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Case Comprehensive Cancer Center Newsletter

September 13, 2010


Cleveland Clinic Researcher Helps Organize International XMRV Meeting
Plain Dealer - Sep 8, 2010
Robert Silverman is a cancer biologist at the Cleveland Clinic instrumental in the discovery of the XMRV virus...

Benefits Seen in Removing Healthy Ovaries in Women With Cancer Risk
AOL Health (blog) - Sep 1, 2010
Though most of the findings weren't new and had already been shown in prior studies, cancer geneticist Dr. Georgia Wiesner told AOL Health that the latest ...

Case CCC Scientific Series Wrap-Up

The Case CCC Scientific Series held on August 30 featured presentations by three of the four basic science of cancer pilot project teams. We had an impressive turnout to hear updates on the projects. Thanks to all of the presenters for a job well done! The next Case CCC Scientific Series is November 8.

Commentary by Dr. Susann Brady-Kalnay, Basic Science of Cancer Focus Groups Coordinating Group Member:
A few years ago, we began to re-organize the basic science program in the Cancer Center into smaller focus groups. The focus groups were designed to bring together scientists with mutual research interests, and to increase the likelihood for collaborative research. Two years ago, a pilot grant request for proposals was issued that called for collaborative research within a focus group. As a result, four teams of investigators were awarded funding.

The August Scientific Series featured updates on three of the pilot projects funded by the Case CCC. A fourth project by Matthias Buck and Danny Manor was not be presented.

The first project by Drs. Cathy Carlin and John Wang summarized how two signaling labs began to investigate the cross talk of their signaling pathways that resulted in the regulation of adhesion-dependent events in cancer. This regulation of integrin adhesion-dependent signaling is a new area of research for these two investigators.

The second talk by Drs. Alex Almasan and Shigemi Matsuyama explained how their existing collaboration regarding cell cycle regulation was extended in new directions by pilot grant funding.

The third talk by Drs. Saba Valadkhan (co-investigator Dr. Phil Howe did not present) opened our eyes to a new area of investigation into the role of non-coding RNAs in signal transduction and cancer. Saba's research illustrates the depth of RNA research that exists in our outstanding RNA Center. Furthermore, her research gives us ideas about pursuing the role of RNA in our own projects with the new RNA core that is sponsored by the Cancer Center.


Susan G. Komen for the Cure

Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants are intended to establish a training program headed by a mentor to support qualified students who are dedicated to pursuing research in breast cancer disparities. Funding award will be individual support of up to $45,000 annually for 2 years with a 3rd year progress based option for up to three trainees.

Pre-Application Deadline: September 30
Full Application Deadline: November 2


NCI Cancer Clinical Investigator Team Leadership Award

Dr. Smitha Krishnamurthi was awarded a Cancer Clinical Investigator Team Leadership Award from the NCI.

CTSC Pilot Awards

Dr. Catherine Demko was recently awarded a 2010 CTSC Annual Pilot Award.

Basic Science of Cancer Focus Group Updates

Message from Drs. Susann Brady-Kalnay and George Stark
There has been a reorganization of the focus groups within the Cancer Cell Signaling Program. We discussed this at the retreat, but wanted to make sure the entire program membership was aware of this change. We are merging our original five focus groups into three larger groups in order to increase critical mass and enhance the likelihood of collaborative activity.

The new focus groups will be:

Cytokine Signaling, Inflammation, and Cancer
(Merged from Inflammation, Infection and Cancer; Stats and the signaling component of TGF beta)
Leaders: Drs. Xiaoxia Li and George Stark

Nuclear Receptor Signaling and Hormone Responsive Cancers
(Nuclear Receptors with a new name to emphasize the Breast and Prostate Cancer component)
Leaders: Drs. David Danielpour and Noa Noy

Tumor Microenvironment and Metastasis
(New name from merging Tumor Cell Signaling with Vascular Biology)
Leader: Dr. Danny Manor

We hope that everyone will continue to participate in as many focus groups as they have a scientific interest in. Please contact Tracy Rehl for more information.


The official Case CCC logo is available on the templates page of the Cancer Center website. Co-branded PowerPoint templates are also available on that page.

As a reminder, the NCI-designated Comprehensive Cancer Center logo may only be used in conjunction with the Case CCC logo.


Cell Death Regulation Program/ DNA Damage Response Meetings

As a follow up to the Cell Death Regulation (Program 2) mini retreat in June, the Program will be hosting a series of monthly meetings to examine topics in DNA damage response. The first meeting will be Thursday, September 16 from 4-6 pm in WRB 1402. Drs. Tom Radivoyevitch and Charles Kunos will present DNA damage Checkpoints and RNRM. There will be an open time at the end of the meeting to discuss related scientific efforts, potential collaboration, and other topics. Additional meetings will alternate between CWRU and the Cleveland Clinic. Light refreshments will be provided. Please RSVP to Kristin Waite. We look forward to seeing you there.

