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Case Comprehensive Cancer Center Newsletter

July 26, 2010


The Marilyn B. Gula Mountains of Hope Foundation Donates Additional Research ...
EurekAlert (press release) - Jul 26, 2010
... UH "Miracle Fund," said William Schiemann, PhD, associate professor and co-director, breast cancer program leader at Case Comprehensive Cancer Center. ...

Will the FDA Revoke Bevacizumab's Approval for Breast Cancer?
Medscape - Jul 21, 2010
Mikkael Sekeres, MD, MS, from the Cleveland Clinic Taussig Cancer Institute in Ohio, argued that bevacizumab failed to demonstrate a clinically meaningful ...

Oklahoma Scientist's Work Could Lead to Faster Colon Cancer Diagnosis
NewsOK.com - Jul 20, 2010
Montgomery said through her collaboration with Dr. Sanford Markowitz at the Case Comprehensive Cancer Center in Cleveland they can predict with about 60 ...


Member Funding News

The Case Western Reserve University/University Hospitals Case Medical Center Center for AIDS Research (CFAR), led by Drs. Jonathan Karn and Michael Lederman, has received a five-year renewal grant from the NIH for $9 million. The additional funding will help provide clinical and technical support for HIV-related research projects at CWRU, UH, MetroHealth Medical Center, the Cleveland Clinic and several sites abroad. The money will also help support new projects linking HIV and cancer.

Bingcheng Wang, PhD recently received funding from the Prayers From Maria Foundation, a local organization dedicated to funding global research into the causes, prevention, treatments, and cure for the deadliest childhood brain tumors known as gliomas. Click here to find out more.

Message from the FDA: Reorganization of the Office of Oncology Drug Products (OODP)

As part of recent organizational changes within the Office of New Drugs, the Office of Oncology Drug Products (OODP) is planning a reorganization that reaffirms our commitment to improve the efficiency and consistency of oncology product development and review.

OODP has been comprised of three divisions–the Division of Oncology Drug Products, the Division of Biologic Oncology Products, and the Division of Hematology Products. The proposed reorganization–expected to take effect in 2011–will change our name from OODP to the Office of Hematology and Oncology Products (OHOP) and create a new structure with four divisions:

  • The Division of Hematology Products (DHP)
  • The Division of Hematology Oncology Toxicology (DHOT)
  • The Division of Oncology Products 1 (DOP 1)
  • The Division of Oncology Products 2 (DOP 2)

The Oncology Program, which coordinates oncology activities across FDA Centers and with the National Cancer Institute (NCI) and other cancer-related organizations, will remain in the Immediate Office.

Key features of the reorganization:

  • The review of biologic and drug products will be integrated within each review division. Previously, separate divisions within the office reviewed either biologic products or drug products. Integrating these products is consistent with the review structure in other OND offices and will foster the development of our staff's expertise.
  • Review staff within the two divisions of oncology products will specialize in specific oncologic diseases (e.g., breast cancer, gastrointestinal cancer, melanoma). This approach will align FDA's oncology review with the organizational structure of leading cancer centers, academic programs, NCI and NHLBI. Disease-specific orientation of our reviewers will promote their professional growth and improve the consistency of our regulatory advice and decisions.
  • There will be a distinct division, DHOT, dedicated to reviewing the non-clinical pharmacology and toxicology of oncology products. This change recognizes the increased importance of these disciplines as the science of oncology drug development becomes more complex. It will also foster greater support of and closer collaboration among our pharmatox staff.

With these organizational enhancements, we will be in the best position to meet the needs of an increasingly more complex area of drug development and medicine.

Toward Improving the Quality of Cancer Care Monograph Available Free of Charge

Copies of the monograph Toward Improving the Quality of Cancer Care: Addressing the Interfaces of Primary & Oncology-Related Subspecialty Care are now available. To order one copy of the monograph free of charge, e-mail Susan Scott and include your name and mailing address.

Varmus Town Hall Meeting Webcast

An archived webcast of the Town Hall Meeting held by new NCI Director Dr. Harold Varmus on July 12 is available for viewing.

