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Case Comprehensive Cancer Center Newsletter

February 28, 2011

CASE CCC IN THE NEWS

Cleveland Clinic Researchers Hopeful About Study Findings, Promise of Future Prostate Cancer Test
Plain Dealer - Feb 22, 2011
"The exciting thing is that we have identified the gene expression signature of [these genes] that we think predicts [cancer recurrence]," said urologist Dr. Eric Klein, chairman of the Glickman Urological and Kidney Institute at the Clinic.


MARK YOUR CALENDARS

Cancer Center Seminar Series: Retinoids and Cancer
noy

Friday, March 4
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, March 4 at the next Cancer Center Seminar Series featuring Noa Noy, PhD. Dr. Noy, Professor of Pharmacology, will present Retinoids and Cancer.

Dr. Noy has had a long-standing interest in understanding the physiological functions and mechanisms of action and of nuclear hormone receptors, especially as related to receptors that respond to retinoids (vitamin A and its metabolites). Her laboratory discovered that the transcriptional activities of retinoic acid (RA) are mediated by two different nuclear receptors, RAR and PPARβ/δ. Furthermore, the group found that RA signaling partitions between these pathways through the actions of two binding proteins: CRABP-II, which delivers RA to RARs, and FABP5, which shuttles the hormone to the alternate receptor PPARβ/δ. The laboratory showed that dysregulation of the balance between these two pathways underlies the RA-resistance of some cancers. On-going work aims to develop novel anticarcinogenic agents that will inhibit mammary carcinoma growth by restoring proper RA signaling. Recently, the Noy laboratory established that the parental vitamin A molecule, retinol, which has long been believed to function solely through active metabolites, is in fact a signaling molecule in its own right, which can regulate gene transcription through the JAK/STAT cascade. These observations indicate the scope of the biological activities of vitamin A is broader than previously suspected.

Cancer Imaging Program Cellular Imaging Focus Group "Mini Talk"

The leaders of the Cancer Imaging Program invite you to attend a Cellular Imaging Focus Group "Mini Talk", Monday, February 28 at 3:30 pm in Wearn B-37. Drs. David Wilson, Zhenghong Lee and Alex Huang are featured presenters. All are welcome and encouraged to attend. Please contact Drs. Zhenghong Lee (zxl11@case.edu) or James Basilion (james.basilion@case.edu) for more information.

Case CCC Scientific Series

The next installment of the Case CCC Scientific Series is scheduled for Thursday, April 21 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413). Drs. Anton Gorbachev, Neetu Gupta and Alex Huang will discuss the topic of Immunology. Presentations will be followed by a short receptions. All are encouraged to attend.

CWRU Research Best Practices Day

Registration is open for the CWRU Research Best Practices Day, Friday, March 18 from 8 am - 2 pm in Wolstein Auditorium (WRB 1-413). Planned sessions include Responsible Conduct of Research, Conflicts of Interests in Research, Technology Transfer, Human Subjects Protections, and Research Financials. Investigators, study coordinators, department assistants, graduate students and others involved in research at CWRU and the affiliated hospitals are encouraged to attend.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


FUNDING OPPORTUNITIES

American Cancer Society Research Scholar Grants

With a primary focus on beginning investigators, the ACS Extramural Grants Program seeks to support and promote high impact and innovative cancer research across a wide range of disciplines to meet critically important needs in the control of cancer. Each year, the Society receives approximately 2,000 requests for research funding and health care professional training support. All proposals are subjected to multiple levels of peer review to identify the most meritorious and innovative projects for funding. The Society offers extramural support for research and training via five programs: Health Professional Training in Grant Control, Molecular Genetics and Biochemistry of Cancer, Cancer Cell Biology and Metastasis, Preclinical and Translational Cancer Research, Clinical Cancer Research and Immunology, and Cancer Control and Prevention Research.

Applications are being accepted for ACS Research Scholar Grants, which provide the resources for investigator-initiated research in a variety of cancer-relevant areas. Applicants must be independent, self-directed researchers within six years of their first academic appointment.

Applicants to the ACS Cancer Control and Prevention Research Program ONLY may be at any career stage provided the focus of their project is either: 1) health policy/health services research or 2) cancer disparity reduction.

Deadline: April 1


NCI CANCER BULLETIN

February 22, 2011

News
Featured Article: Some Women May Not Need More Extensive Lymph Node Surgery for Breast Cancer

Dutasteride May Slow Growth of Early-Stage Prostate Cancer

Bisphosphonate Use May Reduce Colorectal Cancer Risk

Common Genetic Deletion Found in Brain Cancers

More DNA Rearrangements Found in Prostate Cancers

Certain Physicians Are More Likely to Refer Patients to Clinical Trials

In Depth
Targeted Therapies May Be Effective Against Rare Pancreatic Cancer

Profiles in Cancer Research: Dr. Robin Yabroff

Featured Clinical Trial: Treating Multiply Relapsed or Refractory Hairy Cell Leukemia

Updates
HHS Update

FDA Update

Cancer.gov Update

Notes

EVENTS

calendar

**All events are open to anyone interested in attending

February 28

Pathology Research Seminar
William Schiemann, PhD
Associate Professor, General Medical Sciences-Oncology
CWRU/UH
Topic: Oncogenic TGF-β Signaling in Breast Cancer
12 pm WRB 1-413

SDIG Meeting
Xiaoqing Yu
PhD Student, Epidemiology and Biostatistics
CWRU
Topic: How Well do Alignment Programs Perform on Sequencing Data with Varying Qualities and Obtained from Repeat Regions?
2:30 pm WRB 1-403

Cancer Imaging Program Cellular Imaging Focus Group "Mini Talk"
Speakers: Drs. David Wilson, Zhenghong Lee and Alex Huang
3:30 pm Wearn B-37