Science Café Cleveland

The October 11 Science Café Cleveland will feature Drs. Ruth Keri and Agata Exner, who will be presenting Pills and needles are so 20th century: How advancements in drug target discovery and drug delivery are shifting the strategy in the battle against cancer. Drinks start at 6:30 pm and discussion begins around 7 pm in the Tasting Room on the second floor of the Great Lakes Brewing Company. Science cafés provide an informal public forum for the open discussion of current science issues; they are based on the European salon model and many such cafés are currently active throughout much of the world.

2010 Cleveland Nanomedicine Summit

Registration is open for the 2010 Cleveland NanoMedicine Summit, October 18-19 at the InterContinental Hotel. Co-hosted by the Cleveland Clinic and CWRU, this event will continue its incredibly successful format that brings together scientists, clinicians, business professionals, investors, and others to investigate sustainable solutions of multidisciplinary methodologies to further advance the use of nanomedicine in clinical practice. Clinical and research abstracts on the topic of nanoparticles for diagnostics, imaging, and therapeutics will be accepted through October 1. Cancer Center members Drs. Vinod Labhasetwar, James Basilion and Maciej Zborowski are on the Organizing Committee.

Graft versus Host Disease Conference

Together with the Case CCC, the Meredith A. Cowden Foundation presents the 2010 National GVHD Symposium to be held at Corporate College East on Thursday, November 4. This unique one-day program will be a two-track conference (one for physicians and one for patients) focusing on cutting edge research and new treatments. Continuing medical education credits will be offered for attending and participating medical providers.

Featured Case CCC presenters include: Drs. Stan Gerson, Ken Cooke, Matt Kalaycio and Jeff Auletta.


Featured Article: Targeted Drug for Melanoma Shows Promise in Early Clinical Testing

For Women with BRCA Mutations, Prophylactic Surgery Reduces Cancer Risk

Less-intensive Treatment Regimen Effective against Multiple Myeloma

Lower-dose Treatments for Early-stage Hodgkin Lymphoma Do Not Compromise Results

Chemotherapy Affects Brain Structure of Breast Cancer Patients

Consuming High Levels of Red Meat and Fat May Increase Liver Cancer Risk

Cancer Patients Leaving Hospice Early Boost Medicare Expenditures

Inside NCI: A Conversation with Dr. Crystal Mackall about Pediatric Oncology

In Depth
Palliative Care Improves Survival, Quality of Life in Advanced Lung Cancer

Autophagy: The Strange Dining Habits of Cancer Cells

Featured Clinical Trial: Comparing Post-transplant Therapies for Multiple Myeloma Patients




**All events are open to anyone interested in attending

September 13

David Satcher Lecture Series
Edward Barksdale Jr, MD
Professor and Division Chief, Pediatric Surgery
Topic: The Measure of Our Success
12 pm Kulas Auditorium (Lakeside 5th fl)

Pathology Research Seminar
Xiao-Jiang Li, MD, PhD
Professor, Human Genetics
Emory University
Topic: Polyglutamine Disease Neuropathology
12 pm WRB 1413

Physiology and Biophysics Seminar
Kevin Currie, PhD
Assistant Professor, Anesthesiology and Pharmacology
Vanderbilt University
Topic: Activity-dependent Regulation of Ca2+ Channels and Stimulus Secretion Coupling
4 pm SOM E501

September 14

Department of Medicine Grand Rounds
Alan Saber, MD
Associate Professor, Surgery
Topic: Bariatric Surgery: What Every PCP or Medical Resident Should Know
12 pm Kulas Auditorium (Lakeside 5th fl)

Immunology Seminar
James Malter, MD
Professor, Pathology and Laboratory Medicine
University of Wisconsin-Madison
Topic: Pinning Down Signaling in the Immune and Nervous Systems: The Role of Peptidyl-Prolyl Isomerases
12 pm WRN 1413

Taussig Cancer Institute Core Curriculum Series
Topic: Bioethics
12 pm R3-002 Cleveland Clinic

September 15

Developmental Therapeutics Program (DTP) meeting canceled

ICC Grand Rounds
Erica Campagnaro, MD
Assistant Professor, Medicine- Hem/Onc
Topic: Introduction to Multiple Myeloma
8 am Lerner Tower B-151