2011 Case CCC Scientific Retreat

Help us schedule the 2011 Case CCC Scientific Retreat. Please click here to take a short two-question survey and let us know the best time of year to hold the retreat. We appreciate your input!



**All events are open to anyone interested in attending

July 26

July 27

July 28

ICC Grand Rounds
Henry Koon, MD
Assistant Professor, Medicine- Div. of Hem/Onc
Topic: Current Therapies for Melanoma
8 am Lerner Tower B-151

July 29

Inflammation, Infection and Cancer Focus Group Meeting canceled

Taussig Cancer Institute Core Curriculum
Edward Copelan, MD
Professor, Hematologic Oncology & Blood Disorders
CWRU/ Cleveland Clinic
Topic: Management of AML
12 pm R3-002 Cleveland Clinic

July 30

Taussig Cancer Institute Grand Rounds will resume September 10

Cancer Center Research in Progress Seminar will resume in September

Hematology and Oncology Special Seminar
Naoto Ueno, MD, PhD, FACP
Associate Professor, Medicine and Associate Internist, Breast Medical Oncology- Cancer Medicine
University of Texas MD Anderson Cancer Center
Topic: Molecular Changes and Targeted Therapy in Inflammatory Breast Cancer
8 am Wearn 137


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series
August 30
4-7 pm WRB 1-413

Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413


Advanced Training Institute on Health Behavior Theory
July 25-August 1
Madison, WI

Third Annual Golf Skills Clinic for Kids Kicking Cancer
August 2
Washington Golf Learning Center, Newburgh Heights, OH

2010 caBIG Annual Meeting: Building a Collaborative Biomedical Network
September 13-15
Washington, DC

Oncology Congress
October 15-17
San Francisco, CA

2010 Cleveland Nanomedicine Summit
October 18-19
InterContinental Hotel, Cleveland, OH
Clinical and research abstracts will be accepted through September 3

International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
October 18-19
Purdue University, West Lafayette, IN

ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
October 18-20
Hollywood, FL
Call for Abstracts

Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH


AACR Grant Funding

Applications are currently being accepted for the following AACR funding opportunities:

AACR-Genentech BioOncology Career Development Award for Cancer Research on the HER Family Pathway
Open to junior faculty in their first full-time faculty appointment. Proposed research projects must have direct applicability to the HER Family Pathway (basic, translational, clinical, or epidemiological cancer research). Applicants must have a medical degree or hold a combined M.D./Ph.D. and not currently be a candidate for a further doctoral or professional degree. Applicants must have completed postdoctoral studies or clinical fellowships no more than 4 years before the start of the grant term.
Deadline: August 10

AACR Judah Folkman Fellowship for Angiogenesis Research
Open to Postdoctoral and Clinical Research Fellows with a medical degree or a combined MD/PhD working at an academic, medical, or research institution within the United States, who will be in the first 5 years of their postdoctoral training at the start of the grant term. Proposed research projects are restricted to basic, clinical, translational or epidemiological projects that substantially advance the field of angiogenesis research in cancer.
Deadline: August 10

Raymond and Beverly Sackler AACR Fellowships for Ileal Carcinoid Tumor Research
Open to postdoctoral fellows and clinical research fellows working at an academic, medical, or research institution who will be in the first 5 years of their postdoctoral training at the start of the grant term. Applications are invited from researchers currently in the field as well as from investigators with experience in other areas of cancer research who have promising ideas or research approaches that can be applied to ileal carcinoid tumor research. It is anticipated that two fellowships will be funded. Proposed research may be basic, translational, clinical, or epidemiological in nature and must have direct application and relevance to ileal carcinoid tumors.
Deadline: September 15

Caring for Carcinoid Foundation–AACR Grants for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research
Represent a joint effort to promote and support innovative cancer research. These grants are available to independent junior and senior investigators to develop and study new ideas and approaches that have direct application and relevance to carcinoid tumors or pancreatic neuroendocrine tumors. Proposed research may be in any discipline of basic, translational, clinical, or epidemiological cancer research. Applications are invited from researchers currently in the field as well as from investigators with experience in other areas of cancer research who have promising ideas or research approaches that can be applied to carcinoid tumor and pancreatic neuroendocrine tumor research.
Deadline: September 15


Clinical Proteomic Technologies for Cancer (CPTC) 2010 Annual Meeting

The NCI will be hosting the Clinical Proteomic Technologies for Cancer's (CPTC) fourth annual meeting on September 8-9 at the Bethesda North Marriott Hotel & Conference Center in Maryland. This year's event, Establishing the Standards in Clinical Proteomics, will highlight key areas in which CPTC has made significant achievements, including an optimized proteomics pipeline, FDA regulatory science, international open data access policies, and highly-characterized affinity reagents.


