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Case Comprehensive Cancer Center Newsletter

February 14, 2011

CASE CCC IN THE NEWS

More Cancer Centers Publishing Survival Data
Medscape - Feb 10, 2011
Such "transparency" is the future of oncology, according to Brian Bolwell, MD, interim chair of the Taussig Cancer Institute at the Cleveland Clinic in Ohio ...

Cleveland Researchers Receive $3 Million Grant to Study HIV
Crain's Cleveland Business - Feb 10, 2011
The grant from the Richard J. Fasenmyer Foundation will fund joint efforts between the Clinic's Dr. Leonard Calabrese and CWRU's Dr. Michael Lederman. ...

University Hospitals-Case Western Study Links Colon Polyps to Lack of Sleep
Plain Dealer - Feb 8, 2011
The results weren't that surprising, said Dr. Li Li, family medicine physician at UH and the study's principal investigator. "Within the last five years, ...


MESSAGE FROM THE DIRECTOR

Waiting for the Revolution: Personalized Medicine in the Genomic Era

In the February 4 issue of Science, a news-focused article discusses efforts to utilize genomic discoveries and patient evaluation to develop strategies for personalized cancer evaluation as well as the treatment and evaluation of other diseases.

I encourage you to consider this article [Science, 331:526, 2011, Feb 4] as the Cancer Center moves more aggressively into high throughput sequencing for both scientific discovery and assessment of human malignancies. There are many opportunities for us to take advantage of our new capabilities in genomics to carefully strategize further patient-based discovery, identification of high-risk populations and family diseases, as well as the design of treatments that are based on underlying common genomic abnormalities. In addition to simple DNA sequencing, our capabilities now allow us to consider whole genome sequencing, non-coding and microRNA, and careful computational analysis will let us develop strategic interventions based on common abnormal pathways in cancer subsets.

Undoubtedly, one of our next priorities will be to identify groups of investigators who will proceed along this path through pilot funding and other mechanisms. In addition, our biostatisticians are eager to help clinical research groups develop political protocol strategies that take advantage of subsets of patients with particular genomic abnormalities in treatment design and in therapeutic outcomes.

Stan Gerson, MD
Director, Case CCC


MARK YOUR CALENDARS

Cancer Center Seminar Series: Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance
finke

Friday, February 18
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, February 18 at the next Cancer Center Seminar Series featuring James Finke, PhD. Dr. Finke, Professor of Immunology, will present Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance.

Dr. Finke's research effort is directed toward defining the mechanisms by which the tumor microenvironment can negatively influence the development of T cell immunity to cancer. The major focus has been on T cell suppression mechanisms in patients with renal cell carcinoma, where he has worked with urologists and medical oncologists that treat this disease. The role of myeloid derived suppressor cells (MDSCs) in immune suppression has become a major focus in his laboratory over the past six years. His lab showed MDSCs were increased in the peripheral blood of RCC patients, and in vitro depletion of these cells significantly reversed T cell suppression. The lab also showed that the TKI sunitinib, which is now the front line therapy for metastatic RCC, reduces the number of myeloid derived suppressor cells in RCC patients and in three mouse tumor models that were tested, resulting in improved T cell function. They are beginning to define the mechanisms by which sunitinib inhibits MDSC accumulation in tumor bearing hosts, and test whether the ability of sunitinib to restore T cell responses will improve immunotherapeutic outcomes when combined with vaccines or adoptive T cell therapy.

Cancer Imaging Program Cellular Imaging Focus Group "Mini Talk"

The leaders of the Cancer Imaging Program invite you to attend a Cellular Imaging Focus Group "Mini Talk", Monday, February 28 at 3:30 pm in Wearn B-37. Drs. David Wilson, Zhenghong Lee and Alex Huang are featured presenters. All are welcome and encouraged to attend. Please contact Drs. Zhenghong Lee (zxl11@case.edu) or James Basilion (james.basilion@case.edu) for more information.

Integrated Genomics Shared Resource (IGSR) Lecture

As part of its planned vigorous outreach program, the Cancer Center's newly formed Integrated Genomics Shared Resource (IGSR) will host a talk by speaker Mark Adams, PhD on RNA-Sequencing, Tuesday, February 15 at 2 pm in BRB 105. This promises to be a highly informative lecture and should interest anyone who is curious about or contemplating projects involving quantitation of mRNA, miRNA, snRNA etc using the latest deep sequencing technologies. Dr Adams' address will be broad, covering such topics as: the challenges, technical limitations, cost, data storage and analysis.

For further information on this and other upcoming IGSR-sponsored presentations, please contact Patrick Leahy, Scientific Coordinator, Integrated Genomics Shared resource (ISGR) at 368-0761 or Patrick.Leahy@case.edu.


