February 14, 2011
CASE CCC IN THE NEWS
More Cancer Centers Publishing Survival Data
Cleveland Researchers Receive $3 Million Grant to Study HIV
University Hospitals-Case Western Study Links Colon Polyps to Lack of Sleep
MESSAGE FROM THE DIRECTOR
Waiting for the Revolution: Personalized Medicine in the Genomic Era
In the February 4 issue of Science, a news-focused article discusses efforts to utilize genomic discoveries and patient evaluation to develop strategies for personalized cancer evaluation as well as the treatment and evaluation of other diseases.
I encourage you to consider this article [Science, 331:526, 2011, Feb 4] as the Cancer Center moves more aggressively into high throughput sequencing for both scientific discovery and assessment of human malignancies. There are many opportunities for us to take advantage of our new capabilities in genomics to carefully strategize further patient-based discovery, identification of high-risk populations and family diseases, as well as the design of treatments that are based on underlying common genomic abnormalities. In addition to simple DNA sequencing, our capabilities now allow us to consider whole genome sequencing, non-coding and microRNA, and careful computational analysis will let us develop strategic interventions based on common abnormal pathways in cancer subsets.
Undoubtedly, one of our next priorities will be to identify groups of investigators who will proceed along this path through pilot funding and other mechanisms. In addition, our biostatisticians are eager to help clinical research groups develop political protocol strategies that take advantage of subsets of patients with particular genomic abnormalities in treatment design and in therapeutic outcomes.
Stan Gerson, MD
MARK YOUR CALENDARS
Cancer Center Seminar Series: Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance
Friday, February 18
Please join us Friday, February 18 at the next Cancer Center Seminar Series featuring James Finke, PhD. Dr. Finke, Professor of Immunology, will present Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance.
Dr. Finke's research effort is directed toward defining the mechanisms by which the tumor microenvironment can negatively influence the development of T cell immunity to cancer. The major focus has been on T cell suppression mechanisms in patients with renal cell carcinoma, where he has worked with urologists and medical oncologists that treat this disease. The role of myeloid derived suppressor cells (MDSCs) in immune suppression has become a major focus in his laboratory over the past six years. His lab showed MDSCs were increased in the peripheral blood of RCC patients, and in vitro depletion of these cells significantly reversed T cell suppression. The lab also showed that the TKI sunitinib, which is now the front line therapy for metastatic RCC, reduces the number of myeloid derived suppressor cells in RCC patients and in three mouse tumor models that were tested, resulting in improved T cell function. They are beginning to define the mechanisms by which sunitinib inhibits MDSC accumulation in tumor bearing hosts, and test whether the ability of sunitinib to restore T cell responses will improve immunotherapeutic outcomes when combined with vaccines or adoptive T cell therapy.
Cancer Imaging Program Cellular Imaging Focus Group "Mini Talk"
The leaders of the Cancer Imaging Program invite you to attend a Cellular Imaging Focus Group "Mini Talk", Monday, February 28 at 3:30 pm in Wearn B-37. Drs. David Wilson, Zhenghong Lee and Alex Huang are featured presenters. All are welcome and encouraged to attend. Please contact Drs. Zhenghong Lee (email@example.com) or James Basilion (firstname.lastname@example.org) for more information.
Integrated Genomics Shared Resource (IGSR) Lecture
As part of its planned vigorous outreach program, the Cancer Center's newly formed Integrated Genomics Shared Resource (IGSR) will host a talk by speaker Mark Adams, PhD on RNA-Sequencing, Tuesday, February 15 at 2 pm in BRB 105. This promises to be a highly informative lecture and should interest anyone who is curious about or contemplating projects involving quantitation of mRNA, miRNA, snRNA etc using the latest deep sequencing technologies. Dr Adams' address will be broad, covering such topics as: the challenges, technical limitations, cost, data storage and analysis.
For further information on this and other upcoming IGSR-sponsored presentations, please contact Patrick Leahy, Scientific Coordinator, Integrated Genomics Shared resource (ISGR) at 368-0761 or Patrick.Leahy@case.edu.
Lymphoma Research Foundation
The Lymphoma Research Foundation (LRF) Mantle Cell Lymphoma Consortium seeks proposals for Exploratory/Developmental Grants in mantle cell lymphoma. Applications to this initiative must explore or seek to develop novel basic scientific ideas with a concentration on translational medicine. Collaborations between basic and clinical investigators are fundamental to the kinds of applications being sought. The applications should clearly focus on MCL and have a high degree of relevance to research questions pertinent to MCL.
The Lymphoma Research Foundation (LRF) Follicular Lymphoma Consortium also seeks proposals for high quality research studies in follicular lymphoma (FL. Applications to this initiative must include the study of primary FL patient samples to assure relevance to the human disease.
Deadline: March 17
Prevent Cancer Foundation
The Prevent Cancer Foundation is accepting proposals for research grants and fellowships that demonstrate potential for impact on cancer prevention. The Foundation defines cancer prevention as the "reduction of cancer incidence through research, education and early detection".
Deadline: February 28
Case CCC Members Named AAAS Fellows- UPDATE
Drs. Ram Ganapathi and Qing Wang were accidentally omitted from last week's announcement of recently elected Fellows to the American Association for the Advancement of Science (AAAS). Dr. Ganapathi was recognized for his achievement in Pharmaceutical Sciences, and Dr. Wang for Medical Sciences.
New cancer research protocols requiring IRB review will be submitted, reviewed and stored electronically using the Case Cancer IRB electronic, web-based submission and review database provided by iMedRIS™ Data Corporation.
Part 4 (How to Respond to Stipulations) and Part 5 (How to submit Amendments) of the iMedRIS™ training sessions will be offered through February. All interactive training will be accessible online using Adobe Acrobat Connect and telephone conference line and can be accessed at personal workstations.
NCI CANCER BULLETIN
February 8, 2011
**All events are open to anyone interested in attending
1st Mark A. Smith Memorial Lecture Pathology Research Seminar
Physiology and Biophysics Seminar
Taussig Cancer Institute Core Curriculum Series
Integrated Genomics Shared Resource (IGSR) Lecture
Hematology and Oncology Division Research Conference
Department of Immunology Faculty Research in Progress Seminar
Developmental Therapeutics Program Meeting
Is Cancer Curable?
Department of Stem Cell Biology and Regenerative Medicine Seminar
Physiology and Biophysics Faculty Candidate Seminar
Taussig Cancer Institute Grand Rounds
Cell Biology Seminar Series
Cancer Center Seminar Series
Cancer Center Research in Progress Seminar
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS
Breast Cancer Detection and Management: Issues for 2011
Case CCC Annual Scientific Retreat
ADDITIONAL UPCOMING SEMINARS & EVENTS
Active Living Research Annual Conference
14th Annual Meeting of the Translational Research Cancer Centers Consortium 2011
Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
Fourth Annual Translational to Clinical (T2C) Wound Care Conference
2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
4th International Symposium on Cancer Metastasis and the Lymphovascular System
International Society for Stem Cell Research (ISSCR) Annual Meeting
Cancer Health Disparities Summit 2011
8th International Conference of the Society for Integrative Oncology
PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES
Multiple Myeloma Research Foundation 2011 Senior Research Award Program
Multiple Myeloma Research Foundation 2011 Research Fellow Award Program
NIH BULLETIN – Notices and Funding Opportunities
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
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