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February 14, 2011 |
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CASE CCC IN THE NEWSMore Cancer Centers Publishing Survival Data Cleveland Researchers Receive $3 Million Grant to Study HIV University Hospitals-Case Western Study Links Colon Polyps to Lack of Sleep MESSAGE FROM THE DIRECTORWaiting for the Revolution: Personalized Medicine in the Genomic EraIn the February 4 issue of Science, a news-focused article discusses efforts to utilize genomic discoveries and patient evaluation to develop strategies for personalized cancer evaluation as well as the treatment and evaluation of other diseases. I encourage you to consider this article [Science, 331:526, 2011, Feb 4] as the Cancer Center moves more aggressively into high throughput sequencing for both scientific discovery and assessment of human malignancies. There are many opportunities for us to take advantage of our new capabilities in genomics to carefully strategize further patient-based discovery, identification of high-risk populations and family diseases, as well as the design of treatments that are based on underlying common genomic abnormalities. In addition to simple DNA sequencing, our capabilities now allow us to consider whole genome sequencing, non-coding and microRNA, and careful computational analysis will let us develop strategic interventions based on common abnormal pathways in cancer subsets. Undoubtedly, one of our next priorities will be to identify groups of investigators who will proceed along this path through pilot funding and other mechanisms. In addition, our biostatisticians are eager to help clinical research groups develop political protocol strategies that take advantage of subsets of patients with particular genomic abnormalities in treatment design and in therapeutic outcomes. Stan Gerson, MD MARK YOUR CALENDARSCancer Center Seminar Series: Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance
Friday, February 18 Please join us Friday, February 18 at the next Cancer Center Seminar Series featuring James Finke, PhD. Dr. Finke, Professor of Immunology, will present Sunitinib Regulation of Myeloid Derived Suppressor Cells in Cancer; Impact on Immune Function and Resistance. Dr. Finke's research effort is directed toward defining the mechanisms by which the tumor microenvironment can negatively influence the development of T cell immunity to cancer. The major focus has been on T cell suppression mechanisms in patients with renal cell carcinoma, where he has worked with urologists and medical oncologists that treat this disease. The role of myeloid derived suppressor cells (MDSCs) in immune suppression has become a major focus in his laboratory over the past six years. His lab showed MDSCs were increased in the peripheral blood of RCC patients, and in vitro depletion of these cells significantly reversed T cell suppression. The lab also showed that the TKI sunitinib, which is now the front line therapy for metastatic RCC, reduces the number of myeloid derived suppressor cells in RCC patients and in three mouse tumor models that were tested, resulting in improved T cell function. They are beginning to define the mechanisms by which sunitinib inhibits MDSC accumulation in tumor bearing hosts, and test whether the ability of sunitinib to restore T cell responses will improve immunotherapeutic outcomes when combined with vaccines or adoptive T cell therapy. Cancer Imaging Program Cellular Imaging Focus Group "Mini Talk"The leaders of the Cancer Imaging Program invite you to attend a Cellular Imaging Focus Group "Mini Talk", Monday, February 28 at 3:30 pm in Wearn B-37. Drs. David Wilson, Zhenghong Lee and Alex Huang are featured presenters. All are welcome and encouraged to attend. Please contact Drs. Zhenghong Lee (zxl11@case.edu) or James Basilion (james.basilion@case.edu) for more information. Integrated Genomics Shared Resource (IGSR) LectureAs part of its planned vigorous outreach program, the Cancer Center's newly formed Integrated Genomics Shared Resource (IGSR) will host a talk by speaker Mark Adams, PhD on RNA-Sequencing, Tuesday, February 15 at 2 pm in BRB 105. This promises to be a highly informative lecture and should interest anyone who is curious about or contemplating projects involving quantitation of mRNA, miRNA, snRNA etc using the latest deep sequencing technologies. Dr Adams' address will be broad, covering such topics as: the challenges, technical limitations, cost, data storage and analysis. For further information on this and other upcoming IGSR-sponsored presentations, please contact Patrick Leahy, Scientific Coordinator, Integrated Genomics Shared resource (ISGR) at 