Physiology and Biophysics Seminar
Ruhong Zhou, PhD
Manager, Protein Science Group
Computational Biology Center
Thomas J. Watson Research Center
Topic: Large Scale Molecular Modeling with BlueGene Supercomputer
4 pm SOM E501


March 1

Cancer Center Postdoctoral Candidate Seminar
Sanjib Chowdhury, PhD
Brattain Laboratory, Eppley Cancer Center University of Nebraska
Topic: A Novel Function for TGFβ Signaling as a Metastatic Suppressor
10 am WRB 3-136

Cancer Biology Seminar
Manmeet Ahluwalia, MD
Section Head, Brain Tumor and Neuro-Oncology Center
Cleveland Clinic
Topic: High Grade Gliomas: The Past, Present and Future
11 am NC1-202 Cleveland Clinic

Immunology Seminar: Aikawa Lecture
Thomas Nutman, MD
Chief, Helminth Immunology Section
National Institute of Allergy and Infectious Diseases
Topic: Helminth Parasites Impose Bystander Controls on Responses to Intracellular Pathogens in Human Co-Infections
12 pm BRB 105

Department of Medicine Grand Rounds
Thomas Zenty III
Chief Executive Officer
University Hospitals
Topic: A Hospital Perspective on the Impact of Health Care Reform on Patient Care
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
Roy Silverstein, MD
Professor, Cell Biology
CWRU/ Cleveland Clinic
Topic: Thrombophilia
12 pm R3-002 Cleveland Clinic


March 2

Hematology and Oncology Division Research Conference
Tamila Kindwall-Keller, DO
Assistant Professor, Medicine- Hem/Onc
CWRU/UH
Topic: Single vs. Double Unit Non-Myeloablative Umbilical Cord Blood Transplantation
8 am Lerner Tower B-151


March 3

Neurosciences Seminar
Robert Miller, PhD
Professor, Neurosciences
Vice Dean for Research, School of Medicine
CWRU
Topic: Modulating Myelin Repair
12:10 pm BRB 105

2010 Science Nobel Prizes: What Were They Given For?
Timothy Atherton, PhD: Physics Prize
Paul Tesar, PhD: Physiology or Medicine Prize
Yanming Wang, PhD: Chemistry Prize
4:15 pm Rockefeller 301


March 4

Hematology/Oncology Fellows
Susan Padrino, MD
Assistant Professor, Psychiatry
CWRU/UH
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Miguel Villalona, MD
Professor, Medical Oncology and Pharmacology
Ohio State University
Topic: K Ras and DNA Repair: Novel Targets in Cancer Treatment
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Noa Noy, PhD
Professor, Pharmacology
CWRU
Topic: Retinoids and Cancer
12 pm BRB 105

Cancer Center Research in Progress Seminar
Yehong Huang
Jacobberger Lab, Div. of General Medical Sciences-Oncology
CWRU/UH
Topic: Effect of B Cyclin on Mitotic Entry and Progression in Mammalian Somatic Cells
4 pm WRB 3-136

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East
Details to follow

Case CCC Annual Scientific Retreat
July 8-9
Details to follow

ADDITIONAL UPCOMING SEMINARS & EVENTS

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5
Las Vegas, Nevada
Details

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29
Bethesda North Marriott Hotel & Conference Center in Bethesda, Maryland
Details

Fourth Annual Translational to Clinical (T2C) Wound Care Conference
April 8-9
Ohio Union, Ohio State University, Columbus
Details

Midwest Blood Club 9th Annual Symposium
April 21-22
Cincinnati Children's Hospital Medical Center
Details

2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29
Omni Shoreham in Washington, DC
Abstract Deadline: December 16
Details

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati
Details

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City
Abstract Submission Deadline: March 15
Details

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada
Details

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland
Details

8th International Conference of the Society for Integrative Oncology
November 10-12
InterContinental Hotel Cleveland
Details



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Prevent Cancer Foundation
Deadline: February 28

Leukemia and Lymphoma Society Translational Research Program
Mandatory LOI Deadline: March 1
Full Application Deadline: March 15

Cancer Research Institute Investigator Award
Deadline: March 1

Lustgarten Foundation Spring 2011: Translational Research Innovator Awards
Concept Proposal Deadline: March 14
Full Application Deadline: May 2

James S. McDonnell Foundation 21st Century Science Research Awards
Deadline: March 15

Lymphoma Research Foundation Mantle Cell Lymphoma (MCL) Exploratory/Developmental Grant
Deadline: March 17

Follicular Lymphoma Research Initiative Clinical Studies Grant
Deadline: March 17

Multiple Myeloma Research Foundation 2011 Research Fellow Award Program
Deadline: March 29

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 31


Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Testing Tobacco Products Promoted to Reduce Harm (R21) (PA-09-047)

Correlative Studies with Specimens from Multi-Site Trials (R01) (PA-08-134)

Exploratory Studies in Cancer Detection, Diagnosis, and Prognosis (R21) (PA-08-267)

Public Comment Period Open on Proposed Adoption and Implementation of the Guide for the Care and Use of Laboratory Animals: Eighth Edition (NOT-OD-11-042)

Reminder of Requirement for Certification Letter for Applications in Response to Kirschstein-NRSA for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (PA-11-112) (NOT-OD-11-046)

Notice of Change in Policy on the Submission of Reference Forms (Letters of Reference) for Kirschstein-NRSA Fellowship (F) Applications (NOT-OD-11-047)

Announcing the Transition of Single Research Project Cooperative Agreements (Single Project U01s) to Electronic Submission for Due Dates on or After May 25, 2011 (NOT-OD-11-048)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.