic: Identification of Cas as a Substrate of PTPN14 4 pm WRB 3-136 Case CCC Calendar LRI Calendar UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS Breast Cancer Detection and Management: Issues for 2011 May 20 Hilton Cleveland East Brochure Case CCC Annual Scientific Retreat July 8-9 Details to follow ADDITIONAL UPCOMING SEMINARS & EVENTS Fourth Annual Translational to Clinical (T2C) Wound Care Conference April 8-9 Ohio Union, Ohio State University, Columbus Details Midwest Blood Club 9th Annual Symposium April 21-22 Cincinnati Children's Hospital Medical Center Details 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting April 27-29 Omni Shoreham in Washington, DC Details Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation May 1-4 Westin Hotel Cincinnati Details 4th International Symposium on Cancer Metastasis and the Lymphovascular System May 12-14 New York City Details 2nd Annual Department of Medicine Research Day May 16 12-5 pm Wolstein Research Building auditorium and lobby Details Race for the Place June 5 Beachwood Place Mall Details International Society for Stem Cell Research (ISSCR) Annual Meeting June 15-18 Toronto, Canada Details Cancer Health Disparities Summit 2011 July 13-15 Bethesda North Marriott Hotel in Rockville, Maryland Details 8th International Conference of the Society for Integrative Oncology November 10-12 InterContinental Hotel Cleveland Details

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES
Avon Foundation Breast Cancer Research Program Cycle 2 LOI Deadline: May 6 Cycle 2 Full Proposal Deadline: July 5 Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research Deadline: August 17 Lustgarten Foundation Fall 2011: Basic Research Innovator Awards Concept Proposal Deadline: September 14 Full Application Deadline: October 31 Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC) Deadline: Open	AACR Scholar-in-Training Awards - Other Conferences and Meetings Deadline: Open International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships Application Deadline: Open NCI Short-Term Scientist Exchange Program Application Deadline: Open James S. McDonnell Foundation Collaborative Activity Awards Application Deadline: Open
NIH BULLETIN – Notices and Funding Opportunities Genetic Screens to Enhance Zebrafish Research (R01) (PAR-11-130) Enhancing Zebrafish Research with Research Tools and Techniques (R01) (PAR-11-131)
Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216-844-8317 phone 216-844-7832 fax gillian.irwin@case.edu	HELP US HELP YOU! If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu.