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Case Comprehensive Cancer Center Newsletter

March 29, 2010

MESSAGE FROM THE DIRECTOR– NCI Sponsored Adaptive Design Clinical Trial in Breast Cancer

The latest issue of the "NCI Bulletin" features the report, I-SPY2: Breast-cancer Trial Aims to Speed Drugs to the Clinic, on the use of a creative adaptive design for drug evaluation in metastatic breast cancer based on biomarkers of disease. The investigator team is breaking out of the fixed drug randomization design to orient the trial towards the best fit profile of molecular biomarkers.

This study will enroll 300 women with advanced breast cancer who will receive novel agents based on their tumor profile. I have discussed with many of you the need to move towards this tumor marker approach to clinical trial and drug evaluation, and the need to develop patient centric studies on this basis. To be successful, we need to develop analytical tools to assess responses and comparisons. The potential is higher response rates, more rapid tests of hypotheses, termination of trials for which the specific relationship between target and drug does not result in responses, and development of databases on tumor markers and tumor responses.

This issue should be given consideration by basic, translational and clinical investigators, as well as our biostatisticians!

Stan Gerson, MD
Director, Case CCC


NCI Cancer Bulletin

Featured Article
I-SPY2: Breast Cancer Trial Aims to Speed Drugs to the Clinic

Cancer Research Highlights
Many Older Colorectal Cancer Patients Do Not Receive Adjuvant Chemotherapy

Drug Slows Progression of Cutaneous T-Cell Lymphoma

Prognostic Marker for Hodgkin Lymphoma Could Improve Care

Nanoparticle-based Therapy Triggers RNA Interference in Human Tumors

Guest Director's Update: Dr. Ann O'Mara and Andrea M. Denicoff
Improving Delivery of Quality Cancer Care


CASE CCC IN THE NEWS

ODAC Delays Approval of Omacetaxine to Treat Adult CML
HemOncToday - Mar 23, 2010
... of cells it was clinically irrelevant," said Mikkael Sekeres, MD, MS, associate professor of medicine at the Cleveland Clinic Taussig Cancer Institute. ...


CALL FOR APPLICATIONS– Cancer Research Training Award

The NCI is pleased to request applications from qualified candidates for a Cancer Research Training Award (CRTA). The CRTA provides an outstanding opportunity for an individual with a strong interest in understanding how cancer care and cancer control activities influence patterns of care and trends in cancer, specifically in the fields of cancer screening and the use of biomarkers in population-based research. The CRTA appointment is a one- or two-year position with the Applied Research Program, Division of Cancer Control and Population Sciences of the NCI.

This position provides an exciting and unique opportunity to work with leaders in the fields of diet, weight, and physical activity related to cancer and other chronic diseases. The position will allow contact with a large number of scientists representing disciplines of epidemiology, nutritionists, assessment, clinicians, policy researchers, and other cross-cutting arenas of application.

The position is opened until filled. For further information, please click here.


MESSAGE FROM DR. ERNEST BORDEN– CEC Pilot Studies

As you are likely aware, the Veridex technology can be applied to the assessment of a population of circulating endothelial cells (CECs). We have now established from our own completed pilot studies a normal range for circulating endothelial cells. About 70% of patients with active cancer have values above this range. This is consistent with the published research data issued by Veridex. The expressed endothelial proteins used to detect these cells are different than those used to detect circulating tumor cells.

There are few published research reports yet which have assessed changes after any therapeutic interventions in cancer --- chemotherapy, biologicals, TKI, radiation, or surgery. Or how these change with tumor reduction? Furthermore little or nothing is known about CEC levels in primary disease vs. metastasis --- or metastasis in different locations, e.g. bone vs. liver? And whether the current markers being used, which assess a more mature endothelial cell population, are the correct ones? Finally whether or not a measure of the % of captured endothelial cells is mitotically active would give more information?

We still have several opportunities open for pilot study ideas, and I would be willing to discuss your ideas with you via email or phone.

We will ultimately require you to submit the following information (limited to 1 page) to John Pellecchia:

  • PI
  • Study Title and Objective/Rationale (Tumor-type, therapeutic intervention/schedule)
  • Eligible patients; desired number of samples (<15)
  • Plans for obtaining external support (NIH, pharma, foundation based) for definitive study
  • Contact information for research RN for scheduling and consenting purposes

If you have any questions please do not hesitate to discuss with John Pellecchia or myself. Final approval to proceed with your pilot study will be granted by Derek Raghavan and myself, and should normally be available within a week of submission.

Ernest Borden, MD
216.444.8183
bordene@ccf.org


MARK YOUR CALENDARS– Clinical Development of Stem Cell Therapies: Scientific, Regulatory and Ethical Considerations

Join representatives from academia, industry, and regulatory agencies to analyze the transitional process from discovery and regulatory approval to the therapeutic use of stem cell products at the upcoming symposium, Clinical Development of Stem Cell Therapies: Scientific, Regulatory and Ethical Considerations, April 12-13 in Bethesda, MD. Experts will present specific examples of, and solutions for, issues related to the preclinical, CMC, and clinical stages of development for stem cell products.

For more information, please click here.

EVENTS

**All events are open to anyone interested in attending

March 29

SDIG Meeting
David Serre, PhD
Assistant Staff, Genomic Medicine Institute
CWRU/ Cleveland Clinic
Topic: Analyzing RNA-seq Data
2:30 pm WRB 1-413


March 30

Immunology Seminar
Jim Kazura, MD
Professor, Medicine and International Health
Director, Center for Global Health and Diseases
CWRU/ UH
Topic: Validating Targets of Naturally Acquired Immunity to Malaria During the Epidemiological Transition in Africa
12 pm WRB 1-413


March 31

Grand Rounds
Barbara Daly, PhD, RN
Associate Professor, Nursing
CWRU/ UH
Topic: Transitions in Goals of Care: Right Message, Right Time, Right Words
8 am Lerner B-151

CSCRM Lunch and Learn Seminar
Jerry Ortolano, PhD
Senior VP Scientific Affairs
Pall Medical
Topic: Enabling Translational Medicine Using Filter-Based Cell Recovery Tools
12-2 pm WRB 2-136

Pathology Graduate Student Seminar
Julie Wolfram
Lee/Smith Labs
CWRU/ UH
Topic: The Role of Myc in Hypertrophic Cardiomyopathy
12 pm WRB 1-413

Pathology Dissertation Defense
Rocky Cipriano
Stark Lab
CWRU/ Cleveland Clinic
Topic: Discovery of a Novel Family of Oncogenes Using a Validation-Based Forward Genetic Strategy
2 pm WRB 3-136


April 1

Neurosciences Alumna Seminar
Lori Taylor, PhD
Elan Pharmaceuticals
Topic: Tysabri (natalizumab): A Unique Therapy for Multiple Sclerosis
12:10 pm BRB 105


April 2

Taussig Cancer Institute Grand Rounds canceled

Hem/Onc Fellows Seminar
Margaret Liotta, MD
Fellow, Gynecologic Oncology
CWRU/ UH
Topic: Chemotherapy in Ovarian Cancer
8 am Wearn 137

Cancer Center Seminar Series/ Blood Club
Ann Schwartz, PhD, MPH
Professor, Internal Medicine
Karmanos Cancer Institute/Wayne State University School of Medicine
Topic: Genetic Susceptibility to Lung Cancer
12 pm BRB 105

Cancer Center Research in Progress Seminar
Mark Jackson, PhD
Assistant Professor, Pathology
CWRU/ UH
Topic: Discovery of Novel Cancer-Associated Proteins Using Forward Genetics
4 pm WRB 3-136

more

For a complete listing of LRI seminars click here.


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Women's Cancer: Screening and Prevention in 2010
May 7
Hilton Cleveland East, Beachwood
Details

Case CCC Scientific Retreat
July 9-10
The Lodge at Sawmill Creek Resort


ADDITIONAL UPCOMING SEMINARS & EVENTS

Midwest Tissue Engineering Consortium (M-TEC) Annual Meeting
April 16-17
Wolstein Research Building and Hovorka Atrium
Details

AACR 101st Annual Meeting
April 17-21
Washington, DC
Details

Midwest Blood Club Symposium
May 6-7
Indiana University School of Medicine
Details

CTTE 2010 Short Course: "Cell-Based Therapies & Tissue Engineering"
May 17-20
Clapp and Millis Hall
Detail

Business Education Course: "The Business of Regenerative Medicine: From Stem Cells to the Market Place"
July 12-15
Dively Building
Details

Advanced Training Institute on Health Behavior Theory
July 25-August 1
Madison, WI
Details


MARK YOUR CALENDARS– Women's Cancer: Screening and Prevention in 2010

Registration is open for the Case CCC Symposium, Women's Cancer: Screening and Prevention in 2010, May 7 at the Hilton Cleveland East in Beachwood.

Course Overview: Early detection of cancer saves lives. Controversy exists regarding guidelines for cancer screening in women. Mammograms are not consistently obtained and women do not participate in colon cancer screening as frequently as men. Educating practitioners to the benefits of breast, cervical, endometrial, and colorectal cancer screening could help promote health practices. The indications for genetic testing for breast and ovarian cancer susceptibility will be discussed. While practitioners generally understand the harms and benefits of postmenopausal hormone replacement therapy, the specific outcomes with respect to breast and uterine cancer merit further exploration. Discussion of health choices (weight-reduction surgery, prophylactic mastectomy, smoking cessation) and their role in cancer prevention will aid practitioners in guiding patients.

Click here to register and view the brochure. CME credits are available.



FACULTY CANDIDATE SEARCH– Associate Director for Basic Research

The Case CCC is currently accepting applications for the position of Associate Director for Basic Research. As we continue our search, we ask that people in the Cancer Center community encourage any qualified candidate to apply for the position. If you would like to nominate someone for the position, please contact Tracy Rehl (tracy.rehl@case.edu).

Click here to view the job description.


CASE CCC ON FACEBOOK AND LINKEDIN– Join Us!

We are always trying to foster communication and collaboration across the cancer center community any way that we can. The Case CCC has set up a page on Facebook and LinkedIn, so please become a fan of us on Facebook or join our group on LinkedIn, and encourage others to do so as well. Please help us spread the word.

We encourage you to post events, relevant news articles, items of discussion, etc… Your feedback is appreciated!

PREVIOUSLY ANNOUNCED OPPORTUNITIES

DOD Prostate Cancer Research Program (PCRP) Exploration–Hypothesis Development Award
Application Deadline: March 31

DOD Prostate Cancer Research Program (PCRP) Impact Award
Application Deadline: March 31

Larry and Helen Hoag Foundation 2010 Clinical Translational Research Career Development Awards in Pediatric Cancer
Deadline: April 1

ACS Postdoctoral Fellowships
Deadline: April 1

ACS Mentored Research Scholar Grants in Applied and Clinical Research
Deadline: April 1

ACS Research Scholar Grants A. In Basic, Preclinical and Epidemiology Research (includes Senior Investigators for this Special Initiative)
Deadline: April 1

ACS Research Scholar Grants B. In Health Policy and Health Services Research
Deadline: April 1

ACS Research Scholar Grants C. In Psychosocial and Behavioral Research
Deadline: April 1

ACS Postdoctoral Fellowships
Deadline: April 1

ACS: Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection, and Treatment
Deadline: April 1

CTSC Pilot Grants
CWRU, UH and MetroHealth Deadline: April 1
Cleveland Clinic Deadline: April 13

DOD BCRP Predoctoral Traineeship Award
Application Deadline: April 7

DOD BCRP Postdoctoral Fellowship Award
Application Deadline: April 7

DOD BCRP Era of Hope Scholar Award
Application Deadline: April 7

DOD BCRP Innovator Award
Application Deadline: April 7

DOD Peer Reviewed Medical Research Program (PRMRP) Concept Award
Application Deadline: April 8

DOD BCRP Idea Award
Pre-Application Deadline: April 21
Application Deadline: May 5

DOD Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Awards
Pre-Application Deadline: April 22
Application Deadline: May 13

DOD Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award
Pre-Application Deadline: April 22
Application Deadline: May 13

DOD NFRP Clinical Trial Award
Pre-Application Deadline: April 29
Application Deadline: May 20

DOD NFRP Investigator-Initiated Research Award
Pre-Application Deadline: April 29
Application Deadline: May 20

DOD NFRP Investigator-Initiated Focused Research Award
Pre-Application Deadline: April 29
Application Deadline: May 20

DOD NFRP Exploration–Hypothesis Development Award
Pre-Application Deadline: April 29
Application Deadline: May 20

DOD NFRP New Investigator Award
Pre-Application Deadline: April 29
Application Deadline: May 20

DOD NFRP Postdoctoral Traineeship Award
Pre-Application Deadline: April 29
Application Deadline: May 20

ASH Junior Faculty Scholar Award
LOI Deadline: May 1

ASH Fellow Scholar Award
LOI Deadline: May 1

DOD BCRP Idea Award
Application Deadline: May 5

DOD PCRP Health Disparity Research Award
Pre-Application Deadline: May 5
Application Deadline: May 26

DOD PCRP Health Disparity Training Award
Pre-Application Deadline: May 5
Application Deadline: May 26

DOD PCRP Laboratory - Clinical Transition Award
Pre-Application Deadline: May 5
Application Deadline: May 26


DOD PCRP Physician Research Training Award
Pre-Application Deadline: May 5
Application Deadline: May 26

DOD PCRP Population-Based Research Award
Pre-Application Deadline: May 5
Application Deadline: May 26

DOD PCRP Prostate Cancer Training Award
Pre-Application Deadline: May 5
Application Deadline: May 26

DOD Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award
Application Deadline: May 13

DOD Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Awards
Application Deadline: May 13

DOD NFRP Clinical Trial Award
Application Deadline: May 20

DOD NFRP Investigator-Initiated Research Award
Application Deadline: May 20

DOD NFRP Investigator-Initiated Focused Research Award
Application Deadline: May 20

DOD NFRP Exploration–Hypothesis Development Award
Application Deadline: May 20

DOD NFRP New Investigator Award
Application Deadline: May 20

DOD NFRP Postdoctoral Traineeship Award
Application Deadline: May 20

DOD PCRP Health Disparity Research Award
Application Deadline: May 26

DOD PCRP Health Disparity Training Award
Application Deadline: May 26

DOD PCRP Laboratory - Clinical Transition Award
Application Deadline: May 26

DOD PCRP Physician Research Training Award
Application Deadline: May 26

DOD PCRP Population-Based Research Award
Application Deadline: May 26

DOD PCRP Prostate Cancer Training Award
Application Deadline: May 26

IOTF Oncology Product Research/Review Fellows
Deadline: May 30

Damon Runyon-Rachleff Innovation Award
Pre-Proposal Deadline: June 1

DOD Prostate Cancer Research Program (PCRP) Idea Development Awards
Application Deadline: June 9

DOD Prostate Cancer Research Program (PCRP) Synergistic Idea Development Awards
Application Deadline: June 9

DOD Ovarian Cancer Research Program (OCRP) Translational Pilot Award
Application Deadline: June 10

DOD BCRP Inter-Institutional Training Award
Application Deadline: June 23

DOD BCRP Multi-Team Award
Application Deadline: June 23

DOD BCRP Transformative Vision Award
Application Deadline: June 23

DOD Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award
Application Deadline: August 5

IOTF Cancer Prevention Fellows
Deadline: September 1

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Notice of Termination of Selected Research Training and Research Career Development Award Funding Opportunity Announcements (NOT-OD-10-069)

Final Ruth L. Kirschstein National Research Service Award (Kirschstein-NRSA) Policy for Tuition, Fees, and Health Insurance on Training Grants and Fellowships (NOT-OD-10-073)

Correction of Council Review Dates for PAR-08-147, Quick-Trials for Imaging and Image-Guided Interventions: Exploratory Grants (R21) (NOT-CA-10-020)

Diet Composition and Energy Balance (R01) (PA-10-152)

Paul Calabresi Career Development Award for Clinical Oncology (K12) (PAR-10-155)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.