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Case Comprehensive Cancer Center Newsletter

July 6, 2010


Case CCC Retreat: Thinking of Cancer as a Disease, Not a Cell Line

The focus of this year's retreat is on translational cancer research with a bias towards disease-based research efforts and cancer cohorts. We will feature a few new initiatives this year that are priorities for the Cancer Center. These reflect trends developing in funding efforts for the National Cancer Institute.

First, the trends coming out of NCI include an interest in focusing our basic research efforts towards identifying targets that may be useful for new drug development, understanding individual cancer susceptibility to specific cancer treatments or using pathways, genomics and other phenotypic characterizations for cancer risk prediction, prognosis and response to experimental as well as conventional treatments.

Presentations by new investigators recruited in the past year will start the program, followed by a luncheon breakout session for each Program to discuss "hot" science, and to consider the strategic direction of the Program. This will be followed by research presentations from the Cancer Signaling, Cancer Imaging, Cell Death Pathways, and Prevention and Control Programs. We will use this to prioritize resources, recruitment and program development to help us develop an overall strategic plan for the Cancer Center. We will continue to put resources into multi-investigator efforts in disease areas to encourage development of larger "team" science in cancer research. Reflecting this, we will have presentations on use of tissue-based research using biorepositories and the use of large cohorts for gene discovery.

Derek Raghavan, MD, PhD, will lead a discussion on Saturday morning on the recent experience from study section, with 4 of our members who sit on grant review committees who will comment on the new 12-page grant and how they are reviewed under the new review format. This will be invaluable for all of us submitting grants in the next year.

Our program includes 73 abstracts from trainees with viewing time throughout the retreat and after dinner poster discussions and evaluation with the 8-9 awards for outstanding posters.

I would like to thank the hard work of the Cancer Center administrative staff and the exceptional effort of the Retreat Planning Committee: Drs. Jill Barnholtz-Sloan, Greg Cooper, David Danielpour, Chris Flask, Ram Ganapathi, Candece Gladson, Danny Manor, Nathan Pennell, John Pink, and Zhenghe Wang.

See you at the retreat!

Stan Gerson, MD


2010 Ohio Cancer Research Associates Grant Awardees

Congratulations to the following Cancer Center Member recipients of 2010 Ohio Cancer Research Associates grant awards!

Barbara Bedogni, PhD [Skin Cancer]
Dissecting the role of the Notch signaling pathway in melanoma metastasis

David Wald, MD, PhD [Leukemia]
Characterization of a novel pathway to selectively target AML cells

Scott Welford, PhD [Radiation Oncology]
The impact of tissue hypoxia on tumor initiation


ASCO Cancer Foundation Improving Cancer Care Grant, funded by Susan G. Komen for the Cure

The ASCO Cancer Foundation® Improving Cancer Care Grant, funded by Susan G. Komen for the Cure®, will provide extramural research funding to address important issues regarding access to healthcare, quality of care, and delivery of care, with general applicability to breast cancer. The goal of this program is to encourage multi-disciplinary research that will have a major impact on cancer care, with general applicability in the breast cancer arena. This grant opportunity is part of the Susan G. Komen for the Cure/ASCO Cancer Foundation Research Initiative.

Required LOI Deadline: September 1



**All events are open to anyone interested in attending

July 5

July 6

July 7

Grand Rounds will resume July 14

July 8

July 9

Taussig Cancer Institute Grand Rounds will resume September 10

Cancer Center Research in Progress Seminar will resume in September

Case CCC Scientific Retreat
The Lodge at Sawmill Creek Resort

July 10

Case CCC Scientific Retreat
The Lodge at Sawmill Creek Resort


For a complete listing of LRI seminars click here.


Cancer Center Scientific Series
August 30
4-7 pm WRB 1-413

Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413


Business Education Course: "The Business of Regenerative Medicine: From Stem Cells to the Market Place"
July 12-15
Dively Building

Advanced Training Institute on Health Behavior Theory
July 25-August 1
Madison, WI

2010 caBIG Annual Meeting: Building a Collaborative Biomedical Network
September 13-15
Washington, DC

Oncology Congress
October 15-17
San Francisco, CA

International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
October 18-19
Purdue University, West Lafayette, IN

ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
October 18-20
Hollywood, FL
Call for Abstracts (Deadline: June 22)


American Cancer Society-Case Comprehensive Cancer Center Pilot Project Funding Opportunity

Pilot funding is available for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology.

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. For more information, please contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu.

IRG pilot project grants are intended to support independent, self-directed investigators early in their careers (assistant professor or equivalent). Applicants for the pilot project grants should be within 6 years of their first independent research or faculty appointment and eligible to apply for an independent national competitive research grant, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Letter of Intent Deadline: Monday, July 26
Application Deadline: Monday, August 9


Featured Article
Genome Studies Start to Unravel Prostate Cancer's Complexity

Cancer Research Highlights
Gefitinib Improves Progression-free Survival for Metastatic Lung Cancers with EGFR Mutations
Study Finds Poor Physician Adherence to Cervical Cancer Screening Guidelines
Targeted Drug Tested in Children with Recurrent Medulloblastoma
Vitamin D Concentrations in Blood Not Linked to Risk of Less Common Cancers
Cancer Survivors More Likely Than Peers to Forgo Medical Care Due to Cost

Guest Director's Update: Dr. Julia H. Rowland, Director, NCI Office of Cancer Survivorship
Cancer Survivorship Research Conference: Recovery and Beyond


DOD PRCRP Idea Awards
Pre-application Deadline: July 14
Application Deadline: October 20

DOD PRCRP Translational New Investigator Awards
Pre-application Deadline: July 14
Application Deadline: October 20

CTSC Pilot Funding for Comparative Effectiveness Research (CER) Infrastructure
Deadline: July 15

Administrative Supplements to Advance Special Translational Research Acceleration Projects on Immune Response Modifiers Currently Funded by NCI (NOT-CA-10-025)
Deadline: July 15

Susan G. Komen for the Cure Promise Grants
Pre Application Deadline: July 26
Full Application Deadline: December 1

Induced Pluripotent Stem Cell Pilot Research Award
Application Deadline: July 30

DOD PRMRP Investigator-Initiated Research Award
Application Deadline: August 5

Mesothelioma Applied Research Foundation
Deadline: August 11

IOTF Cancer Prevention Fellows
Application Deadline: September 1

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Awards
Application Deadline: October 20

DOD Peer Reviewed Cancer Research Program (PRCRP) Translational New Investigator Awards
Application Deadline: October 20

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 1

AACR Scholar-in-Training Awards - Special Conferences
Application Deadline varies

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Amendment: PAR-09-103: Centers for AIDS Research and Developmental Centers for AIDS Research (P30) (NOT-AI-10-033)

Advancing Novel Science in Womens Health Research (ANSWHR) (R21) (PAS-10-226)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.