FUNDING OPPORTUNITIES

Lymphoma Research Foundation

The Lymphoma Research Foundation (LRF) Mantle Cell Lymphoma Consortium seeks proposals for Exploratory/Developmental Grants in mantle cell lymphoma. Applications to this initiative must explore or seek to develop novel basic scientific ideas with a concentration on translational medicine. Collaborations between basic and clinical investigators are fundamental to the kinds of applications being sought. The applications should clearly focus on MCL and have a high degree of relevance to research questions pertinent to MCL.

The Lymphoma Research Foundation (LRF) Follicular Lymphoma Consortium also seeks proposals for high quality research studies in follicular lymphoma (FL. Applications to this initiative must include the study of primary FL patient samples to assure relevance to the human disease.

Deadline: March 17

Prevent Cancer Foundation

The Prevent Cancer Foundation is accepting proposals for research grants and fellowships that demonstrate potential for impact on cancer prevention. The Foundation defines cancer prevention as the "reduction of cancer incidence through research, education and early detection".

Deadline: February 28


ANNOUNCEMENTS

Case CCC Members Named AAAS Fellows- UPDATE

Drs. Ram Ganapathi and Qing Wang were accidentally omitted from last week's announcement of recently elected Fellows to the American Association for the Advancement of Science (AAAS). Dr. Ganapathi was recognized for his achievement in Pharmaceutical Sciences, and Dr. Wang for Medical Sciences.

iMedRIS Training

New cancer research protocols requiring IRB review will be submitted, reviewed and stored electronically using the Case Cancer IRB electronic, web-based submission and review database provided by iMedRIS™ Data Corporation.

Part 4 (How to Respond to Stipulations) and Part 5 (How to submit Amendments) of the iMedRIS™ training sessions will be offered through February. All interactive training will be accessible online using Adobe Acrobat Connect and telephone conference line and can be accessed at personal workstations.

For more information or to download training guides, please visit the iRIS Training Page. To register, please contact Mariesa Malinowski or Mark Tennant.


NCI CANCER BULLETIN

February 8, 2011

News
Featured Article: When Combined with Chemo, Bevacizumab Is Associated with Increased Risk of Death

Starting Hormone Therapy at Menopause Increases Breast Cancer Risk

Vaccine Reduces HPV Infections in Young Men

Adoptive Cell Transfer Targets New Cancer Antigen for Immunotherapy

Mouse Studies Point to Prognostic Test for Prostate Cancer

Protein May Help Predict Cancer Recurrence and Metastasis

In Depth
Coming Home to Roost: The Self-Seeding Hypothesis of Tumor Growth

Featured Clinical Trial: Study of a Statin to Prevent Polyps after Colon Cancer Resection

Translating Clinical Care for Callers to NCI's Cancer Information Service

Updates
FDA Update

Notes

EVENTS

calendar

**All events are open to anyone interested in attending

February 14

1st Mark A. Smith Memorial Lecture Pathology Research Seminar
John Hardy, PhD
Professor, Neuroscience
Institute of Neurology, University College London
Topic: Amyloid Hypothesis of Alzheimer's Disease: Is it Consistent With New Genetic Data?
12 pm WRB 1-413

SDIG Meeting
David Serre, PhD
Assistant Staff, Genomic Medicine Institute
Cleveland Clinic
Topic: Sequencing Mosquitoes: Genomic Approaches to Malaria Biology
2:30 pm WRB 2-136

Physiology and Biophysics Seminar
Bert van den Berg, PhD
Associate Professor, Program in Molecular Medicine
University of Massachusetts
Topic: Cleaning up our Mess: Outer Membrane Transport of Hydrophobic Molecules by Gram-negative Bacteria
4 pm SOM E501


February 15

Neurosciences Seminar
John Hardy, PhD
Professor, Neuroscience
Institute of Neurology, University College London
Topic: Whole Genome Strategies in PD
11 am NE1-205 Cleveland Clinic

Immunology Seminar
John Letterio, MD
Professor, Pediatrics-Hem/Onc
CWRU/ UH
Topic: Cdk5: An Emerging Role in T Cell Signaling and Function
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
David Peereboom, MD
Associate Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Brain Metastases
12 pm R3-002 Cleveland Clinic

Integrated Genomics Shared Resource (IGSR) Lecture
Mark Adams, PhD
Associate Professor, Genetics
CWRU
Topic: RNA-Sequencing
2 pm BRB 105


February 16

Hematology and Oncology Division Research Conference
Nathan Berger, MD
Director, Center for Science, Health and Society
Professor, Medicine-Hem/Onc
CWRU/UH
Topic: Exercise, Energy Balance and Cancer
8 am Lerner Tower B-151