Special Seminar
Greg Plautz, MD
Associate Professor, Center for Surgery Research
CWRU/ Cleveland Clinic
Topic: T Cell Adoptive Immunotherapy of HER2+ Breast Cancer
12 pm NC1-202 Cleveland Clinic

CWRU SOM Louis A. Bloomfield Lecture
Michael Greenberg, PhD
Department Chair and Professor, Neurobiology
Harvard University
Topic: Signaling Networks that Regulate Synapse Development and Cognitive Function
4 pm SOM E401

LRI Showcase Seminar
Thomas Egelhoff, PhD
Professor, Cell Biology
CWRU/ Cleveland Clinic
Topic: Myosin II Motor Proteins: Cytoskeletal Roles in Cancer Cell Migration and Skin Wound Healing
4:30 pm NE1-205 Cleveland Clinic

September 16

Cell Death Regulation Program/ DNA Damage Response Meeting
Tom Radivoyevitch, PhD
Assistant Professor, Epidemiology & Biostatistics
Dr. Charles Kunos
Assistant Professor, Radiation Oncology
Topic: DNA damage Checkpoints and RNRM
4-6 pm WRB 1402

September 17

Hematology and Oncology Fellows
Brenda Cooper, MD
Associate Professor, Department of Medicine- Hem/Onc
Topic: Introduction to Bone Marrow Transplantation
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Jeffrey Bradley, MD
Associate Professor, Radiation Oncology
Washington University/ Siteman Cancer Center
Topic: Current Lung Cancer Research within the RTOG
8 am R3/002-003 Cleveland Clinic

Neurosciences Thesis Defense
Chen Liu
Department of Neurosciences
Topic: Pet-1 is Required Across Different Stages of Life to Regulate Serotonergic Function
12 pm SOM E646

Cancer Center Research in Progress Seminar
Philip Woost, PhD
Senior Research Associate, Jacobberger Lab, Cancer Center
Topic: Signaling in Acute Myeloid Leukemia
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413


2010 caBIG Annual Meeting: Building a Collaborative Biomedical Network
September 13-15
Washington, DC

Third Annual Personalized Health Care National Conference
October 14-15
The Ohio State University, Columbus, OH

Oncology Congress
October 15-17
San Francisco, CA

2010 Cleveland Nanomedicine Summit
October 18-19
InterContinental Hotel, Cleveland, OH
Clinical and research abstracts will be accepted through October 1 (please note new deadline)

International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
October 18-19
Purdue University, West Lafayette, IN

ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
October 18-20
Hollywood, FL
Call for Abstracts

2010 International Conference of RNA Nanotechnology and Therapeutics
October 23- 25
Crowne Plaza Hotel, Cleveland

Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH

Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16




Choose Ohio First Scholarship And Tomas & Evelyn James Fellowship In Bioinformatics, Computational Biology and Medical Informatics
Deadline: September 15

Susan G. Komen for the Cure Postdoctoral Fellowships
Pre-Application Deadline: September 15
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Pre-Application Deadline: September 15
Full Application Deadline: January 5, 2011

Leukemia and Lymphoma Society Scholar Awards
Required LOI Deadline: September 15

Leukemia and Lymphoma Society Scholars in Clinical Research Awards
Required LOI Deadline: September 15

Leukemia and Lymphoma Society Special Fellows
Required LOI Deadline: September 15

Leukemia and Lymphoma Society Special Fellows in Clinical Research (SFCR) Awards
Required LOI Deadline: September 15

Raymond and Beverly Sackler AACR Fellowships for Ileal Carcinoid Tumor Research
Deadline: September 15

Caring for Carcinoid Foundation–AACR Grants for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research
Deadline: September 15

DOD Peer Reviewed Cancer Research Program (PRCRP) Concept Award
Pre-Application Deadline: September 15
Application Deadline: September 29

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

DOD Peer Reviewed Cancer Research Program (PRCRP) Concept Award
Application Deadline: September 29

AACR Princess Takamatsu Memorial Lectureship
Nomination Deadline: September 30

AACR Award for Lifetime Achievement in Cancer Research
Nomination Deadline: September 30

ACS Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families:
Deadline: October 15

ACS Area of Special Interest: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: October 15

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Nomination Deadline: October 15

AACR Richard and Hinda Rosenthal Memorial Award
Nomination Deadline: October 15

DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Awards
Application Deadline: October 20

DOD Peer Reviewed Cancer Research Program (PRCRP) Translational New Investigator Awards
Application Deadline: October 20

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Enhancing Peer Review: Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135)

Amended Status of Applications and Awards Involving Human Embryonic Stem Cells, and Submissions of Stem Cell Lines for Eligibility Consideration (NOT-OD-10-136)

Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.