Active Living Research 2011 Annual Conference

Active Living Research invites abstracts to be considered for presentation at the 2011 Annual Conference on February 22-24, 2011, in San Diego, CA. The theme of the 2011 conference, "Partnerships for Progress in Active Living: From Research to Action," recognizes the importance of engaging experts from multiple disciplines to address critical public health issues, especially active living and obesity.

ALR strongly encourages abstracts related to the conference theme and abstracts on research that generally informs strategies for increasing physical activity among children, especially those at greatest risk for obesity–Black, Latino, American Indian, Asian/Pacific Islander children and youths living in lower-income communities. Abstracts describing research results on all topics related to active living policies and environments also are welcome, as are abstracts with an international focus.

Active Living Research fourth annual "Translating Research to Policy Award"

Active Living Research is announcing the fourth annual "Translating Research to Policy Award" to recognize innovative teams or individuals representing research, policy and/or advocacy who have had success in catalyzing policy or environmental change of relevance to youth physical activity, sedentary behavior and obesity prevention. Our goal is to celebrate achievements, understand how success occurs, and share these stories so others will be inspired to use or adapt new and effective approaches. Nominations can illustrate the impact of research at any policy-making level, including schools, private sector organizations and local, state or federal government agencies or institutions. Examples of settings and topics that are relevant include schools, public or private recreation facilities, transportation, community built environment and the social/media environment.
Deadline: August 6


Susan G. Komen for the Cure Promise Grants
Pre Application Deadline: extended to August 10
Full Application Deadline: December 7

Alex's Lemonade Stand Foundation 'A' Award
Deadline: August 2

Alex's Lemonade Stand Foundation Nursing Grant Program
Deadline: August 2

DOD PRMRP Investigator-Initiated Research Award
Application Deadline: August 5

Mesothelioma Applied Research Foundation
Deadline: August 11

Avon Foundation for Women Breast Health Outreach Program
Deadline: August 27

Induced Pluripotent Stem Cell Pilot Research Award
Application Deadline: extended to August 31

IOTF Cancer Prevention Fellows
Application Deadline: September 1

ASCO Cancer Foundation Improving Cancer Care Grant, funded by Susan G. Komen for the Cure
Required LOI Deadline: September 1

DOD Peer Reviewed Cancer Research Program (PRCRP) Concept Award
Pre-Application Deadline: September 15
Application Deadline: September 29

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

DOD Peer Reviewed Cancer Research Program (PRCRP) Concept Award
Application Deadline: September 29

DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Awards
Application Deadline: October 20

DOD Peer Reviewed Cancer Research Program (PRCRP) Translational New Investigator Awards
Application Deadline: October 20

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

AACR Scholar-in-Training Awards - Special Conferences
Application Deadline varies

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Extension of Comment Period on the Proposed Rule applicable to Regulations on the Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors (NOT-OD-10-113)

Enhancing Peer Review: New NIH Policy on Post-Submission Application Materials (NOT-OD-10-115)

IACUC 101 and 201 PLUS Workshops: August 18-19, 2010 in San Francisco, CA (NOT-OD-10-116) National Institutes of Health

Biosafety in Microbiological and Biomedical Laboratories (BMBL): 5th Edition (NOT-OD-10-117)

Health Promotion Among Racial and Ethnic Minority Males (R01) (PA-10-236)

Health Promotion Among Racial and Ethnic Minority Males (R21) (PA-10-237)

Bioengineering Research Partnerships (BRP)[R01] (PAR-10-234)

Climate Change and Health: Assessing and Modeling Population Vulnerability to Climate Change (R21) (PAR-10-235)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.