Department of Immunology Faculty Research in Progress Seminar
Booki Min, DVM, PhD
Assistant Professor, Immunology
CWRU/ Cleveland Clinic
Topic: Regulating T Cell Homeostasis: Old Questions Are Answered But New Questions Are Raised
12 pm NC1-202 Cleveland Clinic

Developmental Therapeutics Program Meeting
5 pm WRB 2-136


February 17

Is Cancer Curable?
Drs. Stan Gerson and Derek Raghavan
11:30 am Executive Caterers Corporate Club
Registration

Department of Stem Cell Biology and Regenerative Medicine Seminar
Dipanjan Chowdhury, PhD
Assistant Professor, Radiation Oncology
Dana Farber/Harvard Cancer Center
Topic: microRNAs and DNA Repair
1 pm NE1-205 Cleveland Clinic

Physiology and Biophysics Faculty Candidate Seminar
Edward Yu, PhD
Associate Professor, Chemistry
Iowa State University
Topic: Structure and Function of Efflux Pumps
4 pm SOM E501


February 18

Hematology/Oncology Fellows
Rami Manochakian, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Esophageal Cancer
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Ralph Meyer, MD
National Cancer Institute of Canada
Topic: TBD
8 am R3/002-003 Cleveland Clinic

Cell Biology Seminar Series
Peter Scacheri, PhD
Assistant Professor, Genetics
CWRU
Topic: CHARGE syndrome and CHD7: Functional Insights Revealed Through Genomic Studies of Chromatin
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
James Finke, PhD
Professor, Immunology
CWRU/ Cleveland Clinic
Topic: Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance
12 pm BRB 105

Cancer Center Research in Progress Seminar
Topic: TBD
4 pm WRB 3-136

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East
Details to follow

Case CCC Annual Scientific Retreat
July 8-9
Details to follow

ADDITIONAL UPCOMING SEMINARS & EVENTS

Active Living Research Annual Conference
February 22-24
San Diego, CA
Details

14th Annual Meeting of the Translational Research Cancer Centers Consortium 2011
February 24-26
Seven Springs Mountain Resort, Seven Springs, PA
Details

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5
Las Vegas, Nevada
Details

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29
Bethesda North Marriott Hotel & Conference Center in Bethesda, Maryland
Details

Fourth Annual Translational to Clinical (T2C) Wound Care Conference
April 8-9
Ohio Union, Ohio State University, Columbus
Details

2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29
Omni Shoreham in Washington, DC
Abstract Deadline: December 16
Details

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati
Details

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City
Abstract Submission Deadline: March 15
Details

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada
Details

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland
Details

8th International Conference of the Society for Integrative Oncology
November 10-12
InterContinental Hotel Cleveland
Details



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Multiple Myeloma Research Foundation 2011 Senior Research Award Program
Deadline: February 15

2011 Dr. Paul Janssen Award for Biomedical Research
Deadline: February 15

Leukemia Research Foundation
Deadline: February 15

ACS Cancer Research Fellowship
Deadline: February 16

CTSC Translational Research through Community-Academic Partnerships and Community Research
Mandatory LOI: February 17
Full Application Deadline: April 4

ASCO Medical Student Rotation
Deadline: February 21

ASCO Resident Travel Award
Deadline: February 21

Prostate Cancer Foundation (PCF)-Honorable A. David Mazzone Special Challenge Award Research Program
Deadline: February 24

Leukemia and Lymphoma Society Translational Research Program
Mandatory LOI Deadline: March 1
Full Application Deadline: March 15

Cancer Research Institute Investigator Award
Deadline: March 1

Lustgarten Foundation Spring 2011: Translational Research Innovator Awards
Concept Proposal Deadline: March 14
Full Application Deadline: May 2

James S. McDonnell Foundation 21st Century Science Research Awards
Deadline: March 15


Multiple Myeloma Research Foundation 2011 Research Fellow Award Program
Deadline: March 29

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 31

Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30) (PA-10-110)

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31) (PA-10-111)

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (PA-11-112)

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) (PA-11-113)

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) (PA-11-114)

Notice of Change in Policy on the Submission of Plans for Instruction in the Responsible Conduct of Research for Institutional Training Grant (T and D) Applications (NOT-OD-11-039)

IACUC 101 Workshop and PRIM&R 2011 IACUC Conference: March 30-April 1, 2011 in Chicago, IL (NOT-OD-11-041)

NCI Will Participate in RFA-ES-11-002, Dietary Influence on the Human Health Effects of Environmental Exposures (R21) (NOT-CA-11-007)

Request for Information (RFI): Challenges and Opportunities in Single Cell Analysis for Biomedical Research (NOT-RM-11-007)

Centers for AIDS Research and Developmental Centers for AIDS Research (P30) (PAR-11-108)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

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