368-0761 or Patrick.Leahy@case.edu. FUNDING OPPORTUNITIESLymphoma Research FoundationThe Lymphoma Research Foundation (LRF) Mantle Cell Lymphoma Consortium seeks proposals for Exploratory/Developmental Grants in mantle cell lymphoma. Applications to this initiative must explore or seek to develop novel basic scientific ideas with a concentration on translational medicine. Collaborations between basic and clinical investigators are fundamental to the kinds of applications being sought. The applications should clearly focus on MCL and have a high degree of relevance to research questions pertinent to MCL. The Lymphoma Research Foundation (LRF) Follicular Lymphoma Consortium also seeks proposals for high quality research studies in follicular lymphoma (FL. Applications to this initiative must include the study of primary FL patient samples to assure relevance to the human disease. Deadline: March 17 Prevent Cancer FoundationThe Prevent Cancer Foundation is accepting proposals for research grants and fellowships that demonstrate potential for impact on cancer prevention. The Foundation defines cancer prevention as the "reduction of cancer incidence through research, education and early detection". Deadline: February 28 ANNOUNCEMENTSCase CCC Members Named AAAS Fellows- UPDATEDrs. Ram Ganapathi and Qing Wang were accidentally omitted from last week's announcement of recently elected Fellows to the American Association for the Advancement of Science (AAAS). Dr. Ganapathi was recognized for his achievement in Pharmaceutical Sciences, and Dr. Wang for Medical Sciences. iMedRIS TrainingNew cancer research protocols requiring IRB review will be submitted, reviewed and stored electronically using the Case Cancer IRB electronic, web-based submission and review database provided by iMedRIS™ Data Corporation. Part 4 (How to Respond to Stipulations) and Part 5 (How to submit Amendments) of the iMedRIS™ training sessions will be offered through February. All interactive training will be accessible online using Adobe Acrobat Connect and telephone conference line and can be accessed at personal workstations. For more information or to download training guides, please visit the iRIS Training Page. To register, please contact Mariesa Malinowski or Mark Tennant. NCI CANCER BULLETINFebruary 8, 2011News In Depth Updates |
EVENTS
**All events are open to anyone interested in attending February 141st Mark A. Smith Memorial Lecture Pathology Research Seminar SDIG Meeting Physiology and Biophysics Seminar February 15Neurosciences Seminar Immunology Seminar Taussig Cancer Institute Core Curriculum Series Integrated Genomics Shared Resource (IGSR) Lecture February 16Hematology and Oncology Division Research Conference Department of Immunology Faculty Research in Progress Seminar Developmental Therapeutics Program Meeting February 17Is Cancer Curable? Department of Stem Cell Biology and Regenerative Medicine Seminar Physiology and Biophysics Faculty Candidate Seminar February 18Hematology/Oncology Fellows Taussig Cancer Institute Grand Rounds Cell Biology Seminar Series Cancer Center Seminar Series Cancer Center Research in Progress Seminar
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTSBreast Cancer Detection and Management: Issues for 2011 Case CCC Annual Scientific Retreat ADDITIONAL UPCOMING SEMINARS & EVENTSActive Living Research Annual Conference 14th Annual Meeting of the Translational Research Cancer Centers Consortium 2011 Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals 4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science Fourth Annual Translational to Clinical (T2C) Wound Care Conference 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation 4th International Symposium on Cancer Metastasis and the Lymphovascular System International Society for Stem Cell Research (ISSCR) Annual Meeting Cancer Health Disparities Summit 2011 8th International Conference of the Society for Integrative Oncology |
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PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES |
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Multiple Myeloma Research Foundation 2011 Senior Research Award Program |
Multiple Myeloma Research Foundation 2011 Research Fellow Award Program |
NIH BULLETIN – Notices and Funding OpportunitiesCenters for AIDS Research and Developmental Centers for AIDS Research (P30) (PAR-11-108) |
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| Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216-844-8317 phone 216-844-7832 fax gillian.irwin@case.edu |
HELP US HELP YOU!If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu. |
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